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8uaz

Structure of Glutamyl-5'-O-adenosine phosphoramidate/RNase A

Method: X-RAY DIFFRACTION Dmax: 76.4 Å Quality: GOOD
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Ribonuclease pancreatic

OrganismNot specified

UniProt P61823

State in the Current Structure

Assembly Oligomeric State Construct Mutations and Modifications Ligands, Ions and Associated Components Method and Experimental Conditions Structure Quality
1 Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count Chain A； UniProt 27–150 Not recorded WFU (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]amino}pentanedioic acid (non-preferred name) × 1 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25 percent PEG 3350, 20 MM SODIUM CITRATE, PH 5.5. Glutaminyl-5'-O-adenosine phosphoramidate soaking was achieved as follows. 1 uL of a stock solution of 100 mM ligand was added to 2uL of reservoir solution, to achieve a concentration of ~35 mM in the soaking solution. A few RNase A crystals were soaked for 110 - 130 minutes in the soaking solution. Resolution 1.76 Å R-free 0.249
2 Protein monomer Monomer Protein × 1 PDB declaration: monomeric（1） Consistent with protein copy count Chain B； UniProt 27–150 Not recorded WFU (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]amino}pentanedioic acid (non-preferred name) × 1 X-RAY DIFFRACTION X-ray crystallization conditions：VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25 percent PEG 3350, 20 MM SODIUM CITRATE, PH 5.5. Glutaminyl-5'-O-adenosine phosphoramidate soaking was achieved as follows. 1 uL of a stock solution of 100 mM ligand was added to 2uL of reservoir solution, to achieve a concentration of ~35 mM in the soaking solution. A few RNase A crystals were soaked for 110 - 130 minutes in the soaking solution. Resolution 1.76 Å R-free 0.249

Other States of the Same Protein in the Database

Each row is a biological assembly of the same UniProt protein in another PDB entry. The “Difference from current entry” column identifies evidence-level differences; no tag means the currently parsed fields agree.

