2fyu

Crystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor

Method: X-RAY DIFFRACTION Dmax: 155.9 Å Quality: REASONABLE

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial

物种未注明

UniProt P31800

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 22 PDB 声明:22-meric(22) 与蛋白拷贝数一致 链 A; UniProt 35–480 片段:Core1 Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial × 2 (P23004) Cytochrome b × 2 (P00157) Cytochrome c1, heme protein, mitochondrial × 2 (P00125) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Hypothetical protein LOC616871 × 2 (P00129) Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C × 2 (P13271) Ubiquinol-cytochrome c reductase complex 11 kDa protein × 2 (P00126) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Ubiquinol-cytochrome c reductase complex 7.2 kDa protein × 2 (P00130) Ubiquinol-cytochrome c reductase complex 6.4 kDa protein × 2 (P07552) HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION X-ray结晶条件:VAPOR DIFFUSION, SITTING DROP;pH 7.2;277.2 K;50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K 分辨率 2.26 Å R-free 0.283

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly, “相对当前条目”直接指出证据层面的不同;没有差异标签表示当前已读取字段一致。

共 46 个其他 PDB 条目、51 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 UQCR1_BOVIN
Isoform
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–446; UniProt 35–480

Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial

物种未注明

UniProt P23004

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 22 PDB 声明:22-meric(22) 与蛋白拷贝数一致 链 B; UniProt 15–453 片段:Core2 Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial × 2 (P31800) Cytochrome b × 2 (P00157) Cytochrome c1, heme protein, mitochondrial × 2 (P00125) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Hypothetical protein LOC616871 × 2 (P00129) Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C × 2 (P13271) Ubiquinol-cytochrome c reductase complex 11 kDa protein × 2 (P00126) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Ubiquinol-cytochrome c reductase complex 7.2 kDa protein × 2 (P00130) Ubiquinol-cytochrome c reductase complex 6.4 kDa protein × 2 (P07552) HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION X-ray结晶条件:VAPOR DIFFUSION, SITTING DROP;pH 7.2;277.2 K;50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K 分辨率 2.26 Å R-free 0.283

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly, “相对当前条目”直接指出证据层面的不同;没有差异标签表示当前已读取字段一致。

共 47 个其他 PDB 条目、52 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 UQCR2_BOVIN
Isoform
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–439; UniProt 15–453

Cytochrome b

物种未注明

UniProt P00157

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 22 PDB 声明:22-meric(22) 与蛋白拷贝数一致 链 C; UniProt 1–379 片段:cytochrome b Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial × 2 (P31800) Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial × 2 (P23004) Cytochrome c1, heme protein, mitochondrial × 2 (P00125) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Hypothetical protein LOC616871 × 2 (P00129) Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C × 2 (P13271) Ubiquinol-cytochrome c reductase complex 11 kDa protein × 2 (P00126) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Ubiquinol-cytochrome c reductase complex 7.2 kDa protein × 2 (P00130) Ubiquinol-cytochrome c reductase complex 6.4 kDa protein × 2 (P07552) HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION X-ray结晶条件:VAPOR DIFFUSION, SITTING DROP;pH 7.2;277.2 K;50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K 分辨率 2.26 Å R-free 0.283

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly, “相对当前条目”直接指出证据层面的不同;没有差异标签表示当前已读取字段一致。

共 45 个其他 PDB 条目、50 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 CYB_BOVIN
Isoform
PDB实体 3
链与序列区间 作者链 C; PDB构建体 1–379; UniProt 1–379

Cytochrome c1, heme protein, mitochondrial

物种未注明

UniProt P00125

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 22 PDB 声明:22-meric(22) 与蛋白拷贝数一致 链 D; UniProt 1–241 片段:cytochrome c1 Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial × 2 (P31800) Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial × 2 (P23004) Cytochrome b × 2 (P00157) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Hypothetical protein LOC616871 × 2 (P00129) Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C × 2 (P13271) Ubiquinol-cytochrome c reductase complex 11 kDa protein × 2 (P00126) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Ubiquinol-cytochrome c reductase complex 7.2 kDa protein × 2 (P00130) Ubiquinol-cytochrome c reductase complex 6.4 kDa protein × 2 (P07552) HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION X-ray结晶条件:VAPOR DIFFUSION, SITTING DROP;pH 7.2;277.2 K;50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K 分辨率 2.26 Å R-free 0.283

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly, “相对当前条目”直接指出证据层面的不同;没有差异标签表示当前已读取字段一致。

