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7sj4

Human Trio residues 1284-1959 in complex with Rac1

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Triple functional domain protein

Homo sapiens

UniProt O75962

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Ras-related C3 botulinum toxin substrate 1 × 1 （P63000） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1nty 6d8z 6d8z 6d8z

4 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
2nz8 7sj4

2 assemblies

View Construct and Data Evidence
UniProt name TRIO_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 4–679； UniProt 1284–1959

Ras-related C3 botulinum toxin substrate 1

Homo sapiens

UniProt P63000

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 2 Triple functional domain protein × 1 （O75962） water × 2 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1mh1 1ryf 1ryf 1ryh 1ryh 3sbd 3sbd 3sbe 3th5 3th5 4gzl 4gzl

19 assemblies; showing the first 12

Homodimer

None

Homotetramer

None

Other homooligomers
2p2l 2p2l

2 assemblies

Heteromeric or nucleic-acid complex
1foe 1foe 1foe 1foe 1foe 1foe 1foe 1g4u 1i4d 1i4l 1i4l 1i4t

82 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RAC1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 4–195； UniProt 1–192

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id7sj4
Deposition date deposition_date2021-10-15
Structure title titleHuman Trio residues 1284-1959 in complex with Rac1
Keywords keywordsguanine nucleotide exchange factor, GTPase, dbl homology, pleckstrin homology, signaling protein; SIGNALING PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7sj4__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7sj4__assembly_1__model_1 | I(q)

10-2 10-1 105 106 107 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

7sj4__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）25.74 Å
Rg (electron density)24.59 Å
Total Rg25.50 Å
Atom count3885
Residues481
Excluded volume69687 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 7sj4__assembly_1__model_1 dimeric （2） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (3)

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6. Fold Classification (SCOP + CATH) 2 domains

CATH v4.4 (2 domains)

Domain ID domain_id7sj4A01
Class class1 — Mainly Alpha
Architecture architecture20 — Up-down Bundle
Topology topology900 — Dbl Homology Domain; Chain A
Homologous superfamily homologous superfamily10 — Dbl homology (DH) domain
Domain ID domain_id7sj4A02
Class class2 — Mainly Beta
Architecture architecture30 — Roll
Topology topology29 — PH-domain like
Homologous superfamily homologous superfamily30 — Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
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7. Citations (1)