Other PDB Difference from Current Entry 8UAZ Assembly / Oligomeric State Construct Mutations and Modifications Ligands, Ions and Non-polymers Method and Experimental Conditions Structure Quality
1A2W CRYSTAL STRUCTURE OF A 3D DOMAIN-SWAPPED DIMER OF BOVINE PANCREATIC RIBONUCLEASE A Deposited 1998-01-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa） Fragment：SWAPPED HELICAL DOMAIN
Chain B 27–150（124 aa） Fragment：SWAPPED HELICAL DOMAIN
Not recorded CL CHLORIDE ION × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7.5；100 MM PHOSPHATE BUFFER (PH 7.5) 1.6 M AMMONIUM SULFATE 0.6 M NACL 2% PEG400
Resolution 2.10 Å R-free 0.256
1A5P C[40,95]A VARIANT OF BOVINE PANCREATIC RIBONUCLEASE A Deposited 1998-02-17 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：C40A, C95A SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6；PROTEIN WAS CRYSTALLIZED FROM 100 MM CACODYLATE PH 6.0, 2.2 M CSCL, AND 1.5 M AMM SO4. THEN IT WAS SOAKED IN 100 MM CACODYLATE PH 6.0, 80% AMM SO4 FOR 24 HOURS TO REMOVE THE CS IONS.
Resolution 1.60 Å R-free 0.272
1A5Q P93A VARIANT OF BOVINE PANCREATIC RIBONUCLEASE A Deposited 1998-02-17 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：P93A SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 6.8；PROTEIN WAS CRYSTALLIZED FROM 100 MM HEPES PH 7.0, 2.2 M CSCL, AND 1.2 M AMM SO4. THEN IT WAS SOAKED IN 100 MM HEPES PH 7.0, 80% AMM SO4 FOR 24 HOURS TO REMOVE THE CS IONS., pH 6.8
Resolution 2.30 Å R-free 0.273
1AFK CRYSTAL STRUCTURE OF RIBONUCLEASE A IN COMPLEX WITH 5'-DIPHOSPHOADENOSINE-3'-PHOSPHATE Deposited 1997-03-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded PAP 3'-PHOSPHATE-ADENOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；289 K；PROTEIN WAS CRYSTALLIZED FROM 20% PEG 4000, 20 MM SODIUM CITRATE, PH 5.5 AND THEN SOAKED WITH 1MM 5' DIPHOSPHOADENOSINE 3'-PHOSPHATE FOR 2.5 HRS AT 16 C, temperature 289K
Resolution 1.70 Å R-free 0.266
1AFK CRYSTAL STRUCTURE OF RIBONUCLEASE A IN COMPLEX WITH 5'-DIPHOSPHOADENOSINE-3'-PHOSPHATE Deposited 1997-03-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded PAP 3'-PHOSPHATE-ADENOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；289 K；PROTEIN WAS CRYSTALLIZED FROM 20% PEG 4000, 20 MM SODIUM CITRATE, PH 5.5 AND THEN SOAKED WITH 1MM 5' DIPHOSPHOADENOSINE 3'-PHOSPHATE FOR 2.5 HRS AT 16 C, temperature 289K
Resolution 1.70 Å R-free 0.266
1AFL RIBONUCLEASE A IN COMPLEX WITH 5'-DIPHOSPHOADENOSINE 2'-PHOSPHATE AT 1.7 ANGSTROM RESOLUTION Deposited 1997-03-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded ATR 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE × 1 CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；289 K；PROTEIN WAS CRYSTALLIZED FROM 10% PEG 4000, 10 MM SODIUM CITRATE, PH 5.5 AND THEN SOAKED WITH 10 MM 5-DIPHOSPHOADENOSINE 2'- PHOSPHATE FOR 3 HRS AT 16 C, temperature 289K
Resolution 1.70 Å R-free 0.278
1AFL RIBONUCLEASE A IN COMPLEX WITH 5'-DIPHOSPHOADENOSINE 2'-PHOSPHATE AT 1.7 ANGSTROM RESOLUTION Deposited 1997-03-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded ATR 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE × 1 CIT CITRIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；289 K；PROTEIN WAS CRYSTALLIZED FROM 10% PEG 4000, 10 MM SODIUM CITRATE, PH 5.5 AND THEN SOAKED WITH 10 MM 5-DIPHOSPHOADENOSINE 2'- PHOSPHATE FOR 3 HRS AT 16 C, temperature 289K
Resolution 1.70 Å R-free 0.278
1AFU STRUCTURE OF RIBONUCLEASE A AT 2.0 ANGSTROMS FROM MONOCLINIC CRYSTALS Deposited 1997-03-14 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；PROTEIN WAS CRYSTALLIZED FROM 20 MM SODIUM CITRATE BUFFER PH 5.5 AND 20 % PEG 4000.
Resolution 2.00 Å R-free 0.285
1AFU STRUCTURE OF RIBONUCLEASE A AT 2.0 ANGSTROMS FROM MONOCLINIC CRYSTALS Deposited 1997-03-14 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；PROTEIN WAS CRYSTALLIZED FROM 20 MM SODIUM CITRATE BUFFER PH 5.5 AND 20 % PEG 4000.
Resolution 2.00 Å R-free 0.285
1AQP RIBONUCLEASE A COPPER COMPLEX Deposited 1997-07-31 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CU COPPER (II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；ENZYME WAS CRYSTALLIZED FROM MPD WITH 6 MOLAR EXCESS OF COPPER, pH 5.5
Resolution 2.00 Å
1B6V CRYSTAL STRUCTURE OF A HYBRID BETWEEN RIBONUCLEASE A AND BOVINE SEMINAL RIBONUCLEASE Deposited 1999-01-18 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：Q55K, N62K, A64T, Y76K, S80R, E111G, N113K No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.3；pH 4.3
Resolution 2.00 Å R-free 0.256
1B6V CRYSTAL STRUCTURE OF A HYBRID BETWEEN RIBONUCLEASE A AND BOVINE SEMINAL RIBONUCLEASE Deposited 1999-01-18 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Mutation：Q55K, N62K, A64T, Y76K, S80R, E111G, N113K No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.3；pH 4.3
Resolution 2.00 Å R-free 0.256
1BEL HYDROLASE PHOSPHORIC DIESTER, RNA Deposited 1995-12-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 MOH METHANOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.5；60% METHANOL, pH 4.50
Resolution 1.60 Å
1BZQ COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A Deposited 1998-11-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；HANGING DROP METHOD. 5 MG/ML OF THE COMPLEX RESERVOIR SOLUTION IS 0.1 M POTASSIUM PHOSPHATE PH 6.4 15 TO 20% W/V PEG 8000, vapor diffusion - hanging drop
Resolution 2.80 Å R-free 0.282
1BZQ COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A Deposited 1998-11-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 27–150（124 aa）
Not recorded PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；HANGING DROP METHOD. 5 MG/ML OF THE COMPLEX RESERVOIR SOLUTION IS 0.1 M POTASSIUM PHOSPHATE PH 6.4 15 TO 20% W/V PEG 8000, vapor diffusion - hanging drop
Resolution 2.80 Å R-free 0.282
1BZQ COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A Deposited 1998-11-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 27–150（124 aa）
Not recorded PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；HANGING DROP METHOD. 5 MG/ML OF THE COMPLEX RESERVOIR SOLUTION IS 0.1 M POTASSIUM PHOSPHATE PH 6.4 15 TO 20% W/V PEG 8000, vapor diffusion - hanging drop
Resolution 2.80 Å R-free 0.282
1BZQ COMPLEX OF A DROMEDARY SINGLE-DOMAIN VHH ANTIBODY FRAGMENT WITH RNASE A Deposited 1998-11-03 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain D 27–150（124 aa）
Not recorded PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.4；HANGING DROP METHOD. 5 MG/ML OF THE COMPLEX RESERVOIR SOLUTION IS 0.1 M POTASSIUM PHOSPHATE PH 6.4 15 TO 20% W/V PEG 8000, vapor diffusion - hanging drop
Resolution 2.80 Å R-free 0.282
1C0B BOVINE PANCREATIC RIBONUCLEASE A DESICCATED FOR 2.5 DAYS Deposited 1999-07-15 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–128（128 aa）
Not recorded SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 4.5；295 K；58% methanol (v/v), pH 4.5, SMALL TUBES, temperature 295K
Resolution 1.90 Å R-free 0.272
1C0C BOVINE PANCREATIC RIBONUCLEASE A DESICCATED FOR 4.0 DAYS Deposited 1999-07-15 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–128（128 aa）
Not recorded SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions SMALL TUBES；pH 4.5；295 K；58% methanol (v/v), pH 4.5, SMALL TUBES, temperature 295K
Resolution 2.00 Å R-free 0.268
1C8W THR45GLY VARIANT OF RIBONUCLEASE A Deposited 1999-07-30 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 2–125（124 aa） Fragment：RNASE A
Mutation：T45G ACT ACETATE ION × 1 CL CHLORIDE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；293 K；Ammonium sulfate, sodium chloride, sodium acetate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.80 Å
1C9V H12A VARIANT OF RIBONUCLEASE A Deposited 1999-08-03 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：H12A CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；30% ammonium sulfate, 50% sodium chloride, 100mM sodium acetate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.70 Å
1C9X H119A VARIANT OF RIBONUCLEASE A Deposited 1999-08-03 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa） Fragment：RIBONUCLEASE A
Mutation：H119A CL CHLORIDE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；29% ammonium sulfate, 45% sodium chloride, 100mM sodium acetate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.80 Å
1CJQ X-RAY CRYSTALLOGRAPHIC STUDIES OF THE DENATURATION OF THE DENATURATION OF RIBONUCLEASE S. Deposited 1999-04-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–41（15 aa） Fragment：S PEPTIDE
Chain B 50–150（101 aa） Fragment：S PROTEIN
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.75；THE RNASE S CRYSTAL HAS BEEN STABILIZED BY GLUTARALDEHYDE CROSSLINKING AND THEN THE CRYSTAL HAS BEEN SOAKED IN 5M UREA., pH 4.75 DATA COLLECTED ON A CRYSTAL SOAKED IN 5M UREA. THE CRYSTAL WAS STABILIZED BY GLUTARALDEHYDE CROSSLINKING
Resolution 3.00 Å R-free 0.253
1CJQ X-RAY CRYSTALLOGRAPHIC STUDIES OF THE DENATURATION OF THE DENATURATION OF RIBONUCLEASE S. Deposited 1999-04-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 27–41（15 aa） Fragment：S PEPTIDE
Chain B 50–150（101 aa） Fragment：S PROTEIN
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4.75；THE RNASE S CRYSTAL HAS BEEN STABILIZED BY GLUTARALDEHYDE CROSSLINKING AND THEN THE CRYSTAL HAS BEEN SOAKED IN 5M UREA., pH 4.75 DATA COLLECTED ON A CRYSTAL SOAKED IN 5M UREA. THE CRYSTAL WAS STABILIZED BY GLUTARALDEHYDE CROSSLINKING
Resolution 3.00 Å R-free 0.253
1CJR X-RAY CRYSTALLOGRAPHIC STUDIES OF DENATURATION IN RIBONUCLEASE S Deposited 1999-04-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–41（15 aa） Fragment：S PEPTIDE
Chain B 50–150（101 aa） Fragment：S PROTEIN
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 2；pH 2.0 THE CRYSTALS WERE SOAKED AT PH=2.0 AND WERE STABLIZED BY GLUTARALDEHYDE CROSSLINKING.
Resolution 2.30 Å R-free 0.270
1D5D The role of phenylalanine 8 in the stabilization of the s protein-s peptide interaction: packing and cavities Deposited 1999-10-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–15（15 aa） Fragment：RESIDUES 1-15
Mutation：F8M Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.75；293 K；3M CSCL, 35% AMMONIUM SULFATE. 0.1 M SODIUM ACETATE, pH 5.75, VAPOR DIFFUSION, SITTING DROP, temperature 20K
Resolution 2.25 Å R-free 0.218
1D5E The role of phenylalanine 8 in the stabilization of the S protein-S peptide interaction: Packing and cavities Deposited 1999-10-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–15（15 aa） Fragment：RESIDUES 1-15
Mutation：F8(NLE) Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.75；293 K；3M CsCl, 35% Ammonium Sulfate. 0.1 M Sodium Acetate, pH 5.75, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.25 Å R-free 0.231
1D5H Rnase s(f8a). mutant ribonucleasE S. Deposited 1999-10-07 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 1–15（15 aa） Fragment：RESIDUES 1-15
Mutation：F8A Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.75；293 K；3M CsCl, 35% Ammonium Sulfate. 0.1 M Sodium Acetate, pH 5.75, VAPOR DIFFUSION, SITTING DROP, temperature 20K
Resolution 2.25 Å R-free 0.257
1DFJ RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A Deposited 1996-06-29 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain E 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å
1DY5 Deamidated derivative of bovine pancreatic ribonuclease Deposited 2000-01-27 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 ACT ACETATE ION × 1 IPA ISOPROPYL ALCOHOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 5.7；FREE LIQUID DIFFUSION METHOD USED. THE PROTEIN WAS CRYSTALLIZED FROM 50% ISOPROPANOL, 0.05 M AMMONIUM ACETATE, PH 5.7, CONC.=10 MG/ML
Resolution 0.87 Å R-free 0.120
1DY5 Deamidated derivative of bovine pancreatic ribonuclease Deposited 2000-01-27 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Mutation：YES Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 ACT ACETATE ION × 3 IPA ISOPROPYL ALCOHOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 5.7；FREE LIQUID DIFFUSION METHOD USED. THE PROTEIN WAS CRYSTALLIZED FROM 50% ISOPROPANOL, 0.05 M AMMONIUM ACETATE, PH 5.7, CONC.=10 MG/ML
Resolution 0.87 Å R-free 0.120
1EIC CRYSTAL STRUCTURE OF F120A MUTANT OF BOVINE PANCREATIC RIBONUCLEASE A Deposited 2000-02-25 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：F120A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.40 Å R-free 0.254
1EID CRYSTAL STRUCTURE OF F120G MUTANT OF BOVINE PANCREATIC RIBONUCLEASE A Deposited 2000-02-25 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：F120G No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.40 Å R-free 0.265
1EIE CRYSTAL STRUCTURE OF F120W MUTANT OF BOVINE PANCREATIC RIBONUCLEASE A Deposited 2000-02-25 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：F120W No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.40 Å R-free 0.272
1EOS CRYSTAL STRUCTURE OF RIBONUCLEASE A COMPLEXED WITH URIDYLYL(2',5')GUANOSINE (PRODUCTIVE BINDING) Deposited 2000-03-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded U2G URIDYLYL-2'-5'-PHOSPHO-GUANOSINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；PEG4000, sodium citrate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
Resolution 2.00 Å
1EOS CRYSTAL STRUCTURE OF RIBONUCLEASE A COMPLEXED WITH URIDYLYL(2',5')GUANOSINE (PRODUCTIVE BINDING) Deposited 2000-03-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；PEG4000, sodium citrate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
Resolution 2.00 Å
1EOW CRYSTAL STRUCTURE OF RIBONUCLEASE A COMPLEXED WITH URIDYLYL(2',5')GUANOSINE (NON-PRODUCTIVE BINDING) Deposited 2000-03-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 U2G URIDYLYL-2'-5'-PHOSPHO-GUANOSINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions FREE INTERFACE DIFFUSION；pH 5.5；298 K；2-METHYL-2-PROPANOL, pH 5.5, FREE INTERFACE DIFFUSION, temperature 298.0K
Resolution 2.00 Å
1F0V Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping Deposited 2000-05-17 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded PO4 PHOSPHATE ION × 1 GOL GLYCEROL × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M Phosphate buffer, 16 % PEG 4000, 2 % Dioxane, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.70 Å R-free 0.213
1F0V Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping Deposited 2000-05-17 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein–DNA Monomer；Protein × 1 PDB declaration: dimeric
Chain B 27–150（124 aa）
Not recorded PO4 PHOSPHATE ION × 1 GOL GLYCEROL × 9 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M Phosphate buffer, 16 % PEG 4000, 2 % Dioxane, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.70 Å R-free 0.213
1F0V Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping Deposited 2000-05-17 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein–DNA Monomer；Protein × 1 PDB declaration: dimeric
Chain C 27–150（124 aa）
Not recorded PO4 PHOSPHATE ION × 1 GOL GLYCEROL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M Phosphate buffer, 16 % PEG 4000, 2 % Dioxane, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.70 Å R-free 0.213
1F0V Crystal structure of an Rnase A dimer displaying a new type of 3D domain swapping Deposited 2000-05-17 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein–DNA Monomer；Protein × 1 PDB declaration: dimeric
Chain D 27–150（124 aa）
Not recorded PO4 PHOSPHATE ION × 1 GOL GLYCEROL × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.5；293 K；0.1 M Phosphate buffer, 16 % PEG 4000, 2 % Dioxane, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.70 Å R-free 0.213
1FEV CRYSTAL STRUCTURE OF THE ALA4AIB MUTATION IN RNASE S Deposited 2000-07-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–41（15 aa）
Chain B 50–150（101 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.75；298 K；3M CsCl, 35% Ammonium Sulphate, 50 mM Sodium Acetate, pH=5.75 , VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.25 Å R-free 0.229
1FEV CRYSTAL STRUCTURE OF THE ALA4AIB MUTATION IN RNASE S Deposited 2000-07-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 27–41（15 aa）
Chain B 50–150（101 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.75；298 K；3M CsCl, 35% Ammonium Sulphate, 50 mM Sodium Acetate, pH=5.75 , VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 2.25 Å R-free 0.229
1FS3 CRYSTAL STRUCTURE OF WILD-TYPE BOVINE PANCREATIC RIBONUCLEASE A Deposited 2000-09-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.40 Å R-free 0.255
1IZP F46L mutant of bovine pancreatic ribonuclease A Deposited 2002-10-11 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：F46L No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.50 Å R-free 0.225
1IZQ F46V mutant of bovine pancreatic ribonuclease A Deposited 2002-10-11 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：F46V No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.80 Å R-free 0.228
1IZR F46A mutant of bovine pancreatic ribonuclease A Deposited 2002-10-11 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：F46A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.50 Å R-free 0.226
1J7Z Osmolyte Stabilization of Ribonuclease Deposited 2001-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–41（15 aa） Fragment：S PEPTIDE
Chain B 47–150（104 aa） Fragment：S PROTEIN
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.75；293 K；Ammonium Sulfate, cesium Chloride, pH 4.75, VAPOR DIFFUSION, SITTING DROP, temperature 293.0K
Resolution 2.25 Å R-free 0.296
1J7Z Osmolyte Stabilization of Ribonuclease Deposited 2001-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 27–41（15 aa） Fragment：S PEPTIDE
Chain B 47–150（104 aa） Fragment：S PROTEIN
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.75；293 K；Ammonium Sulfate, cesium Chloride, pH 4.75, VAPOR DIFFUSION, SITTING DROP, temperature 293.0K
Resolution 2.25 Å R-free 0.296
1J80 Osmolyte Stabilization of RNase Deposited 2001-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–41（15 aa） Fragment：S PEPTIDE
Chain B 47–150（104 aa） Fragment：S PROTEIN
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.75；293 K；Ammonium Sulfate, cesium Chloride, pH 4.75, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
Resolution 2.10 Å R-free 0.282
1J80 Osmolyte Stabilization of RNase Deposited 2001-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 27–41（15 aa） Fragment：S PEPTIDE
Chain B 47–150（104 aa） Fragment：S PROTEIN
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.75；293 K；Ammonium Sulfate, cesium Chloride, pH 4.75, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
Resolution 2.10 Å R-free 0.282
1J81 Osmolyte Stabilization of RNase Deposited 2001-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–41（15 aa） Fragment：S PEPTIDE
Chain B 47–150（104 aa） Fragment：S PROTEIN
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.75；293 K；Ammonium Sulfate, cesium Chloride, pH 4.75, VAPOR DIFFUSION, SITTING DROP, temperature 293.0K
Resolution 2.20 Å R-free 0.250
1J81 Osmolyte Stabilization of RNase Deposited 2001-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 27–41（15 aa） Fragment：S PEPTIDE
Chain B 47–150（104 aa） Fragment：S PROTEIN
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.75；293 K；Ammonium Sulfate, cesium Chloride, pH 4.75, VAPOR DIFFUSION, SITTING DROP, temperature 293.0K
Resolution 2.20 Å R-free 0.250
1J82 Osmolyte Stabilization of RNase Deposited 2001-05-19 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–41（15 aa） Fragment：S PEPTIDE
Chain B 47–150（104 aa） Fragment：S PROTEIN
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.75；298 K；Ammonium Sulfate, cesium Chloride, pH 4.75, VAPOR DIFFUSION, SITTING DROP, temperature 298.0K
Resolution 2.30 Å R-free 0.256
1JN4 The Crystal Structure of Ribonuclease A in complex with 2'-deoxyuridine 3'-pyrophosphate (P'-5') adenosine Deposited 2001-07-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded 139 ADENOSINE-5'-[TRIHYDROGEN DIPHOSPHATE] P'-3'-ESTER WITH 2'-DEOXYURIDINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP at 289K
Resolution 1.80 Å R-free 0.295
1JN4 The Crystal Structure of Ribonuclease A in complex with 2'-deoxyuridine 3'-pyrophosphate (P'-5') adenosine Deposited 2001-07-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP at 289K
Resolution 1.80 Å R-free 0.295
1JS0 Crystal Structure of 3D Domain-swapped RNase A Minor Trimer Deposited 2001-08-15 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 3 PDB declaration: trimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Chain C 27–150（124 aa）
Not recorded SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 3.7；277 K；PEG 10,000, amonium sulfate, pH 3.7, VAPOR DIFFUSION, HANGING DROP, temperature 277K
Resolution 2.20 Å R-free 0.257
1JVT CRYSTAL STRUCTURE OF RIBONUCLEASE A (LIGAND-FREE FORM) Deposited 2001-08-31 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；PEG 4000, sodium citrate, pH 5.00, VAPOR DIFFUSION, HANGING DROP at 298K
Resolution 2.05 Å R-free 0.240
1JVT CRYSTAL STRUCTURE OF RIBONUCLEASE A (LIGAND-FREE FORM) Deposited 2001-08-31 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；PEG 4000, sodium citrate, pH 5.00, VAPOR DIFFUSION, HANGING DROP at 298K
Resolution 2.05 Å R-free 0.240
1JVU CRYSTAL STRUCTURE OF RIBONUCLEASE A (COMPLEXED FORM) Deposited 2001-08-31 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded C2P CYTIDINE-2'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；PEG 4000, sodium citrate, pH 5.00, VAPOR DIFFUSION, HANGING DROP at 298K
Resolution 1.78 Å R-free 0.240
1JVU CRYSTAL STRUCTURE OF RIBONUCLEASE A (COMPLEXED FORM) Deposited 2001-08-31 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；PEG 4000, sodium citrate, pH 5.00, VAPOR DIFFUSION, HANGING DROP at 298K
Resolution 1.78 Å R-free 0.240
1JVV CRYSTAL STRUCTURE OF RIBONUCLEASE A (RETRO-SOAKED FORM) Deposited 2001-08-31 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；PEG 4000, sodium citrate, pH 5.00, VAPOR DIFFUSION, HANGING DROP at 298K. THE CRYSTAL WAS PREVIOUSLY SOAKED WITH 2'-CMP AND THEN RETRO-SOAKED BY WASHING OUT THE NUCLEOTIDE
Resolution 2.20 Å R-free 0.260
1JVV CRYSTAL STRUCTURE OF RIBONUCLEASE A (RETRO-SOAKED FORM) Deposited 2001-08-31 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；PEG 4000, sodium citrate, pH 5.00, VAPOR DIFFUSION, HANGING DROP at 298K. THE CRYSTAL WAS PREVIOUSLY SOAKED WITH 2'-CMP AND THEN RETRO-SOAKED BY WASHING OUT THE NUCLEOTIDE
Resolution 2.20 Å R-free 0.260
1KF2 Atomic Resolution Structure of RNase A at pH 5.2 Deposited 2001-11-19 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 5.2；298 K；2-propanol, pH 5.2, LIQUID DIFFUSION, temperature 298K
Resolution 1.10 Å
1KF3 Atomic Resolution Structure of RNase A at pH 5.9 Deposited 2001-11-19 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 5.9；298 K；2-propanol, pH 5.9, LIQUID DIFFUSION, temperature 298K
Resolution 1.05 Å
1KF4 Atomic Resolution Structure of RNase A at pH 6.3 Deposited 2001-11-19 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 6.3；298 K；2-propanol, pH 6.3, LIQUID DIFFUSION, temperature 298.0K
Resolution 1.10 Å
1KF5 Atomic Resolution Structure of RNase A at pH 7.1 Deposited 2001-11-19 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 7.1；298 K；2-propanol, pH 7.1, LIQUID DIFFUSION, temperature 298.0K
Resolution 1.15 Å
1KF7 Atomic Resolution Structure of RNase A at pH 8.0 Deposited 2001-11-19 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 8；298 K；2-propanol, pH 8.0, LIQUID DIFFUSION, temperature 298.0K
Resolution 1.15 Å
1KF8 Atomic resolution structure of RNase A at pH 8.8 Deposited 2001-11-19 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 8.8；298 K；2-propanol, pH 8.8, LIQUID DIFFUSION, temperature 298.0K
Resolution 1.15 Å
1KH8 Structure of a cis-proline (P114) to glycine variant of Ribonuclease A Deposited 2001-11-29 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：P114G SO4 SULFATE ION × 1 CS CESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.6；303 K；NaPO4, CsCl2, ammonium sulfate, pH 6.6, VAPOR DIFFUSION, HANGING DROP, temperature 303K
Resolution 2.00 Å R-free 0.219
1LSQ RIBONUCLEASE A WITH ASN 67 REPLACED BY A BETA-ASPARTYL RESIDUE Deposited 1996-06-25 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å
1LSQ RIBONUCLEASE A WITH ASN 67 REPLACED BY A BETA-ASPARTYL RESIDUE Deposited 1996-06-25 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å
1O0F RNASE A in complex with 3',5'-ADP Deposited 2003-02-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded A3P ADENOSINE-3'-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20% PEG 4000, 20MM SODIUM CITRATE, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.50 Å R-free 0.271
1O0F RNASE A in complex with 3',5'-ADP Deposited 2003-02-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded A3P ADENOSINE-3'-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20% PEG 4000, 20MM SODIUM CITRATE, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.50 Å R-free 0.271
1O0H Ribonuclease A in complex with 5'-ADP Deposited 2003-02-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20mM SODIUM CITRATE BUFFER, 20% PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.20 Å R-free 0.221
1O0H Ribonuclease A in complex with 5'-ADP Deposited 2003-02-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded ADP ADENOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20mM SODIUM CITRATE BUFFER, 20% PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.20 Å R-free 0.221
1O0M Ribonuclease A in complex with uridine-2'-phosphate Deposited 2003-02-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded U2P PHOSPHORIC ACID MONO-[2-(2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-YL] ESTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20mM SODIUM CITRATE BUFFER, 20% PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.50 Å R-free 0.244
1O0M Ribonuclease A in complex with uridine-2'-phosphate Deposited 2003-02-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded U2P PHOSPHORIC ACID MONO-[2-(2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-4-HYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-3-YL] ESTER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20mM SODIUM CITRATE BUFFER, 20% PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.50 Å R-free 0.244
1O0N Ribonuclease A in complex with uridine-3'-phosphate Deposited 2003-02-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded U3P 3'-URIDINEMONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20mM SODIUM CITRATE BUFFER, 20% PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.50 Å R-free 0.241
1O0N Ribonuclease A in complex with uridine-3'-phosphate Deposited 2003-02-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded U3P 3'-URIDINEMONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20mM SODIUM CITRATE BUFFER, 20% PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.50 Å R-free 0.241
1O0O Ribonuclease A in complex with adenosine-2',5'-diphosphate Deposited 2003-02-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded A2P ADENOSINE-2'-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20mM Sodium citrate Buffer, 20% PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.20 Å R-free 0.228
1O0O Ribonuclease A in complex with adenosine-2',5'-diphosphate Deposited 2003-02-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded A2P ADENOSINE-2'-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20mM Sodium citrate Buffer, 20% PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.20 Å R-free 0.228
1QHC CRYSTAL STRUCTURE OF RIBONUCLEASE A IN COMPLEX WITH 5'-PHOSPHO-2'-DEOXYURIDINE-3'-PYROPHOSPHATE ADENOSINE-3'-PHOSPHATE Deposited 1999-05-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded PUA ADENYLATE-3'-PHOSPHATE-[[2'-DEOXY-URIDINE-5'-PHOSPHATE]-3'-PHOSPHATE] × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；CRYSTALLIZED FROM 20% PEG 4000, 20 MM SODIUM CITRATE, PH 5.5, VAPOR DIFFUSION, HANGING DROP
Resolution 1.70 Å R-free 0.260
1QHC CRYSTAL STRUCTURE OF RIBONUCLEASE A IN COMPLEX WITH 5'-PHOSPHO-2'-DEOXYURIDINE-3'-PYROPHOSPHATE ADENOSINE-3'-PHOSPHATE Deposited 1999-05-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded PUA ADENYLATE-3'-PHOSPHATE-[[2'-DEOXY-URIDINE-5'-PHOSPHATE]-3'-PHOSPHATE] × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；CRYSTALLIZED FROM 20% PEG 4000, 20 MM SODIUM CITRATE, PH 5.5, VAPOR DIFFUSION, HANGING DROP
Resolution 1.70 Å R-free 0.260
1RAR CRYSTAL STRUCTURE OF A FLUORESCENT DERIVATIVE OF RNASE A Deposited 1993-03-02 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 28–150（123 aa）
Not recorded CL CHLORIDE ION × 3 AEN 5-(1-SULFONAPHTHYL)-ACETYLAMINO-ETHYLAMINE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å
1RAS CRYSTAL STRUCTURE OF A FLUORESCENT DERIVATIVE OF RNASE A Deposited 1993-03-02 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 28–150（123 aa）
Not recorded AEN 5-(1-SULFONAPHTHYL)-ACETYLAMINO-ETHYLAMINE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions CSCL WAS WASHED OUT IN 80% AMMONIUM SULFATE BEFORE DATA COLLECTION.
Resolution 1.70 Å
1RAT EFFECTS OF TEMPERATURE ON PROTEIN STRUCTURE AND DYNAMICS: X-RAY CRYSTALLOGRAPHIC STUDIES OF THE PROTEIN RIBONUCLEASE-A AT NINE DIFFERENT TEMPERATURES FROM 98 TO 320 K Deposited 1991-08-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
1RBB THE CRYSTAL STRUCTURE OF RIBONUCLEASE B AT 2.5-ANGSTROMS RESOLUTION Deposited 1987-09-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å
1RBC CRYSTALLOGRAPHIC STRUCTURES OF RIBONUCLEASE S VARIANTS WITH NONPOLAR SUBSTITUTION AT POSITION 13: PACKING AND CAVITIES Deposited 1992-06-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 47–150（104 aa）
Chain S 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å
1RBD CRYSTALLOGRAPHIC STRUCTURES OF RIBONUCLEASE S VARIANTS WITH NONPOLAR SUBSTITUTION AT POSITION 13: PACKING AND CAVITIES Deposited 1992-06-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 47–150（104 aa）
Chain S 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.70 Å
1RBE CRYSTALLOGRAPHIC STRUCTURES OF RIBONUCLEASE S VARIANTS WITH NONPOLAR SUBSTITUTION AT POSITION 13: PACKING AND CAVITIES Deposited 1992-06-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 47–150（104 aa）
