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1foe

CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1

Method: X-RAY DIFFRACTION
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1. Protein Identity and Related Structures Protein Identity & Related Structures

T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1

Mus musculus

UniProt Q60610

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE × 1 （P63000） SULFATE ION × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE × 1 （P63000） SULFATE ION × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE × 1 （P63000） SULFATE ION × 1 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE × 1 （P63000） SULFATE ION × 1 water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 8 RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE × 4 （P63000） SULFATE ION × 4 water × 8 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 4 RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE × 2 （P63000） SULFATE ION × 2 water × 4 Consistent with protein count
7 Protein heterocomplex Heteromer Protein 4 RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE × 2 （P63000） SULFATE ION × 2 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
3a8n

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1foe 1foe 1foe 1foe 1foe 1foe 1foe 7uiq 7uiq 7uir 7uir

11 assemblies

View Construct and Data Evidence
UniProt name TIAM1_MOUSE
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–377； UniProt 1030–1406 Author chain C； PDBConstruct 1–377； UniProt 1030–1406 Author chain E； PDBConstruct 1–377； UniProt 1030–1406 Author chain G； PDBConstruct 1–377； UniProt 1030–1406

RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE

Homo sapiens

UniProt P63000

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1 × 1 （Q60610） SULFATE ION × 1 water × 2 Consistent with protein count
2 Protein heterocomplex Heteromer Protein 2 T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1 × 1 （Q60610） SULFATE ION × 1 water × 2 Consistent with protein count
3 Protein heterocomplex Heteromer Protein 2 T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1 × 1 （Q60610） SULFATE ION × 1 water × 2 Consistent with protein count
4 Protein heterocomplex Heteromer Protein 2 T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1 × 1 （Q60610） SULFATE ION × 1 water × 2 Consistent with protein count
5 Protein heterocomplex Heteromer Protein 8 T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1 × 4 （Q60610） SULFATE ION × 4 water × 8 Consistent with protein count
6 Protein heterocomplex Heteromer Protein 4 T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1 × 2 （Q60610） SULFATE ION × 2 water × 4 Consistent with protein count
7 Protein heterocomplex Heteromer Protein 4 T-LYMPHOMA INVASION AND METASTASIS INDUCING PROTEIN 1 × 2 （Q60610） SULFATE ION × 2 water × 4 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1mh1 1ryf 1ryf 1ryh 1ryh 3sbd 3sbd 3sbe 3th5 3th5 4gzl 4gzl

19 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers
2p2l 2p2l

2 assemblies

Heteromeric or nucleic-acid complex
1foe 1foe 1foe 1foe 1foe 1foe 1foe 1g4u 1i4d 1i4l 1i4l 1i4t

82 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RAC1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 1–177； UniProt 1–177 Author chain D； PDBConstruct 1–177； UniProt 1–177 Author chain F； PDBConstruct 1–177； UniProt 1–177 Author chain H； PDBConstruct 1–177； UniProt 1–177

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id1foe
Deposition date deposition_date2000-08-27
Structure title titleCRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1
Keywords keywords;DBL HOMOLOGY DOMAIN, PLECKSTRIN HOMOLOGY DOMAIN, GTPASE, GUANINE NUCLEOTIDE EXCHANGE FACTOR, signaling protein, immune system-signaling protein COMPLEX ;; signaling protein, immune system/signaling protein
Experimental Method methodX-RAY DIFFRACTION
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

1foe__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

1foe__assembly_1__model_1 | I(q)

10-2 10-1 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

1foe__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）27.62 Å
Rg (electron density)26.71 Å
Total Rg27.48 Å
Atom count4378
Residues539
Excluded volume78833 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 1foe__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
2 1 1foe__assembly_2__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
3 1 1foe__assembly_3__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
4 1 1foe__assembly_4__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
5 1 1foe__assembly_5__model_1 octameric （8） Success 4.1.3-1-20251215 (887e7ef) View Download
6 1 1foe__assembly_6__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
7 1 1foe__assembly_7__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (4)

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6. Fold Classification (SCOP + CATH) 24 domains

SCOP 2.08 (12 domains)

Domain ID domain_idd1foea1
Class classa — All alpha proteins
Fold Fold folda.87 — DBL homology domain (DH-domain)
Superfamily Superfamily superfamilya.87.1 — DBL homology domain (DH-domain)
Family Family familya.87.1.1 — DBL homology domain (DH-domain)
Domain ID domain_idd1foea2
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.1 — Pleckstrin-homology domain (PH domain)
Domain ID domain_idd1foeb_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd1foec1
Class classa — All alpha proteins
Fold Fold folda.87 — DBL homology domain (DH-domain)
Superfamily Superfamily superfamilya.87.1 — DBL homology domain (DH-domain)
Family Family familya.87.1.1 — DBL homology domain (DH-domain)
Domain ID domain_idd1foec2
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.1 — Pleckstrin-homology domain (PH domain)
Domain ID domain_idd1foed_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd1foee1
Class classa — All alpha proteins
Fold Fold folda.87 — DBL homology domain (DH-domain)
Superfamily Superfamily superfamilya.87.1 — DBL homology domain (DH-domain)
Family Family familya.87.1.1 — DBL homology domain (DH-domain)
Domain ID domain_idd1foee2
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.1 — Pleckstrin-homology domain (PH domain)
Domain ID domain_idd1foef_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins
Domain ID domain_idd1foeg1
Class classa — All alpha proteins
Fold Fold folda.87 — DBL homology domain (DH-domain)
Superfamily Superfamily superfamilya.87.1 — DBL homology domain (DH-domain)
Family Family familya.87.1.1 — DBL homology domain (DH-domain)
Domain ID domain_idd1foeg2
Class classb — All beta proteins
Fold Fold foldb.55 — PH domain-like barrel
Superfamily Superfamily superfamilyb.55.1 — PH domain-like
Family Family familyb.55.1.1 — Pleckstrin-homology domain (PH domain)
Domain ID domain_idd1foeh_
Class classc — Alpha and beta proteins (a/b)
Fold Fold foldc.37 — P-loop containing nucleoside triphosphate hydrolases
Superfamily Superfamily superfamilyc.37.1 — P-loop containing nucleoside triphosphate hydrolases
Family Family familyc.37.1.8 — G proteins

CATH v4.4 (12 domains)

Domain ID domain_id1foeA01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology900 — Dbl Homology Domain; Chain A
Homologous superfamily homologous superfamily10 — Dbl homology (DH) domain
Domain ID domain_id1foeA02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id1foeB00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id1foeC01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology900 — Dbl Homology Domain; Chain A
Homologous superfamily homologous superfamily10 — Dbl homology (DH) domain
Domain ID domain_id1foeC02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id1foeD00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id1foeE01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology900 — Dbl Homology Domain; Chain A
Homologous superfamily homologous superfamily10 — Dbl homology (DH) domain
Domain ID domain_id1foeE02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id1foeF00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
Domain ID domain_id1foeG01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology900 — Dbl Homology Domain; Chain A
Homologous superfamily homologous superfamily10 — Dbl homology (DH) domain
Domain ID domain_id1foeG02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Domain ID domain_id1foeH00
Class class3 — Alpha Beta
Architecture architecture40 — 3-Layer(aba) Sandwich
Topology topology50 — Rossmann fold
Homologous superfamily homologous superfamily300 — P-loop containing nucleotide triphosphate hydrolases
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7. Citations (1)