当前蛋白身份:P41212 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
1JI7 Crystal Structure of TEL SAM Polymer 提交 2001-06-29 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 47–123(77 aa) 片段:TEL SAM domain
链 B 47–123(77 aa) 片段:TEL SAM domain
链 C 47–123(77 aa) 片段:TEL SAM domain
非标准单体:是(mmCIF未提供具体位点) 非标准单体:是(mmCIF未提供具体位点) 非标准单体:是(mmCIF未提供具体位点) SO4 SULFATE ION × 5 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8;298 K;Li2SO4, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 1.45 Å R-free 0.195
1LKY Structure of the wild-type TEL-SAM polymer 提交 2002-04-26 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 47–123(77 aa) 片段:Pointed domain
链 B 47–123(77 aa) 片段:Pointed domain
链 C 47–123(77 aa) 片段:Pointed domain
链 D 47–123(77 aa) 片段:Pointed domain
链 E 47–123(77 aa) 片段:Pointed domain
链 F 47–123(77 aa) 片段:Pointed domain
突变:V80R 突变:A61D 突变:V80R 突变:A61D 突变:V80R 突变:A61D SO4 SULFATE ION × 11 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8.5;298 K;5% PEG 4000 2.0 M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.30 Å R-free 0.283
1LKY Structure of the wild-type TEL-SAM polymer 提交 2002-04-26 Assembly 2 蛋白同源多聚体 同源多聚体;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 47–123(77 aa) 片段:Pointed domain
链 B 47–123(77 aa) 片段:Pointed domain
链 C 47–123(77 aa) 片段:Pointed domain
链 D 47–123(77 aa) 片段:Pointed domain
链 E 47–123(77 aa) 片段:Pointed domain
链 F 47–123(77 aa) 片段:Pointed domain
突变:V80R 突变:A61D 突变:V80R 突变:A61D 突变:V80R 突变:A61D SO4 SULFATE ION × 11 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8.5;298 K;5% PEG 4000 2.0 M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.30 Å R-free 0.283
1LKY Structure of the wild-type TEL-SAM polymer 提交 2002-04-26 Assembly 3 蛋白同源多聚体 同源多聚体;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 47–123(77 aa) 片段:Pointed domain
链 B 47–123(77 aa) 片段:Pointed domain
链 C 47–123(77 aa) 片段:Pointed domain
链 D 47–123(77 aa) 片段:Pointed domain
链 E 47–123(77 aa) 片段:Pointed domain
链 F 47–123(77 aa) 片段:Pointed domain
突变:V80R 突变:A61D 突变:V80R 突变:A61D 突变:V80R 突变:A61D SO4 SULFATE ION × 11 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8.5;298 K;5% PEG 4000 2.0 M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.30 Å R-free 0.283
1LKY Structure of the wild-type TEL-SAM polymer 提交 2002-04-26 Assembly 4 蛋白同源多聚体 同源多聚体;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 47–123(77 aa) 片段:Pointed domain
链 B 47–123(77 aa) 片段:Pointed domain
链 C 47–123(77 aa) 片段:Pointed domain
链 D 47–123(77 aa) 片段:Pointed domain
链 E 47–123(77 aa) 片段:Pointed domain
链 F 47–123(77 aa) 片段:Pointed domain
突变:V80R 突变:A61D 突变:V80R 突变:A61D 突变:V80R 突变:A61D SO4 SULFATE ION × 11 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8.5;298 K;5% PEG 4000 2.0 M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.30 Å R-free 0.283
1LKY Structure of the wild-type TEL-SAM polymer 提交 2002-04-26 Assembly 5 蛋白同源多聚体 同源多聚体;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 47–123(77 aa) 片段:Pointed domain
链 B 47–123(77 aa) 片段:Pointed domain
链 C 47–123(77 aa) 片段:Pointed domain
链 D 47–123(77 aa) 片段:Pointed domain
链 E 47–123(77 aa) 片段:Pointed domain
链 F 47–123(77 aa) 片段:Pointed domain
突变:V80R 突变:A61D 突变:V80R 突变:A61D 突变:V80R 突变:A61D SO4 SULFATE ION × 11 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8.5;298 K;5% PEG 4000 2.0 M ammonium sulfate, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 2.30 Å R-free 0.283
2DAO Solution structure of ETS domain Transcriptional factor ETV6 protein 提交 2005-12-14 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 338–442(105 aa) 片段:ETS domain
未记录 未记录非水小分子 SOLUTION NMR
NMR测量条件 pH 7;296 K;离子强度(mmCIF原始值)120;压力 ambient