Chain S 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.75 Å
1RBE CRYSTALLOGRAPHIC STRUCTURES OF RIBONUCLEASE S VARIANTS WITH NONPOLAR SUBSTITUTION AT POSITION 13: PACKING AND CAVITIES Deposited 1992-06-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 47–150（104 aa）
Chain S 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.75 Å
1RBF CRYSTALLOGRAPHIC STRUCTURES OF RIBONUCLEASE S VARIANTS WITH NONPOLAR SUBSTITUTION AT POSITION 13: PACKING AND CAVITIES Deposited 1992-06-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 47–150（104 aa）
Chain S 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1RBG CRYSTALLOGRAPHIC STRUCTURES OF RIBONUCLEASE S VARIANTS WITH NONPOLAR SUBSTITUTION AT POSITION 13: PACKING AND CAVITIES Deposited 1992-06-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 47–150（104 aa）
Chain S 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1RBG CRYSTALLOGRAPHIC STRUCTURES OF RIBONUCLEASE S VARIANTS WITH NONPOLAR SUBSTITUTION AT POSITION 13: PACKING AND CAVITIES Deposited 1992-06-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 47–150（104 aa）
Chain S 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1RBH CRYSTALLOGRAPHIC STRUCTURES OF RIBONUCLEASE S VARIANTS WITH NONPOLAR SUBSTITUTION AT POSITION 13: PACKING AND CAVITIES Deposited 1992-06-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 47–150（104 aa）
Chain S 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.70 Å
1RBH CRYSTALLOGRAPHIC STRUCTURES OF RIBONUCLEASE S VARIANTS WITH NONPOLAR SUBSTITUTION AT POSITION 13: PACKING AND CAVITIES Deposited 1992-06-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 47–150（104 aa）
Chain S 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.70 Å
1RBI CRYSTALLOGRAPHIC STRUCTURES OF RIBONUCLEASE S VARIANTS WITH NONPOLAR SUBSTITUTION AT POSITION 13: PACKING AND CAVITIES Deposited 1992-06-12 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 47–150（104 aa）
Chain S 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1RBJ RIBONUCLEASE B COMPLEX WITH D(TETRA-(DEOXY-ADENYLATE)) Deposited 1995-05-22 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；277 K；VAPOR DIFFUSION, temperature 277.00K
Resolution 2.70 Å
1RBN THE STRUCTURE OF RIBONUCLEASE A DERIVATIVE II AT 2.1 ANGSTROMS RESOLUTION Deposited 1994-03-29 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded P5P PURINE RIBOSIDE-5'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.10 Å
1RBW RIBONUCLEASE A (E.C.3.1.27.5) WITH GUANIDINIUM Deposited 1995-07-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded GAI GUANIDINE × 4 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.69 Å R-free 0.206
1RBX RIBONUCLEASE A (E.C.3.1.27.5) CONTROL Deposited 1995-07-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.69 Å R-free 0.198
1RCA STRUCTURE OF THE CRYSTALLINE COMPLEX OF DEOXYCYTIDYLYL-3',5'-GUANOSINE (3',5'-DCPDG) CO-CRYSTALISED WITH RIBONUCLEASE AT 1.9 ANGSTROMS RESOLUTION. RETROBINDING IN PANCREATIC RNASEA IS INDEPENDENT OF MODE OF INHIBITOR INTROMISSION Deposited 1994-07-18 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded PO4 PHOSPHATE ION × 1 CGP 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å
1RCN CRYSTAL STRUCTURE OF THE RIBONUCLEASE A D(APTPAPAPG) COMPLEX : DIRECT EVIDENCE FOR EXTENDED SUBSTRATE RECOGNITION Deposited 1994-05-27 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: dimeric
Chain E 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.32 Å
1RHA WATER DEPENDENT DOMAIN MOTION AND FLEXIBILITY IN RIBONUCLEASE A AND THE INVARIANT FEATURES IN ITS HYDRATION SHELL. AN X-RAY STUDY OF TWO LOW HUMIDITY CRYSTAL FORMS OF THE ENZYME Deposited 1994-11-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
1RHB WATER DEPENDENT DOMAIN MOTION AND FLEXIBILITY IN RIBONUCLEASE A AND THE INVARIANT FEATURES IN ITS HYDRATION SHELL. AN X-RAY STUDY OF TWO LOW HUMIDITY CRYSTAL FORMS OF THE ENZYME Deposited 1994-11-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
1RNC NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE Deposited 1991-10-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 5GP GUANOSINE-5'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
1RND NEWLY OBSERVED BINDING MODE IN PANCREATIC RIBONUCLEASE Deposited 1991-10-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 DGP 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
1RNM RIBONUCLEASE A COMPLEX WITH CYTIDYLIC ACID (5'CMP) CRYSTALLIZED FROM 80% AMMONIUM SULPHATE Deposited 1995-11-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain E 27–150（124 aa）
Not recorded SO4 SULFATE ION × 3 C5P CYTIDINE-5'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；pH 5.5
Resolution 2.00 Å
1RNM RIBONUCLEASE A COMPLEX WITH CYTIDYLIC ACID (5'CMP) CRYSTALLIZED FROM 80% AMMONIUM SULPHATE Deposited 1995-11-08 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain E 27–150（124 aa）
Not recorded SO4 SULFATE ION × 6 C5P CYTIDINE-5'-MONOPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；pH 5.5
Resolution 2.00 Å
1RNN RIBONUCLEASE A COMPLEX WITH CYTIDYLIC ACID (5'CMP) CRYSTALLIZED FROM 8M SODIUM FORMATE Deposited 1995-11-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain E 27–150（124 aa）
Not recorded C5P CYTIDINE-5'-MONOPHOSPHATE × 1 FMT FORMIC ACID × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；pH 5.5
Resolution 1.80 Å
1RNO RIBONUCLEASE A CRYSTALLIZED FROM 80% AMMONIUM SULPHATE Deposited 1995-11-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；pH 5.5
Resolution 1.90 Å
1RNQ RIBONUCLEASE A CRYSTALLIZED FROM 8M SODIUM FORMATE Deposited 1995-11-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded FMT FORMIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；pH 5.5
Resolution 2.00 Å
1RNU REFINEMENT OF THE CRYSTAL STRUCTURE OF RIBONUCLEASE S. COMPARISON WITH AND BETWEEN THE VARIOUS RIBONUCLEASE A STRUCTURES Deposited 1992-02-19 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.60 Å
1RNV REFINEMENT OF THE CRYSTAL STRUCTURE OF RIBONUCLEASE S. COMPARISON WITH AND BETWEEN THE VARIOUS RIBONUCLEASE A STRUCTURES Deposited 1992-02-19 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.60 Å
1RNW RECOMBINANT RIBONUCLEASE A CRYSTALLIZED FROM 80% AMMONIUM SULPHATE Deposited 1996-11-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；CRYSTALLIZED FROM 80% AMMONIUM SULFATE, pH 5.5
Resolution 1.80 Å
1RNX RIBONUCLEASE A CRYSTALLIZED FROM 3M SODIUM CHLORIDE, 30% AMMONIUM SULFATE Deposited 1996-04-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；CRYSTALLIZED FROM 80% AMMONIUM SULFATE (PDB ENTRY 1RNO), pH 5.5
Resolution 1.90 Å
1RNY RIBONUCLEASE A CRYSTALLIZED FROM 3M CESIUM CHLORIDE, 30% AMMONIUM SULFATE Deposited 1996-04-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 4 CS CESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；CRYSTALLIZED FROM 80% AMMONIUM SULFATE (PDB ENTRY 1RNO), pH 5.5
Resolution 2.00 Å
1RNZ RIBONUCLEASE A CRYSTALLIZED FROM 2.5M SODIUM CHLORIDE, 3.3M SODIUM FORMATE Deposited 1996-11-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；CRYSTALLIZED FROM 2.5M SODIUM CHLORIDE, 3.3M SODIUM FORMATE, pH 5.5
Resolution 1.90 Å
1ROB STRUCTURE OF THE CRYSTALLINE COMPLEX OF CYTIDYLIC ACID (2'-CMP) WITH RIBONUCLEASE AT 1.6 ANGSTROMS RESOLUTION Deposited 1993-08-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded C2P CYTIDINE-2'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.60 Å
1RPF THE STRUCTURES OF RNASE COMPLEXED WITH 3'-CMP AND D(CPA): ACTIVE SITE CONFORMATION AND CONSERVED WATER MOLECULES Deposited 1994-08-29 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded C3P CYTIDINE-3'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å
1RPG STRUCTURES OF RNASE A COMPLEXED WITH 3'-CMP AND D(CPA): ACTIVE SITE CONFORMATION AND CONSERVED WATER MOLECULES Deposited 1994-08-29 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CPA 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.40 Å
1RPH STRUCTURES OF RNASE A COMPLEXED WITH 3'-CMP AND D(CPA): ACTIVE SITE CONFORMATION AND CONSERVED WATER MOLECULES Deposited 1994-08-29 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.20 Å
1RSM THE 2-ANGSTROMS RESOLUTION STRUCTURE OF A THERMOSTABLE RIBONUCLEASE A CHEMICALLY CROSS-LINKED BETWEEN LYSINE RESIDUES 7 AND 41 Deposited 1985-08-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded NIN DINITROPHENYLENE × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å
1RTA CRYSTAL STRUCTURE DISPOSITION OF THYMIDYLIC ACID TETRAMER IN COMPLEX WITH RIBONUCLEASE A Deposited 1992-08-28 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein–DNA Monomer；Protein × 1 PDB declaration: dimeric
Chain E 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions THE COMPLEX WAS FORMED BY DIFFUSION OF DNA INTO THE NATIVE CRYSTALS.
Resolution 2.50 Å
1RTB CRYSTAL STRUCTURE DISPOSITION OF THYMIDYLIC ACID TETRAMER IN COMPLEX WITH RIBONUCLEASE A Deposited 1992-08-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.50 Å
1RUV RIBONUCLEASE A-URIDINE VANADATE COMPLEX: HIGH RESOLUTION RESOLUTION X-RAY STRUCTURE (1.3 A) Deposited 1995-07-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded UVC URIDINE-2',3'-VANADATE × 1 TBU TERTIARY-BUTYL ALCOHOL × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.25 Å
1SRN THE REFINED CRYSTAL STRUCTURE OF A FULLY ACTIVE SEMISYNTHETIC RIBONUCLEASE AT 1.8 ANGSTROMS RESOLUTION Deposited 1990-10-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–144（118 aa）
Chain B 137–150（14 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions THE MOTHER LIQUOR WAS 80 PER CENT SATURATED AMMONIUM SULFATE, PH 5.2.
Resolution 1.80 Å
1SSA A STRUCTURAL INVESTIGATION OF CATALYTICALLY MODIFIED F12OL AND F12OY SEMISYNTHETIC RIBONUCLEASES Deposited 1993-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–144（118 aa）
Chain B 135–148（14 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions THE MOTHER LIQUOR WAS 80 % SATURATED AMMONIUM SULFATE, PH 5.2.
Resolution 2.00 Å
1SSB A STRUCTURAL INVESTIGATION OF CATALYTICALLY MODIFIED F12OL AND F12OY SEMISYNTHETIC RIBONUCLEASES Deposited 1993-08-03 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–144（118 aa）
Chain B 111–124（14 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions THE MOTHER LIQUOR WAS 80 % SATURATED AMMONIUM SULFATE, PH 5.2.
Resolution 2.00 Å
1SSC THE 1.6 ANGSTROMS STRUCTURE OF A SEMISYNTHETIC RIBONUCLEASE CRYSTALLIZED FROM AQUEOUS ETHANOL. COMPARISON WITH CRYSTALS FROM SALT SOLUTIONS AND WITH RNASE A FROM AQUEOUS ALCOHOL SOLUTIONS Deposited 1994-10-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–138（112 aa）
Chain B 140–150（11 aa）
Not recorded PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.00 Å
1U1B Structure of bovine pancreatic Ribonuclease A in complex with 3'-phosphothymidine (3'-5')-pyrophosphate adenosine 3'-phosphate Deposited 2004-07-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded PAX 5'-PHOSPHOTHYMIDINE (3'-5')-PYROPHOSPHATE ADENOSINE 3'-PHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；27% PEG 4000, 20 mM sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.00 Å R-free 0.258
1U1B Structure of bovine pancreatic Ribonuclease A in complex with 3'-phosphothymidine (3'-5')-pyrophosphate adenosine 3'-phosphate Deposited 2004-07-15 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded PAX 5'-PHOSPHOTHYMIDINE (3'-5')-PYROPHOSPHATE ADENOSINE 3'-PHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；27% PEG 4000, 20 mM sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.00 Å R-free 0.258
1W4O Binding of Nonnatural 3'-Nucleotides to Ribonuclease A Deposited 2004-07-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded UA3 URACIL ARABINOSE-3'-PHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20MM SODIUM CITRATE BUFFER, PH5.5, PEG 4000 (25% W/V), pH 5.50
Resolution 1.60 Å R-free 0.248
1W4O Binding of Nonnatural 3'-Nucleotides to Ribonuclease A Deposited 2004-07-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20MM SODIUM CITRATE BUFFER, PH5.5, PEG 4000 (25% W/V), pH 5.50
Resolution 1.60 Å R-free 0.248
1W4P Binding of Nonnatural 3'-Nucleotides to Ribonuclease A Deposited 2004-07-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded UM3 2'-DEOXYURIDINE 3'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20MM SODIUM CITRATE BUFFER, PH5.5, CONTAINING PEG4000 (25% W/V), pH 5.50
Resolution 1.69 Å R-free 0.226
1W4P Binding of Nonnatural 3'-Nucleotides to Ribonuclease A Deposited 2004-07-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded UM3 2'-DEOXYURIDINE 3'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20MM SODIUM CITRATE BUFFER, PH5.5, CONTAINING PEG4000 (25% W/V), pH 5.50
Resolution 1.69 Å R-free 0.226
1W4Q Binding of Nonnatural 3'-Nucleotides to Ribonuclease A Deposited 2004-07-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded UMF 2'-FLUORO-2'-DEOXYURIDINE 3'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20MM SODIUM CITRATE, BUFFER PH 5.5, PEG 4000(25% W/V)
Resolution 1.68 Å R-free 0.241
1W4Q Binding of Nonnatural 3'-Nucleotides to Ribonuclease A Deposited 2004-07-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded UMF 2'-FLUORO-2'-DEOXYURIDINE 3'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20MM SODIUM CITRATE, BUFFER PH 5.5, PEG 4000(25% W/V)
Resolution 1.68 Å R-free 0.241
1XPS BOVINE RIBONUCLEASE A (PHOSPHATE-FREE) (93 % HUMIDITY) Deposited 1998-02-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.248
1XPS BOVINE RIBONUCLEASE A (PHOSPHATE-FREE) (93 % HUMIDITY) Deposited 1998-02-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å R-free 0.248
1XPT BOVINE RIBONUCLEASE A (PHOSPHATE-FREE) Deposited 1998-02-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.222
1XPT BOVINE RIBONUCLEASE A (PHOSPHATE-FREE) Deposited 1998-02-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.90 Å R-free 0.222
1YMN The study of reductive unfolding pathways of RNase A (Y92L mutant) Deposited 2005-01-21 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：Y92L No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.9；301 K；Ammonium sulfate, Sodium chloride, pH 4.9, VAPOR DIFFUSION, HANGING DROP, temperature 301K
Resolution 1.45 Å R-free 0.219
1YMR The study of reductive unfolding pathways of RNase A (Y92A mutant) Deposited 2005-01-21 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：Y92A No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.9；301 K；Ammonium sulfate, Sodium chloride, pH 4.9, VAPOR DIFFUSION, HANGING DROP, temperature 301K
Resolution 1.50 Å R-free 0.261
1YMW The study of reductive unfolding pathways of RNase A (Y92G mutant) Deposited 2005-01-21 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：Y92G No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.9；301 K；Ammonium sulfate, Sodium chloride, pH 4.9, VAPOR DIFFUSION, HANGING DROP, temperature 301K
Resolution 1.50 Å R-free 0.244
1Z3L X-Ray Crystal Structure of a Mutant Ribonuclease S (F8Anb) Deposited 2005-03-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain E 47–150（104 aa）
Chain S 27–41（15 aa）
Mutation：F8AA3, M13NLE Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions Batch method；pH 5.75；293 K；ammonium sulfate, cesium chloride, sodium acetate, pH 5.75, Batch method, temperature 293K
Resolution 1.80 Å R-free 0.226
1Z3L X-Ray Crystal Structure of a Mutant Ribonuclease S (F8Anb) Deposited 2005-03-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain E 47–150（104 aa）
Chain S 27–41（15 aa）
Mutation：F8AA3, M13NLE Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions Batch method；pH 5.75；293 K；ammonium sulfate, cesium chloride, sodium acetate, pH 5.75, Batch method, temperature 293K
Resolution 1.80 Å R-free 0.226
1Z3M Crystal structure of mutant Ribonuclease S (F8Nva) Deposited 2005-03-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain E 47–150（104 aa）
Chain S 27–41（15 aa）
Mutation：F8NVA, M13NLE Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions Batch method；pH 5.75；293 K；ammonium sulfate, cesium chloride, sodium acetate, pH 5.75, Batch method, temperature 293K
Resolution 2.00 Å R-free 0.247
1Z3M Crystal structure of mutant Ribonuclease S (F8Nva) Deposited 2005-03-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain E 47–150（104 aa）
Chain S 27–41（15 aa）
Mutation：F8NVA, M13NLE Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions Batch method；pH 5.75；293 K；ammonium sulfate, cesium chloride, sodium acetate, pH 5.75, Batch method, temperature 293K
Resolution 2.00 Å R-free 0.247
1Z3P X-Ray crystal structure of a mutant Ribonuclease S (M13Nva) Deposited 2005-03-14 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain E 47–150（104 aa）
Chain S 27–41（15 aa）
Mutation：M13NVA Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions Batch method；pH 5.2；293 K；ammonium sulfate, cesium chloride, sodium acetate, pH 5.2, Batch method, temperature 293K
Resolution 2.00 Å R-free 0.233
1Z6D Ribonuclease A- IMP complex Deposited 2005-03-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IMP INOSINIC ACID × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20mM sodium citrate, 20% PEG4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.54 Å R-free 0.234
1Z6D Ribonuclease A- IMP complex Deposited 2005-03-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded IMP INOSINIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20mM sodium citrate, 20% PEG4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.54 Å R-free 0.234
1Z6D Ribonuclease A- IMP complex Deposited 2005-03-22 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 27–150（124 aa）
Not recorded IMP INOSINIC ACID × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20mM sodium citrate, 20% PEG4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.54 Å R-free 0.234
1Z6S Ribonuclease A- AMP complex Deposited 2005-03-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；Sodium citrate, PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.50 Å R-free 0.231
1Z6S Ribonuclease A- AMP complex Deposited 2005-03-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；Sodium citrate, PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.50 Å R-free 0.231
2AAS HIGH-RESOLUTION THREE-DIMENSIONAL STRUCTURE OF RIBONUCLEASE A IN SOLUTION BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY Deposited 1992-11-20 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule SOLUTION NMR mmCIF provides none of the parsed conditions Resolution not provided
2APQ Crystal Structure of an Active Site Mutant of Bovine Pancreatic Ribonuclease A (H119A-RNase A) with a 10-Glutamine expansion in the C-terminal hinge-loop. Deposited 2005-08-16 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：H119A - GQ10G expansion between G112 and N113 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7.3；293 K；0.4M Potassium Sodium tartrate tetrahydrate, pH 7.3, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.80 Å R-free 0.215
2BLP RNase before unattenuated X-RAY burn Deposited 2005-03-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；30 % PEG 5000 MME,1 M SODIUM CHLORIDE,50 MM PH 4.5 SODIUM ACETATE
Resolution 1.40 Å R-free 0.176
2BLZ RNAse after a high dose X-ray "burn" Deposited 2005-03-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions 30 % PEG 5000 MME, 1 M SODIUM CHLORIDE,50 MM PH 4.5 SODIUM ACETATE
Resolution 1.40 Å R-free 0.181
2E33 Structural basis for selection of glycosylated substrate by SCFFbs1 ubiquitin ligase Deposited 2006-11-20 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Heteromer；Protein × 2 PDB declaration: dimeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7.5；293 K；2.0% (v/v) PEG 400, 0.1M HEPES, 2.1M ammonium sulfate, pH 7.5, VAPOR DIFFUSION, SITTING DROP, temperature 293K
Resolution 2.70 Å R-free 0.288
2E3W X-ray structure of native RNase A Deposited 2006-11-30 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.89；292 K；Well solution: Combination of Hampton Index Reagents 3 and 9, Final solution: 0.1 M Bis-tris, 1.0 M ammonium sulfate, 1.5 M NaCl, pH 5.89, Drop: 2 microliter well solution + 2 microliter 10 mg/ml protein solution in water, VAPOR DIFFUSION, HANGING DROP, temperature 292K
Resolution 1.05 Å R-free 0.208
2G4W anomalous substructure of ribonuclease A (C2) Deposited 2006-02-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.84 Å R-free 0.274
2G4W anomalous substructure of ribonuclease A (C2) Deposited 2006-02-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded CL CHLORIDE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.84 Å R-free 0.274
2G4X Anomalous substructure od ribonuclease A (P3221) Deposited 2006-02-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 5 SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.95 Å R-free 0.224
2G8Q The crystal structure of RNase A from monoclinic crystals at 100 K Deposited 2006-03-03 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；20 MM SODIUM CITRATE BUFFER AND 20 % PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
Resolution 1.50 Å R-free 0.218
2G8Q The crystal structure of RNase A from monoclinic crystals at 100 K Deposited 2006-03-03 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；20 MM SODIUM CITRATE BUFFER AND 20 % PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
Resolution 1.50 Å R-free 0.218
2G8R The crystal structure of the RNase A- 3-N-piperidine-4-carboxyl-3-deoxy-ara-uridine complex Deposited 2006-03-03 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded N3E 1-[3-(4-CARBOXYPIPERIDIN-1-YL)-3-DEOXY-BETA-D-ARABINOFURANOSYL]PYRIMIDINE-2,4(1H,3H)-DIONE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；20mM SODIUM CITRATE BUFFER AND 20% PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
Resolution 1.70 Å R-free 0.230
2G8R The crystal structure of the RNase A- 3-N-piperidine-4-carboxyl-3-deoxy-ara-uridine complex Deposited 2006-03-03 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；20mM SODIUM CITRATE BUFFER AND 20% PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
Resolution 1.70 Å R-free 0.230
2NUI X-ray Structure of synthetic [D83A]RNase A Deposited 2006-11-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：D83A CL CHLORIDE ION × 3 BTB 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.89；0.1 M Bis-Tris, 1.0 M ammonium sulfate, 1.5 M NaCl, pH 5.89, Drop 1:1 well:protein solution in H2O, VAPOR DIFFUSION, HANGING DROP
Resolution 1.10 Å R-free 0.193
2OP2 Crystal structure of RNase double-mutant V43C R85C with extra disulphide bond Deposited 2007-01-26 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：V43C, R85C No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.9；295 K；AMMONIUM SULFATE, SODIUM CHLORIDE, pH 4.9, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.60 Å R-free 0.220
2OQF Structure of a synthetic, non-natural analogue of RNase A: [N71K(Ade), D83A]RNase A Deposited 2007-01-31 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：N71K(Ade), D83A Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.30 Å R-free 0.291
2OQF Structure of a synthetic, non-natural analogue of RNase A: [N71K(Ade), D83A]RNase A Deposited 2007-01-31 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Mutation：N71K(Ade), D83A Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.30 Å R-free 0.291
2OQF Structure of a synthetic, non-natural analogue of RNase A: [N71K(Ade), D83A]RNase A Deposited 2007-01-31 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain C 27–150（124 aa）
Mutation：N71K(Ade), D83A Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.30 Å R-free 0.291
2OQF Structure of a synthetic, non-natural analogue of RNase A: [N71K(Ade), D83A]RNase A Deposited 2007-01-31 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain D 27–150（124 aa）
Mutation：N71K(Ade), D83A Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.30 Å R-free 0.291
2P42 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.8A resolution: SE3-mono-2 crystal form with three se-met sites (M34, M51, M83) in vhh scaffold Deposited 2007-03-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；295 K；HAMPTON RESEARCH INDEX SCREEN, SOLUTION #85: MGCL2, PEG3350, HEPES BUFFER, PH 7.5, VAPOR DIFFUSION, temperature 295K
Resolution 1.80 Å R-free 0.215
2P42 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.8A resolution: SE3-mono-2 crystal form with three se-met sites (M34, M51, M83) in vhh scaffold Deposited 2007-03-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；295 K；HAMPTON RESEARCH INDEX SCREEN, SOLUTION #85: MGCL2, PEG3350, HEPES BUFFER, PH 7.5, VAPOR DIFFUSION, temperature 295K
Resolution 1.80 Å R-free 0.215
2P43 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.65A resolution: SE3-mono-1 crystal form with three se-met sites (M34, M51, M83) in vhh scaffold Deposited 2007-03-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7；295 K；HAMPTON RESEARCH INDEX SCREEN, SOLUTION #89: PEG 3350, SUCCINIC ACID, PH 7.0, VAPOR DIFFUSION, temperature 295K
Resolution 1.65 Å R-free 0.202
2P44 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.8A resolution: SE5A-mono-1 crystal form with five se-met sites (M34, M51, F68M, M83, L86M) in vhh scaffold Deposited 2007-03-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.5；295 K；HAMPTON RESEARCH INDEX SCREEN, SOLUTION #85: MGCL2, PEG 3350, TRIS BUFFER, PH 8.5, VAPOR DIFFUSION, temperature 295K
Resolution 1.80 Å R-free 0.238
2P45 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.1A resolution: SE5B-ORTHO-1 crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. Deposited 2007-03-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 5.5；295 K；HAMPTON RESEARCH INDEX SCREEN, SOLUTION #74: LI2SO4, PEG 3350, BIS-TRIS BUFFER, PH 5.5, VAPOR DIFFUSION, temperature 295K
Resolution 1.10 Å R-free 0.195
2P46 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 2.5A resolution: se5b-ortho-2 crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. Deposited 2007-03-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded ZN ZINC ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；295 K；HAMPTON RESEARCH INDEX SCREEN, SOLUTION #93: ZN(CH2H3O2)2, PEG 3350, pH 8.0, VAPOR DIFFUSION, temperature 295K
Resolution 2.50 Å R-free 0.299
2P46 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 2.5A resolution: se5b-ortho-2 crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. Deposited 2007-03-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 27–150（124 aa）
Not recorded ZN ZINC ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8；295 K；HAMPTON RESEARCH INDEX SCREEN, SOLUTION #93: ZN(CH2H3O2)2, PEG 3350, pH 8.0, VAPOR DIFFUSION, temperature 295K
Resolution 2.50 Å R-free 0.299
2P47 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 2.5A resolution: SE5B-TRI crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. Deposited 2007-03-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 7.5；295 K；HAMPTON RESEARCH INDEX SCREEN, SOLUTION #68: (NH4)SO4, PEG 3350, HEPES BUFFER, PH 7.5, VAPOR DIFFUSION, temperature 295K
Resolution 2.50 Å R-free 0.294
2P48 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 2.3A resolution: SE5B-tetra crystal form with five se-met sites (L4M, M34, M51, F68M, M83) in vhh scaffold. Deposited 2007-03-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 5.5；295 K；HAMPTON RESEARCH INDEX SCREEN, SOLUTION #66: (NH4)2SO4, PEG 3350, BIS-TRIS, PH 5.5, VAPOR DIFFUSION, temperature 295K
Resolution 2.30 Å R-free 0.297
2P49 Complex of a camelid single-domain vhh antibody fragment with RNASE A at 1.4A resolution: native mono_1 crystal form Deposited 2007-03-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 8.5；295 K；HAMPTON RESEARCH INDEX SCREEN, SOLUTION #85: MGCL2, PEG 3350, TRIS BUFFER PH 8.5, VAPOR DIFFUSION, temperature 295K
Resolution 1.38 Å R-free 0.185
2P4A X-ray structure of a camelid affinity matured single-domain vhh antibody fragment in complex with RNASE A Deposited 2007-03-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 5.5；295 K；HAMPTON RESEARCH INDEX SCREEN, SOLUTION #67, pH 5.5, VAPOR DIFFUSION, temperature 295K
Resolution 1.90 Å R-free 0.218
2P4A X-ray structure of a camelid affinity matured single-domain vhh antibody fragment in complex with RNASE A Deposited 2007-03-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION；pH 5.5；295 K；HAMPTON RESEARCH INDEX SCREEN, SOLUTION #67, pH 5.5, VAPOR DIFFUSION, temperature 295K
Resolution 1.90 Å R-free 0.218
2QCA A New Crystal Form of Bovine Pancreatic RNase A in Complex with 2'-Deoxyguanosine-5'-monophosphate Deposited 2007-06-19 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded DGP 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；295 K；Reservoir: 0.6 ml of 30% PEG 3350 in 0.1 M HEPES at pH 7.0. Sample: 2 ul 10-40 mg/ml Protein in 0.1 M HEPES at pH 7.0 and 2 ul of 0.1 M DGP, cholesterol, thymine and oxamic acid in 15% PEG 3350 and 9.1 M HEPES at pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 295K, pH 7.00
Resolution 1.33 Å R-free 0.177
2RAT EFFECTS OF TEMPERATURE ON PROTEIN STRUCTURE AND DYNAMICS: X-RAY CRYSTALLOGRAPHIC STUDIES OF THE PROTEIN RIBONUCLEASE-A AT NINE DIFFERENT TEMPERATURES FROM 98 TO 320 K Deposited 1991-08-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
2RNS REFINEMENT OF THE CRYSTAL STRUCTURE OF RIBONUCLEASE S. COMPARISON WITH AND BETWEEN THE VARIOUS RIBONUCLEASE A STRUCTURES Deposited 1992-02-19 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.60 Å
2W5G RNASE A-5'-ATP COMPLEX Deposited 2008-12-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20% PEG 4000, 0.02M SODIUM CITRATE BUFFER, PH 5.5
Resolution 1.70 Å R-free 0.230
2W5G RNASE A-5'-ATP COMPLEX Deposited 2008-12-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20% PEG 4000, 0.02M SODIUM CITRATE BUFFER, PH 5.5
Resolution 1.70 Å R-free 0.230
2W5I RNASE A-AP3A COMPLEX Deposited 2008-12-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20% PEG 4000, 0.02M SODIUM CITRATE BUFFER, PH 5.5
Resolution 2.40 Å R-free 0.273
2W5I RNASE A-AP3A COMPLEX Deposited 2008-12-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded ATP ADENOSINE-5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20% PEG 4000, 0.02M SODIUM CITRATE BUFFER, PH 5.5
