9b60

GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of TMD-TARPgamma2

Method: ELECTRON MICROSCOPY D_max: 111.9 Å Quality: GOOD

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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Voltage-dependent calcium channel gamma-2 subunit

Mus musculus

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物异源复合物蛋白 × 8 PDB 声明：octameric（8）与蛋白拷贝数一致	链 E； UniProt 1–323 链 F； UniProt 1–323 链 G； UniProt 1–323 链 H； UniProt 1–323	未记录	Isoform Flip of Glutamate receptor 2 × 4 （P19491）	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8；Tris adjusted to pH 8 using HCl cryo-EM玻璃化条件：冷冻剂 ETHANE	分辨率 2.57 Å

数据库中的同蛋白其他状态

以下每一行都是同一 UniProt 蛋白在另一个 PDB 条目中的 biological assembly， “相对当前条目”直接指出证据层面的不同；没有差异标签表示当前已读取字段一致。

其他 PDB	相对当前条目 9B60	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
3JXT Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand 提交 2009-09-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 D 318–323（6 aa）片段：C-terminal motif of Stargazin: UNP O88602 residues 318-323	突变：R318(4DB) 非标准单体：是（mmCIF未提供具体位点）	ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；1.0 M Sodium citrate, 0.1 M Tris-HCl pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.50 Å R-free 0.214
3JXT Crystal structure of the third PDZ domain of SAP-102 in complex with a fluorogenic peptide-based ligand 提交 2009-09-21	构建体不同突变/修饰不同聚集状态不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 318–323（6 aa）片段：C-terminal motif of Stargazin: UNP O88602 residues 318-323	突变：R318(4DB) 非标准单体：是（mmCIF未提供具体位点）	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.5；277 K；1.0 M Sodium citrate, 0.1 M Tris-HCl pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.50 Å R-free 0.214
5KBS Cryo-EM structure of GluA2-0xSTZ at 8.7 Angstrom resolution 提交 2016-06-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 2–208（207 aa）链 B 2–208（207 aa）链 C 2–208（207 aa）链 D 2–208（207 aa）	突变：N241E, V382L, G384E, N385D, V758L,N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L,N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L,N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L,N241E, V382L, G384E, N385D, V758L	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；3 blot force, 8.0 s blot time	分辨率 8.70 Å
5KBT Cryo-EM structure of GluA2-1xSTZ complex at 6.4 Angstrom resolution 提交 2016-06-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 2–208（207 aa）链 B 2–208（207 aa）链 C 2–208（207 aa）链 D 2–208（207 aa）	突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；3 blot force, 8.0 s blot time	分辨率 6.40 Å
5KBU Cryo-EM structure of GluA2-2xSTZ complex at 7.8 Angstrom resolution 提交 2016-06-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 2–208（207 aa）链 B 2–208（207 aa）链 C 2–208（207 aa）链 D 2–208（207 aa）	突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；3 blot force, 8.0 s blot time	分辨率 7.80 Å
5WEO Activated GluA2 complex bound to glutamate, cyclothiazide, and STZ in digitonin 提交 2017-07-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 2–208（207 aa）片段：UNP P19491 residues 25-847, UNP O88602 2-208 linked via LINKER GT 链 B 2–208（207 aa）片段：UNP P19491 residues 25-847, UNP O88602 2-208 linked via LINKER GT 链 C 2–208（207 aa）片段：UNP P19491 residues 25-847, UNP O88602 2-208 linked via LINKER GT 链 D 2–208（207 aa）片段：UNP P19491 residues 25-847, UNP O88602 2-208 linked via LINKER GT	突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.20 Å
8FP4 GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 500mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na610) 提交 2023-01-04	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E	CL CHLORIDE ION × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.40 Å
8FP9 GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) 提交 2023-01-04	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E	CA CALCIUM ION × 1 CL CHLORIDE ION × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100 mM) and cyclothiazide (CTZ, 0.33 mM) were added before freezing. The 1 M L-glutamic acid stock solution was adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.44 Å
8FPG GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg) 提交 2023-01-04	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E	CL CHLORIDE ION × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 0.1 mM) and cyclothiazide (CTZ, 0.33 mM) were added before freezing. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.32 Å
8FPS GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K) 提交 2023-01-05	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E	CL CHLORIDE ION × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.38 Å
8FQ1 GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 150mM CaCl2, 330uM CTZ, and 100mM L-glutamate (Open-Ca150) 提交 2023-01-05	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E	CA CALCIUM ION × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 5.59 Å
8FQ5 GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Na110) 提交 2023-01-05	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E	CL CHLORIDE ION × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.34 Å
8FQB GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 10mM CaCl2, 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Ca10) 提交 2023-01-05	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E	CA CALCIUM ION × 1 CL CHLORIDE ION × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.36 Å
8FQF GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na260) 提交 2023-01-06	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E 突变：K52E, K53E	CL CHLORIDE ION × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.29 Å
8VHV Transmembrane AMPA Receptor Regulatory Protein Subunit Gamma 2 提交 2024-01-02	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 1–208（208 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.30 Å
9B5Z GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of LBD-TMD-TARPgamma2 提交 2024-03-23	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.71 Å
9B61 GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of LBD-TMD-TARPgamma2 提交 2024-03-23	实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl. 4 micro litter of protein in buffer was mixed with 1 micro litter of 50mM citric acid buffer (the 50mM citric acid buffer was prepared by diluting 0.5M citric acid/sodium citrate buffer at pH4.0) immediately before applying the sample to the grid. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.81 Å
9B63 GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of TMD-TARPgamma2 提交 2024-03-23	实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl. 4 micro litter of protein in buffer was mixed with 1 micro litter of 50mM citric acid buffer (the 50mM citric acid buffer was prepared by diluting 0.5M citric acid/sodium citrate buffer at pH4.0) immediately before applying the sample to the grid. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.76 Å
9B64 GluA2 flip Q in complex with TARPgamma2 at pH5, class23, structure of LBD-TMD-TARPgamma2 提交 2024-03-23	实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl. 4 micro litter of protein in buffer was mixed with 1 micro litter of 50mM citric acid buffer (the 50mM citric acid buffer was prepared by diluting 0.5M citric acid/sodium citrate buffer at pH4.0) immediately before applying the sample to the grid. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.56 Å
9B67 GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of LBD-TMD-TARPgamma2 提交 2024-03-23	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.39 Å
9B6A GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of LBD-TMD-TARPgamma2 提交 2024-03-23	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）链 G 1–323（323 aa）链 H 1–323（323 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.35 Å
9DHP Resting state 1 of the GluA2-gamma2 complex 提交 2024-09-04	构建体不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 6–208（203 aa）链 F 6–208（203 aa）链 G 6–208（203 aa）链 H 6–208（203 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.18 Å
9DHQ Resting state 2 of the GluA2-gamma2 complex 提交 2024-09-04	构建体不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 6–208（203 aa）链 F 6–208（203 aa）链 G 6–208（203 aa）链 H 6–208（203 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.78 Å
9DHR Glutamate activated state of the GluA2-gamma2 complex 提交 2024-09-04	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 6–208（203 aa）链 F 6–208（203 aa）链 G 6–208（203 aa）链 H 6–208（203 aa）	未记录	GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.54 Å
9DHS Desensitized state 1 of the GluA2-gamma2 complex 提交 2024-09-04	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 6–208（203 aa）链 F 6–208（203 aa）链 G 6–208（203 aa）链 H 6–208（203 aa）	未记录	GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.48 Å
9DHT Desensitized state 2 of the GluA2-gamma2 complex 提交 2024-09-04	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 6–208（203 aa）链 F 6–208（203 aa）链 G 6–208（203 aa）链 H 6–208（203 aa）	未记录	GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.31 Å
9E4Y GluA2-gamma2 complex bound to memantine, glutamate, and cyclothiazide 提交 2024-10-25	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 3–208（206 aa）链 F 3–208（206 aa）链 G 3–208（206 aa）链 H 3–208（206 aa）	未记录	377 Memantine × 1 GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.30 Å
9E4Z GluA2-gamma2 complex bound glutamate and cyclothiazide 提交 2024-10-25	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 3–208（206 aa）链 F 3–208（206 aa）链 G 3–208（206 aa）链 H 3–208（206 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.70 Å
9P9B Activated GluA4 homotetrameric AMPAR. 提交 2025-06-24	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–208（207 aa）链 F 2–208（207 aa）链 G 2–208（207 aa）链 H 2–208（207 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.31 Å
9P9C Active substate 1 of the GluA4 homotetramer. 提交 2025-06-24	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–208（207 aa）链 F 2–208（207 aa）链 G 2–208（207 aa）链 H 2–208（207 aa）	未记录	CYZ CYCLOTHIAZIDE × 4 GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.01 Å
9P9D Active substate 2 of the GluA4 homotetramer. 提交 2025-06-24	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–208（207 aa）链 F 2–208（207 aa）链 G 2–208（207 aa）链 H 2–208（207 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.82 Å
9P9E Active substate 3 of the GluA4 homotetramer. 提交 2025-06-24	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–208（207 aa）链 F 2–208（207 aa）链 G 2–208（207 aa）链 H 2–208（207 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.82 Å
9P9F Active substate 4 of the GluA4 homotetramer. 提交 2025-06-24	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–208（207 aa）链 F 2–208（207 aa）链 G 2–208（207 aa）链 H 2–208（207 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.89 Å
9P9G Active substate 5 of the GluA4 homotetramer. 提交 2025-06-24	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 2–208（207 aa）链 F 2–208（207 aa）链 G 2–208（207 aa）链 H 2–208（207 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.06 Å
9ZKM The LBD-TMD structure of native mouse AMPAR with 4 TARPs 提交 2025-12-07	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）	未记录	PLM PALMITIC ACID × 12 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 8 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 8	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.13 Å
9ZKN The TMD structure of native mouse AMPAR with 4 TARPs 提交 2025-12-07	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 E 1–323（323 aa）链 F 1–323（323 aa）	未记录	PLM PALMITIC ACID × 11 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 8 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 8	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.80 Å
9ZKQ The LBD-TMD structure of native mouse AMPAR with 3 TARPs 1 CNIH 提交 2025-12-07	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 F 1–323（323 aa）	未记录	PLM PALMITIC ACID × 10 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 8 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 6	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.36 Å
9ZKR The TMD structure of native mouse AMPAR with 3 TARPs 1 CNIH 提交 2025-12-07	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 F 1–323（323 aa）	未记录	PLM PALMITIC ACID × 10 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 8 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 7	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.08 Å
9ZKU The LBD-TMD structure of native mouse AMPAR with 3 TARPs 1 CNIH and PRRT1/SynDIG4 提交 2025-12-07	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 9 PDB 声明：nonameric	链 F 1–323（323 aa）	未记录	PLM PALMITIC ACID × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 7 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.75 Å
9ZKW The LBD-TMD structure of native mouse AMPAR with 3 TARPs 提交 2025-12-07	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 7 PDB 声明：heptameric	链 E 1–323（323 aa）	未记录	PLM PALMITIC ACID × 6 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 8 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 5	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.33 Å