NMR样品组成 1.19mM ETS domain U-15N, 13C; 20mM d-Tris-HCl(pH 7.0); 100mM NaCl; 1mM d-DTT; 0.02% NaN3; 90%H2O, 10%D2O | 90% H2O/10% D2O
分辨率未提供
2QB0 Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker. 提交 2007-06-15 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 47–123(77 aa)
链 D 47–123(77 aa)
突变:E80V MN MANGANESE (II) ION × 2 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.56 Å R-free 0.252
2QB0 Structure of the 2TEL crystallization module fused to T4 lysozyme with an Ala-Gly-Pro linker. 提交 2007-06-15 Assembly 2 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 47–123(77 aa)
链 C 47–123(77 aa)
突变:E80V MN MANGANESE (II) ION × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 2.56 Å R-free 0.252
5L0P Symmetry-based assembly of a two-dimensional protein lattice 提交 2016-07-27 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 47–124(78 aa) 片段:3 x TelSAM (UNP residues 47-124) + FUR (UNP residues 3-83) with connecting linkers
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8;290 K;100 mM Tris, pH 8.0, 3.5 M sodium chloride
分辨率 2.30 Å R-free 0.236
7JU2 Crystal structure of the monomeric ETV6 PNT domain 提交 2020-08-19 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 43–125(83 aa) 片段:PNT domain
突变:A93D,V112E FMT FORMIC ACID × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298.15 K;2.8 M Sodium Acetate
分辨率 1.85 Å R-free 0.234
7JU2 Crystal structure of the monomeric ETV6 PNT domain 提交 2020-08-19 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 43–125(83 aa) 片段:PNT domain
突变:A93D,V112E FMT FORMIC ACID × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298.15 K;2.8 M Sodium Acetate
分辨率 1.85 Å R-free 0.234
7N1O The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone 提交 2021-05-27 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 46–123(78 aa)
突变:1TEL: R41A,D46G,V112E,K122A,vWa: R49A,C175A,V112A,K112A MG MAGNESIUM ION × 1 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.7;298 K;100 mM BisTris, 3.0 M NaCl
分辨率 2.77 Å R-free 0.228
7N2B A DARPin semi-rigidly fused to the 3TEL crystallization chaperone 提交 2021-05-28 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–121(75 aa)
链 A 47–124(78 aa)
突变:V67E 突变:V67E 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.4;298 K;200 mM L-Proline, 100 mM HEPES, 10 % w/v Polyethylene glycol 3350
分辨率 3.22 Å R-free 0.242
7N2B A DARPin semi-rigidly fused to the 3TEL crystallization chaperone 提交 2021-05-28 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 47–121(75 aa)
链 B 47–124(78 aa)
突变:V67E 突变:V67E 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.4;298 K;200 mM L-Proline, 100 mM HEPES, 10 % w/v Polyethylene glycol 3350
分辨率 3.22 Å R-free 0.242
7T8J The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL crystallization chaperone via a GSGG linker 提交 2021-12-16 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–121(75 aa)
突变:R80S,V112E,C610A,C644A CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;1.2 uL of 1 mg/mL protein in 50 mM Tris pH 8.8, 200 mM KCl combined with 1.2 uL of 100 mM Bis-tris-propane, 2.5 M Ammonium Nitrate
分辨率 1.89 Å R-free 0.235
7TDY The ubiquitin-associated domain of human thirty-eight negative kinase 1, flexibly fused to the 1TEL crystallization chaperone via a 2-glycine linker and crystallized at low protein concentration 提交 2022-01-03 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–120(74 aa)
突变:R80S,V112E,C610A,C644A FMT FORMIC ACID × 6 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;1.2 uL of 2 mg/mL protein combined with 1.2 uL of 100 mM Bis-Tris, pH 7.00, 250 mM Mg-Formate.