Resolution 2.40 Å R-free 0.273
2W5K RNASE A-NADPH COMPLEX Deposited 2008-12-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20% PEG 4000, 0.02M SODIUM CITRATE BUFFER, PH 5.5
Resolution 1.70 Å R-free 0.205
2W5K RNASE A-NADPH COMPLEX Deposited 2008-12-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded NDP NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20% PEG 4000, 0.02M SODIUM CITRATE BUFFER, PH 5.5
Resolution 1.70 Å R-free 0.205
2W5L RNASE A-NADP COMPLEX Deposited 2008-12-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20% PEG 4000, 0.02M SODIUM CITRATE BUFFER, PH 5.5
Resolution 1.70 Å R-free 0.227
2W5L RNASE A-NADP COMPLEX Deposited 2008-12-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded NAP NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20% PEG 4000, 0.02M SODIUM CITRATE BUFFER, PH 5.5
Resolution 1.70 Å R-free 0.227
2W5M RNASE A-PYROPHOSPHATE ION COMPLEX Deposited 2008-12-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded POP PYROPHOSPHATE 2- × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20% PEG 4000, 0.02M SODIUM CITRATE BUFFER, PH 5.5
Resolution 1.80 Å R-free 0.222
2W5M RNASE A-PYROPHOSPHATE ION COMPLEX Deposited 2008-12-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded POP PYROPHOSPHATE 2- × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.5；20% PEG 4000, 0.02M SODIUM CITRATE BUFFER, PH 5.5
Resolution 1.80 Å R-free 0.222
2XOG Functional and Structural Analyses of N-Acylsulfonamide-Linked Dinucleoside Inhibitors of Ribonuclease A Deposited 2010-08-16 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SFB (2S,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-N-[[(2S,3S,4R,5R)-5-(2,4-DIOXOPYRIMIDIN-1-YL)-4-HYDROXY-2-(HYDROXYMETHYL)OXOLAN-3-YL]METHYLSULFONYL]-3,4-DIHYDROXY-OXOLANE-2-CARBOXAMIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5；25 % PEG 4000, 20 MM NA CITRATE PH 5.0
Resolution 1.72 Å R-free 0.246
2XOG Functional and Structural Analyses of N-Acylsulfonamide-Linked Dinucleoside Inhibitors of Ribonuclease A Deposited 2010-08-16 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded SFB (2S,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-N-[[(2S,3S,4R,5R)-5-(2,4-DIOXOPYRIMIDIN-1-YL)-4-HYDROXY-2-(HYDROXYMETHYL)OXOLAN-3-YL]METHYLSULFONYL]-3,4-DIHYDROXY-OXOLANE-2-CARBOXAMIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5；25 % PEG 4000, 20 MM NA CITRATE PH 5.0
Resolution 1.72 Å R-free 0.246
2XOI Functional and Structural Analyses of N-Acylsulfonamide-Linked Dinucleoside Inhibitors of Ribonuclease A Deposited 2010-08-17 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SFB (2S,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-N-[[(2S,3S,4R,5R)-5-(2,4-DIOXOPYRIMIDIN-1-YL)-4-HYDROXY-2-(HYDROXYMETHYL)OXOLAN-3-YL]METHYLSULFONYL]-3,4-DIHYDROXY-OXOLANE-2-CARBOXAMIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5；25 % PEG 4000, 20 MM NA CITRATE PH 5.0
Resolution 1.72 Å R-free 0.246
2XOI Functional and Structural Analyses of N-Acylsulfonamide-Linked Dinucleoside Inhibitors of Ribonuclease A Deposited 2010-08-17 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded SFB (2S,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-N-[[(2S,3S,4R,5R)-5-(2,4-DIOXOPYRIMIDIN-1-YL)-4-HYDROXY-2-(HYDROXYMETHYL)OXOLAN-3-YL]METHYLSULFONYL]-3,4-DIHYDROXY-OXOLANE-2-CARBOXAMIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5；25 % PEG 4000, 20 MM NA CITRATE PH 5.0
Resolution 1.72 Å R-free 0.246
3A1R Neutron crystal structure analysis of bovine pancreatic ribonuclease A Deposited 2009-04-21 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule NEUTRON DIFFRACTION
X-ray crystallization conditions pH 6.2；298 K；50% tert-butyl alcohol, temperature 298K, then the crystal was soaked in heavy water solution, PH6.2, for two months, BATCH
Resolution 1.70 Å R-free 0.238
3D6O The RNase A- 5'-Deoxy-5'-N-(ethyl isonipecotatyl)uridine complex Deposited 2008-05-20 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded U1S 1-{5-deoxy-5-[4-(ethoxycarbonyl)piperidin-1-yl]-alpha-L-arabinofuranosyl}pyrimidine-2,4(1H,3H)-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, Sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.58 Å R-free 0.227
3D6O The RNase A- 5'-Deoxy-5'-N-(ethyl isonipecotatyl)uridine complex Deposited 2008-05-20 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, Sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.58 Å R-free 0.227
3D6P RNase A- 5'-Deoxy-5'-N-morpholinouridine complex Deposited 2008-05-20 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded U2S 1-(5-deoxy-5-morpholin-4-yl-alpha-L-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, SODIUM CITRATE, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.60 Å R-free 0.219
3D6P RNase A- 5'-Deoxy-5'-N-morpholinouridine complex Deposited 2008-05-20 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, SODIUM CITRATE, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.60 Å R-free 0.219
3D6Q The RNase A- 5'-Deoxy-5'-N-piperidinouridine complex Deposited 2008-05-20 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded FLC CITRATE ANION × 2 U3S 1-(5-deoxy-5-piperidin-1-yl-alpha-L-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；PEG 4000, SODIUM CITRATE, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.60 Å R-free 0.209
3D6Q The RNase A- 5'-Deoxy-5'-N-piperidinouridine complex Deposited 2008-05-20 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；PEG 4000, SODIUM CITRATE, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.60 Å R-free 0.209
3D7B The Ribonuclease A- 5'-Deoxy-5'-N-pyrrolidinouridine complex Deposited 2008-05-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded FLC CITRATE ANION × 2 U4S 1-(5-deoxy-5-pyrrolidin-1-yl-alpha-L-arabinofuranosyl)pyrimidine-2,4(1H,3H)-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；PEG 4000, SODIUM CITRATE, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.60 Å R-free 0.213
3D7B The Ribonuclease A- 5'-Deoxy-5'-N-pyrrolidinouridine complex Deposited 2008-05-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；PEG 4000, SODIUM CITRATE, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.60 Å R-free 0.213
3D8Y RNase A- 5'-Deoxy-5'-N-piperidinothymidine complex Deposited 2008-05-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded FLC CITRATE ANION × 2 T3S 5'-deoxy-5'-piperidin-1-ylthymidine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, SODIUM CITRATE, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.72 Å R-free 0.230
3D8Y RNase A- 5'-Deoxy-5'-N-piperidinothymidine complex Deposited 2008-05-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, SODIUM CITRATE, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.72 Å R-free 0.230
3D8Z RNase A- 5'-Deoxy-5'-N-pyrrolidinothymidine complex Deposited 2008-05-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded TXS 1-(2,5-dideoxy-5-pyrrolidin-1-yl-beta-L-erythro-pentofuranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, SODIUM CITRATE, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.98 Å R-free 0.240
3D8Z RNase A- 5'-Deoxy-5'-N-pyrrolidinothymidine complex Deposited 2008-05-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded FLC CITRATE ANION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, SODIUM CITRATE, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.98 Å R-free 0.240
3DH5 Crystal structure of bovine pancreatic ribonuclease A (wild-type) Deposited 2008-06-17 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 1.60 Å R-free 0.215
3DH5 Crystal structure of bovine pancreatic ribonuclease A (wild-type) Deposited 2008-06-17 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 8 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 1.60 Å R-free 0.215
3DH6 Crystal structure of bovine pancreatic ribonuclease A variant (V47A) Deposited 2008-06-17 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：V47A CL CHLORIDE ION × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 1.60 Å R-free 0.260
3DH6 Crystal structure of bovine pancreatic ribonuclease A variant (V47A) Deposited 2008-06-17 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Mutation：V47A CL CHLORIDE ION × 8 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 1.60 Å R-free 0.260
3DI7 Crystal structure of bovine pancreatic ribonuclease A variant (V54A) Deposited 2008-06-20 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：V54A CL CHLORIDE ION × 3 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 1.60 Å R-free 0.240
3DI7 Crystal structure of bovine pancreatic ribonuclease A variant (V54A) Deposited 2008-06-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Mutation：V54A CL CHLORIDE ION × 6 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 1.60 Å R-free 0.240
3DI8 Crystal structure of bovine pancreatic ribonuclease A variant (V57A) Deposited 2008-06-20 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：V57A CL CHLORIDE ION × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 1.60 Å R-free 0.226
3DI8 Crystal structure of bovine pancreatic ribonuclease A variant (V57A) Deposited 2008-06-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Mutation：V57A CL CHLORIDE ION × 8 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 1.60 Å R-free 0.226
3DI9 Crystal structure of bovine pancreatic ribonuclease A variant (I81A) Deposited 2008-06-20 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：I81A CL CHLORIDE ION × 2 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 2.00 Å R-free 0.243
3DI9 Crystal structure of bovine pancreatic ribonuclease A variant (I81A) Deposited 2008-06-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Mutation：I81A CL CHLORIDE ION × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 2.00 Å R-free 0.243
3DIB Crystal structure of bovine pancreatic ribonuclease A variant (I106A) Deposited 2008-06-20 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：I106A CL CHLORIDE ION × 5 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 1.40 Å R-free 0.218
3DIB Crystal structure of bovine pancreatic ribonuclease A variant (I106A) Deposited 2008-06-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Mutation：I106A CL CHLORIDE ION × 10 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 1.40 Å R-free 0.218
3DIC Crystal structure of bovine pancreatic ribonuclease A variant (V108A) Deposited 2008-06-20 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：V108A CL CHLORIDE ION × 3 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 1.60 Å R-free 0.210
3DIC Crystal structure of bovine pancreatic ribonuclease A variant (V108A) Deposited 2008-06-20 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Mutation：V108A CL CHLORIDE ION × 6 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, vapor diffusion, hanging drop, temperature 298K
Resolution 1.60 Å R-free 0.210
3DXG Ribonuclease A- uridine 5' phosphate complex Deposited 2008-07-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded U5P URIDINE-5'-MONOPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.39 Å R-free 0.254
3DXG Ribonuclease A- uridine 5' phosphate complex Deposited 2008-07-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded U5P URIDINE-5'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.39 Å R-free 0.254
3DXH Ribonuclease A uridine 5' diphosphate complex Deposited 2008-07-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded UDP URIDINE-5'-DIPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.40 Å R-free 0.225
3DXH Ribonuclease A uridine 5' diphosphate complex Deposited 2008-07-24 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded UDP URIDINE-5'-DIPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；PEG 4000, sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.40 Å R-free 0.225
3EUX Crystal Structure of Crosslinked Ribonuclease A Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.65 Å R-free 0.249
3EUX Crystal Structure of Crosslinked Ribonuclease A Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.65 Å R-free 0.249
3EUY Crystal Structure of Ribonuclease A in 50% Dioxane Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded DIO 1,4-DIETHYLENE DIOXIDE × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.95 Å R-free 0.241
3EUY Crystal Structure of Ribonuclease A in 50% Dioxane Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded DIO 1,4-DIETHYLENE DIOXIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.95 Å R-free 0.241
3EUZ Crystal Structure of Ribonuclease A in 50% Dimethylformamide Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded DMF DIMETHYLFORMAMIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.84 Å R-free 0.229
3EUZ Crystal Structure of Ribonuclease A in 50% Dimethylformamide Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.84 Å R-free 0.229
3EV0 Crystal Structure of Ribonuclease A in 70% Dimethyl Sulfoxide Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded DMS DIMETHYL SULFOXIDE × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.76 Å R-free 0.237
3EV0 Crystal Structure of Ribonuclease A in 70% Dimethyl Sulfoxide Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded DMS DIMETHYL SULFOXIDE × 7 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.76 Å R-free 0.237
3EV1 Crystal Structure of Ribonuclease A in 70% Hexanediol Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded HEZ HEXANE-1,6-DIOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 2.00 Å R-free 0.294
3EV1 Crystal Structure of Ribonuclease A in 70% Hexanediol Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded HEZ HEXANE-1,6-DIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 2.00 Å R-free 0.294
3EV2 Crystal Structure of Ribonuclease A in 70% Isopropanol Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 2.02 Å R-free 0.246
3EV2 Crystal Structure of Ribonuclease A in 70% Isopropanol Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 2.02 Å R-free 0.246
3EV3 Crystal Structure of Ribonuclease A in 70% t-Butanol Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.68 Å R-free 0.233
3EV3 Crystal Structure of Ribonuclease A in 70% t-Butanol Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded TBU TERTIARY-BUTYL ALCOHOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.68 Å R-free 0.233
3EV4 Crystal Structure of Ribonuclease A in 50% Trifluoroethanol Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded ETF TRIFLUOROETHANOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.93 Å R-free 0.219
3EV4 Crystal Structure of Ribonuclease A in 50% Trifluoroethanol Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded ETF TRIFLUOROETHANOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.93 Å R-free 0.219
3EV5 Crystal Structure of Ribonuclease A in 1M Trimethylamine N-Oxide Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded TMO trimethylamine oxide × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.68 Å R-free 0.261
3EV5 Crystal Structure of Ribonuclease A in 1M Trimethylamine N-Oxide Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.68 Å R-free 0.261
3EV6 Crystal Structure of Ribonuclease A in 50% R,S,R-Bisfuranol Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded RSF (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.76 Å R-free 0.249
3EV6 Crystal Structure of Ribonuclease A in 50% R,S,R-Bisfuranol Deposited 2008-10-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded RSF (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；291 K；PEG 4000, sodium citrate, pH 5.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.76 Å R-free 0.249
3FKZ X-ray structure of the non covalent swapped form of the S16G/T17N/A19P/A20S/K31C/S32C mutant of bovine pancreatic ribonuclease Deposited 2008-12-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Mutation：S16G, T17N, A19P, A20S, K31C, S32C Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：S16G, T17N, A19P, A20S, K31C, S32C Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；30% PEG 4000, 0.2M lithium sulfate, 0.1M Tris/HCl, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.99 Å R-free 0.246
3FL0 X-ray structure of the non covalent swapped form of the Q28L/K31C/S32C mutant of bovine pancreatic ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE Deposited 2008-12-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Mutation：Q28L, K31C, S32C Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：Q28L, K31C, S32C Non-standard monomer：Yes (specific site not provided by mmCIF) CGP 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；21% PEG 35000, 0.2M sodium acetate, 0.1M Tris/HCl, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.94 Å R-free 0.227
3FL1 X-ray structure of the non covalent swapped form of the A19P/Q28L/K31C/S32C mutant of bovine pancreatic ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE Deposited 2008-12-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Mutation：A19P, Q28L, K31C, S32C Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：A19P, Q28L, K31C, S32C Non-standard monomer：Yes (specific site not provided by mmCIF) CGP 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；26% PEG 4000, 0.2M ammonium sulfate, 0.1M Tris/HCl, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.90 Å R-free 0.223
3FL3 X-ray structure of the ligand free non covalent swapped form of the A19P/Q28L/K31C/S32C mutant of bovine pancreatic ribonuclease Deposited 2008-12-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Other combination Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Mutation：A19P, Q28L, K31C, S32C Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：A19P, Q28L, K31C, S32C Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；26% PEG 4000, 0.2M ammonium sulfate, 0.1M Tris/HCl, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.60 Å R-free 0.217
3I67 Ribonuclease A by LB nanotemplate method after high X-Ray dose on ESRF ID14-2 beamline Deposited 2009-07-06 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；1.75M ammonium sulphate, 2.0M Sodium Chloride, 100mM Na-acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.30 Å R-free 0.237
3I6F Ribonuclease A by Classical hanging drop method before high X-Ray dose on ESRF ID14-2 beamline Deposited 2009-07-07 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；pH 7.0, VAPOR DIFFUSION, HANGING DROP
Resolution 1.30 Å R-free 0.220
3I6H Ribonuclease A by LB nanotemplate method before high X-Ray dose on ESRF ID14-2 beamline Deposited 2009-07-07 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；1.75M ammonium sulphate, 2.0M Sodium Chloride, 100mM Na-acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.30 Å R-free 0.233
3I6J Ribonuclease A by Classical hanging drop method after high X-Ray dose on ESRF ID14-2 beamline Deposited 2009-07-07 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；1.75M ammonium sulphate, 2.0M Sodium Chloride, 100mM Na-acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.30 Å R-free 0.234
3I7W High pressure structure of wild-type RNase A (0.67 GPa) Deposited 2009-07-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.35 Å R-free 0.295
3I7X High pressure structure of I106A RNase A variant (0.35 GPa) Deposited 2009-07-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：I106A CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；298 K；ammonium sulfate, sodium chloride, sodium acetate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 298.0K
Resolution 2.60 Å R-free 0.241
3I7Y High pressure structure of I106A variant of RNase A (0.48 GPa) Deposited 2009-07-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：I106A CL CHLORIDE ION × 3 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 2.40 Å R-free 0.241
3JW1 Crystal Structure of Bovine Pancreatic Ribonuclease Complexed with Uridine-5'-monophosphate at 1.60 A Resolution Deposited 2009-09-17 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded U5P URIDINE-5'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；0.1 M HEPES BUFFER; Reservoir of 25% PEG3350 in water; droplets were 5-10 mM in basic fuchsin, tobramycin, uridine-5'-monophosphate and 1 mM in ribonuclease A, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 1.60 Å R-free 0.253
3JW1 Crystal Structure of Bovine Pancreatic Ribonuclease Complexed with Uridine-5'-monophosphate at 1.60 A Resolution Deposited 2009-09-17 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded U5P URIDINE-5'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions pH 7；298 K；0.1 M HEPES BUFFER; Reservoir of 25% PEG3350 in water; droplets were 5-10 mM in basic fuchsin, tobramycin, uridine-5'-monophosphate and 1 mM in ribonuclease A, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 298K
Resolution 1.60 Å R-free 0.253
3LXO The crystal structure of ribonuclease A in complex with thymidine-3'-monophosphate Deposited 2010-02-25 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded T3P THYMIDINE-3'-PHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；294 K；20% ammonium sulfate, 2M NaCl, pH 5.5., VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 1.55 Å R-free 0.181
3LXO The crystal structure of ribonuclease A in complex with thymidine-3'-monophosphate Deposited 2010-02-25 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded T3P THYMIDINE-3'-PHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；294 K；20% ammonium sulfate, 2M NaCl, pH 5.5., VAPOR DIFFUSION, HANGING DROP, temperature 294K
Resolution 1.55 Å R-free 0.181
3MWQ Crystal structure of ribonuclease A tandem enzymes and their interaction with the cytosolic ribonuclease inhibitor Deposited 2010-05-06 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 5 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.9；286 K；30% PEG 8000, 0.2M ammonium sulfate, pH 5.9, VAPOR DIFFUSION, HANGING DROP, temperature 286K
Resolution 1.68 Å R-free 0.216
3MWR Crystal structure of ribonuclease A tandem enzymes and their interaction with the cytosolic ribonuclease inhibitor Deposited 2010-05-06 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 4 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.9；286 K；30% PEG 8000, 0.2M ammonium sulfate, pH 5.9, VAPOR DIFFUSION, HANGING DROP, temperature 286K
Resolution 1.85 Å R-free 0.207
3MX8 Crystal structure of ribonuclease A tandem enzymes and their interaction with the cytosolic ribonuclease inhibitor Deposited 2010-05-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 5 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.9；286 K；30% PEG 8000, 0.2M ammonium sulfate, pH 5.9, VAPOR DIFFUSION, HANGING DROP, temperature 286K
Resolution 2.10 Å R-free 0.258
3MZQ RNase crystals grown by the hanging drop method Deposited 2010-05-12 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 23–150（128 aa）
Not recorded CL CHLORIDE ION × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；1.7M Ammonium sulfate, 2M NaCal, 0.1M Sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.50 Å R-free 0.193
3MZQ RNase crystals grown by the hanging drop method Deposited 2010-05-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 23–150（128 aa）
Not recorded CL CHLORIDE ION × 8 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；295 K；1.7M Ammonium sulfate, 2M NaCal, 0.1M Sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 295K
Resolution 1.50 Å R-free 0.193
3MZR RNase crystals grown in loops/micromounts Deposited 2010-05-12 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 23–150（128 aa）
Not recorded CL CHLORIDE ION × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions Crystals grown in loops；pH 5.5；295 K；1.7M Ammonium sulfate, 2M NaCal, 0.1M Sodium acetate, pH 5.5, Crystals grown in loops, temperature 295K
Resolution 1.50 Å R-free 0.193
3MZR RNase crystals grown in loops/micromounts Deposited 2010-05-12 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 23–150（128 aa）
Not recorded CL CHLORIDE ION × 8 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions Crystals grown in loops；pH 5.5；295 K；1.7M Ammonium sulfate, 2M NaCal, 0.1M Sodium acetate, pH 5.5, Crystals grown in loops, temperature 295K
Resolution 1.50 Å R-free 0.193
3OQY Semi-synthetic ribonuclease S: para-cyano-phenylalanine at position 8 Deposited 2010-09-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 47–150（104 aa） Fragment：UNP residues 47-150
Chain b 27–41（15 aa） Fragment：UNP residues 27-41
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；279 K；25% PEG 4000, 0.08M ammonium acetate, 0.1 M sodium citrate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 279K
Resolution 1.49 Å R-free 0.222
3OQY Semi-synthetic ribonuclease S: para-cyano-phenylalanine at position 8 Deposited 2010-09-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 47–150（104 aa） Fragment：UNP residues 47-150
Chain a 27–41（15 aa） Fragment：UNP residues 27-41
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；279 K；25% PEG 4000, 0.08M ammonium acetate, 0.1 M sodium citrate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 279K
Resolution 1.49 Å R-free 0.222
3OQZ Semi-synthetic ribonuclease S: meta-cyano-phenylalanine at position 8 Deposited 2010-09-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 47–150（104 aa） Fragment：UNP residues 47-150
Chain a 27–41（15 aa） Fragment：UNP residues 27-41
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；279 K；25% PEG 4000, 0.08M ammonium acetate, 0.1 M sodium citrate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 279K
Resolution 2.50 Å R-free 0.268
3OQZ Semi-synthetic ribonuclease S: meta-cyano-phenylalanine at position 8 Deposited 2010-09-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 47–150（104 aa） Fragment：UNP residues 47-150
Chain b 27–41（15 aa） Fragment：UNP residues 27-41
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；279 K；25% PEG 4000, 0.08M ammonium acetate, 0.1 M sodium citrate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 279K
Resolution 2.50 Å R-free 0.268
3OR0 Semi-synthetic ribonuclease S: cyanylated homocysteine at position 13 Deposited 2010-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 47–150（104 aa） Fragment：UNP residues 47-150
Chain a 27–41（15 aa） Fragment：UNP residues 27-41
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；279 K；25% PEG 4000, 0.08M ammonium acetate, 0.1 M sodium citrate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 279K
Resolution 2.30 Å R-free 0.271
3OR0 Semi-synthetic ribonuclease S: cyanylated homocysteine at position 13 Deposited 2010-09-05 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 47–150（104 aa） Fragment：UNP residues 47-150
Chain b 27–41（15 aa） Fragment：UNP residues 27-41
Non-standard monomer：Yes (specific site not provided by mmCIF) No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.6；279 K；25% PEG 4000, 0.08M ammonium acetate, 0.1 M sodium citrate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 279K
Resolution 2.30 Å R-free 0.271
3QL1 Crystal Structure of Ribonuclease A Variant A4C/D83E/V118C Deposited 2011-02-02 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：A4C, D83E, V118C SO4 SULFATE ION × 1 EDO 1,2-ETHANEDIOL × 1 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.8；293 K；0.1M sodium acetate, 0.2 M ammonium sulfate, 25% (w/v) PEG 4000, 10mM copper chloride, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.29 Å R-free 0.190
3QL2 Crystal Structure of Ribonuclease A Variant A4C/D83E/V118C Deposited 2011-02-02 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：A4C, D83E, V118C SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.8；293 K；0.1M sodium acetate, 0.2M ammonium sulfate, 25% (w/v) PEG 4000, 10mM calcium chloride, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.49 Å R-free 0.209
3QL2 Crystal Structure of Ribonuclease A Variant A4C/D83E/V118C Deposited 2011-02-02 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Mutation：A4C, D83E, V118C SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.8；293 K；0.1M sodium acetate, 0.2M ammonium sulfate, 25% (w/v) PEG 4000, 10mM calcium chloride, pH 4.8, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.49 Å R-free 0.209
3QSK 5 Histidine Variant of the anti-RNase A VHH in Complex with RNAse A Deposited 2011-02-21 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；293 K；25% PEG 3.350, 0.2M lithium sulfate monohydrate, 0.1M bis-tris, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 1.75 Å R-free 0.246
3RAT EFFECTS OF TEMPERATURE ON PROTEIN STRUCTURE AND DYNAMICS: X-RAY CRYSTALLOGRAPHIC STUDIES OF THE PROTEIN RIBONUCLEASE-A AT NINE DIFFERENT TEMPERATURES FROM 98 TO 320 K Deposited 1991-08-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
3RH1 X-ray Structure of a cis-proline (P114) to alanine variant of Ribonuclease A Deposited 2011-04-11 Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Mutation：P114A CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6.6；293 K；35% ammonium sulphate, 50% NaCl, 0.1M sodium acetate pH 6.6, VAPOR DIFFUSION, HANGING DROP, temperature 293.0K
Resolution 2.10 Å R-free 0.242
3RID X-ray structure of the C-terminal swapped dimer of P114A variant of Ribonuclease A Deposited 2011-04-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Mutation：P114A Mutation：P114A CGP 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；17-19% PEG 20000, 0.1M cacodylate, 100-150 mg/ml trehalose, 11mM dCpdG, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.0K
Resolution 2.18 Å R-free 0.249
3RID X-ray structure of the C-terminal swapped dimer of P114A variant of Ribonuclease A Deposited 2011-04-13 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 27–150（124 aa）
Chain D 27–150（124 aa）
Mutation：P114A Mutation：P114A CGP 2'-DEOXYCYTIDINE-2'-DEOXYGUANOSINE-3',5'-MONOPHOSPHATE × 2 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6.5；293 K；17-19% PEG 20000, 0.1M cacodylate, 100-150 mg/ml trehalose, 11mM dCpdG, pH 6.5, VAPOR DIFFUSION, SITTING DROP, temperature 293.0K
Resolution 2.18 Å R-free 0.249