共 47 个其他 PDB 条目、52 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 CY1_BOVIN
Isoform
PDB实体 4
链与序列区间 作者链 D; PDB构建体 1–241; UniProt 1–241

Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial

物种未注明

UniProt P13272

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 22 PDB 声明:22-meric(22) 与蛋白拷贝数一致 链 E; UniProt 79–274 链 I; UniProt 1–78 片段:Iron-sulfur protein 片段:Iron-sulfur protein signal sequence Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial × 2 (P31800) Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial × 2 (P23004) Cytochrome b × 2 (P00157) Cytochrome c1, heme protein, mitochondrial × 2 (P00125) Hypothetical protein LOC616871 × 2 (P00129) Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C × 2 (P13271) Ubiquinol-cytochrome c reductase complex 11 kDa protein × 2 (P00126) Ubiquinol-cytochrome c reductase complex 7.2 kDa protein × 2 (P00130) Ubiquinol-cytochrome c reductase complex 6.4 kDa protein × 2 (P07552) HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION X-ray结晶条件:VAPOR DIFFUSION, SITTING DROP;pH 7.2;277.2 K;50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K 分辨率 2.26 Å R-free 0.283

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly, “相对当前条目”直接指出证据层面的不同;没有差异标签表示当前已读取字段一致。

共 48 个其他 PDB 条目、53 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 UCRI_BOVIN
Isoform
PDB实体 5, 9
链与序列区间 作者链 E; PDB构建体 1–196; UniProt 79–274 作者链 I; PDB构建体 1–78; UniProt 1–78

Hypothetical protein LOC616871

物种未注明

UniProt P00129

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 22 PDB 声明:22-meric(22) 与蛋白拷贝数一致 链 F; UniProt 1–110 片段:subunit 6 Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial × 2 (P31800) Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial × 2 (P23004) Cytochrome b × 2 (P00157) Cytochrome c1, heme protein, mitochondrial × 2 (P00125) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C × 2 (P13271) Ubiquinol-cytochrome c reductase complex 11 kDa protein × 2 (P00126) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Ubiquinol-cytochrome c reductase complex 7.2 kDa protein × 2 (P00130) Ubiquinol-cytochrome c reductase complex 6.4 kDa protein × 2 (P07552) HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION X-ray结晶条件:VAPOR DIFFUSION, SITTING DROP;pH 7.2;277.2 K;50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K 分辨率 2.26 Å R-free 0.283

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly, “相对当前条目”直接指出证据层面的不同;没有差异标签表示当前已读取字段一致。

共 45 个其他 PDB 条目、50 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 UCR6_BOVIN
Isoform
PDB实体 6
链与序列区间 作者链 F; PDB构建体 1–110; UniProt 1–110

Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C

物种未注明

UniProt P13271

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 22 PDB 声明:22-meric(22) 与蛋白拷贝数一致 链 G; UniProt 1–81 片段:subunit 7 Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial × 2 (P31800) Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial × 2 (P23004) Cytochrome b × 2 (P00157) Cytochrome c1, heme protein, mitochondrial × 2 (P00125) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Hypothetical protein LOC616871 × 2 (P00129) Ubiquinol-cytochrome c reductase complex 11 kDa protein × 2 (P00126) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Ubiquinol-cytochrome c reductase complex 7.2 kDa protein × 2 (P00130) Ubiquinol-cytochrome c reductase complex 6.4 kDa protein × 2 (P07552) HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION X-ray结晶条件:VAPOR DIFFUSION, SITTING DROP;pH 7.2;277.2 K;50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K 分辨率 2.26 Å R-free 0.283

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly, “相对当前条目”直接指出证据层面的不同;没有差异标签表示当前已读取字段一致。

共 47 个其他 PDB 条目、52 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 UCRQ_BOVIN
Isoform
PDB实体 7
链与序列区间 作者链 G; PDB构建体 1–81; UniProt 1–81

Ubiquinol-cytochrome c reductase complex 11 kDa protein

物种未注明

UniProt P00126

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 22 PDB 声明:22-meric(22) 与蛋白拷贝数一致 链 H; UniProt 1–78 片段:subunit 8 Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial × 2 (P31800) Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial × 2 (P23004) Cytochrome b × 2 (P00157) Cytochrome c1, heme protein, mitochondrial × 2 (P00125) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Hypothetical protein LOC616871 × 2 (P00129) Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C × 2 (P13271) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Ubiquinol-cytochrome c reductase complex 7.2 kDa protein × 2 (P00130) Ubiquinol-cytochrome c reductase complex 6.4 kDa protein × 2 (P07552) HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION X-ray结晶条件:VAPOR DIFFUSION, SITTING DROP;pH 7.2;277.2 K;50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K 分辨率 2.26 Å R-free 0.283

