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9c7r

Diheteromeric GluN1/GluN2A (M817V) in digitonin complexed with glycine, glutamate, and GNE-4123

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Glutamate receptor ionotropic, NMDA 1, Green fluorescent protein chimera

Rattus norvegicus

UniProt P35439

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 4 其他Polymer 20 Glutamate receptor ionotropic, NMDA 2A, Green fluorescent protein chimera × 2 （P42212,Q00959） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 20 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1pb7 1pb8 1pb9 1pbq 1pbq 1y1m 1y1m 1y1z 1y20 4kfq 4kfq 6ove

12 assemblies

Homodimer
1y1m 3q41 3q41 4kcc

4 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2a5t 4nf4 4nf5 4nf6 4nf8 4pe5 5dex 5fxg 5fxh 5fxi 5fxj 5fxk

105 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name NMDZ1_RAT
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–847； UniProt 1–847 Author chain C； PDBConstruct 1–847； UniProt 1–847

Glutamate receptor ionotropic, NMDA 1, Green fluorescent protein chimera

Rattus norvegicus

UniProt P42212

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 4 其他Polymer 20 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 20 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1bfp 1c4f 1cv7 1ema 1emb 1emg 1f09 1f0b 1gfl 1gfl 1h6r 1h6r

379 assemblies; showing the first 12

Homodimer
1eme 1emf 1emk 1eml 1emm 1kp5 1kp5 1kp5 1myw 2b3q 2b3q 2emd

31 assemblies; showing the first 12

Homotetramer
1b9c 1emc 1hcj 1hcj 1kp5 1kp5 1w7s 1w7t 2ah8 5mse

10 assemblies

Other homooligomers
1w7u 5hbd 5hge 5hw9 6as9 6mdr

6 assemblies

Heteromeric or nucleic-acid complex
2jad 3ek4 3ek7 3ek8 3ekh 3ekj 3evr 3evu 3evv 3g9a 3k1k 3k1k

319 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name GFP_AEQVI
Isoform —
PDB entities 1, 2
Chains and sequence ranges Author chain A； PDBConstruct 859–1095； UniProt 2–238 Author chain C； PDBConstruct 859–1095； UniProt 2–238 Author chain B； PDBConstruct 878–1114； UniProt 2–238 Author chain D； PDBConstruct 878–1114； UniProt 2–238

Glutamate receptor ionotropic, NMDA 2A, Green fluorescent protein chimera

Aequorea victoria

UniProt Q00959

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 4 其他Polymer 20 Glutamate receptor ionotropic, NMDA 1, Green fluorescent protein chimera × 2 （P35439,P42212） 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose × 20 2-acetamido-2-deoxy-beta-D-glucopyranose × 15 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
2a5s 6ove

2 assemblies

Homodimer
2a5s

1 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2a5t 4nf4 4nf5 4nf6 4nf8 5dex 5i56 5i57 5i58 5i59 5jty 5tpw

59 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name NMDE1_RAT
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–877； UniProt 1–866 Author chain D； PDBConstruct 1–877； UniProt 1–866

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id9c7r
Deposition date deposition_date2024-06-11
Structure title titleDiheteromeric GluN1/GluN2A (M817V) in digitonin complexed with glycine, glutamate, and GNE-4123
Keywords keywordsion channel, NMDA, positive allosteric modulator, pre-open pore conformation, TRANSPORT PROTEIN; TRANSPORT PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9c7r__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9c7r__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

9c7r__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）53.16 Å
Rg (electron density)53.51 Å
Total Rg53.54 Å
Atom count25867
Residues3173
Excluded volume462940 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 9c7r__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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7. Citations (1)