共 39 个其他 PDB 条目、40 个 assembly。打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	CCG2_MOUSE
Isoform	—
PDB实体	1
链与序列区间	作者链 E； PDB构建体 1–323； UniProt 1–323 作者链 F； PDB构建体 1–323； UniProt 1–323 作者链 G； PDB构建体 1–323； UniProt 1–323 作者链 H； PDB构建体 1–323； UniProt 1–323

Isoform Flip of Glutamate receptor 2

Rattus norvegicus

UniProt P19491

当前结构中的状态

Assembly	聚集状态	构建体	突变与修饰	配体、离子与共同组分	实验方法与环境	结构质量
1	蛋白异源复合物异源复合物蛋白 × 8 PDB 声明：octameric（8）与蛋白拷贝数一致	链 A； UniProt 1–883 链 B； UniProt 1–883 链 C； UniProt 1–883 链 D； UniProt 1–883	未记录	Voltage-dependent calcium channel gamma-2 subunit × 4 （O88602）	ELECTRON MICROSCOPY cryo-EM缓冲液：pH 8；Tris adjusted to pH 8 using HCl cryo-EM玻璃化条件：冷冻剂 ETHANE	分辨率 2.57 Å

数据库中的同蛋白其他状态

其他 PDB	相对当前条目 9B60	Assembly / 聚集状态	构建体	突变与修饰	配体、离子与非聚合物	实验方法与环境	结构质量
1FTJ CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION 提交 2000-09-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J)) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J))	未记录	ZN ZINC ION × 1 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M Cacodylate 15% PEG 8000 0.2 M Zinc Acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 4K	分辨率 1.90 Å R-free 0.266
1FTJ CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION 提交 2000-09-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J)) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J))	未记录	ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M Cacodylate 15% PEG 8000 0.2 M Zinc Acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 4K	分辨率 1.90 Å R-free 0.266
1FTJ CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION 提交 2000-09-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J)) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J))	未记录	ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M Cacodylate 15% PEG 8000 0.2 M Zinc Acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 4K	分辨率 1.90 Å R-free 0.266
1FTJ CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION 提交 2000-09-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J)) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J)) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J)) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J))	未记录	ZN ZINC ION × 5 GLU GLUTAMIC ACID × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M Cacodylate 15% PEG 8000 0.2 M Zinc Acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 4K	分辨率 1.90 Å R-free 0.266
1FTJ CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH GLUTAMATE AT 1.9 RESOLUTION 提交 2000-09-12	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 5 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J)) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J)) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J))	未记录	ZN ZINC ION × 3 GLU GLUTAMIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；0.1 M Cacodylate 15% PEG 8000 0.2 M Zinc Acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 4K	分辨率 1.90 Å R-free 0.266
1FTK CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2I) IN COMPLEX WITH KAINATE AT 1.6 A RESOLUTION 提交 2000-09-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 404–528（125 aa）片段：LIGAND BINDING CORE, S1S2I 链 A 653–796（144 aa）片段：LIGAND BINDING CORE, S1S2I	未记录	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15% PEG 8000 50 mM potassium phosphate , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.60 Å R-free 0.261
1FTL CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH THE ANTAGONIST DNQX AT 1.8 A RESOLUTION 提交 2000-09-12	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	DNQ 6,7-DINITROQUINOXALINE-2,3-DIONE × 2 SO4 SULFATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；19% PEG 4000 0.3 M ammonium sulfate 0.1 M sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.80 Å R-free 0.272
1FTM CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION 提交 2000-09-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 1 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15% PEG 8000 0.2 M Zinc Acetate 0.1 M Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.70 Å R-free 0.247
1FTM CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION 提交 2000-09-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 2 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15% PEG 8000 0.2 M Zinc Acetate 0.1 M Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.70 Å R-free 0.247
1FTM CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION 提交 2000-09-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 C 413–527（115 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 2 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15% PEG 8000 0.2 M Zinc Acetate 0.1 M Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.70 Å R-free 0.247
1FTM CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION 提交 2000-09-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 5 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15% PEG 8000 0.2 M Zinc Acetate 0.1 M Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.70 Å R-free 0.247
1FTM CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION 提交 2000-09-12	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 5 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：GLUR2-FLOP LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15% PEG 8000 0.2 M Zinc Acetate 0.1 M Cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.70 Å R-free 0.247
1FTO CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN THE APO STATE AT 2.0 A RESOLUTION 提交 2000-09-12	构建体不同突变/修饰不同聚集状态不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；22% PEG 8000 0.3 M ammonium sulfate 0.1 M sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.00 Å R-free 0.287
1FTO CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN THE APO STATE AT 2.0 A RESOLUTION 提交 2000-09-12	构建体不同突变/修饰不同聚集状态不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；22% PEG 8000 0.3 M ammonium sulfate 0.1 M sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.00 Å R-free 0.287
1FW0 CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH KAINATE AT 2.0 A RESOLUTION 提交 2000-09-20	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5；274 K；10% PEG 1450, 0.1 M sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 274K	分辨率 1.90 Å R-free 0.308
1GR2 STRUCTURE OF A GLUTAMATE RECEPTOR LIGAND BINDING CORE (GLUR2) COMPLEXED WITH KAINATE 提交 1998-09-17	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 404–528（125 aa）片段：LIGAND BINDING DOMAIN 链 A 652–796（145 aa）片段：LIGAND BINDING DOMAIN	未记录	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 5；50 MM KIPI, PH 5.0, 14% PEG 8K	分辨率 1.90 Å R-free 0.273
1LB8 Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with AMPA at 2.3 resolution 提交 2002-04-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）片段：ligand-binding core (flop) 链 A 653–796（144 aa）片段：ligand-binding core (flop)	突变：L483Y 突变：L483Y	AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；PEG 8000, ammonium sulfate, sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K	分辨率 2.30 Å R-free 0.267
1LB8 Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with AMPA at 2.3 resolution 提交 2002-04-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）片段：ligand-binding core (flop) 链 B 653–796（144 aa）片段：ligand-binding core (flop)	突变：L483Y 突变：L483Y	AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；PEG 8000, ammonium sulfate, sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K	分辨率 2.30 Å R-free 0.267
1LB9 Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with antagonist DNQX at 2.3 A resolution 提交 2002-04-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）片段：ligand binding core (flop) 链 A 653–796（144 aa）片段：ligand binding core (flop)	突变：L483Y 突变：L483Y	DNQ 6,7-DINITROQUINOXALINE-2,3-DIONE × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；PEG 4000, ammonium sulfate, sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K	分辨率 2.30 Å R-free 0.268
1LB9 Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with antagonist DNQX at 2.3 A resolution 提交 2002-04-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）片段：ligand binding core (flop) 链 B 653–796（144 aa）片段：ligand binding core (flop)	突变：L483Y 突变：L483Y	DNQ 6,7-DINITROQUINOXALINE-2,3-DIONE × 1 SO4 SULFATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；PEG 4000, ammonium sulfate, sodium acetate, pH 5.0, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K	分辨率 2.30 Å R-free 0.268
1LBB Crystal structure of the GluR2 ligand binding domain mutant (S1S2J-N754D) in complex with kainate at 2.1 A resolution 提交 2002-04-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）片段：ligand binding core (flop) 链 A 653–796（144 aa）片段：ligand binding core (flop)	突变：N754D 突变：N754D	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；PEG 1000, Li2SO4, phosphate-citrate, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.0K	分辨率 2.10 Å R-free 0.260
1M5B X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH 2-Me-Tet-AMPA AT 1.85 A RESOLUTION. 提交 2002-07-09	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：flop ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：flop ligand binding core (S1S2J) 链 C 413–527（115 aa）片段：flop ligand binding core (S1S2J) 链 C 653–796（144 aa）片段：flop ligand binding core (S1S2J)	未记录	ZN ZINC ION × 3 BN1 (S)-2-AMINO-3-[3-HYDROXY-5-(2-METHYL-2H-TETRAZOL-5-YL)ISOXAZOL-4-YL]PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.85 Å R-free 0.234
1M5B X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH 2-Me-Tet-AMPA AT 1.85 A RESOLUTION. 提交 2002-07-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：flop ligand binding core (S1S2J) 链 B 653–796（144 aa）片段：flop ligand binding core (S1S2J)	未记录	ZN ZINC ION × 4 BN1 (S)-2-AMINO-3-[3-HYDROXY-5-(2-METHYL-2H-TETRAZOL-5-YL)ISOXAZOL-4-YL]PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.85 Å R-free 0.234
1M5B X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH 2-Me-Tet-AMPA AT 1.85 A RESOLUTION. 提交 2002-07-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：flop ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：flop ligand binding core (S1S2J) 链 B 413–527（115 aa）片段：flop ligand binding core (S1S2J) 链 B 653–796（144 aa）片段：flop ligand binding core (S1S2J) 链 C 413–527（115 aa）片段：flop ligand binding core (S1S2J) 链 C 653–796（144 aa）片段：flop ligand binding core (S1S2J)	未记录	ZN ZINC ION × 5 BN1 (S)-2-AMINO-3-[3-HYDROXY-5-(2-METHYL-2H-TETRAZOL-5-YL)ISOXAZOL-4-YL]PROPIONIC ACID × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.85 Å R-free 0.234
1M5C X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH Br-HIBO AT 1.65 A RESOLUTION 提交 2002-07-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：flop ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：flop ligand binding core (S1S2J)	未记录	BRH (S)-2-AMINO-3-(4-BROMO-3-HYDROXY-ISOXAZOL-5-YL)PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；PEG 1450, Li2SO4, phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.65 Å R-free 0.221
1M5D X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH Br-HIBO AT 1.73 A RESOLUTION 提交 2002-07-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：flop ligand binding core (S1S2J-Y702F) 链 A 653–796（144 aa）片段：flop ligand binding core (S1S2J-Y702F)	突变：Y190F 突变：Y190F	SO4 SULFATE ION × 4 BRH (S)-2-AMINO-3-(4-BROMO-3-HYDROXY-ISOXAZOL-5-YL)PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；PEG 3350, Li2SO4, phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.73 Å R-free 0.215
