HER2/ErbB2 extracellular domain (ECD) from a near full-length construct solubilized in amphipols.

Method: ELECTRON MICROSCOPY D_max: 86.0 Å Quality: EXCELLENT

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9qbh
deposition_date	2025-03-02
last_revision	2025-08-13
title	HER2/ErbB2 extracellular domain (ECD) from a near full-length construct solubilized in amphipols.
keywords	Receptor, tyrosine kinase, transmembrane, HER2, SIGNALING PROTEIN; SIGNALING PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	26.90 Å
rg_electron	25.79 Å
i0	56944000.00
molecular_weight	56044.0 kDa
excluded_volume	68995 Å³
envelope_volume	84665 Å³
shell_volume	27875 Å³
envelope_diameter	89.5 Å
shell_rg	32.57 Å
envelope_rg	25.96 Å
shape_rg	25.75 Å
total_rg	26.61 Å
total_atoms	7682
n_residues	508
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	86.0 Å
rg_real	26.85 Å
rg_real_error	0.58 Å
i0_real	5.6940e+07
i0_real_error	7.5680e+05
rg_reciprocal	26.87 Å
i0_reciprocal	56940000.0000
total_estimate	0.9053
solution_quality	EXCELLENT a EXCELLENT solution
n_peaks	2
r_peak_primary	29.1 Å
skewness	0.251
kurtosis	-0.529
angular_range	— – 0.2950 Å⁻¹
current_alpha	0.0000
highest_alpha	4567000.0000
n_real_points	60
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.936; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.989; Smooth: 0.969

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4. Crystallography & Experiment

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5. Entities & Polymer Info (1)

Entity 1 polymer

description	Receptor tyrosine-protein kinase erbB-2,Green fluorescent protein
formula_weight	146737.2 kDa
ec_number	2.7.10.1
mutation	Del1-22,Del1030-1255,C789S,C805S,C965S.
src_method	man
entity_count	1

Polymer

type	polypeptide(L)
strand_id	A
atom_count	7682

MKFLVNVALVFMVVYISYIYADYKDDDDKHHHHHHHHHHLEVLFQGPYPYDVPDYATQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQRASPLTSIISAVVGILLVVVLGVVFGILIKRRQQKIRKYTMRRLLQETELVEPLTPSGAMPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGISLTSTVQLVTQLMPYGSLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSESRPRFRELVSEFSRMARDPQRFVVIQNEDLGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGLEVLFQGPGSMSKGEELFTGVVPILVELDGDVNGHKFSVRGEGEGDATNGKLTLKFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKRHDFFKSAMPEGYVQERTISFKDDGTYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNFNSHNVYITADKQKNGIKANFKIRHNVEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSVLSKDPNEKRDHMVLLEFVTAAGITHGMDELYK

Source

organism	Aequorea victoria
ncbi_taxonomy_id	6100
host_organism	Spodoptera frugiperda

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.77 Å
resolution_method	—
num_particles	364430

fit	/app/data/saxs_computation/qb/9qbh/9qbh.fit
pddf	/app/data/pr_computation/qb/9qbh/9qbh.pr.out
profile	/app/data/saxs_computation/qb/9qbh/9qbh.dat

HER2/ErbB2 extracellular domain (ECD) from a near full-length construct solubilized in amphipols.

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

EM 3D

5. Entities & Polymer Info (1)

Entity 1 polymer

Polymer

Source

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)