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly, “相对当前条目”直接指出证据层面的不同;没有差异标签表示当前已读取字段一致。

共 46 个其他 PDB 条目、51 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 UCRH_BOVIN
Isoform
PDB实体 8
链与序列区间 作者链 H; PDB构建体 1–78; UniProt 1–78

Ubiquinol-cytochrome c reductase complex 7.2 kDa protein

物种未注明

UniProt P00130

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 22 PDB 声明:22-meric(22) 与蛋白拷贝数一致 链 J; UniProt 1–62 片段:subunit 10 Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial × 2 (P31800) Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial × 2 (P23004) Cytochrome b × 2 (P00157) Cytochrome c1, heme protein, mitochondrial × 2 (P00125) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Hypothetical protein LOC616871 × 2 (P00129) Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C × 2 (P13271) Ubiquinol-cytochrome c reductase complex 11 kDa protein × 2 (P00126) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Ubiquinol-cytochrome c reductase complex 6.4 kDa protein × 2 (P07552) HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION X-ray结晶条件:VAPOR DIFFUSION, SITTING DROP;pH 7.2;277.2 K;50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K 分辨率 2.26 Å R-free 0.283

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly, “相对当前条目”直接指出证据层面的不同;没有差异标签表示当前已读取字段一致。

共 47 个其他 PDB 条目、52 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 UCR10_BOVIN
Isoform
PDB实体 10
链与序列区间 作者链 J; PDB构建体 1–62; UniProt 1–62

Ubiquinol-cytochrome c reductase complex 6.4 kDa protein

物种未注明

UniProt P07552

当前结构中的状态

Assembly 聚集状态 构建体 突变与修饰 配体、离子与共同组分 实验方法与环境 结构质量
1 蛋白异源复合物 异源复合物 蛋白 × 22 PDB 声明:22-meric(22) 与蛋白拷贝数一致 链 K; UniProt 1–56 片段:subunit 11 Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial × 2 (P31800) Ubiquinol-cytochrome-c reductase complex core protein 2, mitochondrial × 2 (P23004) Cytochrome b × 2 (P00157) Cytochrome c1, heme protein, mitochondrial × 2 (P00125) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Hypothetical protein LOC616871 × 2 (P00129) Ubiquinol-cytochrome c reductase complex ubiquinone-binding protein QP-C × 2 (P13271) Ubiquinol-cytochrome c reductase complex 11 kDa protein × 2 (P00126) Ubiquinol-cytochrome c reductase iron-sulfur subunit, mitochondrial × 2 (P13272) Ubiquinol-cytochrome c reductase complex 7.2 kDa protein × 2 (P00130) HEM PROTOPORPHYRIN IX CONTAINING FE × 6 FDN (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE × 2 FES FE2/S2 (INORGANIC) CLUSTER × 2 X-RAY DIFFRACTION X-ray结晶条件:VAPOR DIFFUSION, SITTING DROP;pH 7.2;277.2 K;50 mM MOPS 7.2pH, 20 mM Ammonium acetate, 20% glycerol.Incubation with 2-5 mol excess of JG144. Precipitant 12% PEG4000, 0.5 M KCl, 0.1% DHPC; Protein:PPT ratio 1:0.57, VAPOR DIFFUSION, SITTING DROP, temperature 277.2K 分辨率 2.26 Å R-free 0.283

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly, “相对当前条目”直接指出证据层面的不同;没有差异标签表示当前已读取字段一致。

共 29 个其他 PDB 条目、32 个 assembly。 打开独立比较页并筛选聚集状态

查看构建体与数据证据
UniProt名称 UCR11_BOVIN
Isoform
PDB实体 11
链与序列区间 作者链 K; PDB构建体 1–56; UniProt 1–56

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

SAXS 散射曲线 SAXS Profile

SAXS profile for 2fyu

P(r) 距离分布 P(r) Distribution

P(r) distribution for 2fyu
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2. 结构基本信息 2. Structure Basics

条目编号 entry_id2fyu
沉积日期 deposition_date2006-02-08
结构标题 titleCrystal structure of bovine heart mitochondrial bc1 with jg144 inhibitor
关键词 keywordsTransmembrane helices, 11 protein complex, OXIDOREDUCTASE; OXIDOREDUCTASE
实验方法 methodX-RAY DIFFRACTION