分辨率 1.53 Å R-free 0.217
7TW7 Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SAM 提交 2022-02-06 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–123(77 aa)
突变:A4R, E67V, A77K ZN ZINC ION × 1 SAM S-ADENOSYLMETHIONINE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.5;293.15 K;11-17% Reagent Alcohol, 0.1-0.3M Lithium Sulfate, and 0.1M Sodium Citrate pH 5.5
分辨率 1.62 Å R-free 0.218
7TW8 Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SAH 提交 2022-02-06 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–123(77 aa)
突变:A4R, E67V, A77K SAH S-ADENOSYL-L-HOMOCYSTEINE × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.5;293.15 K;11-17% Reagent Alcohol, 0.1-0.3M Lithium Sulfate and 0.1M Sodium Citrate pH 5.5
分辨率 1.55 Å R-free 0.206
7TW9 Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to Sinefungin 提交 2022-02-06 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–123(77 aa)
突变:A4R, E67V, A77K SFG SINEFUNGIN × 1 ZN ZINC ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 EOH ETHANOL × 1 MOH METHANOL × 5 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.5;293.15 K;11-17% Reagent Alcohol, 0.1-0.3M Lithium Sulfate, and 0.1M Sodium Citrate pH 5.5
分辨率 1.41 Å R-free 0.232
7U4W The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL crystallization chaperone via a 2-glycine linker and crystallized at traditional protein concentration 提交 2022-03-01 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–121(75 aa)
突变:R80S,V112E,C610A,C644A 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;298 K;1.2 uL of 15 mg/mL protein combined with 1.2 uL of 100 mM Bis-Tris, pH 6.50, 750 mM Mg-Formate
分辨率 2.10 Å R-free 0.276
7U4Z The ubiquitin-associated domain of human thirty-eight negative kinase-1 flexibly fused to the 1TEL crystallization chaperone via a 2-glycine linker and crystallized at very low protein concentration 提交 2022-03-01 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–121(75 aa)
突变:R80S,V112E,C610A,C644A K POTASSIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;298 K;1.2 uL of 0.5 mg/mL protein combined with 1.2 uL of 100 mM Bis-Tris, pH 6.00, 630-750 mM Mg-Formate.
分辨率 2.03 Å R-free 0.232
8BWU Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the SS148 inhibitor 提交 2022-12-07 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–123(77 aa)
未记录 6NR (2~{S})-2-azanyl-4-[[(2~{S},3~{S},4~{R},5~{R})-5-(4-azanyl-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;291 K;100 mM bicine/Trizma pH 8.5; 10% w/v PEG 20.000, 20% v/v PEG MME 550; 20 mM D-glucose, 20 mM D-mannose, 20 mM D-galactose, 20 mM L-fucose, 20 mM D-xylose, 20 mM N-acetyl-D-glucosamine
分辨率 2.36 Å R-free 0.264
8E1F Sterile Alpha Motif Domain of Human Translocation ETS Leukemia, Non-Polymer Crystal Form 提交 2022-08-10 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–124(78 aa) 片段:Sterile Alpha Motif Domain, residues 47-126
突变:R35S, V67E CL CHLORIDE ION × 1 SO4 SULFATE ION × 1 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.9;298 K;200mM MgSO4 Heptahydrate, 20% w/v Polyethylene Glycol 3,350
分辨率 2.16 Å R-free 0.229
8E1F Sterile Alpha Motif Domain of Human Translocation ETS Leukemia, Non-Polymer Crystal Form 提交 2022-08-10 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 47–124(78 aa) 片段:Sterile Alpha Motif Domain, residues 47-126
突变:R35S, V67E CL CHLORIDE ION × 1 SO4 SULFATE ION × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.9;298 K;200mM MgSO4 Heptahydrate, 20% w/v Polyethylene Glycol 3,350
分辨率 2.16 Å R-free 0.229
8E1F Sterile Alpha Motif Domain of Human Translocation ETS Leukemia, Non-Polymer Crystal Form 提交 2022-08-10 Assembly 3 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 47–124(78 aa) 片段:Sterile Alpha Motif Domain, residues 47-126
突变:R35S, V67E CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.9;298 K;200mM MgSO4 Heptahydrate, 20% w/v Polyethylene Glycol 3,350
分辨率 2.16 Å R-free 0.229