1M5E X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH ACPA AT 1.46 A RESOLUTION 提交 2002-07-09	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：GluR2-flop ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：GluR2-flop ligand binding core (S1S2J) 链 C 413–527（115 aa）片段：GluR2-flop ligand binding core (S1S2J) 链 C 653–796（144 aa）片段：GluR2-flop ligand binding core (S1S2J)	未记录	ZN ZINC ION × 4 AM1 (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.46 Å R-free 0.216
1M5E X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH ACPA AT 1.46 A RESOLUTION 提交 2002-07-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：GluR2-flop ligand binding core (S1S2J) 链 B 653–796（144 aa）片段：GluR2-flop ligand binding core (S1S2J)	未记录	ZN ZINC ION × 8 AM1 (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID × 2 ACT ACETATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.46 Å R-free 0.216
1M5E X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH ACPA AT 1.46 A RESOLUTION 提交 2002-07-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：GluR2-flop ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：GluR2-flop ligand binding core (S1S2J) 链 B 413–527（115 aa）片段：GluR2-flop ligand binding core (S1S2J) 链 B 653–796（144 aa）片段：GluR2-flop ligand binding core (S1S2J) 链 C 413–527（115 aa）片段：GluR2-flop ligand binding core (S1S2J) 链 C 653–796（144 aa）片段：GluR2-flop ligand binding core (S1S2J)	未记录	ZN ZINC ION × 8 AM1 (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID × 3 ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.46 Å R-free 0.216
1M5F X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH ACPA AT 1.95 A RESOLUTION 提交 2002-07-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：flop ligand binding core (S1S2J-Y702F) 链 A 653–796（144 aa）片段：flop ligand binding core (S1S2J-Y702F) 链 C 413–527（115 aa）片段：flop ligand binding core (S1S2J-Y702F) 链 C 653–796（144 aa）片段：flop ligand binding core (S1S2J-Y702F)	突变：Y190F 突变：Y190F 突变：Y190F 突变：Y190F	ZN ZINC ION × 2 AM1 (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.95 Å R-free 0.230
1M5F X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH ACPA AT 1.95 A RESOLUTION 提交 2002-07-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：flop ligand binding core (S1S2J-Y702F) 链 B 653–796（144 aa）片段：flop ligand binding core (S1S2J-Y702F)	突变：Y190F 突变：Y190F	ZN ZINC ION × 8 AM1 (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID × 2 ACT ACETATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.95 Å R-free 0.230
1M5F X-RAY STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J-Y702F) IN COMPLEX WITH ACPA AT 1.95 A RESOLUTION 提交 2002-07-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：flop ligand binding core (S1S2J-Y702F) 链 A 653–796（144 aa）片段：flop ligand binding core (S1S2J-Y702F) 链 B 413–527（115 aa）片段：flop ligand binding core (S1S2J-Y702F) 链 B 653–796（144 aa）片段：flop ligand binding core (S1S2J-Y702F) 链 C 413–527（115 aa）片段：flop ligand binding core (S1S2J-Y702F) 链 C 653–796（144 aa）片段：flop ligand binding core (S1S2J-Y702F)	突变：Y190F 突变：Y190F 突变：Y190F 突变：Y190F 突变：Y190F 突变：Y190F	ZN ZINC ION × 6 AM1 (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID × 3 ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 8000, Zn(OAc)2, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.95 Å R-free 0.230
1MM6 crystal structure of the GluR2 ligand binding core (S1S2J) in complex with quisqualate in a non zinc crystal form at 2.15 angstroms resolution 提交 2002-09-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	SO4 SULFATE ION × 3 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 2 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 8K, ammonium sulfate, sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.15 Å R-free 0.237
1MM7 Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in a Zinc Crystal Form at 1.65 Angstroms Resolution 提交 2002-09-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 8K, zinc acetate, sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.65 Å R-free 0.237
1MM7 Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in a Zinc Crystal Form at 1.65 Angstroms Resolution 提交 2002-09-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 8K, zinc acetate, sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.65 Å R-free 0.237
1MQD X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate. 提交 2002-09-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 A 653–794（142 aa）片段：GluR2-flop ligand-binding core (S1S2J)	未记录	SO4 SULFATE ION × 2 SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 2 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.2；279 K；20% PEG 8000, 0.1M lithium sulfate, 0.1M cacodylate, pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.46 Å R-free 0.192
1MQD X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate. 提交 2002-09-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 B 653–794（142 aa）片段：GluR2-flop ligand-binding core (S1S2J)	未记录	SO4 SULFATE ION × 2 SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.2；279 K；20% PEG 8000, 0.1M lithium sulfate, 0.1M cacodylate, pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.46 Å R-free 0.192
1MQD X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate. 提交 2002-09-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 C 653–794（142 aa）片段：GluR2-flop ligand-binding core (S1S2J)	未记录	SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.2；279 K；20% PEG 8000, 0.1M lithium sulfate, 0.1M cacodylate, pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.46 Å R-free 0.192
1MQD X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.46 A resolution. Crystallization in the presence of lithium sulfate. 提交 2002-09-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 D 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 D 653–794（142 aa）片段：GluR2-flop ligand-binding core (S1S2J)	未记录	SO4 SULFATE ION × 2 SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.2；279 K；20% PEG 8000, 0.1M lithium sulfate, 0.1M cacodylate, pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.46 Å R-free 0.192
1MQG Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Iodo-Willardiine at 2.15 Angstroms Resolution 提交 2002-09-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：ligand binding core (S1S2J) 链 B 413–527（115 aa）片段：ligand binding core (S1S2J)	未记录	SO4 SULFATE ION × 2 IWD 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 GOL GLYCEROL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.2；277 K；PEG 1000, Phosphate-citrate buffer, Li sulfate, pH 4.2, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.15 Å R-free 0.233
1MQH Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Bromo-Willardiine at 1.8 Angstroms Resolution 提交 2002-09-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：ligand binding core (S1S2J)	未记录	BWD 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 8K, ammonium sulfate, Na Acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.80 Å R-free 0.231
1MQI Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Fluoro-Willardiine at 1.35 Angstroms Resolution 提交 2002-09-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：ligand binding core (S1S2J)	未记录	FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 8K, NaCl, Na Citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.35 Å R-free 0.218
1MQJ Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with willardiine at 1.65 angstroms resolution 提交 2002-09-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：ligand binding core (S1S2J)	未记录	ZN ZINC ION × 2 HWD 2-AMINO-3-(2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；PEG 5K MME, Na Citrate, zinc acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.65 Å R-free 0.229
1MS7 X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate 提交 2002-09-19	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 A 653–796（144 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 C 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 C 653–796（144 aa）片段：GluR2-flop ligand-binding core (S1S2J)	未记录	ZN ZINC ION × 2 SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；17% PEG 8000, 0.05M zinc acetate, 0.1M cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.97 Å R-free 0.213
1MS7 X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate 提交 2002-09-19	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 B 653–796（144 aa）片段：GluR2-flop ligand-binding core (S1S2J)	未记录	ZN ZINC ION × 8 SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；17% PEG 8000, 0.05M zinc acetate, 0.1M cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.97 Å R-free 0.213
1MS7 X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-Des-Me-AMPA at 1.97 A resolution, Crystallization in the presence of zinc acetate 提交 2002-09-19	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 A 653–796（144 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 B 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 B 653–796（144 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 C 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 C 653–796（144 aa）片段：GluR2-flop ligand-binding core (S1S2J)	未记录	ZN ZINC ION × 6 SHI (S)-2-AMINO-3-(3-HYDROXY-ISOXAZOL-4-YL)PROPIONIC ACID × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；17% PEG 8000, 0.05M zinc acetate, 0.1M cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.97 Å R-free 0.213
1MXU CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) in complex with bromo-willardiine (Control for the crystal titration experiments) 提交 2002-10-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3 BWD 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8K, ammonium sulfate, zinc acetate, BrW and sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.80 Å R-free 0.234
1MXU CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) in complex with bromo-willardiine (Control for the crystal titration experiments) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4 BWD 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8K, ammonium sulfate, zinc acetate, BrW and sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.80 Å R-free 0.234
1MXU CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) in complex with bromo-willardiine (Control for the crystal titration experiments) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 5 BWD 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8K, ammonium sulfate, zinc acetate, BrW and sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.80 Å R-free 0.234
1MXV crystal titration experiments (AMPA co-crystals soaked in 10 mM BrW) 提交 2002-10-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.95 Å R-free 0.248
1MXV crystal titration experiments (AMPA co-crystals soaked in 10 mM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.95 Å R-free 0.248
1MXV crystal titration experiments (AMPA co-crystals soaked in 10 mM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 5	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.95 Å R-free 0.248
1MXW crystal titration experiments (AMPA co-crystals soaked in 1 mM BrW) 提交 2002-10-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.252
1MXW crystal titration experiments (AMPA co-crystals soaked in 1 mM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.252
1MXW crystal titration experiments (AMPA co-crystals soaked in 1 mM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 5	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.252
1MXX crystal titration experiments (AMPA co-crystals soaked in 100 uM BrW) 提交 2002-10-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.00 Å R-free 0.250