3RN3 SEGMENTED ANISOTROPIC REFINEMENT OF BOVINE RIBONUCLEASE A BY THE APPLICATION OF THE RIGID-BODY TLS MODEL Deposited 1991-10-30 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.45 Å
3RSD STRUCTURE OF THE D121N VARIANT OF RIBONUCLEASE A Deposited 1998-02-05 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：D121N No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions batch method；pH 5.2；LYOPHILIZED D121N RNASE A WAS DISSOLVED IN UNBUFFERED WATER TO A CONCENTRATION OF 60MG/ ML. CRYSTALLIZATION WAS PERFORMED IN SMALL SILICONIZED TUBES USING THE BATCH METHOD. A SOLUTION (25UL) OF THE ENZYME WAS MIXED WITH AN EQUAL VOLUME OF 95% (V/V) 2-METHYL-2,4-PENTANEDIOL IN 0.10 M MES BUFFER, PH 5.2. CRYSTALS APPEARED WITHIN SEVERAL MONTHS., batch method
Resolution 1.60 Å
3RSK STRUCTURE OF THE K7A/R10A/K66A VARIANT OF RIBONUCLEASE A Deposited 1998-04-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：K7A, R10A, K66A ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；CRYSTALS WERE PREPARED USING THE HANGING DROP METHOD. LYOPHILIZED K7A/R10A/K66A RNASE A WAS DISSOLVED IN UNBUFFERED WATER TO A CONCENTRATION OF 60MG/ML. DROPS CONSISTING OF PROTEIN SOLUTION (1.5UL), WATER (1.5UL), AND RESERVOIR SOLUTION (3.0UL) WERE SUSPENDED OVER 0.5 ML OF RESERVOIR SOLUTION [0.1M SODIUM ACETATE BUFFER, PH 4.5, CONTAINING 36% PEG 4000., vapor diffusion - hanging drop
Resolution 2.00 Å
3RSP STRUCTURE OF THE P93G VARIANT OF RIBONUCLEASE A Deposited 1997-10-20 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：P93G CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；6UL DROPS COMPOSED OF 15MG/ML PROTEIN,50MM SODIUM ACETATE AT PH 6.0, 15% SATURATED AMMONIUM SULFATE AND 25% SATURATED SODIUM CHLORIDE WERE SUSPENDED OVER 0.5ML WELLS CONTAINING 100MM SODIUM ACETATE, PH 6.0, 30% SATURATED AMMONIUM SULFATE AND 50% SATURATED SODIUM CHLORIDE. TEMPERATURE: 20C., vapor diffusion - hanging drop
Resolution 1.70 Å
3SRN STRUCTURAL CHANGES THAT ACCOMPANY THE REDUCED CATALYTIC EFFICIENCY OF TWO SEMISYNTHETIC RIBONUCLEASE ANALOGS Deposited 1991-05-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–139（113 aa）
Chain B 98–106（9 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions THE MOTHER LIQUOR WAS 80 PERCENT SATURATED AMMONIUM SULFATE, PH 5.2.
Resolution 2.00 Å
4AO1 High resolution crystal structure of bovine pancreatic ribonuclease crystallized using ionic liquid Deposited 2012-03-23 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 4.5；RIBONUCLEASE A FROM BOVINE PANCREAS (SIGMA) HAS BEEN DISSOLVED IN 50 MM SODIUM ACETATE BUFFER (PH 4.57) AND CRYSTALLIZED BY THE SITTING DROP DIFFUSION METHOD
Resolution 1.58 Å R-free 0.196
4G8V Crystal structure of Ribonuclease A in complex with 5a Deposited 2012-07-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded 0EY 1-{[1-(alpha-L-arabinofuranosyl)-1H-1,2,3-triazol-4-yl]methyl}-2,4-dioxo-1,2,3,4-tetrahydropyrimidine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；25% PEG 4000, 20 mM Nacitrate, pH 5,5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.70 Å R-free 0.237
4G8V Crystal structure of Ribonuclease A in complex with 5a Deposited 2012-07-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；289 K；25% PEG 4000, 20 mM Nacitrate, pH 5,5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.70 Å R-free 0.237
4G8Y Crystal structure of Ribonuclease A in complex with 5b Deposited 2012-07-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded 0FT 1-{[1-(alpha-L-arabinofuranosyl)-1H-1,2,3-triazol-4-yl]methyl}-5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；25% PEG 4000, 20 mM Nacitrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.80 Å R-free 0.257
4G8Y Crystal structure of Ribonuclease A in complex with 5b Deposited 2012-07-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；25% PEG 4000, 20 mM Nacitrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.80 Å R-free 0.257
4G90 Crystal structure of Ribonuclease A in complex with 5e Deposited 2012-07-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded 0G0 1-{[1-(alpha-L-arabinofuranosyl)-1H-1,2,3-triazol-4-yl]methyl}-5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；25% PEG 4000, 20 mM Nacitrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.90 Å R-free 0.236
4G90 Crystal structure of Ribonuclease A in complex with 5e Deposited 2012-07-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；25% PEG 4000, 20 mM Nacitrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 289K
Resolution 1.90 Å R-free 0.236
4J5Z Crystal structure of Ribonuclease A in aqueous solution: One of twelve in MSCS set Deposited 2013-02-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；35% ammonium sulfate, 1.5 M sodium chloride, 35 mg/mL protein in 20 mM sodium phosphate buffer, pH 6.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.80 Å R-free 0.210
4J60 Crystal structure of Ribonuclease A soaked in 25% Cyclopentanol: One of twelve in MSCS set Deposited 2013-02-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 YEG cyclopentanol × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；35% ammonium sulfate, 1.5 M sodium chloride, 35 mg/mL protein in 20 mM sodium phosphate buffer, pH 6.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.69 Å R-free 0.195
4J61 Crystal structure of Ribonuclease A soaked in 40% Cyclopentanone: One of twelve in MSCS set Deposited 2013-02-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 MFW cyclopentanone × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；35% ammonium sulfate, 1.5 M sodium chloride, 35 mg/mL protein in 20 mM sodium phosphate buffer, pH 6.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.69 Å R-free 0.194
4J62 Crystal structure of Ribonuclease A soaked in 40% Cyclohexanol: One of twelve in MSCS set Deposited 2013-02-11 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 CXL CYCLOHEXANOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；35% ammonium sulfate, 1.5 M sodium chloride, 35 mg/mL protein in 20 mM sodium phosphate buffer, pH 6.0, vapor diffusion, hanging drop, temperature 291K
Resolution 2.04 Å R-free 0.226
4J63 Crystal structure of Ribonuclease A soaked in 40% Cyclohexanone: One of twelve in MSCS set Deposited 2013-02-11 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 CYH CYCLOHEXANONE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；35% ammonium sulfate, 1.5 M sodium chloride, 35 mg/mL protein in 20 mM sodium phosphate buffer, pH 6.0, vapor diffusion, hanging drop, temperature 291K
Resolution 2.04 Å R-free 0.219
4J64 Crystal structure of Ribonuclease A soaked in 40% Dioxane: One of twelve in MSCS set Deposited 2013-02-11 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded DIO 1,4-DIETHYLENE DIOXIDE × 4 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；35% ammonium sulfate, 1.5 M sodium chloride, 35 mg/mL protein in 20 mM sodium phosphate buffer, pH 6.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.78 Å R-free 0.209
4J65 Crystal structure of Ribonuclease A soaked in 40% Dimethylformamide: One of twelve in MSCS set Deposited 2013-02-11 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 DMF DIMETHYLFORMAMIDE × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；35% ammonium sulfate, 1.5 M sodium chloride, 35 mg/mL protein in 20 mM sodium phosphate buffer, pH 6.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.96 Å R-free 0.234
4J66 Crystal structure of Ribonuclease A soaked in 25% Dimethyl sulfoxide: One of twelve in MSCS set Deposited 2013-02-11 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 DMS DIMETHYL SULFOXIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；35% ammonium sulfate, 1.5 M sodium chloride, 35 mg/mL protein in 20 mM sodium phosphate buffer, pH 6.0, vapor diffusion, hanging drop, temperature 291K
Resolution 2.04 Å R-free 0.238
4J67 Crystal structure of Ribonuclease A soaked in 50% 1,6-Hexanediol: One of twelve in MSCS set Deposited 2013-02-11 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 HEZ HEXANE-1,6-DIOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；35% ammonium sulfate, 1.5 M sodium chloride, 35 mg/mL protein in 20 mM sodium phosphate buffer, pH 6.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.86 Å R-free 0.220
4J68 Crystal structure of Ribonuclease A soaked in 40% Isopropanol: One of twelve in MSCS set Deposited 2013-02-11 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 IPA ISOPROPYL ALCOHOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；35% ammonium sulfate, 1.5 M sodium chloride, 35 mg/mL protein in 20 mM sodium phosphate buffer, pH 6.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.78 Å R-free 0.208
4J69 Crystal structure of Ribonuclease A soaked in 50% S,R,S-bisfuranol: One of twelve in MSCS set Deposited 2013-02-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 4 RSG (3S,3aR,6aS)-hexahydrofuro[2,3-b]furan-3-ol × 18 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；35% ammonium sulfate, 1.5 M sodium chloride, 35 mg/mL protein in 20 mM sodium phosphate buffer, pH 6.0, vapor diffusion, hanging drop, temperature 291K
Resolution 1.89 Å R-free 0.222
4J6A Crystal structure of Ribonuclease A soaked in 40% 2,2,2-Trifluoroethanol: One of twelve in MSCS set Deposited 2013-02-11 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 ETF TRIFLUOROETHANOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；291 K；35% ammonium sulfate, 1.5 M sodium chloride, 35 mg/mL protein in 20 mM sodium phosphate buffer, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
Resolution 2.04 Å R-free 0.204
4K7L Crystal structure of RNase S variant (K7C/Q11C) Deposited 2013-04-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–41（15 aa） Fragment：unp residues 27-41
Chain B 47–150（104 aa） Fragment：unp residues 47-150
Mutation：K7C, Q11C SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 4；292 K；0.1 M Citric Acid, 2.4 M Ammonium Sulfate, pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 292K
Resolution 1.38 Å R-free 0.188
4K7M Crystal structure of RNase S variant (K7C/Q11C) with bound mercury ions Deposited 2013-04-17 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa） Fragment：unp residues 27-150
Mutation：K7C, Q11C HG MERCURY (II) ION × 2 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 3.9；292 K；0.1 M Citric Acid, 2.1 M Ammonium Sulfate, pH 3.9, VAPOR DIFFUSION, HANGING DROP, temperature 292K
Resolution 1.80 Å R-free 0.205
4K7M Crystal structure of RNase S variant (K7C/Q11C) with bound mercury ions Deposited 2013-04-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa） Fragment：unp residues 27-150
Mutation：K7C, Q11C HG MERCURY (II) ION × 4 SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 3.9；292 K；0.1 M Citric Acid, 2.1 M Ammonium Sulfate, pH 3.9, VAPOR DIFFUSION, HANGING DROP, temperature 292K
Resolution 1.80 Å R-free 0.205
4L55 X-ray structure of the adduct between bovine pancreatic ribonuclease and AziRu Deposited 2013-06-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded RU RUTHENIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；20% PEG 4000, sodium citrate, pH 5.00, VAPOR DIFFUSION, HANGING DROP at 298K soaked in a satured solution of AziRu
Resolution 1.65 Å R-free 0.244
4L55 X-ray structure of the adduct between bovine pancreatic ribonuclease and AziRu Deposited 2013-06-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded RU RUTHENIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；20% PEG 4000, sodium citrate, pH 5.00, VAPOR DIFFUSION, HANGING DROP at 298K soaked in a satured solution of AziRu
Resolution 1.65 Å R-free 0.244
4MXF X-ray structure of the adduct between bovine pancreatic ribonuclease and Auoxo6, a dinuclear gold(III) complex with -dioxo bridges linking the two metal centers Deposited 2013-09-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded AU GOLD ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；20% PEG4000 and 20 mM sodium citrate buffer pH 5.0. Crystals appeared within 7 days. After two weeks, crystals were soaked in a solution of the gold-based drug dissolved in DMSO and in 50 mM sodium citrate buffer pH 5.0. At the final, concentrations of metallodrugs and protein were in at least 1:1 ratio., VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.25 Å R-free 0.268
4MXF X-ray structure of the adduct between bovine pancreatic ribonuclease and Auoxo6, a dinuclear gold(III) complex with -dioxo bridges linking the two metal centers Deposited 2013-09-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；20% PEG4000 and 20 mM sodium citrate buffer pH 5.0. Crystals appeared within 7 days. After two weeks, crystals were soaked in a solution of the gold-based drug dissolved in DMSO and in 50 mM sodium citrate buffer pH 5.0. At the final, concentrations of metallodrugs and protein were in at least 1:1 ratio., VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.25 Å R-free 0.268
4O36 Semisynthetic RNase S1-15-H7/11-Q10 Deposited 2013-12-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–41（15 aa） Fragment：unp residues 27-41
Chain B 47–150（104 aa） Fragment：unp residues 47-150
Mutation：K7H, R10Q, Q11H SO4 SULFATE ION × 1 CL CHLORIDE ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 3.8；292 K；100 mM sodium citrate 2.4 M ammonium sulfate, pH 3.8, VAPOR DIFFUSION, HANGING DROP, temperature 292K
Resolution 1.22 Å R-free 0.226
4O37 seminsynthetic RNase S1-15-3Pl-7/11 Deposited 2013-12-18 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–41（15 aa） Fragment：S-peptide
Chain B 47–150（104 aa） Fragment：S-protein
Mutation：K7-> 3Pl, Q11-> 3Pl, M13 -> Nle Non-standard monomer：Yes (specific site not provided by mmCIF) Mutation：wild type CL CHLORIDE ION × 1 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 3.8；292 K；100 mM sodium citrate 2.2 M ammonium sulfate, pH 3.8, VAPOR DIFFUSION, HANGING DROP, temperature 292K
Resolution 1.40 Å R-free 0.211
4OKF RNase S in complex with an artificial peptide Deposited 2014-01-22 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–41（15 aa） Fragment：S-peptide: unp residues 27-41
Chain B 47–150（104 aa） Fragment：S-protein: unp residues 47-150
Mutation：A6(DHA), M13(NLE) Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 CL CHLORIDE ION × 12 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.1；292 K；0.1 M sodium citrate, 2.4 M ammoniumsulfate, pH 4.1, VAPOR DIFFUSION, HANGING DROP, temperature 292K
Resolution 1.54 Å R-free 0.210
4OOH Structure of RIBONUCLEASE A at 40C Deposited 2014-02-02 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa） Fragment：UNP residues27-150
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；313 K；3M sodium chloride, 30% Ammonium Sulphate, 0.1M sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 313K
Resolution 1.89 Å R-free 0.221
4OOH Structure of RIBONUCLEASE A at 40C Deposited 2014-02-02 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa） Fragment：UNP residues27-150
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；313 K；3M sodium chloride, 30% Ammonium Sulphate, 0.1M sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 313K
Resolution 1.89 Å R-free 0.221
4OT4 X-ray Structure of the Adduct formed between cisplatin and Ribonuclease A Deposited 2014-02-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CPT Cisplatin × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；Crystals of RNase A were grown by hanging-drop vapor diffusion technique at 298 K mixing a protein solution containing 20 mg mL-1 of RNase A with equal volumes of reservoir solution. Well diffracting crystals appeared within 15days from the following conditions:20% PEG4000 and 20 mM sodium citrate buffer pH 5.0. , VAPOR DIFFUSION, HANGING DROP
Resolution 1.85 Å R-free 0.247
4OT4 X-ray Structure of the Adduct formed between cisplatin and Ribonuclease A Deposited 2014-02-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded CPT Cisplatin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；Crystals of RNase A were grown by hanging-drop vapor diffusion technique at 298 K mixing a protein solution containing 20 mg mL-1 of RNase A with equal volumes of reservoir solution. Well diffracting crystals appeared within 15days from the following conditions:20% PEG4000 and 20 mM sodium citrate buffer pH 5.0. , VAPOR DIFFUSION, HANGING DROP
Resolution 1.85 Å R-free 0.247
4PEQ Structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease I Deposited 2014-04-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa） Fragment：UNP residues 27-150
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；1:1 protein solution (20 mM HEPES-NaOH, 10 mM DTT, 2% w/v glycerol, pH 7.5) to well solution (100 mM malic acid/MES/Tris, pH 4.0, 25% PEG1500), cryoprotectant: 100 mM malic acid/MES/Tris, pH 4.0, 25% PEG1500, 15% ethylene glycol
Resolution 2.21 Å R-free 0.226
4PEQ Structure of bovine ribonuclease inhibitor complexed with bovine ribonuclease I Deposited 2014-04-24 Different construct Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain C 27–150（124 aa） Fragment：UNP residues 27-150
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4；298 K；1:1 protein solution (20 mM HEPES-NaOH, 10 mM DTT, 2% w/v glycerol, pH 7.5) to well solution (100 mM malic acid/MES/Tris, pH 4.0, 25% PEG1500), cryoprotectant: 100 mM malic acid/MES/Tris, pH 4.0, 25% PEG1500, 15% ethylene glycol
Resolution 2.21 Å R-free 0.226
4POU VHH-metal in Complex with RNase A Deposited 2014-02-26 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein heterocomplex Heteromer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 8.5；298.15 K；25% PEG 3,350, 0.1M Bis-Tris, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 298.15K
Resolution 1.75 Å R-free 0.230
4QH3 X-ray structure of the adduct formed between bovine pancreatic ribonuclease and trans-dimethylamine methylamine dichlorido platinum(II) Deposited 2014-05-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded I83 bis(chloranyl)-(dimethylamino)-(methylamino)platinum × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；293 K；20% PEG4000, 10 mM sodium citrate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.275
4QH3 X-ray structure of the adduct formed between bovine pancreatic ribonuclease and trans-dimethylamine methylamine dichlorido platinum(II) Deposited 2014-05-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded I83 bis(chloranyl)-(dimethylamino)-(methylamino)platinum × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；293 K；20% PEG4000, 10 mM sodium citrate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K
Resolution 2.00 Å R-free 0.275
4RAT EFFECTS OF TEMPERATURE ON PROTEIN STRUCTURE AND DYNAMICS: X-RAY CRYSTALLOGRAPHIC STUDIES OF THE PROTEIN RIBONUCLEASE-A AT NINE DIFFERENT TEMPERATURES FROM 98 TO 320 K Deposited 1991-08-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
4RSD STRUCTURE OF THE D121A VARIANT OF RIBONUCLEASE A Deposited 1998-02-05 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：D121A ACT ACETATE ION × 1 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions pH 5.3；DROPS CONSISTING OF 1.5UL OF A 60MG/ML PROTEIN SOLUTION, 1.5UL OF H2O AND 3UL OF RESERVOIR SOLUTION WERE SUSPENDED OVER A 0.5ML RESERVOIR CONTAINING A SOLUTION OF 2.5M NAOAC, PH 5.3 IN SATURATING NACL. TEMP. 20C.
Resolution 1.60 Å
4RSK STRUCTURE OF THE K7A/R10A/K66A VARIANT OF RIBONUCLEASE A COMPLEXED WITH 3'-UMP Deposited 1998-04-09 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：K7A, R10A, K66A U3P 3'-URIDINEMONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；CRYSTALS WERE PREPARED USING THE HANGING DROP METHOD. LYOPHILIZED K7A/R10A/K66A RNASE A WAS DISSOLVED IN UNBUFFERED WATER TO A CONCENTRATION OF 60MG/ML. DROPS CONSISTING OF PROTEIN SOLUTION (1.5MICROLITER), WATER (1.5MICROLITER), AND RESERVOIR SOLUTION (3.0MICROLITER) WERE SUSPENDED OVER 0.5 ML OF RESERVOIR SOLUTION (0.1M SODIUM ACETATE BUFFER, PH 4.5, CONTAINING 36% PEG 4000). THE COMPLEX WITH 3'-UMP WAS PREPARED BY SOAKING CRYSTALS IN MOTHER LIQUOR CONTAINING 5MM 3'-UMP FOR 2 DAYS., vapor diffusion - hanging drop
Resolution 2.10 Å
4RTE The X-ray structure of bovine pancreatic ribonuclease incubated in the presence of an excess of cisplatin (1:10 ratio) Deposited 2014-11-14 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CPT Cisplatin × 4 CL CHLORIDE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；protein concentration 15 mg mL-1 and a precipitant solution containing 30 % ammonium sulfate and 3.0 M sodium chloride, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.95 Å R-free 0.224
4RTE The X-ray structure of bovine pancreatic ribonuclease incubated in the presence of an excess of cisplatin (1:10 ratio) Deposited 2014-11-14 Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Not recorded CPT Cisplatin × 8 CL CHLORIDE ION × 6 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 7；298 K；protein concentration 15 mg mL-1 and a precipitant solution containing 30 % ammonium sulfate and 3.0 M sodium chloride, pH 7, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 1.95 Å R-free 0.224
4S0Q The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and carboplatin Deposited 2015-01-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded QPT carboplatin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；Crystals of the RNase A-carboplatin adduct have been obtained by soaking experiments where pre-grown monoclinic protein crystals were incubated with an excess of the platinum drug (at a protein to platinum ratio 1:10). Crystals of RNase A were grown by hanging-drop vapor mixing 1 L of RNase A at 20 mg mL-1 with equal volumes of reservoir solution containing 20% PEG4000 and 20 mM sodium citrate buffer pH 5.0 at 298 K. Two weeks after their appearance, crystals were soaked for four days in a solution of Carboplatin dissolved in 10 L of reservoir. At the final, Pt drug:protein concentrations were in 10:1 ratio., VAPOR DIFFUSION, HANGING DROP
Resolution 2.09 Å R-free 0.262
4S0Q The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and carboplatin Deposited 2015-01-04 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded QPT carboplatin × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；Crystals of the RNase A-carboplatin adduct have been obtained by soaking experiments where pre-grown monoclinic protein crystals were incubated with an excess of the platinum drug (at a protein to platinum ratio 1:10). Crystals of RNase A were grown by hanging-drop vapor mixing 1 L of RNase A at 20 mg mL-1 with equal volumes of reservoir solution containing 20% PEG4000 and 20 mM sodium citrate buffer pH 5.0 at 298 K. Two weeks after their appearance, crystals were soaked for four days in a solution of Carboplatin dissolved in 10 L of reservoir. At the final, Pt drug:protein concentrations were in 10:1 ratio., VAPOR DIFFUSION, HANGING DROP
Resolution 2.09 Å R-free 0.262
4S18 The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and oxaliplatin Deposited 2015-01-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded 1PT CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II) × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；RNase A was crystallized at room temperature mixing 1 L solution of protein at 20 mg mL-1 with an equal volume of reservoir solution containing 20% PEG4000 and 20 mM sodium citrate buffer pH 5.0. Two weeks after their appearance, single crystals were soaked for four days in a solution of Oxaliplatin dissolved in 10 L of reservoir. At the final, Pt drugs:protein concentrations were in 10:1 ratio, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.27 Å R-free 0.301
4S18 The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and oxaliplatin Deposited 2015-01-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded 1PT CYCLOHEXANE-1(R),2(R)-DIAMINE-PLATINUM(II) × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；298 K；RNase A was crystallized at room temperature mixing 1 L solution of protein at 20 mg mL-1 with an equal volume of reservoir solution containing 20% PEG4000 and 20 mM sodium citrate buffer pH 5.0. Two weeks after their appearance, single crystals were soaked for four days in a solution of Oxaliplatin dissolved in 10 L of reservoir. At the final, Pt drugs:protein concentrations were in 10:1 ratio, VAPOR DIFFUSION, HANGING DROP, temperature 298K
Resolution 2.27 Å R-free 0.301
4SRN STRUCTURAL CHANGES THAT ACCOMPANY THE REDUCED CATALYTIC EFFICIENCY OF TWO SEMISYNTHETIC RIBONUCLEASE ANALOGS Deposited 1991-05-20 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–139（113 aa）
Chain B 140–150（11 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions THE MOTHER LIQUOR WAS 80 PERCENT SATURATED AMMONIUM SULFATE, PH 5.2.
Resolution 2.00 Å
4WYN The crystal structure of the A109G mutant of RNase A Deposited 2014-11-17 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Mutation：A109G No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M MIB buffer, 20% (w/v) PEG 1,500
Resolution 1.80 Å R-free 0.203
4WYN The crystal structure of the A109G mutant of RNase A Deposited 2014-11-17 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Mutation：A109G No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；294 K；0.1 M MIB buffer, 20% (w/v) PEG 1,500
Resolution 1.80 Å R-free 0.203
4WYP The crystal structure of the A109G mutant of RNase A in complex with 5'AMP Deposited 2014-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Mutation：A109G Mutation：A109G AMP ADENOSINE MONOPHOSPHATE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 7；294 K；MIB Buffer, PEG 6,000
Resolution 1.50 Å R-free 0.186
4WYZ The crystal structure of the A109G mutant of RNase A in complex with 3'UMP Deposited 2014-11-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa） Fragment：residues 27-150
Mutation：A109G U3P 3'-URIDINEMONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；MIB buffer, PEG 1500
Resolution 1.45 Å R-free 0.171
4WYZ The crystal structure of the A109G mutant of RNase A in complex with 3'UMP Deposited 2014-11-18 Different construct Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa） Fragment：residues 27-150
Mutation：A109G U3P 3'-URIDINEMONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 6；293 K；MIB buffer, PEG 1500
Resolution 1.45 Å R-free 0.171
4ZZ4 Neutron crystal structure of ribonuclease A determined by the real space D/H contrast method Deposited 2015-05-22 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 1 NEUTRON DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；293 K；a H2O-solvent crystal was sealed in a capillary with D2O-buffer containing 20 mg/mL ribonuclease A, 0.05 M sodium acetate, and 50% 2-d8-propanol (pD 5.8) to exchange hydrogen atoms in the crystal with deuterium atoms.
Resolution 1.80 Å R-free 0.221
5D6U X-ray crystal structure of ribonuclease A determined for the real space D/H contrast method Deposited 2015-08-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 5.8；293 K；20 mg/mL ribonuclease A, 0.05 M sodium acetate, 50% 2-propanol
Resolution 1.52 Å R-free 0.156
5D97 Neutron crystal structure of H2O-solvent ribonuclease A Deposited 2015-08-18 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 1 NEUTRON DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 5.8；293 K；20 mg/mL ribonuclease A, 0.05 M sodium acetate, 50% 2-propanol
Resolution 1.80 Å R-free 0.222
5E5E X-ray structure of the adduct formed in the reaction between RNase A and a neutral organometallic derivative [Pt(pbi)(Me)(DMSO)], pbi=2-(2'-pyridil)benzimidazole (compound 3) Deposited 2015-10-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded PT PLATINUM (II) ION × 2 DMS DIMETHYL SULFOXIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；RNase A crystals were grown by hanging drop vapor diffusion method using a reservoir solution containing 22-24 % (w/v) PEG4K, 10 mM sodium citrate pH 5.1-5.3. The crystals are monoclinic, space group C2, with two molecules in the asymmetric unit. The adduct was prepared by a three-days soaking in a solution that comprised the standard mother liquor used for the crystal growth to which a 2.5 mM solution of compound 3was added
Resolution 1.98 Å R-free 0.254
5E5E X-ray structure of the adduct formed in the reaction between RNase A and a neutral organometallic derivative [Pt(pbi)(Me)(DMSO)], pbi=2-(2'-pyridil)benzimidazole (compound 3) Deposited 2015-10-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；RNase A crystals were grown by hanging drop vapor diffusion method using a reservoir solution containing 22-24 % (w/v) PEG4K, 10 mM sodium citrate pH 5.1-5.3. The crystals are monoclinic, space group C2, with two molecules in the asymmetric unit. The adduct was prepared by a three-days soaking in a solution that comprised the standard mother liquor used for the crystal growth to which a 2.5 mM solution of compound 3was added
Resolution 1.98 Å R-free 0.254
5E5F X-ray structure of the complex between RNase A and compound 4-PF6 ([(PPh3)Au(mi-pbi)Pt(Me)(DMSO)][PF6]), the heterobimetallic derivative obtained in the reaction between the organometallic compound [Pt(pbi)(Me)(DMSO)], pbi=2-(2'-pyridil)benzimidazole (compound 3) and the gold(I) compound [Au(Ph3P)][PF6] Deposited 2015-10-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded AU GOLD ION × 1 SO4 SULFATE ION × 1 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；RNase A crystals were obtained using the procedure previously described by Vitagliano et al., 200028. Briefly, crystals of the protein were grown by hanging drop vapor diffusion method using a reservoir solution containing 22-24 % (w/v) PEG4K, 10 mM sodium citrate pH 5.1-5.3. The crystals are monoclinic, space group C2, with two molecules in the asymmetric unit. The adducts were prepared by a three-days soaking in a solution that comprised the standard mother liquor used for the crystal growth to which a 2.5-5 mM solution of each compound was added. Crystal soaked in this solution were mounted for the X-ray data collection without using a cryoprotectant, as done in previous studies30.
Resolution 1.68 Å R-free 0.234