8E1F Sterile Alpha Motif Domain of Human Translocation ETS Leukemia, Non-Polymer Crystal Form 提交 2022-08-10 Assembly 4 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 D 47–124(78 aa) 片段:Sterile Alpha Motif Domain, residues 47-126
突变:R35S, V67E MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.9;298 K;200mM MgSO4 Heptahydrate, 20% w/v Polyethylene Glycol 3,350
分辨率 2.16 Å R-free 0.229
8FRJ Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC0946 提交 2023-01-07 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–123(77 aa)
突变:A4R, E67V, A77K ZN ZINC ION × 1 AW2 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.5;293.15 K;11-17% Reagent Alcohol, 0.1-0.3M Lithium Sulfate and 0.1M Sodium Citrate pH 5.5
分辨率 1.57 Å R-free 0.204
8FRK Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC8158 提交 2023-01-07 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–123(77 aa)
突变:A4R,E67V,A77K ZN ZINC ION × 1 EOH ETHANOL × 1 MJ7 5'-S-(4-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}butyl)-5'-thioadenosine × 1 K POTASSIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.5;293.15 K;11-17% Reagent Alcohol, 0.1-0.3M Lithium Sulfate and 0.1M Sodium Citrate pH 5.5
分辨率 1.61 Å R-free 0.251
8FT6 The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Ala-Ala linker variant, SUMO tag-free preparation. 提交 2023-01-11 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–124(78 aa)
突变:R14A,V77E,K87A,R89A,R91A,A225V CIT CITRIC ACID × 1 IOD IODIDE ION × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;0.2M Ammonium citrate tribasic, 20% w/v PEG 3350
分辨率 2.62 Å R-free 0.234
8FT8 The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Thr-Val linker variant, SUMO tag-free preparation 提交 2023-01-11 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–124(78 aa)
突变:R14A,V77E,K87A,R89A,R91T,A92V,A225V GOL GLYCEROL × 1 CL CHLORIDE ION × 3 K POTASSIUM ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;0.1M HEPES, 2.0M ammonium sulfate
分辨率 1.60 Å R-free 0.204
8FZ3 Sterile Alpha Motif of Human Translocation ETS Leukemia, Non-Polymer Crystal Form 提交 2023-01-27 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–123(77 aa)
突变:R45S, V77E CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.2;298 K;1.4 M Sodium phosphate monobasic monohydrate/Potassium phosphate dibasic pH 8.2
分辨率 2.78 Å R-free 0.267
8FZ3 Sterile Alpha Motif of Human Translocation ETS Leukemia, Non-Polymer Crystal Form 提交 2023-01-27 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 47–123(77 aa)
突变:R45S, V77E PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.2;298 K;1.4 M Sodium phosphate monobasic monohydrate/Potassium phosphate dibasic pH 8.2
分辨率 2.78 Å R-free 0.267
8FZ3 Sterile Alpha Motif of Human Translocation ETS Leukemia, Non-Polymer Crystal Form 提交 2023-01-27 Assembly 3 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 47–123(77 aa)
突变:R45S, V77E CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.2;298 K;1.4 M Sodium phosphate monobasic monohydrate/Potassium phosphate dibasic pH 8.2
分辨率 2.78 Å R-free 0.267
8FZ3 Sterile Alpha Motif of Human Translocation ETS Leukemia, Non-Polymer Crystal Form 提交 2023-01-27 Assembly 4 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 D 47–123(77 aa)
突变:R45S, V77E 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.2;298 K;1.4 M Sodium phosphate monobasic monohydrate/Potassium phosphate dibasic pH 8.2
分辨率 2.78 Å R-free 0.267
8FZU The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Thr-Val linker variant, Expressed with SUMO tag 提交 2023-01-30 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–111(65 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;0.1M HEPES 2.0M ammonium sulfate
分辨率 1.90 Å R-free 0.266
8FZU The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Thr-Val linker variant, Expressed with SUMO tag 提交 2023-01-30 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 47–111(65 aa)
未记录 K POTASSIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;0.1M HEPES 2.0M ammonium sulfate