3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier50.75
回转半径 Rg (电子) rg_electron50.37
零角强度 I(0) i0786144000.00
分子量 molecular_weight236090.0 kDa
排除体积 excluded_volume296820 ų
包络体积 envelope_volume444220 ų
水化壳体积 shell_volume75110 ų
包络直径 envelope_diameter166.2
壳层 Rg shell_rg51.79
包络 Rg envelope_rg49.63
形状 Rg shape_rg50.36
总 Rg total_rg50.47
总原子数 total_atoms16633
残基数 n_residues2099
球谐函数阶数 n_harmonics20
q 范围 q_range— – 0.5000 −1
数据点数 n_points101
壳层类型 shell_typedirectional
溶剂电子密度 solvent_density0.3340 e/ų
壳层衬度 contrast_shell0.0300 e/ų
CRYSOL 版本 crysol_version4.1.3

4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax155.9
Rg (实空间) rg_real50.95
Rg 误差 (实空间) rg_real_error1.53
I(0) (实空间) i0_real7.8610e+08
I(0) 误差 (实空间) i0_real_error1.5100e+07
Rg (倒空间) rg_reciprocal50.56
I(0) (倒空间) i0_reciprocal785700000.0000
解质量估计 total_estimate0.5960
解质量评级 solution_quality REASONABLE a REASONABLE solution
P(r) 峰数 n_peaks2
主峰位置 r_peak_primary45.3
偏度 Skewness skewness0.408
峰度 Kurtosis kurtosis-0.624
角度范围 angular_range— – 0.1550 −1
当前正则化参数 α current_alpha0.0000
最高正则化参数 α highest_alpha94760000.0000
实空间数据点数 n_real_points32
GNOM 版本 gnom_version4.1.3
质量判据 quality_criteria AN1: 0.000; Oscil: 0.932; Stabil: 0.999; Sysdev: 0.003; Positv: 1.000; Valcen: 0.939; Smooth: 0.004

5. 晶体学与实验 5. Crystallography & Experiment

6. 实体与聚合物信息 Entities & Polymers (15)

7. 折叠分类 (SCOP + CATH) 31 domains

SCOP 2.08 (16 domains)

结构域编号 domain_idd2fyua1
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.185 — LuxS/MPP-like metallohydrolase
超家族 Superfamily superfamilyd.185.1 — LuxS/MPP-like metallohydrolase
家族 Family familyd.185.1.1 — MPP-like
结构域编号 domain_idd2fyua2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.185 — LuxS/MPP-like metallohydrolase
超家族 Superfamily superfamilyd.185.1 — LuxS/MPP-like metallohydrolase
家族 Family familyd.185.1.1 — MPP-like
结构域编号 domain_idd2fyub1
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.185 — LuxS/MPP-like metallohydrolase
超家族 Superfamily superfamilyd.185.1 — LuxS/MPP-like metallohydrolase
家族 Family familyd.185.1.1 — MPP-like
结构域编号 domain_idd2fyub2
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.185 — LuxS/MPP-like metallohydrolase
超家族 Superfamily superfamilyd.185.1 — LuxS/MPP-like metallohydrolase
家族 Family familyd.185.1.1 — MPP-like
结构域编号 domain_idd2fyuc1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.32 — a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
超家族 Superfamily superfamilyf.32.1 — a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
家族 Family familyf.32.1.1 — a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
结构域编号 domain_idd2fyuc2
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.21 — Heme-binding four-helical bundle
超家族 Superfamily superfamilyf.21.1 — Transmembrane di-heme cytochromes
家族 Family familyf.21.1.2 — Cytochrome b of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
结构域编号 domain_idd2fyud1
类 Class classa — All alpha proteins
折叠类型 Fold folda.3 — Cytochrome c
超家族 Superfamily superfamilya.3.1 — Cytochrome c
家族 Family familya.3.1.3 — Cytochrome bc1 domain
结构域编号 domain_idd2fyud2
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.23 — Single transmembrane helix
超家族 Superfamily superfamilyf.23.11 — Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor
家族 Family familyf.23.11.1 — Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor
结构域编号 domain_idd2fyue1
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.23 — Single transmembrane helix
超家族 Superfamily superfamilyf.23.12 — ISP transmembrane anchor
家族 Family familyf.23.12.1 — ISP transmembrane anchor
结构域编号 domain_idd2fyue2
类 Class classb — All beta proteins
折叠类型 Fold foldb.33 — ISP domain
超家族 Superfamily superfamilyb.33.1 — ISP domain
家族 Family familyb.33.1.1 — Rieske iron-sulfur protein (ISP)
结构域编号 domain_idd2fyuf_
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.27 — 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
超家族 Superfamily superfamilyf.27.1 — 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
家族 Family familyf.27.1.1 — 14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
结构域编号 domain_idd2fyug_
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.23 — Single transmembrane helix
超家族 Superfamily superfamilyf.23.13 — Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
家族 Family familyf.23.13.1 — Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
结构域编号 domain_idd2fyuh_
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.28 — Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
超家族 Superfamily superfamilyf.28.1 — Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
家族 Family familyf.28.1.1 — Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
结构域编号 domain_idd2fyui_
类 Class classd — Alpha and beta proteins (a+b)
折叠类型 Fold foldd.184 — Non-globular alpha+beta subunits of globular proteins
超家族 Superfamily superfamilyd.184.1 — Non-globular alpha+beta subunits of globular proteins
家族 Family familyd.184.1.3 — Ubiquinol-cytochrome c reductase 8 kDa protein
结构域编号 domain_idd2fyuj_
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.23 — Single transmembrane helix
超家族 Superfamily superfamilyf.23.14 — Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
家族 Family familyf.23.14.1 — Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
结构域编号 domain_idd2fyuk_
类 Class classf — Membrane and cell surface proteins and peptides
折叠类型 Fold foldf.23 — Single transmembrane helix
超家族 Superfamily superfamilyf.23.15 — Subunit XI (6.4 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
家族 Family familyf.23.15.1 — Subunit XI (6.4 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)