5E5F X-ray structure of the complex between RNase A and compound 4-PF6 ([(PPh3)Au(mi-pbi)Pt(Me)(DMSO)][PF6]), the heterobimetallic derivative obtained in the reaction between the organometallic compound [Pt(pbi)(Me)(DMSO)], pbi=2-(2'-pyridil)benzimidazole (compound 3) and the gold(I) compound [Au(Ph3P)][PF6] Deposited 2015-10-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；RNase A crystals were obtained using the procedure previously described by Vitagliano et al., 200028. Briefly, crystals of the protein were grown by hanging drop vapor diffusion method using a reservoir solution containing 22-24 % (w/v) PEG4K, 10 mM sodium citrate pH 5.1-5.3. The crystals are monoclinic, space group C2, with two molecules in the asymmetric unit. The adducts were prepared by a three-days soaking in a solution that comprised the standard mother liquor used for the crystal growth to which a 2.5-5 mM solution of each compound was added. Crystal soaked in this solution were mounted for the X-ray data collection without using a cryoprotectant, as done in previous studies30.
Resolution 1.68 Å R-free 0.234
5ET4 Structure of RNase A-K7H/R10H in complex with 3'-CMP Deposited 2015-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 4 PDB declaration: tetrameric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Chain C 27–150（124 aa）
Chain D 27–150（124 aa）
Mutation：K7H, R10H Mutation：K7H, R10H Mutation：K7H, R10H Mutation：K7H, R10H C3P CYTIDINE-3'-MONOPHOSPHATE × 4 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5；289 K；800 uL crystallisation condition reservoir formed by 27% PEG4000 and 20 mM sodium cacodylate buffer, pH 5.0. Crystals grew from droplets of 1 uL of protein solution and an equal volume of reservoir solution.
Resolution 2.10 Å R-free 0.321
5JLG The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and compound I, a piano-stool organometallic Ru(II) arene compound containing an O,S-chelating ligand Deposited 2016-04-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded RU RUTHENIUM ION × 1 6L6 methyl (2Z)-3-hydroxy-3-(3-hydroxyphenyl)prop-2-ene(dithioate) × 1 DMS DIMETHYL SULFOXIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% PEG 4k 10 mM sodium citrate pH 5.1
Resolution 1.79 Å R-free 0.236
5JLG The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and compound I, a piano-stool organometallic Ru(II) arene compound containing an O,S-chelating ligand Deposited 2016-04-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded RU RUTHENIUM ION × 1 6L6 methyl (2Z)-3-hydroxy-3-(3-hydroxyphenyl)prop-2-ene(dithioate) × 1 DMS DIMETHYL SULFOXIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% PEG 4k 10 mM sodium citrate pH 5.1
Resolution 1.79 Å R-free 0.236
5JMG X-ray structure of the complex between bovine pancreatic ribonuclease and pentachlorocarbonyliridate(III) (4 days of soaking) Deposited 2016-04-29 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IR IRIDIUM ION × 4 CL CHLORIDE ION × 2 CMO CARBON MONOXIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4K, 10 mM sodium citrate pH 5.1
Resolution 1.85 Å R-free 0.226
5JMG X-ray structure of the complex between bovine pancreatic ribonuclease and pentachlorocarbonyliridate(III) (4 days of soaking) Deposited 2016-04-29 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded IR IRIDIUM ION × 1 CL CHLORIDE ION × 3 CMO CARBON MONOXIDE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4K, 10 mM sodium citrate pH 5.1
Resolution 1.85 Å R-free 0.226
5JML X-ray structure of the complex between bovine pancreatic ribonuclease and penthachlorocarbonyliridate(III) (2 months of soaking) Deposited 2016-04-29 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IR IRIDIUM ION × 5 O OXYGEN ATOM × 1 CL CHLORIDE ION × 2 CMO CARBON MONOXIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4K, 10 mM soium citrate pH 5.1
Resolution 2.29 Å R-free 0.294
5JML X-ray structure of the complex between bovine pancreatic ribonuclease and penthachlorocarbonyliridate(III) (2 months of soaking) Deposited 2016-04-29 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded IR IRIDIUM ION × 3 CL CHLORIDE ION × 3 CMO CARBON MONOXIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4K, 10 mM soium citrate pH 5.1
Resolution 2.29 Å R-free 0.294
5NA9 The X-ray structure of bovine pancreatic ribonuclease incubated in the presence of an excess of carboplatin (1:10 ratio) Deposited 2017-02-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded QPT carboplatin × 1 CS CESIUM ION × 4 CL CHLORIDE ION × 9 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；277 K；1.5 M ammonium sulfate - 0.1 M sodium acetate pH 5.5 - 3.0 M cesium chloride
Resolution 2.07 Å R-free 0.244
5NJ7 The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and arsenoplatin-1 Deposited 2017-03-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded A6R arsenoplatin-1 × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% w/v PEG4K, 10 mM sodium acetate pH 5.1. Crystals of RNase A-AP-1 were formed by soaking pre-grown RNase A crystals for 3 h in a solution containing 5 mM AP-1 dissolved in DMSO and then added to the reservoir.
Resolution 2.15 Å R-free 0.250
5NJ7 The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and arsenoplatin-1 Deposited 2017-03-28 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded A6R arsenoplatin-1 × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% w/v PEG4K, 10 mM sodium acetate pH 5.1. Crystals of RNase A-AP-1 were formed by soaking pre-grown RNase A crystals for 3 h in a solution containing 5 mM AP-1 dissolved in DMSO and then added to the reservoir.
Resolution 2.15 Å R-free 0.250
5OBC X-ray structure of the adduct formed upon reaction of ribonuclease A with the compound fac-[RuII(CO)3Cl2(N3-IM), IM=imidazole Deposited 2017-06-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded RU2 pentakis(oxidaniumyl)-(oxidaniumylidynemethyl)ruthenium × 1 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；18% PEG4K, 10 mM sodium citrate pH 5.1 Soaking: 4 days Ligand concen-tration: 5 mM
Resolution 2.07 Å R-free 0.272
5OBC X-ray structure of the adduct formed upon reaction of ribonuclease A with the compound fac-[RuII(CO)3Cl2(N3-IM), IM=imidazole Deposited 2017-06-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded RU2 pentakis(oxidaniumyl)-(oxidaniumylidynemethyl)ruthenium × 1 9Q8 tris(oxidaniumylidynemethyl)-tris(oxidanyl)ruthenium × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；18% PEG4K, 10 mM sodium citrate pH 5.1 Soaking: 4 days Ligand concen-tration: 5 mM
Resolution 2.07 Å R-free 0.272
5OBD X-ray structure of the adduct formed upon reaction of ribonuclease A with the compound fac-[RuII(CO)3Cl2(N3-MIM), MIM=methyl-imidazole Deposited 2017-06-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded 9Q8 tris(oxidaniumylidynemethyl)-tris(oxidanyl)ruthenium × 1 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；22% PEG4K, 10 mM sodium cit-rate pH 5.1 Soaking: 14 days Ligand concentration: 5 mM
Resolution 1.98 Å R-free 0.279
5OBD X-ray structure of the adduct formed upon reaction of ribonuclease A with the compound fac-[RuII(CO)3Cl2(N3-MIM), MIM=methyl-imidazole Deposited 2017-06-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded 9Q8 tris(oxidaniumylidynemethyl)-tris(oxidanyl)ruthenium × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；22% PEG4K, 10 mM sodium cit-rate pH 5.1 Soaking: 14 days Ligand concentration: 5 mM
Resolution 1.98 Å R-free 0.279
5OBE X-ray structure of the adduct formed upon reaction of ribonuclease A with the compound fac-[RuII(CO)3Cl2(N3-MBI), MBI=methyl-benzimidazole Deposited 2017-06-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded RU2 pentakis(oxidaniumyl)-(oxidaniumylidynemethyl)ruthenium × 1 PO4 PHOSPHATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；22% PEG4K, 10 mM sodium citrate pH 5.1 Soaking: 3 days Ligand con-centration: 5 mM
Resolution 1.82 Å R-free 0.236
5OBE X-ray structure of the adduct formed upon reaction of ribonuclease A with the compound fac-[RuII(CO)3Cl2(N3-MBI), MBI=methyl-benzimidazole Deposited 2017-06-26 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded 9Q8 tris(oxidaniumylidynemethyl)-tris(oxidanyl)ruthenium × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；298 K；22% PEG4K, 10 mM sodium citrate pH 5.1 Soaking: 3 days Ligand con-centration: 5 mM
Resolution 1.82 Å R-free 0.236
5OGH Structure of RNase A at high resolution (1.16 A) in complex with 3'-CMP and sulphate ions Deposited 2017-07-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded C3P CYTIDINE-3'-MONOPHOSPHATE × 2 SO4 SULFATE ION × 1 CL CHLORIDE ION × 5 NA SODIUM ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；0.54 M ammonium sulphate, 1.25 M sodium chloride, 0.1 M sodium acetate pH 6.0
Resolution 1.16 Å R-free 0.135
5OLD X-ray structure of the adduct formed upon reaction of ribonuclease A with a tetranuclear Pt-thiosemicarbazone compound Deposited 2017-07-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded PT PLATINUM (II) ION × 2 DMS DIMETHYL SULFOXIDE × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；22% PEG4K 0.01 M sodium citrate pH 5.1
Resolution 1.78 Å R-free 0.250
5OLD X-ray structure of the adduct formed upon reaction of ribonuclease A with a tetranuclear Pt-thiosemicarbazone compound Deposited 2017-07-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded PT PLATINUM (II) ION × 2 DMS DIMETHYL SULFOXIDE × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293 K；22% PEG4K 0.01 M sodium citrate pH 5.1
Resolution 1.78 Å R-free 0.250
5RAT Effects of temperature on protein structure and dynamics: X-ray crystallographic studies of the protein ribonuclease-A at nine different temperatures from 98 TO 320 K Deposited 1991-08-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
5RSA COMPARISON OF TWO INDEPENDENTLY REFINED MODELS OF RIBONUCLEASE-A Deposited 1985-04-29 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded PO4 PHOSPHATE ION × 1 Experimental method not declared mmCIF provides none of the parsed conditions Resolution not provided
6ETK Atomic resolution structure of RNase A (data collection 1) Deposited 2017-10-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 5.3；293 K；Free-interface diffusion of a 10 uL of 30 mg ml-1 protein solution, 20 mM sodium citrate at pH 5.3 agaist 10 ul isopropanol 99.9% isopropanol.
Resolution 0.85 Å R-free 0.150
6ETL Atomic resolution structure of RNase A (data collection 2) Deposited 2017-10-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；pH 5.3；293 K；Free-interface diffusion of a 10 uL of 30 mg ml-1 protein solution, 20 mM sodium citrate at pH 5.3 agaist 10 ul isopropanol 99.9% isopropanol.
Resolution 0.85 Å R-free 0.122
6ETM Atomic resolution structure of RNase A (data collection 3) Deposited 2017-10-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；293 K；Free-interface diffusion of a 10 uL of 30 mg ml-1 protein solution, 20 mM sodium citrate at pH 5.3 agaist 10 ul isopropanol 99.9% isopropanol.
Resolution 0.92 Å R-free 0.136
6ETN Atomic resolution structure of RNase A (data collection 4) Deposited 2017-10-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；293 K；Free-interface diffusion of a 10 uL of 30 mg ml-1 protein solution, 20 mM sodium citrate at pH 5.3 agaist 10 ul isopropanol 99.9% isopropanol.
Resolution 0.92 Å R-free 0.141
6ETO Atomic resolution structure of RNase A (data collection 5) Deposited 2017-10-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；293 K；Free-interface diffusion of a 10 uL of 30 mg ml-1 protein solution, 20 mM sodium citrate at pH 5.3 agaist 10 ul isopropanol 99.9% isopropanol.
Resolution 1.02 Å R-free 0.165
6ETP Atomic resolution structure of RNase A (data collection 6) Deposited 2017-10-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 4 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；293 K；Free-interface diffusion of a 10 uL of 30 mg ml-1 protein solution, 20 mM sodium citrate at pH 5.3 agaist 10 ul isopropanol 99.9% isopropanol.
Resolution 1.02 Å R-free 0.178
6ETQ Atomic resolution structure of RNase A (data collection 7) Deposited 2017-10-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；293 K；Free-interface diffusion of a 10 uL of 30 mg ml-1 protein solution, 20 mM sodium citrate at pH 5.3 agaist 10 ul isopropanol 99.9% isopropanol.
Resolution 1.08 Å R-free 0.212
6ETR Atomic resolution structure of RNase A (data collection 8) Deposited 2017-10-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded IPA ISOPROPYL ALCOHOL × 3 X-RAY DIFFRACTION
X-ray crystallization conditions LIQUID DIFFUSION；293 K；Free-interface diffusion of a 10 uL of 30 mg ml-1 protein solution, 20 mM sodium citrate at pH 5.3 agaist 10 ul isopropanol 99.9% isopropanol.
Resolution 1.17 Å R-free 0.231
6F60 The x-ray structure of bovine pancreatic ribonuclease in complex with a five-coordinate platinum(II) compound containing a sugar ligand Deposited 2017-12-04 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 DVW five-coordinate platinum(II) compound × 1 DW5 five-coordinate platinum(II) compound × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；293.15 K；22% PEG 4K 0.01 M sodium citrate pH 5.1
Resolution 1.14 Å R-free 0.194
6GOK X-ray structure of the adduct formed upon reaction of bovine pancreatic ribonuclease with a Pd(II) complex bearing N,N-pyridylbenzimidazole derivative with an alkylated sulphonate side chain Deposited 2018-06-01 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded PD PALLADIUM ION × 1 F6Q N,N-pyridylbenzimidazole derivative-Pd complex × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；20% PEG4000 10 mM sodium citrate buffer pH 5.1
Resolution 2.65 Å R-free 0.255
6GOK X-ray structure of the adduct formed upon reaction of bovine pancreatic ribonuclease with a Pd(II) complex bearing N,N-pyridylbenzimidazole derivative with an alkylated sulphonate side chain Deposited 2018-06-01 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded PD PALLADIUM ION × 1 F6Q N,N-pyridylbenzimidazole derivative-Pd complex × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；20% PEG4000 10 mM sodium citrate buffer pH 5.1
Resolution 2.65 Å R-free 0.255
6PVU RNase A in complex with hexametaphosphate Deposited 2019-07-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded P0S 2,4,6,8,10,12-hexahydroxy-2lambda~5~,4lambda~5~,6lambda~5~,8lambda~5~,10lambda~5~,12lambda~5~-cyclohexaphosphoxane-2,4,6,8,10,12-hexone × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；20 mM sodium citrate, 20% PEG 4000
Resolution 1.49 Å R-free 0.236
6PVU RNase A in complex with hexametaphosphate Deposited 2019-07-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded P0S 2,4,6,8,10,12-hexahydroxy-2lambda~5~,4lambda~5~,6lambda~5~,8lambda~5~,10lambda~5~,12lambda~5~-cyclohexaphosphoxane-2,4,6,8,10,12-hexone × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；20 mM sodium citrate, 20% PEG 4000
Resolution 1.49 Å R-free 0.236
6PVV RNase A in complex with p5A Deposited 2019-07-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded 5FA ADENOSINE-5'-PENTAPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；20 mM sodium citrate, 20% PEG 4000
Resolution 1.65 Å R-free 0.223
6PVV RNase A in complex with p5A Deposited 2019-07-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded 5FA ADENOSINE-5'-PENTAPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；20 mM sodium citrate, 20% PEG 4000
Resolution 1.65 Å R-free 0.223
6PVW RNase A in complex with cp4pA Deposited 2019-07-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded OZV 5'-O-[(R)-hydroxy{[(4R,8S)-4,6,8-trihydroxy-2,4,6,8-tetraoxo-1,3,5,7,2lambda~5~,4lambda~5~,6lambda~5~,8lambda~5~-tetroxatetraphosphocan-2-yl]oxy}phosphoryl]adenosine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；20 mM sodium citrate, 20% PEG 4000
Resolution 1.60 Å R-free 0.226
6PVW RNase A in complex with cp4pA Deposited 2019-07-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded P0J 2,4,6,8-tetrahydroxy-1,3,5,7,2lambda~5~,4lambda~5~,6lambda~5~,8lambda~5~-tetroxatetraphosphocane-2,4,6,8-tetrone × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；20 mM sodium citrate, 20% PEG 4000
Resolution 1.60 Å R-free 0.226
6PVX RNase A in complex with p5U Deposited 2019-07-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded U5F 5'-O-[(R)-hydroxy{[(S)-hydroxy{[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]oxy}phosphoryl]uridine × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；20 mM sodium citrate, 20% (v/v) PEG 4000
Resolution 1.55 Å R-free 0.228
6PVX RNase A in complex with p5U Deposited 2019-07-21 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded U5F 5'-O-[(R)-hydroxy{[(S)-hydroxy{[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]oxy}phosphoryl]uridine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；298 K；20 mM sodium citrate, 20% (v/v) PEG 4000
Resolution 1.55 Å R-free 0.228
6QE9 The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and complex I, a pentacoordinate Pt(II) compound containing 2,9-dimethyl-1,10-phenanthroline, dimethylfumarate, methyl and iodine as ligands Deposited 2019-01-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 J9H pentacoordinate Pt(II) compound × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% PEG4K 0.01 M sodium citrate pH 5.1
Resolution 2.03 Å R-free 0.254
6QE9 The X-ray structure of the adduct formed in the reaction between bovine pancreatic ribonuclease and complex I, a pentacoordinate Pt(II) compound containing 2,9-dimethyl-1,10-phenanthroline, dimethylfumarate, methyl and iodine as ligands Deposited 2019-01-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded J9H pentacoordinate Pt(II) compound × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% PEG4K 0.01 M sodium citrate pH 5.1
Resolution 2.03 Å R-free 0.254
6RAT EFFECTS OF TEMPERATURE ON PROTEIN STRUCTURE AND DYNAMICS: X-RAY CRYSTALLOGRAPHIC STUDIES OF THE PROTEIN RIBONUCLEASE-A AT NINE DIFFERENT TEMPERATURES FROM 98 TO 320 K Deposited 1991-08-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
6XHC Structure of glycinyl 5'-O-adenosine phosphoramidate Deposited 2020-06-18 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded V2G 2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]amino]ethanoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25%, PEG 3350, 20 MM SODIUM CITRATE, PH 5.5, Glycinyl-O5'-adenosine phosphoramidate was soaked into the crystals using a stock solution of 100 mM, to achieve ~35 mM in the soaking solution
Resolution 1.60 Å R-free 0.237
6XHC Structure of glycinyl 5'-O-adenosine phosphoramidate Deposited 2020-06-18 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded V2G 2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]amino]ethanoic acid × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25%, PEG 3350, 20 MM SODIUM CITRATE, PH 5.5, Glycinyl-O5'-adenosine phosphoramidate was soaked into the crystals using a stock solution of 100 mM, to achieve ~35 mM in the soaking solution
Resolution 1.60 Å R-free 0.237
6XHD Structure of Prolinyl-5'-O-adenosine phosphoramidate Deposited 2020-06-18 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded K POTASSIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25% PEG 3350, 20 MM SODIUM CITRATE, PH 5.5 Prolinyl-5'-O-adenosine phosphoramidate soaking was achieved as follows. 1 uL of a stock solution of 100 mM ligand was added to 2uL of reservoir solution, to achieve a concentration of ~33 mM in the soaking solution. A few RNase A crystals were soaked for 45 - 90 minutes in the soaking solution
Resolution 1.51 Å R-free 0.217
6XHD Structure of Prolinyl-5'-O-adenosine phosphoramidate Deposited 2020-06-18 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded V2P (2~{S})-1-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]pyrrolidine-2-carboxylic acid × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25% PEG 3350, 20 MM SODIUM CITRATE, PH 5.5 Prolinyl-5'-O-adenosine phosphoramidate soaking was achieved as follows. 1 uL of a stock solution of 100 mM ligand was added to 2uL of reservoir solution, to achieve a concentration of ~33 mM in the soaking solution. A few RNase A crystals were soaked for 45 - 90 minutes in the soaking solution
Resolution 1.51 Å R-free 0.217
6XHE Structure of beta-prolinyl 5'-O-adenosine phosphoramidate Deposited 2020-06-18 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25% PEG 3350, 20 MM SODIUM CITRATE, PH 5.5, Glycinyl-5'-O-adenosine phosphoramidate soaking was achieved as follows. 1 uL of a stock solution of 50 mM ligand was added to 2uL of reservoir solution, to achieve a concentration of ~25 mM in the soaking solution. A few RNase A crystals were soaked for 45 - 90 minutes in the soaking solution
Resolution 1.88 Å R-free 0.265
6XHE Structure of beta-prolinyl 5'-O-adenosine phosphoramidate Deposited 2020-06-18 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded V2J 5'-O-[(S)-[(3S)-3-carboxypyrrolidin-1-yl](hydroxy)phosphoryl]adenosine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25% PEG 3350, 20 MM SODIUM CITRATE, PH 5.5, Glycinyl-5'-O-adenosine phosphoramidate soaking was achieved as follows. 1 uL of a stock solution of 50 mM ligand was added to 2uL of reservoir solution, to achieve a concentration of ~25 mM in the soaking solution. A few RNase A crystals were soaked for 45 - 90 minutes in the soaking solution
Resolution 1.88 Å R-free 0.265
6XHF Structure of Phenylalanyl-5'-O-adenosine phosphoramidate Deposited 2020-06-18 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded V2S (2~{S})-2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]amino]-3-phenyl-propanoic acid × 1 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25% PEG 3350, 20 MM SODIUM CITRATE, PH 5.5 Phenylalanyl-O5'-adenosine phosphoramidate was soaked into the crystals using a stock solution of 100 mM, to achieve ~35 mM in the soaking solution
Resolution 1.45 Å R-free 0.231
6XHF Structure of Phenylalanyl-5'-O-adenosine phosphoramidate Deposited 2020-06-18 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded V2S (2~{S})-2-[[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]amino]-3-phenyl-propanoic acid × 1 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25% PEG 3350, 20 MM SODIUM CITRATE, PH 5.5 Phenylalanyl-O5'-adenosine phosphoramidate was soaked into the crystals using a stock solution of 100 mM, to achieve ~35 mM in the soaking solution
Resolution 1.45 Å R-free 0.231
6XVX X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (high resolution) Deposited 2020-01-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain AAA 27–150（124 aa）
Not recorded ACT ACETATE ION × 8 RH3 RHODIUM(III) ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% PEG 4K 10 mM sodium citrate buffer pH 5.1
Resolution 1.40 Å R-free 0.233
6XVX X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (high resolution) Deposited 2020-01-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain BBB 27–150（124 aa）
Not recorded ACT ACETATE ION × 9 RH3 RHODIUM(III) ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% PEG 4K 10 mM sodium citrate buffer pH 5.1
Resolution 1.40 Å R-free 0.233
6XW0 X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (low resolution) Deposited 2020-01-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain AAA 27–150（124 aa）
Not recorded RH3 RHODIUM(III) ION × 4 ACT ACETATE ION × 8 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% PEG4K 10 mM sodium citrate pH 5.1
Resolution 1.80 Å R-free 0.218
6XW0 X-ray structure obtained upon reaction of dirhodium tetraacetate with RNase A (low resolution) Deposited 2020-01-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain BBB 27–150（124 aa）
Not recorded RH3 RHODIUM(III) ION × 4 ACT ACETATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% PEG4K 10 mM sodium citrate pH 5.1
Resolution 1.80 Å R-free 0.218
6YO1 Crystal structure of ribonuclease A solved by vanadium SAD phasing Deposited 2020-04-14 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded UVC URIDINE-2',3'-VANADATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20 mM sodium citrate pH 5.5, 28 % PEG 4000 with 20 mM uridine/ortho-vanadate
Resolution 1.90 Å R-free 0.213
6YO1 Crystal structure of ribonuclease A solved by vanadium SAD phasing Deposited 2020-04-14 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded UVC URIDINE-2',3'-VANADATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；20 mM sodium citrate pH 5.5, 28 % PEG 4000 with 20 mM uridine/ortho-vanadate
Resolution 1.90 Å R-free 0.213
7P4R Ultra High Resolution X-ray Structure of Orthorhombic Bovine Pancreatic Ribonuclease at 100K Deposited 2021-07-12 Different mutation/modification Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain AAA 27–150（124 aa）
Mutation：None EOH ETHANOL × 11 SO4 SULFATE ION × 7 X-RAY DIFFRACTION
X-ray crystallization conditions EVAPORATION；pH 7；277 K；100mg of powdered Ribonuclease A in 1ml of distilled water dissolved in 2ml of ice cold absolute ethanol.
Resolution 0.85 Å R-free 0.129
7P8R X-ray structure of the adduct of a vanadium picolinate complex with RNase A at pH 5.1 Deposited 2021-07-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded AIV hydroxy(oxo)bis(pyridine-2-carboxylato-kappa~2~N,O)vanadium(3+) × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG 4K 10 mM sodium citrate pH 5.1
Resolution 1.27 Å R-free 0.222
7P8R X-ray structure of the adduct of a vanadium picolinate complex with RNase A at pH 5.1 Deposited 2021-07-23 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG 4K 10 mM sodium citrate pH 5.1
Resolution 1.27 Å R-free 0.222
7PNI X-ray structure of the adduct formed upon reaction of Pt(II) complex 2c with ribonuclease A Deposited 2021-09-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain AAA 27–150（124 aa）
Not recorded PT PLATINUM (II) ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4K 10 mM sodium citrate pH 5.1
Resolution 2.13 Å R-free 0.275
7PNI X-ray structure of the adduct formed upon reaction of Pt(II) complex 2c with ribonuclease A Deposited 2021-09-07 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain BBB 27–150（124 aa）
Not recorded PT PLATINUM (II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4K 10 mM sodium citrate pH 5.1
Resolution 2.13 Å R-free 0.275
7Q75 Room temperature structure of RNase A at atmospheric pressure Deposited 2021-11-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 CL CHLORIDE ION × 3 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；295 K；10-20 mg/ml protein dissolved in 0.1 M sodium acetate pH 4.5 was mixed in a 1:1 ratio with precipitant containing 0.1 M sodium acetate pH 4.5, 1.2-1.5 M ammonium sulphate and 2-2.5 M sodium chloride and equilibrated for one to two days at room-temperature.
Resolution 1.64 Å R-free 0.189
7Q76 Room temperature structure of RNase A at 22 MPa helium gas pressure in a sapphire capillary Deposited 2021-11-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 CL CHLORIDE ION × 3 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；295 K；10-20 mg/ml protein dissolved in 0.1 M sodium acetate pH 4.5 was mixed in a 1:1 ratio with precipitant containing 0.1 M sodium acetate pH 4.5, 1.2-1.5 M ammonium sulphate and 2-2.5 M sodium chloride and equilibrated for one to two days at room-temperature.
Resolution 1.48 Å R-free 0.180
7Q77 Room temperature structure of RNase A at 50 MPa helium gas pressure in a sapphire capillary Deposited 2021-11-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 CL CHLORIDE ION × 3 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；295 K；10-20 mg/ml protein dissolved in 0.1 M sodium acetate pH 4.5 was mixed in a 1:1 ratio with precipitant containing 0.1 M sodium acetate pH 4.5, 1.2-1.5 M ammonium sulphate and 2-2.5 M sodium chloride and equilibrated for one to two days at room-temperature.
Resolution 1.60 Å R-free 0.188
7Q78 Room temperature structure of RNase A at 72 MPa helium gas pressure in a sapphire capillary Deposited 2021-11-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 CL CHLORIDE ION × 3 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；295 K；10-20 mg/ml protein dissolved in 0.1 M sodium acetate pH 4.5 was mixed in a 1:1 ratio with precipitant containing 0.1 M sodium acetate pH 4.5, 1.2-1.5 M ammonium sulphate and 2-2.5 M sodium chloride and equilibrated for one to two days at room-temperature.
Resolution 1.52 Å R-free 0.183
7Q79 Room temperature structure of RNase A at 100 MPa helium gas pressure in a sapphire capillary Deposited 2021-11-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 CL CHLORIDE ION × 3 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；295 K；10-20 mg/ml protein dissolved in 0.1 M sodium acetate pH 4.5 was mixed in a 1:1 ratio with precipitant containing 0.1 M sodium acetate pH 4.5, 1.2-1.5 M ammonium sulphate and 2-2.5 M sodium chloride and equilibrated for one to two days at room temperature.
Resolution 1.55 Å R-free 0.188
7Q7A Room temperature structure of RNase A at 120 MPa helium gas pressure in a sapphire capillary Deposited 2021-11-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 CL CHLORIDE ION × 3 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；295 K；10-20 mg/ml protein dissolved in 0.1 M sodium acetate pH 4.5 was mixed in a 1:1 ratio with precipitant containing 0.1 M sodium acetate pH 4.5, 1.2-1.5 M ammonium sulphate and 2-2.5 M sodium chloride and equilibrated for one to two days at room temperature.
Resolution 1.56 Å R-free 0.190
7Q7B Room temperature structure of RNase A at atmospheric pressure in a sapphire capillary after high helium gas pressure release Deposited 2021-11-09 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 2 CL CHLORIDE ION × 3 NA SODIUM ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；295 K；10-20 mg/ml protein dissolved in 0.1 M sodium acetate pH 4.5 was mixed in a 1:1 ratio with precipitant containing 0.1 M sodium acetate pH 4.5, 1.2-1.5 M ammonium sulphate and 2-2.5 M sodium chloride and equilibrated for one to two days at room temperature.
Resolution 1.78 Å R-free 0.184