分辨率 1.90 Å R-free 0.266
8FZU The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Thr-Val linker variant, Expressed with SUMO tag 提交 2023-01-30 Assembly 3 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 47–111(65 aa)
未记录 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;0.1M HEPES 2.0M ammonium sulfate
分辨率 1.90 Å R-free 0.266
8FZV The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Ala-Ala linker variant, expressed with SUMO tag 提交 2023-01-30 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–111(65 aa)
未记录 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.6;298 K;100 mM sodium acetate, pH 4.6, 2.0 M sodium formate
分辨率 3.29 Å R-free 0.314
8FZV The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Ala-Ala linker variant, expressed with SUMO tag 提交 2023-01-30 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 47–111(65 aa)
未记录 UNX UNKNOWN LIGAND × 32 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.6;298 K;100 mM sodium acetate, pH 4.6, 2.0 M sodium formate
分辨率 3.29 Å R-free 0.314
8FZV The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Ala-Ala linker variant, expressed with SUMO tag 提交 2023-01-30 Assembly 3 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 47–111(65 aa)
未记录 UNX UNKNOWN LIGAND × 58 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.6;298 K;100 mM sodium acetate, pH 4.6, 2.0 M sodium formate
分辨率 3.29 Å R-free 0.314
8THA 1TEL, non-compressed, double-helical crystal form 提交 2023-07-14 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–124(78 aa)
突变:V112E,R80S 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;293 K;0.5 M Bis-Tris, 0.35 M Mg-Formate, 5 mg/mL protein
分辨率 1.68 Å R-free 0.215
9CPL The ubiquitin-associated domain of human thirty-eight negative kinase 1, fused to the 2TEL crystallization chaperone via a 2-glycine linker 提交 2024-07-18 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–124(78 aa)
链 A 47–121(75 aa)
突变:First TELSAM:R80S,V112E,Second TELSAM: R80S,UBA Domain: C610A,C644A 突变:First TELSAM:R80S,V112E,Second TELSAM: R80S,UBA Domain: C610A,C644A FMT FORMIC ACID × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;298 K;100mM BisTris, pH 6.0, 960mM Mg-formate
分辨率 2.40 Å R-free 0.263
9DB5 A DARPin fused to the 1TEL crystallization chaperone via a proline-alanine linker 提交 2024-08-23 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–121(75 aa) 片段:residues 47-121 (Uniprot numbering) of Transcription factor ETV6
未记录 ACY ACETIC ACID × 13 NA SODIUM ION × 8 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 4.6;294 K;4.0 M Ammonium acetate, 0.1 M Sodium acetate trihydrate
分辨率 1.57 Å R-free 0.196
9DOC The von Willebrand factor A domain of human capillary morphogenesis gene II, flexibly fused to the 1TEL crystallization chaperone, Thr-Val linker variant, at 1.2 Angstrom resolution 提交 2024-09-18 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–121(75 aa) 片段:von Willebrand factor A domain of CMG2
突变:TELSAM: R80S,V112E (Uniprot numbering),vWA: C175A (Uniprot numbering) GOL GLYCEROL × 1 PO4 PHOSPHATE ION × 2 MG MAGNESIUM ION × 7 NA SODIUM ION × 5 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.25;298 K;100 mM Bis-Tris, pH 7.25, 1350 mM Sodium Potassium Phosphate
分辨率 1.19 Å R-free 0.197
9DP8 A DARPin fused to the 1TEL crystallization chaperone via a helical Lys-Gln-Arg linker 提交 2024-09-20 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–124(78 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 5.5;298 K;0.1 M BIS-TRIS pH 5.5, 0.3 M Magnesium formate dihydrate
分辨率 3.47 Å R-free 0.298
9DVG Crystal Structure of a DARPin Fused to the 1TEL Crystallization Chaperone via a Direct Helical Fusion in a 2-Fold Crystal Form 提交 2024-10-07 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–121(75 aa)
突变:V112E in ETV6 (Uniprot numbering) 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;298 K;1.5 M Ammonium Phosphate Dibasic, 0.1 M Tris