1MXX crystal titration experiments (AMPA co-crystals soaked in 100 uM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.00 Å R-free 0.250
1MXX crystal titration experiments (AMPA co-crystals soaked in 100 uM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 5	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.00 Å R-free 0.250
1MXY crystal titration experiments (AMPA co-crystals soaked in 10 uM BrW) 提交 2002-10-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.95 Å R-free 0.259
1MXY crystal titration experiments (AMPA co-crystals soaked in 10 uM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.95 Å R-free 0.259
1MXY crystal titration experiments (AMPA co-crystals soaked in 10 uM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 5	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.95 Å R-free 0.259
1MXZ crystal titration experiments (AMPA co-crystals soaked in 1 uM BrW) 提交 2002-10-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.256
1MXZ crystal titration experiments (AMPA co-crystals soaked in 1 uM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.256
1MXZ crystal titration experiments (AMPA co-crystals soaked in 1 uM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 5	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.256
1MY0 crystal titration experiments (AMPA co-crystals soaked in 100 nM BrW) 提交 2002-10-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.249
1MY0 crystal titration experiments (AMPA co-crystals soaked in 100 nM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.249
1MY0 crystal titration experiments (AMPA co-crystals soaked in 100 nM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 5	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.249
1MY1 crystal titration experiments (AMPA co-crystals soaked in 10 nM BrW) 提交 2002-10-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.248
1MY1 crystal titration experiments (AMPA co-crystals soaked in 10 nM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.248
1MY1 crystal titration experiments (AMPA co-crystals soaked in 10 nM BrW) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 5	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.248
1MY2 crystal titration experiment (AMPA complex control) 提交 2002-10-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.80 Å R-free 0.244
1MY2 crystal titration experiment (AMPA complex control) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.80 Å R-free 0.244
1MY2 crystal titration experiment (AMPA complex control) 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 5 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, zinc acetate, sodium cacodylate, pH 6.5 and AMPA, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.80 Å R-free 0.244
1MY3 crystal structure of glutamate receptor ligand-binding core in complex with bromo-willardiine in the Zn crystal form 提交 2002-10-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3 BWD 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, ammonium sulfate, zinc acetate and sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.75 Å R-free 0.255
1MY3 crystal structure of glutamate receptor ligand-binding core in complex with bromo-willardiine in the Zn crystal form 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4 BWD 2-AMINO-3-(5-BROMO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, ammonium sulfate, zinc acetate and sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.75 Å R-free 0.255
1MY4 crystal structure of glutamate receptor ligand-binding core in complex with iodo-willardiine in the Zn crystal form 提交 2002-10-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3 IWD 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；PEG4K, ammonium sulfate, zinc acetate and Tris-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.262
1MY4 crystal structure of glutamate receptor ligand-binding core in complex with iodo-willardiine in the Zn crystal form 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4 IWD 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；PEG4K, ammonium sulfate, zinc acetate and Tris-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.262
1MY4 crystal structure of glutamate receptor ligand-binding core in complex with iodo-willardiine in the Zn crystal form 提交 2002-10-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–796（144 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 5 IWD 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7.5；277 K；PEG4K, ammonium sulfate, zinc acetate and Tris-HCl, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.262
1N0T X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution. 提交 2002-10-15	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J). 链 A 653–796（144 aa）片段：GluR2-flop ligand-binding core (S1S2J). 链 C 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J). 链 C 653–796（144 aa）片段：GluR2-flop ligand-binding core (S1S2J).	未记录	AT1 (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID × 2 SO4 SULFATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.2；279 K；PEG 3350, AMMONIUM SULFATE, SODIUM ACETATE pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 2.10 Å R-free 0.245
1N0T X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with the antagonist (S)-ATPO at 2.1 A resolution. 提交 2002-10-15	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J). 链 B 653–796（144 aa）片段：GluR2-flop ligand-binding core (S1S2J). 链 D 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J). 链 D 653–796（144 aa）片段：GluR2-flop ligand-binding core (S1S2J).	未记录	AT1 (S)-2-AMINO-3-(5-TERT-BUTYL-3-(PHOSPHONOMETHOXY)-4-ISOXAZOLYL)PROPIONIC ACID × 2 SO4 SULFATE ION × 2 ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.2；279 K；PEG 3350, AMMONIUM SULFATE, SODIUM ACETATE pH 5.2, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 2.10 Å R-free 0.245
1NNK X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions. 提交 2003-01-14	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 A 653–796（144 aa）片段：GluR2-flop ligand-binding core (S1S2J)	未记录	ZN ZINC ION × 4 CL CHLORIDE ION × 2 CE2 3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；zinc acetate, cacodylate, PEG8000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.85 Å R-free 0.245
1NNP X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.9 A resolution. Crystallization without zinc ions. 提交 2003-01-14	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：GluR2-flop ligand-binding core (S1S2J) 链 B 653–796（144 aa）片段：GluR2-flop ligand-binding core (S1S2J)	未记录	SO4 SULFATE ION × 2 CE2 3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.6；279 K；ammonium sulfate, PEG8000, sodium acetate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.90 Å R-free 0.216
1P1N GluR2 Ligand Binding Core (S1S2J) Mutant L650T in Complex with Kainate 提交 2003-04-13	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：ligand binding core (S1S2J)	突变：L138T 突变：L138T	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；PEG 4000, ammonium sulfate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.60 Å R-free 0.252
1P1O Crystal structure of the GluR2 ligand-binding core (S1S2J) mutant L650T in complex with quisqualate 提交 2003-04-13	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：ligand binding core (S1S2J)	突变：L138T 突变：L138T	SO4 SULFATE ION × 4 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；PEG4000, ammonium sulfate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.60 Å R-free 0.235
1P1Q Crystal structure of the GluR2 ligand binding core (S1S2J) L650T mutant in complex with AMPA 提交 2003-04-13	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：ligand binding core (S1S2J) 链 C 413–527（115 aa）片段：ligand binding core (S1S2J) 链 C 653–796（144 aa）片段：ligand binding core (S1S2J)	突变：L138T 突变：L138T 突变：L138T 突变：L138T	ZN ZINC ION × 3 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, cacodylate, zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.00 Å R-free 0.270
1P1Q Crystal structure of the GluR2 ligand binding core (S1S2J) L650T mutant in complex with AMPA 提交 2003-04-13	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：ligand binding core (S1S2J) 链 B 653–796（144 aa）片段：ligand binding core (S1S2J)	突变：L138T 突变：L138T	ZN ZINC ION × 4 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；PEG8000, cacodylate, zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.00 Å R-free 0.270
1P1U Crystal structure of the GluR2 ligand-binding core (S1S2J) L650T mutant in complex with AMPA (ammonium sulfate crystal form) 提交 2003-04-14	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：ligand binding core (S1S2J) 链 B 413–527（115 aa）片段：ligand binding core (S1S2J) 链 B 653–796（144 aa）片段：ligand binding core (S1S2J)	突变：L138T 突变：L138T 突变：L138T 突变：L138T	SO4 SULFATE ION × 1 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；PEG4000, ammonium sulfate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.00 Å R-free 0.271
1P1W Crystal structure of the GluR2 ligand-binding core (S1S2J) with the L483Y and L650T mutations and in complex with AMPA 提交 2003-04-14	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：ligand binding core (S1S2J) 链 B 413–527（115 aa）片段：ligand binding core (S1S2J) 链 B 653–796（144 aa）片段：ligand binding core (S1S2J)	突变：L94Y,L138T 突变：L94Y,L138T 突变：L94Y,L138T 突变：L94Y,L138T	SO4 SULFATE ION × 2 AMQ (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；277 K；PEG4000, ammonium sulfate, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.80 Å R-free 0.264
1SYH X-RAY STRUCTURE OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 1.85 A RESOLUTION. 提交 2004-04-01	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–796（384 aa）片段：GLUR2-FLOP LIGAND-BINDING CORE (S1S2J)	未记录	CPW (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；PEG8000, cacodylate, (NH4)2SO4 , pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 1.80 Å R-free 0.199
1SYI X-RAY STRUCTURE OF THE Y702F MUTANT OF THE GLUR2 LIGAND-BINDING CORE (S1S2J) IN COMPLEX WITH (S)-CPW399 AT 2.1 A RESOLUTION. 提交 2004-04-01	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–796（384 aa）片段：GLUR2-FLOP LIGAND-BINDING CORE (S1S2J) 链 B 413–796（384 aa）片段：GLUR2-FLOP LIGAND-BINDING CORE (S1S2J)	突变：Y702F 突变：Y702F	CPW (S)-2-AMINO-3-(1,3,5,7-PENTAHYDRO-2,4-DIOXO-CYCLOPENTA[E]PYRIMIDIN-1-YL) PROIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；280 K；PEG8000, CACODYLATE, (NH4)2SO4, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.10 Å R-free 0.254
1WVJ Exploring the GluR2 ligand-binding core in complex with the bicyclic AMPA analogue (S)-4-AHCP 提交 2004-12-15	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–796（144 aa）	未记录	SO4 SULFATE ION × 4 IBC 3-(3-HYDROXY-7,8-DIHYDRO-6H-CYCLOHEPTA[D]ISOXAZOL-4-YL)-L-ALANINE × 2 GOL GLYCEROL × 6	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；PEG 3350, phosphate-citrate buffer, lithium sulfate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.75 Å R-free 0.214
1XHY X-ray structure of the Y702F mutant of the GluR2 ligand-binding core (S1S2J) in complex with kainate at 1.85 A resolution 提交 2004-09-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：GluR2 flop ligand-binding core (S1S2J), UNP residues 413-527 and 653-796 链 A 653–796（144 aa）片段：GluR2 flop ligand-binding core (S1S2J), UNP residues 413-527 and 653-796	突变：Y702F 突变：Y702F	SO4 SULFATE ION × 10 KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；280 K；PEG1000, Li2SO4, cacodylate , pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 1.85 Å R-free 0.207