CATH v4.4 (15 domains)

结构域编号 domain_id2fyuA01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology830 — Cytochrome Bc1 Complex; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Metalloenzyme, LuxS/M16 peptidase-like
结构域编号 domain_id2fyuA02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology830 — Cytochrome Bc1 Complex; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Metalloenzyme, LuxS/M16 peptidase-like
结构域编号 domain_id2fyuB01
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology830 — Cytochrome Bc1 Complex; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Metalloenzyme, LuxS/M16 peptidase-like
结构域编号 domain_id2fyuB02
类 Class class3 — Alpha Beta
架构 Architecture architecture30 — 2-Layer Sandwich
拓扑 Topology topology830 — Cytochrome Bc1 Complex; Chain A, domain 1
同源超家族 H-superfamily homologous superfamily10 — Metalloenzyme, LuxS/M16 peptidase-like
结构域编号 domain_id2fyuC00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology810 — Cytochrome Bc1 Complex; Chain C
同源超家族 H-superfamily homologous superfamily10 — Cytochrome Bc1 Complex; Chain C
结构域编号 domain_id2fyuD01
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology760 — Cytochrome Bc1 Complex; Chain D, domain 2
同源超家族 H-superfamily homologous superfamily10 — Cytochrome c-like domain
结构域编号 domain_id2fyuD02
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily100 — Cytochrome c1, transmembrane anchor, C-terminal
结构域编号 domain_id2fyuE01
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily270 — Ubiquinol cytochrome reductase, transmembrane domain
结构域编号 domain_id2fyuE02
类 Class class2 — Mainly Beta
架构 Architecture architecture102 — 3-layer Sandwich
拓扑 Topology topology10 — Rieske Iron-sulfur Protein
同源超家族 H-superfamily homologous superfamily10 — Rieske [2Fe-2S] iron-sulphur domain
结构域编号 domain_id2fyuF00
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology1090 — Cytochrome Bc1 Complex; Chain F
同源超家族 H-superfamily homologous superfamily10 — Cytochrome b-c1 complex subunit 7
结构域编号 domain_id2fyuG00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily210 — Cytochrome b-c1 complex subunit 8
结构域编号 domain_id2fyuH00
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology287 — Helix Hairpins
同源超家族 H-superfamily homologous superfamily20 — Ubiquinol-cytochrome C reductase hinge domain
结构域编号 domain_id2fyuI00
类 Class class2 — Mainly Beta
架构 Architecture architecture10 — Ribbon
拓扑 Topology topology210 — Cytochrome Bc1 Complex; Chain I
同源超家族 H-superfamily homologous superfamily10 — Cytochrome Bc1 Complex; Chain I
结构域编号 domain_id2fyuJ00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily260 — Cytochrome b-c1 complex subunit 9
结构域编号 domain_id2fyuK00
类 Class class1 — Mainly Alpha
架构 Architecture architecture20 — Up-down Bundle
拓扑 Topology topology5 — Single alpha-helices involved in coiled-coils or other helix-helix interfaces
同源超家族 H-superfamily homologous superfamily220

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9. 文件与曲线 (10)