分辨率 3.54 Å R-free 0.301
9E4Q A DARPin fused to the 3TEL crystallization chaperone via a gly-gly-gly fusion 提交 2024-10-25 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–124(78 aa)
链 A 47–121(75 aa)
未记录 SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;298 K;0.05 M Ammonium sulfate, 0.05 M BIS-TRIS pH 6.5, Polyethylene glycol 600
分辨率 3.58 Å R-free 0.324
9FEH Crystal structure of SARS-CoV-2 nsp14 methyltransferase domain in complex with the STM957 inhibitor 提交 2024-05-20 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–123(77 aa)
未记录 A1IB6 ~{N}-[[(2~{R},3~{S},4~{R},5~{R})-5-[4-azanyl-5-(2-pyridin-3-ylethynyl)pyrrolo[2,3-d]pyrimidin-7-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl]-3-cyano-~{N}-ethyl-4-methoxy-benzenesulfonamide × 1 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;291 K;12.5% w/v PEG 4000, 20% w/v 1,2,6-hexanetriol; 100mM Gly-Gly/AMPD pH 8.5; 10mM spermine, 10mM spermidine, 10mM 1,4-diaminobutane, 10mM DL-ornithine
分辨率 1.99 Å R-free 0.230
9NGE The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to a double trigger variant of the 1TEL crystallization chaperone 提交 2025-02-22 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–122(76 aa)
突变:R80S,L96E,V112E in ETV6, and L591V,C610A,C644A in TNK1 (Uniprot numbering) PEG DI(HYDROXYETHYL)ETHER × 3 K POTASSIUM ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;293 K;0.2M Ammonium citrate tribasic pH 7.0, 20% w/v Polyethylene Glycol 3350
分辨率 2.02 Å R-free 0.230
9NGE The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to a double trigger variant of the 1TEL crystallization chaperone 提交 2025-02-22 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 47–122(76 aa)
突变:R80S,L96E,V112E in ETV6, and L591V,C610A,C644A in TNK1 (Uniprot numbering) K POTASSIUM ION × 1 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;293 K;0.2M Ammonium citrate tribasic pH 7.0, 20% w/v Polyethylene Glycol 3350
分辨率 2.02 Å R-free 0.230
9O0H The ubiquitin-associated domain of human thirty-eight negative kinase 1, fused to the 3TEL crystallization chaperone via a 2-glycine linker 提交 2025-04-02 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 47–124(78 aa) 片段:TNK1 portion is the ubiquitin-associated domain
链 B 47–121(75 aa) 片段:TNK1 portion is the ubiquitin-associated domain
突变:V112E (Uniprot numbering) in the first ETV6 repeat, C610A,C644A (Uniprot numbering) in TNK1 突变:V112E (Uniprot numbering) in the first ETV6 repeat, C610A,C644A (Uniprot numbering) in TNK1 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;298 K;1.5M Ammonium Chloride, 0.1M BIS-TRISpropane pH 7
分辨率 2.24 Å R-free 0.249
9Q4D A DARPin fused to the double trigger 1TEL variant crystallization chaperone via a direct helical fusion 提交 2025-08-20 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–121(75 aa)
突变:L96E, V112E in ETV6 (Uniprot numbering) EDO 1,2-ETHANEDIOL × 7 CL CHLORIDE ION × 4 K POTASSIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5;293 K;0.07M Citric acid, 0.05M BIS-TRIS propane, 16% w/v Polyethylene Glycol 3,350
分辨率 1.30 Å R-free 0.185
9Q9E Crystal structure of a TELSAM-SUMO1 fusion protein 提交 2025-02-26 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–123(77 aa)
突变:V73E 1PE PENTAETHYLENE GLYCOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293 K;Na-phosphate/citric acid pH4.2, PEG600
分辨率 2.05 Å R-free 0.231
9Q9E Crystal structure of a TELSAM-SUMO1 fusion protein 提交 2025-02-26 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 47–123(77 aa)
突变:V73E PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293 K;Na-phosphate/citric acid pH4.2, PEG600
分辨率 2.05 Å R-free 0.231
9Q9E Crystal structure of a TELSAM-SUMO1 fusion protein 提交 2025-02-26 Assembly 3 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 47–123(77 aa)
突变:V73E 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293 K;Na-phosphate/citric acid pH4.2, PEG600
分辨率 2.05 Å R-free 0.231