2AIX X-ray structure of the GLUR2 ligand-binding core (S1S2J) in complex with (s)-thio-atpa at 2.2 a resolution. 提交 2005-08-01	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：GLUR2-FLOP LIGAND-BINDING CORE (S1S2J). 链 A 653–796（144 aa）片段：GLUR2-FLOP LIGAND-BINDING CORE (S1S2J).	未记录	U1K (S)-2-AMINO-3-(3-HYDROXY-5-TERT-BUTYLISOTHIAZOL-4-YL) PROPRIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；279 K；SODIUM CHLORIDE, CACODYLATE, PEG 8000, pH 6.50, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 2.17 Å R-free 0.230
2AL4 CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614. 提交 2005-08-04	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）片段：ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：ligand binding core (S1S2J) 链 B 413–527（115 aa）片段：ligand binding core (S1S2J) 链 B 653–796（144 aa）片段：ligand binding core (S1S2J) 链 F 413–527（115 aa）片段：ligand binding core (S1S2J) 链 F 653–796（144 aa）片段：ligand binding core (S1S2J)	突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker.	ZN ZINC ION × 5 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 3 CX6 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；10-14% PEG8000, 0.1-0.15 M Zinc acetate, 0.1 M sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.70 Å R-free 0.223
2AL4 CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH quisqualate and CX614. 提交 2005-08-04	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 C 413–527（115 aa）片段：ligand binding core (S1S2J) 链 C 653–796（144 aa）片段：ligand binding core (S1S2J) 链 D 413–527（115 aa）片段：ligand binding core (S1S2J) 链 D 653–796（144 aa）片段：ligand binding core (S1S2J) 链 E 413–527（115 aa）片段：ligand binding core (S1S2J) 链 E 653–796（144 aa）片段：ligand binding core (S1S2J)	突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker.	ZN ZINC ION × 5 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 3 CX6 2,3,6A,7,8,9-HEXAHYDRO-11H-[1,4]DIOXINO[2,3-G]PYRROLO[2,1-B][1,3]BENZOXAZIN-11-ONE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；10-14% PEG8000, 0.1-0.15 M Zinc acetate, 0.1 M sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.70 Å R-free 0.223
2AL5 Crystal structure of the GluR2 ligand binding core (S1S2J) in complex with fluoro-willardiine and aniracetam 提交 2005-08-04	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：ligand binding core (S1S2J) 链 A 653–796（144 aa）片段：ligand binding core (S1S2J) 链 B 413–527（115 aa）片段：ligand binding core (S1S2J) 链 B 653–796（144 aa）片段：ligand binding core (S1S2J)	突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker. 突变：The native GluR2 is a membrane protein. Transmembrane regions were genetically removed and replaced with a Gly-Thr linker.	FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 4MP 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；12-14% PEG 8000, 0.25-0.35 M ammonium sulfate and 0.1 M sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.65 Å R-free 0.220
2ANJ Crystal Structure of the Glur2 Ligand Binding Core (S1S2J-Y450W) Mutant in Complex With the Partial Agonist Kainic Acid at 2.1 A Resolution 提交 2005-08-11	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand Binding Core 链 A 653–796（144 aa）片段：Ligand Binding Core	突变：Y61W 突变：Y61W	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；279 K；PEG 8000, Cacodylate, Lithium Sulphate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K, pH 6.50	分辨率 2.10 Å R-free 0.248
2CMO The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209 提交 2006-05-11	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：RESIDUES 413-527,653-796 链 A 653–796（144 aa）片段：RESIDUES 413-527,653-796 链 B 413–527（115 aa）片段：RESIDUES 413-527,653-796 链 B 653–796（144 aa）片段：RESIDUES 413-527,653-796	未记录	SO4 SULFATE ION × 4 M1L 2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC ACID × 1 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；pH 6.50	分辨率 2.65 Å R-free 0.281
2GFE Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution 提交 2006-03-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–795（143 aa）链 C 413–527（115 aa）链 C 653–795（143 aa）	突变：A476E S673D 突变：A476E S673D 突变：A476E S673D 突变：A476E S673D	ZN ZINC ION × 3 GLU GLUTAMIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；1 to 1 mixture of: Reservoir: 14% PEG 8K; 0.1M Na Acetate; 0.1 M Zn Acetate. Protein: 10 mg/ml 0.01 M Na HEPES pH 7.0; 0.02 M NaCl; 0.01 M Na Glutamate; 0.001 M EDTA, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.54 Å R-free 0.227
2GFE Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution 提交 2006-03-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）链 B 653–795（143 aa）	突变：A476E S673D 突变：A476E S673D	ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；1 to 1 mixture of: Reservoir: 14% PEG 8K; 0.1M Na Acetate; 0.1 M Zn Acetate. Protein: 10 mg/ml 0.01 M Na HEPES pH 7.0; 0.02 M NaCl; 0.01 M Na Glutamate; 0.001 M EDTA, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.54 Å R-free 0.227
2GFE Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution 提交 2006-03-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 A 413–527（115 aa）链 A 653–795（143 aa）链 B 413–527（115 aa）链 B 653–795（143 aa）链 C 413–527（115 aa）链 C 653–795（143 aa）	突变：A476E S673D 突变：A476E S673D 突变：A476E S673D 突变：A476E S673D 突变：A476E S673D 突变：A476E S673D	ZN ZINC ION × 5 GLU GLUTAMIC ACID × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；1 to 1 mixture of: Reservoir: 14% PEG 8K; 0.1M Na Acetate; 0.1 M Zn Acetate. Protein: 10 mg/ml 0.01 M Na HEPES pH 7.0; 0.02 M NaCl; 0.01 M Na Glutamate; 0.001 M EDTA, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.54 Å R-free 0.227
2GFE Crystal structure of the GluR2 A476E S673D Ligand Binding Core Mutant at 1.54 Angstroms Resolution 提交 2006-03-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–795（143 aa）链 B 413–527（115 aa）链 B 653–795（143 aa）	突变：A476E S673D 突变：A476E S673D 突变：A476E S673D 突变：A476E S673D	ZN ZINC ION × 3 GLU GLUTAMIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；1 to 1 mixture of: Reservoir: 14% PEG 8K; 0.1M Na Acetate; 0.1 M Zn Acetate. Protein: 10 mg/ml 0.01 M Na HEPES pH 7.0; 0.02 M NaCl; 0.01 M Na Glutamate; 0.001 M EDTA, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.54 Å R-free 0.227
2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant 提交 2006-08-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50	分辨率 2.40 Å R-free 0.281
2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant 提交 2006-08-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50	分辨率 2.40 Å R-free 0.281
2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant 提交 2006-08-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 1 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50	分辨率 2.40 Å R-free 0.281
2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant 提交 2006-08-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 D 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 D 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 1 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50	分辨率 2.40 Å R-free 0.281
2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant 提交 2006-08-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 5 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J) 链 D 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 D 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 7 GLU GLUTAMIC ACID × 4	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50	分辨率 2.40 Å R-free 0.281
2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant 提交 2006-08-21	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 6 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J) 链 D 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 D 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4 GLU GLUTAMIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50	分辨率 2.40 Å R-free 0.281
2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant 提交 2006-08-21	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 7 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 C 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 3 GLU GLUTAMIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50	分辨率 2.40 Å R-free 0.281
2I3V Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant 提交 2006-08-21	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 8 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J) 链 D 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 D 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J)	未记录	ZN ZINC ION × 4 GLU GLUTAMIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；277 K；0.1 M CACODYLATE, 18% PEG 8000, 0.2 M ZINC ACETATE, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50	分辨率 2.40 Å R-free 0.281
2I3W Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant 提交 2006-08-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J)	突变：G729C 突变：G729C	GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；0.1 M CITRATE 20% PEG 3000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.30 Å R-free 0.284
2I3W Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant 提交 2006-08-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J)	突变：G729C 突变：G729C	GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；0.1 M CITRATE 20% PEG 3000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.30 Å R-free 0.284
2I3W Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of S729C mutant 提交 2006-08-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 A 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 413–527（115 aa）片段：LIGAND BINDING CORE (S1S2J) 链 B 653–794（142 aa）片段：LIGAND BINDING CORE (S1S2J)	突变：G729C 突变：G729C 突变：G729C 突变：G729C	GLU GLUTAMIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；0.1 M CITRATE 20% PEG 3000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.30 Å R-free 0.284
2P2A X-ray structure of the GluR2 ligand binding core (S1S2J) in complex with 2-Bn-tet-AMPA at 2.26A resolution 提交 2007-03-07	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：GluR2-Flop ligand-binding core (Residues 413-527, 653-796) 链 A 653–796（144 aa）片段：GluR2-Flop ligand-binding core (Residues 413-527, 653-796) 链 B 413–527（115 aa）片段：GluR2-Flop ligand-binding core (Residues 413-527, 653-796) 链 B 653–796（144 aa）片段：GluR2-Flop ligand-binding core (Residues 413-527, 653-796)	未记录	SO4 SULFATE ION × 3 GLU GLUTAMIC ACID × 1 MP9 2-AMINO-3-[3-HYDROXY-5-(2-BENZYL-2H-5-TETRAZOLYL)-4-ISOXAZOLYL]-PROPIONIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；PEG4000, Sodium Acetate, Ammonium Sulfate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.26 Å R-free 0.273
2XX7 Crystal structure of 1-(4-(1-pyrrolidinylcarbonyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. 提交 2010-11-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-795 链 A 653–795（143 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-795 链 C 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-795 链 C 653–795（143 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-795	突变：YES 突变：YES 突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 1ND 1-[4-(1-PYRROLIDINYLCARBONYL)PHENYL]-3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE × 1 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 2.20 Å R-free 0.218