7QHR Unexpected imidazole coordination to dirhodium tetraacetate complex in a protein environment: insights from X-ray crystallography and quantum chemistry Deposited 2021-12-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded D1O tri-(mi2-acetato-(O, O')-diaqua-dirhodium(II, II) × 1 D3I octaaqua-dirhodium (II, II) fragment × 1 CJI cis-mi2-acetato-(O, O')-N-imidazyl-pentaaqua-dirhodium(II, II) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% PEG 4000 10 mM sodium citrate pH 5.1
Resolution 1.40 Å R-free 0.231
7QHR Unexpected imidazole coordination to dirhodium tetraacetate complex in a protein environment: insights from X-ray crystallography and quantum chemistry Deposited 2021-12-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded D1O tri-(mi2-acetato-(O, O')-diaqua-dirhodium(II, II) × 1 D5A trans-mi2-acetato-(O, O')-N-imidazyl-pentaaqua-dirhodium(II, II) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% PEG 4000 10 mM sodium citrate pH 5.1
Resolution 1.40 Å R-free 0.231
7QPW X-ray structure of the adduct obtained upon reaction of [cis-Rh2(OCOCH3)2(OCOCF3)2] with RNase A (1) Deposited 2022-01-05 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain AAA 27–150（124 aa）
Not recorded F5T cis-bis(mi2-acetato-O, O')-(mi2-trifluoroacetato-O, O')-diaquo-dirhodium (II) × 1 F3I (mi2-acetato-O, O')-hexaaquo-dirhodium (II) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22 % PEG 4K 0.01 M sodium citrate pH 5.1
Resolution 1.15 Å R-free 0.165
7QPW X-ray structure of the adduct obtained upon reaction of [cis-Rh2(OCOCH3)2(OCOCF3)2] with RNase A (1) Deposited 2022-01-05 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain BBB 27–150（124 aa）
Not recorded F5I cis-bis(mi2-acetato-O, O')-tetraaquo-dirhodium(II) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22 % PEG 4K 0.01 M sodium citrate pH 5.1
Resolution 1.15 Å R-free 0.165
7QPY X-ray structure of the adduct obtained upon reaction of [cis-Rh2(OCOCH3)2(OCOCF3)2] with RNase A (3) Deposited 2022-01-05 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded F5T cis-bis(mi2-acetato-O, O')-(mi2-trifluoroacetato-O, O')-diaquo-dirhodium (II) × 1 F3I (mi2-acetato-O, O')-hexaaquo-dirhodium (II) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.1；298 K；22 % PEG 4K 0.01 M sodium citrate pH 5.1
Resolution 1.42 Å R-free 0.212
7QPY X-ray structure of the adduct obtained upon reaction of [cis-Rh2(OCOCH3)2(OCOCF3)2] with RNase A (3) Deposited 2022-01-05 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded F5I cis-bis(mi2-acetato-O, O')-tetraaquo-dirhodium(II) × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；pH 5.1；298 K；22 % PEG 4K 0.01 M sodium citrate pH 5.1
Resolution 1.42 Å R-free 0.212
7QPZ X-ray structure of the adduct obtained upon reaction of [cis-Rh2(OCOCH3)2(OCOCF3)2] with RNase A (4) Deposited 2022-01-05 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded F5T cis-bis(mi2-acetato-O, O')-(mi2-trifluoroacetato-O, O')-diaquo-dirhodium (II) × 1 F5I cis-bis(mi2-acetato-O, O')-tetraaquo-dirhodium(II) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22 % PEG 4K 0.01 M sodium citrate pH 5.1
Resolution 1.45 Å R-free 0.202
7QPZ X-ray structure of the adduct obtained upon reaction of [cis-Rh2(OCOCH3)2(OCOCF3)2] with RNase A (4) Deposited 2022-01-05 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded F5I cis-bis(mi2-acetato-O, O')-tetraaquo-dirhodium(II) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22 % PEG 4K 0.01 M sodium citrate pH 5.1
Resolution 1.45 Å R-free 0.202
7QQ0 X-ray structure of the adduct obtained upon reaction of [cis-Rh2(OCOCH3)2(OCOCF3)2] with RNase A (2) Deposited 2022-01-05 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain AAA 27–150（124 aa）
Not recorded F3I (mi2-acetato-O, O')-hexaaquo-dirhodium (II) × 1 RHF RHODIUM(II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% PEG 4K 10 mM sodium citrate buffer pH 5.1
Resolution 1.32 Å R-free 0.243
7QQ0 X-ray structure of the adduct obtained upon reaction of [cis-Rh2(OCOCH3)2(OCOCF3)2] with RNase A (2) Deposited 2022-01-05 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain BBB 27–150（124 aa）
Not recorded F3I (mi2-acetato-O, O')-hexaaquo-dirhodium (II) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；22% PEG 4K 10 mM sodium citrate buffer pH 5.1
Resolution 1.32 Å R-free 0.243
7QWH X-ray structure of the adduct formed upon reaction of a vanadium hydroxyquinoline complex with RNase A Deposited 2022-01-25 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain AAA 27–150（124 aa）
Not recorded I3Y 2,2-bis($l^{1}-oxidanyl)-3-oxa-1$l^{4}-aza-2$l^{4}-vanadatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaene × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4K, 10 mM sodium citrate buffer pH 5.1
Resolution 1.57 Å R-free 0.222
7QWH X-ray structure of the adduct formed upon reaction of a vanadium hydroxyquinoline complex with RNase A Deposited 2022-01-25 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain BBB 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4K, 10 mM sodium citrate buffer pH 5.1
Resolution 1.57 Å R-free 0.222
7R1P X-ray structure of the adduct formed upon reaction of the gold(I) N-heterocyclic carbene complex Au1 with RNase A Deposited 2022-02-03 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain AAA 27–150（124 aa）
Not recorded AU GOLD ION × 1 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4K 10 mM sodium citrate pH 5.1
Resolution 1.42 Å R-free 0.219
7R1P X-ray structure of the adduct formed upon reaction of the gold(I) N-heterocyclic carbene complex Au1 with RNase A Deposited 2022-02-03 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain BBB 27–150（124 aa）
Not recorded AU GOLD ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4K 10 mM sodium citrate pH 5.1
Resolution 1.42 Å R-free 0.219
7RAT EFFECTS OF TEMPERATURE ON PROTEIN STRUCTURE AND DYNAMICS: X-RAY CRYSTALLOGRAPHIC STUDIES OF THE PROTEIN RIBONUCLEASE-A AT NINE DIFFERENT TEMPERATURES FROM 98 TO 320 K Deposited 1991-08-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
7Z6D X-ray structure of the adduct obtained upon reaction of [Rh2(OCOCH3)(OCOCF3)3] with RNase A (1) Deposited 2022-03-11 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded ACT ACETATE ION × 1 F3I (mi2-acetato-O, O')-hexaaquo-dirhodium (II) × 1 RH Rhodium × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；0.01 M sodium citrate pH 5.1; 22% PEG 4K
Resolution 1.45 Å R-free 0.232
7Z6D X-ray structure of the adduct obtained upon reaction of [Rh2(OCOCH3)(OCOCF3)3] with RNase A (1) Deposited 2022-03-11 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded RH Rhodium × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；0.01 M sodium citrate pH 5.1; 22% PEG 4K
Resolution 1.45 Å R-free 0.232
7Z6G X-ray structure of the adduct obtained upon reaction of [Rh2(OCOCH3)(OCOCF3)3] with RNase A (2) Deposited 2022-03-11 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded F3I (mi2-acetato-O, O')-hexaaquo-dirhodium (II) × 1 RH Rhodium × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；0.01 M sodium cintrate buffer pH 5.1 22% PEG4K
Resolution 1.71 Å R-free 0.236
7Z6G X-ray structure of the adduct obtained upon reaction of [Rh2(OCOCH3)(OCOCF3)3] with RNase A (2) Deposited 2022-03-11 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded RH Rhodium × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；298 K；0.01 M sodium cintrate buffer pH 5.1 22% PEG4K
Resolution 1.71 Å R-free 0.236
8C3B X-ray structure of RNase A upon reaction with a Ruthenium(II)-arene Complexed with Glycosylated Carbene Ligands (5) Deposited 2022-12-23 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain AAA 27–150（124 aa）
Chain BBB 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 R6U (1,3-dimethylimidazol-1-ium-2-yl)-tris(oxidanyl)ruthenium × 1 T9L (1,3-dimethylimidazol-1-ium-2-yl)-tetrakis(oxidanyl)ruthenium × 1 T9U (1,3-dimethyl-2~{H}-imidazol-2-yl)-oxidanyl-oxidanylidene-ruthenium × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4k, 10 mM sodium citrate pH 5.1
Resolution 1.24 Å R-free 0.227
8FHM RNase A-Uridine 5'-Hexaphosphate (RNaseA.p6U) Deposited 2022-12-14 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded U6F 5'-O-[(S)-hydroxy{[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]oxy}phosphoryl]oxy}phosphoryl]uridine × 1 Experimental method not declared
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；25% PEG4000, 20 mM citrate, pH 6, crystal soaked in 50 mM ligand, 30% PEG4000, 25% glycerol, 20 mM citrate
Resolution 1.79 Å R-free 0.231
8FHM RNase A-Uridine 5'-Hexaphosphate (RNaseA.p6U) Deposited 2022-12-14 Different ligand/ion Different experimental method Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded U6F 5'-O-[(S)-hydroxy{[(S)-hydroxy{[(R)-hydroxy{[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]oxy}phosphoryl]oxy}phosphoryl]oxy}phosphoryl]uridine × 2 Experimental method not declared
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；25% PEG4000, 20 mM citrate, pH 6, crystal soaked in 50 mM ligand, 30% PEG4000, 25% glycerol, 20 mM citrate
Resolution 1.79 Å R-free 0.231
8GC9 RNase A-Uridine 5'-Heptaphosphate (RNase A.p7U) Deposited 2023-03-01 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa） Fragment：UNP residues 27-150
Not recorded YWQ uridine 5'-heptaphosphate × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；25% PEG4000, 20 mM citrate, pH 6, crystal soaked in 50 mM ligand, 30% PEG4000, 25% glycerol, 20 mM citrate
Resolution 1.85 Å R-free 0.239
8GC9 RNase A-Uridine 5'-Heptaphosphate (RNase A.p7U) Deposited 2023-03-01 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa） Fragment：UNP residues 27-150
Not recorded YWQ uridine 5'-heptaphosphate × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；25% PEG4000, 20 mM citrate, pH 6, crystal soaked in 50 mM ligand, 30% PEG4000, 25% glycerol, 20 mM citrate
Resolution 1.85 Å R-free 0.239
8GGG RNase A-Adenosine 5'-Hexaphosphate (RNaseA.p6A) Deposited 2023-03-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded ZF9 adenosine 5'-hexaphosphate × 2 GOL GLYCEROL × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；25% PEG4000, 20 mM citrate, pH 6, crystal soaked in 50 mM ligand, 30% PEG4000, 25% glycerol, 20 mM citrate
Resolution 1.86 Å R-free 0.249
8GGG RNase A-Adenosine 5'-Hexaphosphate (RNaseA.p6A) Deposited 2023-03-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded ZF9 adenosine 5'-hexaphosphate × 1 GOL GLYCEROL × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；25% PEG4000, 20 mM citrate, pH 6, crystal soaked in 50 mM ligand, 30% PEG4000, 25% glycerol, 20 mM citrate
Resolution 1.86 Å R-free 0.249
8OQC Dirhodium tetraacetate/ribonuclease A adduct in the P3221 space group (1 h soaking) Deposited 2023-04-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded D1O tri-(mi2-acetato-(O, O')-diaqua-dirhodium(II, II) × 1 FMT FORMIC ACID × 1 CL CHLORIDE ION × 2 VVU dirhodium (II) tetraacetate × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.2；293 K；2.5 M NaCl 3.3 M HCOONa 0.1 M Acetate buffer
Resolution 1.50 Å R-free 0.215
8OQD Dirhodium tetraacetate/ribonuclease A adduct in the P3221 space group (1 h soaking) Deposited 2023-04-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded D1O tri-(mi2-acetato-(O, O')-diaqua-dirhodium(II, II) × 1 FMT FORMIC ACID × 1 CL CHLORIDE ION × 2 VVU dirhodium (II) tetraacetate × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.2；293 K；2.5 M NaCl 3.3 M HCOONa 0.1 M Acetate buffer
Resolution 1.54 Å R-free 0.222
8OQE Dirhodium tetraacetate/ribonuclease A adduct in the P3221 space group (6 h soaking) Deposited 2023-04-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded VVU dirhodium (II) tetraacetate × 1 D1O tri-(mi2-acetato-(O, O')-diaqua-dirhodium(II, II) × 1 FMT FORMIC ACID × 1 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.2；293 K；2.5 M NaCl 3.3 M HCOONa 0.1 M Acetate buffer
Resolution 1.50 Å R-free 0.216
8OQF Cross-linked crystal of Dirhodium tetraacetate/ribonuclease A adduct in the P3221 space group (low temperature data collection) Deposited 2023-04-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded FMT FORMIC ACID × 2 F3I (mi2-acetato-O, O')-hexaaquo-dirhodium (II) × 1 VVU dirhodium (II) tetraacetate × 1 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.2；293 K；2.5 M NaCl 3.3 M HCOONa 0.1 M Acetate buffer
Resolution 1.50 Å R-free 0.224
8OQG Cross-linked crystal of dirhodium tetraacetate/ribonuclease A adduct in the P3221 space group (high temperature data collection) Deposited 2023-04-12 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded VVU dirhodium (II) tetraacetate × 1 VW5 dirhodium (II) oxide × 1 FMT FORMIC ACID × 1 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.2；293 K；2.5 M NaCl 3.3 M HCOONa 0.1 M Acetate buffer
Resolution 1.60 Å R-free 0.202
8PX0 Structure of ribonuclease A, solved at wavelength 2.75 A Deposited 2023-07-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded 0U L-URIDINE-5'-MONOPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；20 mM sodium citrate pH 5.5, 28 % PEG 4000
Resolution 1.80 Å R-free 0.239
8PX0 Structure of ribonuclease A, solved at wavelength 2.75 A Deposited 2023-07-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, SITTING DROP；293 K；20 mM sodium citrate pH 5.5, 28 % PEG 4000
Resolution 1.80 Å R-free 0.239
8R5V Crystal structure of bovine pancreatic ribonuclease A in complex with [Sp-PS]-mU-dT dinucleotide Deposited 2023-11-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 1–150（150 aa）
Chain B 1–150（150 aa）
Not recorded Y4I 1-[(2~{R},4~{S},5~{R})-5-[[[(2~{R},6~{S})-2-[2,4-bis(oxidanylidene)pyrimidin-1-yl]-6-(hydroxymethyl)morpholin-4-yl]-oxidanyl-phosphinothioyl]oxymethyl]-4-oxidanyl-oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione × 1 TF4 DICHLORO-ACETIC ACID × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；281 K；22-25 % (w/v) PEG 4000, 20 mM sodium citrate pH 5.5
Resolution 1.80 Å R-free 0.230
8RAT EFFECTS OF TEMPERATURE ON PROTEIN STRUCTURE AND DYNAMICS: X-RAY CRYSTALLOGRAPHIC STUDIES OF THE PROTEIN RIBONUCLEASE-A AT NINE DIFFERENT TEMPERATURES FROM 98 TO 320 K Deposited 1991-08-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
8RSA CRYSTAL STRUCTURE OF TWO COVALENT NUCLEOSIDE DERIVATIVES OF RIBONUCLEASE A Deposited 1989-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Not recorded ADT 3'-DEOXY-3'-ACETAMIDO-THYMIDINE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å
8S96 RNase A-Adenosine 5'-Heptaphosphate (RNaseA.p7A) Deposited 2023-03-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded ZSF adenosine 5'-heptaphosphate × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；25% PEG4000, 20 mM citrate, pH 6, crystal soaked in 50 mM ligand, 30% PEG4000, 25% glycerol, 20 mM citrate
Resolution 1.68 Å R-free 0.237
8S96 RNase A-Adenosine 5'-Heptaphosphate (RNaseA.p7A) Deposited 2023-03-27 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded ZSF adenosine 5'-heptaphosphate × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 6；295 K；25% PEG4000, 20 mM citrate, pH 6, crystal soaked in 50 mM ligand, 30% PEG4000, 25% glycerol, 20 mM citrate
Resolution 1.68 Å R-free 0.237
8UAX Structure of Alanyl-5'-O-adenosine phosphoramidate/RNase A Deposited 2023-09-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded PEG DI(HYDROXYETHYL)ETHER × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25 percent PEG 3350, 20 MM SODIUM CITRATE, PH 5.5. Alanyl-5'-O-adenosine phosphoramidate soaking was achieved as follows. 1 uL of a stock solution of 100 mM ligand was added to 2uL of reservoir solution, to achieve a concentration of ~35mM in the soaking solution. A few RNase A crystals were soaked for 120 - 130 minutes in the soaking solution.
Resolution 1.90 Å R-free 0.273
8UAX Structure of Alanyl-5'-O-adenosine phosphoramidate/RNase A Deposited 2023-09-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded WFH (2S)-2-{[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]amino}propanoic acid (non-preferred name) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25 percent PEG 3350, 20 MM SODIUM CITRATE, PH 5.5. Alanyl-5'-O-adenosine phosphoramidate soaking was achieved as follows. 1 uL of a stock solution of 100 mM ligand was added to 2uL of reservoir solution, to achieve a concentration of ~35mM in the soaking solution. A few RNase A crystals were soaked for 120 - 130 minutes in the soaking solution.
Resolution 1.90 Å R-free 0.273
8UAY Structure of Arginyl-5'-O-adenosine phosphoramidate/RNase A Deposited 2023-09-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded WF9 (2S)-2-{[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]amino}-5-carbamimidamidopentanoic acid (non-preferred name) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25 percent PEG 3350, 20 MM SODIUM CITRATE, PH 5.5. Arginyl-5'-O-adenosine phosphoramidate soaking was achieved as follows. 1 uL of a stock solution of 100 mM ligand was added to 2uL of reservoir solution, to achieve a concentration of ~33 mM in the soaking solution. A few RNase A crystals were soaked for 110 - 130 minutes in the soaking solution.
Resolution 1.80 Å R-free 0.286
8UAY Structure of Arginyl-5'-O-adenosine phosphoramidate/RNase A Deposited 2023-09-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25 percent PEG 3350, 20 MM SODIUM CITRATE, PH 5.5. Arginyl-5'-O-adenosine phosphoramidate soaking was achieved as follows. 1 uL of a stock solution of 100 mM ligand was added to 2uL of reservoir solution, to achieve a concentration of ~33 mM in the soaking solution. A few RNase A crystals were soaked for 110 - 130 minutes in the soaking solution.
Resolution 1.80 Å R-free 0.286
8UB0 Structure of Histidine-5'-O-adenosine phosphoramidate/RNase A Deposited 2023-09-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 PEG DI(HYDROXYETHYL)ETHER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；25% PEG 3350, 20 mM sodium citrate, pH 5.5, Histidyl-5'-O-adenosine phosphoramidate was soaked into the crystals using a stock solution of 100 mM, to achieve ~35 mM in the soaking solution
Resolution 2.00 Å R-free 0.301
8UB0 Structure of Histidine-5'-O-adenosine phosphoramidate/RNase A Deposited 2023-09-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded A1BA4 (2S)-2-{[(R)-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl]amino}-3-(1H-imidazol-4-yl)propanoic acid (non-preferred name) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；25% PEG 3350, 20 mM sodium citrate, pH 5.5, Histidyl-5'-O-adenosine phosphoramidate was soaked into the crystals using a stock solution of 100 mM, to achieve ~35 mM in the soaking solution
Resolution 2.00 Å R-free 0.301
8UB1 Structure of Butyl-5'-O-adenosine phosphoramidate/RNase A Deposited 2023-09-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；25% PEG 3350, 20 MM SODIUM CITRATE PROTEIN WAS CRYSTALLIZED FROM 25% PEG 3350, 20 MM SODIUM CITRATE, PH 5.5 Butyl-5'-O-adenosine phosphoramidate was soaked into the crystals using a stock solution of 100 mM, to achieve ~35 mM in the soaking solution.
Resolution 1.53 Å R-free 0.297
8UB1 Structure of Butyl-5'-O-adenosine phosphoramidate/RNase A Deposited 2023-09-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded WFL 5'-O-[(R)-(butylamino)(hydroxy)phosphoryl]adenosine × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；25% PEG 3350, 20 MM SODIUM CITRATE PROTEIN WAS CRYSTALLIZED FROM 25% PEG 3350, 20 MM SODIUM CITRATE, PH 5.5 Butyl-5'-O-adenosine phosphoramidate was soaked into the crystals using a stock solution of 100 mM, to achieve ~35 mM in the soaking solution.
Resolution 1.53 Å R-free 0.297
8UB2 Structure of Adenosine monophosphate/RNase A Deposited 2023-09-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded AMP ADENOSINE MONOPHOSPHATE × 1 PEG DI(HYDROXYETHYL)ETHER × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25 percent PEG 3350, 20 MM SODIUM CITRATE, PH 5.5. 5'-O-adenosine monophoshate soaking was achieved as follows. 1 uL of a stock solution of 100 mM ligand was added to 2uL of reservoir solution, to achieve a concentration of ~33 mM in the soaking solution. A few RNase A crystals were soaked for 160 - 180 minutes in the soaking solution
Resolution 1.60 Å R-free 0.262
8UB2 Structure of Adenosine monophosphate/RNase A Deposited 2023-09-22 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded PEG DI(HYDROXYETHYL)ETHER × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；291 K；PROTEIN WAS CRYSTALLIZED FROM 25 percent PEG 3350, 20 MM SODIUM CITRATE, PH 5.5. 5'-O-adenosine monophoshate soaking was achieved as follows. 1 uL of a stock solution of 100 mM ligand was added to 2uL of reservoir solution, to achieve a concentration of ~33 mM in the soaking solution. A few RNase A crystals were soaked for 160 - 180 minutes in the soaking solution
Resolution 1.60 Å R-free 0.262
9EO5 X-ray structure of the adduct formed upon reaction of picoplatin with bovine pancreatic ribonuclease (structure C) Deposited 2024-03-14 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain AAA 27–150（124 aa）
Not recorded NH3 AMMONIA × 2 PT PLATINUM (II) ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；298 K；22% PEG4000, 0.1 M sodium citrate pH 5.1
Resolution 1.99 Å R-free 0.243
9EO5 X-ray structure of the adduct formed upon reaction of picoplatin with bovine pancreatic ribonuclease (structure C) Deposited 2024-03-14 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain BBB 27–150（124 aa）
Not recorded NH3 AMMONIA × 3 PT PLATINUM (II) ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 4.5；298 K；22% PEG4000, 0.1 M sodium citrate pH 5.1
Resolution 1.99 Å R-free 0.243
9FYW X-ray structure of the adduct formed upon reaction of RNase A with [Ru2Cl(D-p-CNPhF)(O2CCH3)3] Deposited 2024-07-04 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 1–150（150 aa）
Not recorded SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；Free-interface diffusion of a 10 uL of 30 mg/ml protein solution, 20 mM sodium citrate at pH 5.3 agaist 10 ul isopropanol 99.9% isopropanol
Resolution 1.40 Å R-free 0.214
9FYW X-ray structure of the adduct formed upon reaction of RNase A with [Ru2Cl(D-p-CNPhF)(O2CCH3)3] Deposited 2024-07-04 Different construct Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 1–150（150 aa）
Not recorded A1IHW 4-[11-(4-cyanophenyl)-1,5-bis($l^{1}-oxidanyl)-3,7-dimethyl-2,4,6,8-tetraoxa-9,11-diaza-1$l^{5},5$l^{5}-diruthenatricyclo[3.3.3.0^{1,5}]undecan-9-yl]benzenecarbonitrile × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；Free-interface diffusion of a 10 uL of 30 mg/ml protein solution, 20 mM sodium citrate at pH 5.3 agaist 10 ul isopropanol 99.9% isopropanol
Resolution 1.40 Å R-free 0.214
9GF9 S-Protease complexed with stapled peptide-like ligand Deposited 2024-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 50–150（101 aa）
Chain G 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 5 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292 K；32.5% PEG4000, 0.2M Li2SO4
Resolution 1.76 Å R-free 0.252
9GF9 S-Protease complexed with stapled peptide-like ligand Deposited 2024-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain B 50–150（101 aa）
Chain H 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292 K；32.5% PEG4000, 0.2M Li2SO4
Resolution 1.76 Å R-free 0.252
9GF9 S-Protease complexed with stapled peptide-like ligand Deposited 2024-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 3 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain C 50–150（101 aa）
Chain I 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292 K；32.5% PEG4000, 0.2M Li2SO4
Resolution 1.76 Å R-free 0.252
9GF9 S-Protease complexed with stapled peptide-like ligand Deposited 2024-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 4 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain D 50–150（101 aa）
Chain J 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292 K；32.5% PEG4000, 0.2M Li2SO4
Resolution 1.76 Å R-free 0.252
9GF9 S-Protease complexed with stapled peptide-like ligand Deposited 2024-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 5 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain E 50–150（101 aa）
Chain K 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292 K；32.5% PEG4000, 0.2M Li2SO4
Resolution 1.76 Å R-free 0.252
9GF9 S-Protease complexed with stapled peptide-like ligand Deposited 2024-08-08 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 6 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain F 50–150（101 aa）
Chain L 27–41（15 aa）
Non-standard monomer：Yes (specific site not provided by mmCIF) SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；292 K；32.5% PEG4000, 0.2M Li2SO4
Resolution 1.76 Å R-free 0.252
9GYS X-ray structure of the adduct formed upon reaction of RNase A with [Ru2(D-p-FPhF)(O2CCH3)2(O2CO)] complex Deposited 2024-10-02 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded SO4 SULFATE ION × 1 A1IQW [Ru2-N,N'-diphenylformamidinate(O2CCH3)2(O2CO)] complex × 3 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4K, 10 mM sodium citrate buffer at pH 5.1
Resolution 1.74 Å R-free 0.260
9GYS X-ray structure of the adduct formed upon reaction of RNase A with [Ru2(D-p-FPhF)(O2CCH3)2(O2CO)] complex Deposited 2024-10-02 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded A1IQW [Ru2-N,N'-diphenylformamidinate(O2CCH3)2(O2CO)] complex × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；22% PEG4K, 10 mM sodium citrate buffer at pH 5.1
Resolution 1.74 Å R-free 0.260
9HN6 X-ray structure of the adduct formed upon reaction of the diiodido analogue of picoplatin with ribonuclease A Deposited 2024-12-10 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain AAA 27–150（124 aa）
Chain BBB 27–150（124 aa）
Not recorded NH3 AMMONIA × 6 PT PLATINUM (II) ION × 13 IOD IODIDE ION × 10 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.1；293 K；20% PEG4000, and 0.1 M sodium citrate pH 5.1
Resolution 1.77 Å R-free 0.276
9JWD Crystal structure of RNAs A treated with sodium cyanide Deposited 2024-10-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CYN CYANIDE ION × 1 GOL GLYCEROL × 1 CL CHLORIDE ION × 3 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；292 K；0.1M sodium acetate buffer pH 5.5. reservoir solution containing 24-34% (NH4)2SO4, 0.1M sodium acetate buffer pH 5.5, and super-saturated solution of NaCl.
Resolution 2.22 Å R-free 0.258
9JWH Crystal structure of native bovine pancreatic RNAs A Deposited 2024-10-10 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded CL CHLORIDE ION × 4 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；292 K；24-34% (NH4)2SO4, 0.1M sodium acetate buffer, super saturated NaCl
Resolution 1.85 Å R-free 0.223
9NCS RNase A in complex with Uridine Vanadate and decavanadates Deposited 2025-02-17 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Not recorded DVT DECAVANADATE × 4 URI URIDINE × 1 VVO oxovanadium(2+) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；Crystallization: 50mM Imidazole pH 5.5, 20% PEG 4000 seeded with crystals grown in 20mM Sodium Citrate pH 5.5, 20% PEG 4000 Ligand soaking: 25mM Imidazole pH 5.5, 25% PEG 4000, 7.5mM Uridine Vanadate
Resolution 1.83 Å R-free 0.209
9O4V RNase A in complex with Pseudouridine Vanadate and decavanadates Deposited 2025-04-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded DVT DECAVANADATE × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；Crystallization: 20mM Sodium Citrate pH 5.5, 25% PEG 4000 seeded with crystals grown in 20mM Sodium Citrate pH 5.5, 20% PEG 4000 Ligand soaking: 16.7mM Imidazole pH 5.5, 30% PEG 4000, 5% glycerol, 5mM Pseudouridine Vanadate
Resolution 1.70 Å R-free 0.205
9O4V RNase A in complex with Pseudouridine Vanadate and decavanadates Deposited 2025-04-08 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 2 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain B 27–150（124 aa）
Not recorded DVT DECAVANADATE × 3 FJF 5-[(2~{S},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-1~{H}-pyrimidine-2,4-dione × 1 VVO oxovanadium(2+) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；Crystallization: 20mM Sodium Citrate pH 5.5, 25% PEG 4000 seeded with crystals grown in 20mM Sodium Citrate pH 5.5, 20% PEG 4000 Ligand soaking: 16.7mM Imidazole pH 5.5, 30% PEG 4000, 5% glycerol, 5mM Pseudouridine Vanadate
Resolution 1.70 Å R-free 0.205
9O5B RNase A in complex with N1-Methylpseudouridine Vanadate and decavanadates Deposited 2025-04-09 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Not recorded 8IZ 5-[(2S,3R,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-1-methyl-pyrimidine-2,4-dione × 1 DVT DECAVANADATE × 4 VVO oxovanadium(2+) × 1 X-RAY DIFFRACTION
X-ray crystallization conditions VAPOR DIFFUSION, HANGING DROP；pH 5.5；289 K；Crystallization: 20mM Sodium Citrate pH 5.5, 25% PEG 4000 seeded with crystals grown in 20mM Sodium Citrate pH 5.5, 20% PEG 4000 Ligand soaking: 16.7mM Imidazole pH 5.5, 30% PEG 4000, 5% glycerol, 5mM N1-methylpseudouridine Vanadate
Resolution 1.71 Å R-free 0.219
9RAT EFFECTS OF TEMPERATURE ON PROTEIN STRUCTURE AND DYNAMICS: X-RAY CRYSTALLOGRAPHIC STUDIES OF THE PROTEIN RIBONUCLEASE-A AT NINE DIFFERENT TEMPERATURES FROM 98 TO 320 K Deposited 1991-08-13 Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein monomer Monomer；Protein × 1 PDB declaration: monomeric
Chain A 27–150（124 aa）
Not recorded No recorded non-water small molecule X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.50 Å
9RSA CRYSTAL STRUCTURE OF TWO COVALENT NUCLEOSIDE DERIVATIVES OF RIBONUCLEASE A Deposited 1989-08-28 Different construct Different mutation/modification Different oligomeric state Different ligand/ion Different experimental conditions Different structure-quality metrics Assembly 1 Protein homooligomer Homooligomer；Protein × 2 PDB declaration: dimeric
Chain A 27–150（124 aa）
Chain B 27–150（124 aa）
Not recorded ADU 3'-DEOXY-3'-ACETAMIDO-URIDINE × 2 X-RAY DIFFRACTION mmCIF provides none of the parsed conditions Resolution 1.80 Å