9YKB The von Willebrand factor A domain of human capillary morphogenesis gene II, fused to the 1TEL crystallization chaperone, Ala-Val linker variant, expressed with SUMO tag. 提交 2025-10-06 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–123(77 aa)
突变:R4A,V67E,K77A,R81A,A82V,C215A MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;298 K;0.1 M BisTrisPropane, 1.5M Ammonium Sulfate
分辨率 2.50 Å R-free 0.194
9YKB The von Willebrand factor A domain of human capillary morphogenesis gene II, fused to the 1TEL crystallization chaperone, Ala-Val linker variant, expressed with SUMO tag. 提交 2025-10-06 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 47–123(77 aa)
突变:R4A,V67E,K77A,R81A,A82V,C215A 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;298 K;0.1 M BisTrisPropane, 1.5M Ammonium Sulfate
分辨率 2.50 Å R-free 0.194
9YKB The von Willebrand factor A domain of human capillary morphogenesis gene II, fused to the 1TEL crystallization chaperone, Ala-Val linker variant, expressed with SUMO tag. 提交 2025-10-06 Assembly 3 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 47–123(77 aa)
突变:R4A,V67E,K77A,R81A,A82V,C215A MG MAGNESIUM ION × 2 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;298 K;0.1 M BisTrisPropane, 1.5M Ammonium Sulfate
分辨率 2.50 Å R-free 0.194
9Z2L The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to the 1TEL crystallization chaperone 提交 2025-11-05 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–122(76 aa)
突变:R46S,V78E,L90V,C109A,C143A SO4 SULFATE ION × 1 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5;298 K;0.6 M Magnesium Sulfate, 0.1 Sodium Acetate
分辨率 2.02 Å R-free 0.274
9Z2L The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to the 1TEL crystallization chaperone 提交 2025-11-05 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 47–122(76 aa)
突变:R46S,V78E,L90V,C109A,C143A CL CHLORIDE ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5;298 K;0.6 M Magnesium Sulfate, 0.1 Sodium Acetate
分辨率 2.02 Å R-free 0.274
9ZB7 A DARPin fused to the 1TEL crystallization chaperone via a direct helical fusion 提交 2025-11-20 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–121(75 aa)
突变:V112E AKG 2-OXOGLUTARIC ACID × 1 NH4 AMMONIUM ION × 1 GOL GLYCEROL × 2 EOH ETHANOL × 2 K POTASSIUM ION × 5 CL CHLORIDE ION × 5 PO4 PHOSPHATE ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.2;298 K;0.4 M Ammonium phosphate monobasic
分辨率 1.24 Å R-free 0.170
9ZNB Crystal Structure of a DARPin Fused to the 1TEL Crystallization Chaperone via a Direct Helical Fusion in a 3-Fold Crystal Form 提交 2025-12-12 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–121(75 aa) 片段:residues 47-121 (Uniprot numbering) of the ETV6 portion
突变:V112E in ETV6 (Uniprot numbering) ACY ACETIC ACID × 1 CL CHLORIDE ION × 4 MG MAGNESIUM ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 4.6;294 K;1.0 M Magnesium sulfate hydrate, 0.1 M Sodium acetate trihydrate pH 4.6
分辨率 1.77 Å R-free 0.220
9ZVU The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to a double trigger variant of the 1TEL crystallization chaperone, alternate crystal form 提交 2025-12-30 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 47–122(76 aa) 片段:TNK1 UBA domain,TNK1 UBA domain
突变:R80S,L96E,V112E,L591V,C610A,C644A TLA L(+)-TARTARIC ACID × 4 NA SODIUM ION × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;0.2M Sodium Tartrate, 16% PEG 3350 Monodisperse
分辨率 1.96 Å R-free 0.247
9ZVU The ubiquitin-associated domain of human thirty-eight negative kinase-1 rigidly fused to a double trigger variant of the 1TEL crystallization chaperone, alternate crystal form 提交 2025-12-30 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 47–122(76 aa) 片段:TNK1 UBA domain,TNK1 UBA domain
突变:R80S,L96E,V112E,L591V,C610A,C644A TLA L(+)-TARTARIC ACID × 3 NA SODIUM ION × 4 SO4 SULFATE ION × 2 TAR D(-)-TARTARIC ACID × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;298 K;0.2M Sodium Tartrate, 16% PEG 3350 Monodisperse
分辨率 1.96 Å R-free 0.247