2XX7 Crystal structure of 1-(4-(1-pyrrolidinylcarbonyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. 提交 2010-11-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-795 链 B 653–795（143 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-795	突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 1ND 1-[4-(1-PYRROLIDINYLCARBONYL)PHENYL]-3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE × 2 SO4 SULFATE ION × 2 ZN ZINC ION × 6	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 2.20 Å R-free 0.218
2XX8 Crystal structure of N,N-dimethyl-4-(3-(trifluoromethyl)-4,5,6,7- tetrahydro-1H-indazol-1-yl)benzamide in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. 提交 2010-11-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 A 653–796（144 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 C 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 C 653–796（144 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796	突变：YES 突变：YES 突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 1NE N,N-DIMETHYL-4-[3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL]BENZAMIDE × 1 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 1.55 Å R-free 0.212
2XX8 Crystal structure of N,N-dimethyl-4-(3-(trifluoromethyl)-4,5,6,7- tetrahydro-1H-indazol-1-yl)benzamide in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. 提交 2010-11-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 B 653–796（144 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796	突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 1NE N,N-DIMETHYL-4-[3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL]BENZAMIDE × 2 SO4 SULFATE ION × 2 ZN ZINC ION × 6	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 1.55 Å R-free 0.212
2XX9 Crystal structure of 1-((2-fluoro-4-(3-(trifluoromethyl)-4,5,6,7- tetrahydro-1H-indazol-1-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. 提交 2010-11-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 B 653–796（144 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796	突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 1NF N,N-DIMETHYL-4-[3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL]BENZAMIDE × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 1.97 Å R-free 0.224
2XX9 Crystal structure of 1-((2-fluoro-4-(3-(trifluoromethyl)-4,5,6,7- tetrahydro-1H-indazol-1-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution. 提交 2010-11-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 A 653–796（144 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 C 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 C 653–796（144 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796	突变：YES 突变：YES 突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 1NF N,N-DIMETHYL-4-[3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL]BENZAMIDE × 1 SO4 SULFATE ION × 1 ZN ZINC ION × 3	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 1.97 Å R-free 0.224
2XXH Crystal structure of 1-(4-(2-oxo-2-(1-pyrrolidinyl)ethyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.5A resolution. 提交 2010-11-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 B 653–796（144 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796	突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 1NG 1-{4-[2-OXO-2-(1-PYRROLIDINYL)ETHYL]PHENYL}-3-( TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE × 2 SO4 SULFATE ION × 2 ZN ZINC ION × 6	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 1.50 Å R-free 0.218
2XXH Crystal structure of 1-(4-(2-oxo-2-(1-pyrrolidinyl)ethyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.5A resolution. 提交 2010-11-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 A 653–796（144 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 C 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 C 653–796（144 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796	突变：YES 突变：YES 突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 1NG 1-{4-[2-OXO-2-(1-PYRROLIDINYL)ETHYL]PHENYL}-3-( TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE × 1 ZN ZINC ION × 2	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 1.50 Å R-free 0.218
2XXI Crystal structure of 1-((4-(3-(trifluoromethyl)-6,7-dihydropyrano(4,3- c(pyrazol-1(4H)-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.6A resolution. 提交 2010-11-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 A 653–796（144 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 C 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 C 653–796（144 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796	突变：YES 突变：YES 突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 JAC 1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE × 1 SO4 SULFATE ION × 1 ZN ZINC ION × 3	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 1.60 Å R-free 0.208
2XXI Crystal structure of 1-((4-(3-(trifluoromethyl)-6,7-dihydropyrano(4,3- c(pyrazol-1(4H)-yl)phenyl)methyl)-2-pyrrolidinone in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 1.6A resolution. 提交 2010-11-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796 链 B 653–796（144 aa）片段：LIGAND BINDING DOMAIN, RESIDUES 413-527,653-796	突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 JAC 1-({4-[3-(TRIFLUOROMETHYL)-6,7-DIHYDROPYRANO[4,3-C]PYRAZOL-1(4H)-YL]PHENYL}METHYL)-2-PYRROLIDINONE × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION mmCIF 未提供已读取条件	分辨率 1.60 Å R-free 0.208
3B6Q Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) Mutant T686A in Complex with Glutamate at 2.0 Resolution 提交 2007-10-29	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–796（144 aa）	突变：T686A 突变：T686A	SO4 SULFATE ION × 2 GLU GLUTAMIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION；pH 8.5；293 K；0.1 M Tris-HCl, 0.15-0.2 M lithium sulfate, 18-21% PEG4000, pH 8.5, VAPOR DIFFUSION, temperature 293K	分辨率 2.00 Å R-free 0.222
3B6T Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686A Mutant in Complex with Quisqualate at 2.1 Resolution 提交 2007-10-29	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–796（144 aa）	突变：T686A 突变：T686A	SO4 SULFATE ION × 2 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1 M Tris-HCl, 0.15-0.2 M lithium sulfate, 18-21% PEG4000, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K	分辨率 2.10 Å R-free 0.274
3B6W Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution 提交 2007-10-29	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–796（144 aa）链 C 413–527（115 aa）链 C 653–796（144 aa）	突变：T686S 突变：T686S 突变：T686S 突变：T686S	SO4 SULFATE ION × 3 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1 M Tris-HCl, 0.15-0.2 M lithium sulfate, 18-21% PEG4000, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K	分辨率 1.70 Å R-free 0.260
3B6W Crystal Structure of the GLUR2 Ligand Binding Core (S1S2J) T686S Mutant in Complex with Glutamate at 1.7 Resolution 提交 2007-10-29	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）链 B 653–796（144 aa）链 D 413–527（115 aa）链 D 653–796（144 aa）	突变：T686S 突变：T686S 突变：T686S 突变：T686S	SO4 SULFATE ION × 1 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8.5；293 K；0.1 M Tris-HCl, 0.15-0.2 M lithium sulfate, 18-21% PEG4000, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 293K	分辨率 1.70 Å R-free 0.260
3B7D Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution 提交 2007-10-30	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–794（142 aa）链 B 413–527（115 aa）链 B 653–794（142 aa）	未记录	CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；40 mM Sodium citrate, 10 mM Ammonium sulfate, 1% PEG 400, pH 6.5, VAPOR DIFFUSION, HANGING DROP	分辨率 2.50 Å R-free 0.283
3B7D Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution 提交 2007-10-30	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 413–527（115 aa）链 C 653–794（142 aa）链 D 413–527（115 aa）链 D 653–794（142 aa）	未记录	CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；40 mM Sodium citrate, 10 mM Ammonium sulfate, 1% PEG 400, pH 6.5, VAPOR DIFFUSION, HANGING DROP	分辨率 2.50 Å R-free 0.283
3B7D Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution 提交 2007-10-30	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 E 413–527（115 aa）链 E 653–794（142 aa）链 F 413–527（115 aa）链 F 653–794（142 aa）	未记录	CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；40 mM Sodium citrate, 10 mM Ammonium sulfate, 1% PEG 400, pH 6.5, VAPOR DIFFUSION, HANGING DROP	分辨率 2.50 Å R-free 0.283
3B7D Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution 提交 2007-10-30	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 G 413–527（115 aa）链 G 653–794（142 aa）链 H 413–527（115 aa）链 H 653–794（142 aa）	未记录	CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；40 mM Sodium citrate, 10 mM Ammonium sulfate, 1% PEG 400, pH 6.5, VAPOR DIFFUSION, HANGING DROP	分辨率 2.50 Å R-free 0.283
3BBR Crystal structure of the iGluR2 ligand binding core (S1S2J-N775S) in complex with a dimeric positive modulator as well as glutamate at 2.25 A resolution 提交 2007-11-11	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding core 链 A 653–796（144 aa）片段：Ligand binding core 链 B 413–527（115 aa）片段：Ligand binding core 链 B 653–796（144 aa）片段：Ligand binding core	突变：N775S 突变：N775S 突变：N775S 突变：N775S	SO4 SULFATE ION × 5 CL CHLORIDE ION × 1 GLU GLUTAMIC ACID × 2 BHY N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dimethanesulfonamide × 1 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；0.3M ammonium sulfate, 0.1M sodium acetate, 25% PEG 4000, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.25 Å R-free 0.231
3BFT Structure of the ligand-binding core of GluR2 in complex with the agonist (S)-TDPA at 2.25 A resolution 提交 2007-11-23	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：residues 1-263 链 A 653–796（144 aa）片段：residues 1-263 链 C 413–527（115 aa）片段：residues 1-263 链 C 653–796（144 aa）片段：residues 1-263	未记录	S2P (2S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid × 2 ZN ZINC ION × 2 NA SODIUM ION × 1 CL CHLORIDE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 2000, cacodylate, zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 2.27 Å R-free 0.250
3BFT Structure of the ligand-binding core of GluR2 in complex with the agonist (S)-TDPA at 2.25 A resolution 提交 2007-11-23	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：residues 1-263 链 B 653–796（144 aa）片段：residues 1-263	未记录	S2P (2S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid × 2 ZN ZINC ION × 6 NA SODIUM ION × 2 CAC CACODYLATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 2000, cacodylate, zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 2.27 Å R-free 0.250
3BFU Structure of the ligand-binding core of GluR2 in complex with the agonist (R)-TDPA at 1.95 A resolution 提交 2007-11-23	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：residues 1-263 链 A 653–796（144 aa）片段：residues 1-263	未记录	R2P (2R)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 2000, cacodylate, ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.95 Å R-free 0.233
3BFU Structure of the ligand-binding core of GluR2 in complex with the agonist (R)-TDPA at 1.95 A resolution 提交 2007-11-23	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：residues 1-263 链 B 653–796（144 aa）片段：residues 1-263	未记录	R2P (2R)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 2000, cacodylate, ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.95 Å R-free 0.233
3BFU Structure of the ligand-binding core of GluR2 in complex with the agonist (R)-TDPA at 1.95 A resolution 提交 2007-11-23	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 413–527（115 aa）片段：residues 1-263 链 C 653–796（144 aa）片段：residues 1-263	未记录	R2P (2R)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 2000, cacodylate, ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.95 Å R-free 0.233