333 other PDB entries and 494 assemblies. Open the comparison page and filter oligomeric states

View Construct and Data Evidence
UniProt name RNAS1_BOVIN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–124； UniProt 27–150 Author chain B； PDBConstruct 1–124； UniProt 27–150

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

SAXS scattering curve SAXS Profile

SAXS profile for 8uaz

P(r) Distance Distribution P(r) Distribution

P(r) distribution for 8uaz
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2. Structure Basics 2. Structure Basics

Entry ID entry_id8uaz
Deposition date deposition_date2023-09-22
最后修订 last_revision2024-10-16
Structure title titleStructure of Glutamyl-5'-O-adenosine phosphoramidate/RNase A
Keywords keywords;RNase-A, Nucleotide Prodrug, Amino Acidyl Phosphoramidate, Glutamyl-5'-AMP, Phosphoramidate Hydrolysis, ProTide, HYDROLASE ;; HYDROLASE
Experimental Method methodX-RAY DIFFRACTION
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3. SAXS Parameters (CRYSOL theoretical calculation) 3. SAXS Parameters (CRYSOL)

Radius of gyration Rg (Guinier) rg_guinier21.39 Å
Radius of gyration Rg (electron density) rg_electron20.97 Å
Forward intensity I(0) i017329900.00
Molecular weight molecular_weight28273.0 kDa
Excluded volume excluded_volume34006 ų
Envelope volume envelope_volume41331 ų
Hydration-shell volume shell_volume17638 ų
Envelope diameter envelope_diameter77.0 Å
Shell Rg shell_rg25.98 Å
Envelope Rg envelope_rg21.20 Å
Shape Rg shape_rg20.95 Å
Total Rg total_rg21.63 Å
Total atoms total_atoms1961
Residues n_residues247
Spherical-harmonic order n_harmonics20
q range q_range— – 0.5000 Å−1
Data points n_points101
Shell type shell_typedirectional
Solvent electron density solvent_density0.3340 e/ų
Shell contrast contrast_shell0.0300 e/ų
CRYSOL version crysol_version4.1.3
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4. P(r) Distance Distribution (GNOM inversion) 4. P(r) Analysis (GNOM)

Maximum dimension Dmax dmax76.4 Å
Rg (real space) rg_real21.53 Å
Rg uncertainty (real space) rg_real_error0.88 Å
I(0) (real space) i0_real1.7330e+07
I(0) uncertainty (real space) i0_real_error2.4200e+05
Rg (reciprocal space) rg_reciprocal21.51 Å
I(0) (reciprocal space) i0_reciprocal17330000.0000
Solution quality estimate total_estimate0.7641
Solution quality rating solution_quality GOOD a GOOD solution
P(r) peaks n_peaks2
Primary peak position r_peak_primary22.5 Å
Skewness Skewness skewness0.503
Kurtosis Kurtosis kurtosis-0.207
Angular range angular_range— – 0.3700 Å−1
Current regularization parameter α current_alpha0.0000
Highest regularization parameter α highest_alpha2891000.0000
Real-space data points n_real_points69
GNOM version gnom_version4.1.3
Quality Criteria quality_criteria AN1: 0.000; Oscil: 0.728; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.745; Smooth: 0.000
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5. Crystallography and Experiment 5. Crystallography & Experiment

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6. Entities and Polymers Entities & Polymers (4)

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8. Citations (1)

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9. Files and Curves (10)