3BFU Structure of the ligand-binding core of GluR2 in complex with the agonist (R)-TDPA at 1.95 A resolution 提交 2007-11-23	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 D 413–527（115 aa）片段：residues 1-263 链 D 653–796（144 aa）片段：residues 1-263	未记录	R2P (2R)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propanoic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；PEG 2000, cacodylate, ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.95 Å R-free 0.233
3BKI Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms 提交 2007-12-06	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 P 413–527（115 aa）链 P 653–796（144 aa）	未记录	FQX [1,2,5]oxadiazolo[3,4-g]quinoxaline-6,7(5H,8H)-dione 1-oxide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP	分辨率 1.87 Å R-free 0.221
3BKI Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms 提交 2007-12-06	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）链 B 653–796（144 aa）	未记录	FQX [1,2,5]oxadiazolo[3,4-g]quinoxaline-6,7(5H,8H)-dione 1-oxide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP	分辨率 1.87 Å R-free 0.221
3BKI Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms 提交 2007-12-06	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 C 413–527（115 aa）链 C 653–796（144 aa）	未记录	FQX [1,2,5]oxadiazolo[3,4-g]quinoxaline-6,7(5H,8H)-dione 1-oxide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP	分辨率 1.87 Å R-free 0.221
3BKI Crystal Structure of the GluR2 ligand binding core (S1S2J) in complex with FQX at 1.87 Angstroms 提交 2007-12-06	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 D 413–527（115 aa）链 D 653–796（144 aa）	未记录	FQX [1,2,5]oxadiazolo[3,4-g]quinoxaline-6,7(5H,8H)-dione 1-oxide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；VAPOR DIFFUSION, HANGING DROP	分辨率 1.87 Å R-free 0.221
3DP6 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to glutamate 提交 2008-07-07	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）片段：S1S2 binding domain 链 A 653–796（144 aa）片段：S1S2 binding domain	未记录	ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；277 K；14-17% PEG 8000, 0.1-0.2 M Zn acetate, 0.1 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50	分辨率 1.55 Å R-free 0.244
3DP6 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to glutamate 提交 2008-07-07	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）片段：S1S2 binding domain 链 B 653–796（144 aa）片段：S1S2 binding domain	未记录	ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；277 K；14-17% PEG 8000, 0.1-0.2 M Zn acetate, 0.1 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50	分辨率 1.55 Å R-free 0.244
3DP6 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to glutamate 提交 2008-07-07	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 C 413–527（115 aa）片段：S1S2 binding domain 链 C 653–796（144 aa）片段：S1S2 binding domain	未记录	ZN ZINC ION × 2 GLU GLUTAMIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；277 K；14-17% PEG 8000, 0.1-0.2 M Zn acetate, 0.1 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K, pH 6.50	分辨率 1.55 Å R-free 0.244
3H03 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to UBP277 提交 2009-04-08	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 A 653–794（142 aa）片段：UNP residues 414-527, 652-794 链 B 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 B 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	UBP 3-[3-(2-carboxyethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-L-alanine × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-16% PEG8K, 0.1-0.15 M Zn acetate, 0.25 M ammonium sulfate, 0.1 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.258
3H03 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to UBP277 提交 2009-04-08	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 D 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 D 653–794（142 aa）片段：UNP residues 414-527, 652-794 链 G 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 G 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	UBP 3-[3-(2-carboxyethyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl]-L-alanine × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-16% PEG8K, 0.1-0.15 M Zn acetate, 0.25 M ammonium sulfate, 0.1 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.258
3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 提交 2009-04-08	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 G 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 G 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.80 Å R-free 0.295
3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 提交 2009-04-08	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 10 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 E 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 E 653–794（142 aa）片段：UNP residues 414-527, 652-794 链 P 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 P 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.80 Å R-free 0.295
3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 提交 2009-04-08	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 11 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 G 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 G 653–794（142 aa）片段：UNP residues 414-527, 652-794 链 J 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 J 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.80 Å R-free 0.295
3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 提交 2009-04-08	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 12 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 H 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 H 653–794（142 aa）片段：UNP residues 414-527, 652-794 链 L 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 L 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.80 Å R-free 0.295
3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 提交 2009-04-08	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 B 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.80 Å R-free 0.295
3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 提交 2009-04-08	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 E 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 E 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.80 Å R-free 0.295
3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 提交 2009-04-08	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 H 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 H 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.80 Å R-free 0.295
3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 提交 2009-04-08	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 5 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 J 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 J 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.80 Å R-free 0.295
3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 提交 2009-04-08	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 6 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 L 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 L 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.80 Å R-free 0.295
3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 提交 2009-04-08	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 7 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 N 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 N 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.80 Å R-free 0.295
3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 提交 2009-04-08	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 8 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 P 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 P 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.80 Å R-free 0.295
3H06 Crystal structure of the binding domain of the AMPA subunit GluR2 bound to the willardiine antagonist, UBP282 提交 2009-04-08	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 9 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 B 653–794（142 aa）片段：UNP residues 414-527, 652-794 链 N 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 N 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	VBP 4-({3-[(2R)-2-amino-2-carboxyethyl]-2,6-dioxo-3,6-dihydropyrimidin-1(2H)-yl}methyl)benzoic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；15-17% PEG8K, 0.2 M Na acetate, 0.2 M Na cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.80 Å R-free 0.295
3H5V Crystal structure of the GluR2-ATD 提交 2009-04-22	构建体不同突变/修饰不同聚集状态不同实验方法不同实验环境不同结构质量不同	Assembly 1 其他组合同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 0–383（384 aa）片段：UNP residues 21-404 链 B 0–383（384 aa）片段：UNP residues 21-404	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；14-16% PEG3350, 100mM TrisHCl, 10mM MgCl2, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.33 Å R-free 0.235
3H5V Crystal structure of the GluR2-ATD 提交 2009-04-22	构建体不同突变/修饰不同聚集状态不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 0–383（384 aa）片段：UNP residues 21-404	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；14-16% PEG3350, 100mM TrisHCl, 10mM MgCl2, pH 8.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.33 Å R-free 0.235
3H5W Crystal structure of the GluR2-ATD in space group P212121 without solvent 提交 2009-04-22	构建体不同突变/修饰不同聚集状态不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 0–383（384 aa）片段：UNP residues 21-404 链 B 0–383（384 aa）片段：UNP residues 21-404	未记录	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；277 K；20% PEG3000, 100mM tri-sodium citrate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.69 Å R-free 0.291
3H6T Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution 提交 2009-04-24	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796 链 A 653–796（144 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796 链 C 413–527（115 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796 链 C 653–796（144 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796	突变：N754S 突变：N754S 突变：N754S 突变：N754S	GLU GLUTAMIC ACID × 2 CYZ CYCLOTHIAZIDE × 2 ZN ZINC ION × 5 GOL GLYCEROL × 6 ACT ACETATE ION × 2 DMS DIMETHYL SULFOXIDE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；279 K；25 % PEG 4000, 0.3 M Zinc acetate, 0.1 M Cacodylate pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 2.25 Å R-free 0.228
3H6T Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and cyclothiazide at 2.25 A resolution 提交 2009-04-24	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796 链 B 653–796（144 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796	突变：N754S 突变：N754S	GLU GLUTAMIC ACID × 2 CYZ CYCLOTHIAZIDE × 2 ZN ZINC ION × 10 GOL GLYCEROL × 6 CAC CACODYLATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6.5；279 K；25 % PEG 4000, 0.3 M Zinc acetate, 0.1 M Cacodylate pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 2.25 Å R-free 0.228
3H6U Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS1493 at 1.85 A resolution 提交 2009-04-24	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796 链 A 653–796（144 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796	突变：N754S 突变：N754S	GLU GLUTAMIC ACID × 2 NS3 (3S)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 SO4 SULFATE ION × 12 GOL GLYCEROL × 4 FLC CITRATE ANION × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 4.5；279 K；25 % PEG 8000, 0.1 M Lithium sulfate, 0.1 M Phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.85 Å R-free 0.215
3H6V Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5206 at 2.10 A resolution 提交 2009-04-24	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796 链 A 653–796（144 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796 链 B 413–527（115 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796 链 B 653–796（144 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796	突变：N754S 突变：N754S 突变：N754S 突变：N754S	GLU GLUTAMIC ACID × 2 NS6 (3R)-3-cyclopentyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 7 DMS DIMETHYL SULFOXIDE × 1	X-RAY DIFFRACTION X-ray结晶条件 pH 4.5；279 K；20 % PEG 4000, 0.3 M Lithium sulfate, 0.1 M Phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 2.10 Å R-free 0.228
3H6W Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution 提交 2009-04-24	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796 链 A 653–796（144 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796	突变：N754S 突变：N754S	GLU GLUTAMIC ACID × 2 NS7 (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide × 2 SO4 SULFATE ION × 2 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；20 % PEG 4000, 0.1 M Ammonium sulfate, 0.1 M Cacodylate pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.49 Å R-free 0.232
3H6W Crystal structure of the iGluR2 ligand-binding core (S1S2J-N754S) in complex with glutamate and NS5217 at 1.50 A resolution 提交 2009-04-24	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796 链 B 653–796（144 aa）片段：iGluR2-flop ligand-binding core: UNP residues 413-796	突变：N754S 突变：N754S	GLU GLUTAMIC ACID × 2 NS7 (3R)-3-cyclopentyl-6-methyl-7-[(4-methylpiperazin-1-yl)sulfonyl]-3,4-dihydro-2H-1,2-benzothiazine 1,1-dioxide × 2 SO4 SULFATE ION × 2 DMS DIMETHYL SULFOXIDE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；20 % PEG 4000, 0.1 M Ammonium sulfate, 0.1 M Cacodylate pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.49 Å R-free 0.232
3HSY High resolution structure of a dimeric GluR2 N-terminal domain (NTD) 提交 2009-06-11	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 其他组合同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 25–400（376 aa）片段：N-terminal Domain, UNP residues 25-400 链 B 25–400（376 aa）片段：N-terminal Domain, UNP residues 25-400	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2 SO4 SULFATE ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 4.8；293 K；200mM ammonium phosphatre, 20% PEG3350, pH4.8, VAPOR DIFFUSION, SITTING DROP, temperature 293K	分辨率 1.75 Å R-free 0.205
3IJO Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide 提交 2009-08-04	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）链 B 653–794（142 aa）链 E 414–527（114 aa）链 E 653–794（142 aa）	未记录	GLU GLUTAMIC ACID × 2 B4D (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 2 ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K	分辨率 2.00 Å R-free 0.234
3IJO Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, althiazide 提交 2009-08-04	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 H 414–527（114 aa）链 H 653–794（142 aa）	未记录	GLU GLUTAMIC ACID × 2 B4D (3S)-6-chloro-3-[(prop-2-en-1-ylsulfanyl)methyl]-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K	分辨率 2.00 Å R-free 0.234
3IJX Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide 提交 2009-08-05	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）链 B 653–794（142 aa）链 D 414–527（114 aa）链 D 653–794（142 aa）	未记录	GLU GLUTAMIC ACID × 2 HCZ 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K	分辨率 2.88 Å R-free 0.257
3IJX Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydrochlorothiazide 提交 2009-08-05	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 H 414–527（114 aa）链 H 653–794（142 aa）	未记录	GLU GLUTAMIC ACID × 2 HCZ 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 2 ZN ZINC ION × 6	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K	分辨率 2.88 Å R-free 0.257
3IK6 Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, chlorothiazide 提交 2009-08-05	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 B 414–527（114 aa）片段：S1S2 binding domain 链 B 653–794（142 aa）片段：S1S2 binding domain 链 E 414–527（114 aa）片段：S1S2 binding domain 链 E 653–794（142 aa）片段：S1S2 binding domain 链 H 414–527（114 aa）片段：S1S2 binding domain 链 H 653–794（142 aa）片段：S1S2 binding domain	未记录	GLU GLUTAMIC ACID × 3 HCZ 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 3 ZN ZINC ION × 5	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K	分辨率 2.10 Å R-free 0.245
3IL1 Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21 提交 2009-08-06	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）片段：S1S2 binding domain 链 B 653–794（142 aa）片段：S1S2 binding domain 链 E 414–527（114 aa）片段：S1S2 binding domain 链 E 653–794（142 aa）片段：S1S2 binding domain	突变：N242S 突变：N242S 突变：N242S 突变：N242S	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 3 B5D (3S)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K	分辨率 2.00 Å R-free 0.234
3IL1 Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, IDRA-21 提交 2009-08-06	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 H 414–527（114 aa）片段：S1S2 binding domain 链 H 653–794（142 aa）片段：S1S2 binding domain	突变：N242S 突变：N242S	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 4 B5D (3S)-7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K	分辨率 2.00 Å R-free 0.234
3ILT Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, trichlormethiazide 提交 2009-08-07	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 3 PDB 声明：trimeric	链 B 414–527（114 aa）片段：S1S2 binding domain 链 B 653–794（142 aa）片段：S1S2 binding domain 链 E 414–527（114 aa）片段：S1S2 binding domain 链 E 653–794（142 aa）片段：S1S2 binding domain 链 H 414–527（114 aa）片段：S1S2 binding domain 链 H 653–794（142 aa）片段：S1S2 binding domain	突变：N242S 突变：N242S 突变：N242S 突变：N242S 突变：N242S 突变：N242S	GLU GLUTAMIC ACID × 3 ZN ZINC ION × 5 TRU 6-CHLORO-3-(DICHLOROMETHYL)-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K	分辨率 2.11 Å R-free 0.261
3ILU Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydroflumethiazide 提交 2009-08-07	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）片段：S1S2 binding domain 链 B 653–794（142 aa）片段：S1S2 binding domain 链 E 414–527（114 aa）片段：S1S2 binding domain 链 E 653–794（142 aa）片段：S1S2 binding domain	突变：N242S 突变：N242S 突变：N242S 突变：N242S	GLU GLUTAMIC ACID × 2 HFZ 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K	分辨率 2.00 Å R-free 0.226
3ILU Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, hydroflumethiazide 提交 2009-08-07	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 H 414–527（114 aa）片段：S1S2 binding domain 链 H 653–794（142 aa）片段：S1S2 binding domain	突变：N242S 突变：N242S	GLU GLUTAMIC ACID × 2 HFZ 6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18 PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 zinc acetate, pH 6.5, vapor diffusion, hanging drop, temperature 277K	分辨率 2.00 Å R-free 0.226
3KG2 AMPA subtype ionotropic glutamate receptor in complex with competitive antagonist ZK 200775 提交 2009-10-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 其他组合同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）片段：sequence database residues 25-847 链 B 25–847（823 aa）片段：sequence database residues 25-847 链 C 25–847（823 aa）片段：sequence database residues 25-847 链 D 25–847（823 aa）片段：sequence database residues 25-847	突变：N241E, N385D, N392Q, K410A, E413A, M414A, E416A, and C589A 突变：N241E, N385D, N392Q, K410A, E413A, M414A, E416A, and C589A 突变：N241E, N385D, N392Q, K410A, E413A, M414A, E416A, and C589A 突变：N241E, N385D, N392Q, K410A, E413A, M414A, E416A, and C589A	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4	X-RAY DIFFRACTION X-ray结晶条件 277 K；Under paraffin oil, temperature 277K	分辨率 3.60 Å R-free 0.296
3KGC Isolated ligand binding domain dimer of GluA2 ionotropic glutamate receptor in complex with glutamate, LY 404187 and ZK 200775 提交 2009-10-28	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 414–527（114 aa）片段：extracellular domains residues 414-527 and 653-795 链 A 654–795（142 aa）片段：extracellular domains residues 414-527 and 653-795 链 B 414–527（114 aa）片段：extracellular domains residues 414-527 and 653-795 链 B 654–795（142 aa）片段：extracellular domains residues 414-527 and 653-795	未记录	GLU GLUTAMIC ACID × 1 SO4 SULFATE ION × 2 LY7 N-[(2S)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide × 1 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5；277 K；19% PEG 4000, 0.3 M ammonium sulfate, 0.1 M sodium acetate, pH 5.0, vapor diffusion, hanging drop, temperature 277K	分辨率 1.55 Å R-free 0.224
3LSF Piracetam bound to the ligand binding domain of GluA2 提交 2010-02-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）链 B 653–794（142 aa）链 E 414–527（114 aa）链 E 653–794（142 aa）	突变：N242S 突变：N242S 突变：N242S 突变：N242S	GLU GLUTAMIC ACID × 2 PZI 2-(2-oxopyrrolidin-1-yl)acetamide × 4 ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18% PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 M zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.85 Å R-free 0.228
3LSF Piracetam bound to the ligand binding domain of GluA2 提交 2010-02-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 H 414–527（114 aa）链 H 653–794（142 aa）	突变：N242S 突变：N242S	GLU GLUTAMIC ACID × 2 PZI 2-(2-oxopyrrolidin-1-yl)acetamide × 4 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18% PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 M zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.85 Å R-free 0.228
3LSL Piracetam bound to the ligand binding domain of GluA2 (flop form) 提交 2010-02-12	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 414–527（114 aa）链 A 653–794（142 aa）链 D 414–527（114 aa）链 D 653–794（142 aa）	未记录	GLU GLUTAMIC ACID × 2 PZI 2-(2-oxopyrrolidin-1-yl)acetamide × 6 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18% PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 M zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.12 Å R-free 0.263
3LSL Piracetam bound to the ligand binding domain of GluA2 (flop form) 提交 2010-02-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 G 414–527（114 aa）链 G 653–794（142 aa）	未记录	GLU GLUTAMIC ACID × 2 PZI 2-(2-oxopyrrolidin-1-yl)acetamide × 6 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18% PEG8K, 0.1 M Na Cacodylate, 0.1-0.15 M zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.12 Å R-free 0.263
3M3L PEPA bound to the ligand binding domain of GluA2 (flop form) 提交 2010-03-09	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 A 653–794（142 aa）片段：UNP residues 414-527, 652-794 链 D 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 D 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	GLU GLUTAMIC ACID × 2 P99 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide × 1 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG 8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.85 Å R-free 0.242
3M3L PEPA bound to the ligand binding domain of GluA2 (flop form) 提交 2010-03-09	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 G 414–527（114 aa）片段：UNP residues 414-527, 652-794 链 G 653–794（142 aa）片段：UNP residues 414-527, 652-794	未记录	GLU GLUTAMIC ACID × 2 P99 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG 8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.85 Å R-free 0.242
3N6V Structure of the GluA2 NTD-dimer interface mutant, T78A 提交 2010-05-26	构建体不同突变/修饰不同聚集状态不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 27–400（374 aa）片段：N-terminal domain 链 B 27–400（374 aa）片段：N-terminal domain	突变：T78A 突变：T78A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；100mM Tris, 200mM MgCl2, 20% PEG 8000, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K	分辨率 3.20 Å R-free 0.265
3N6V Structure of the GluA2 NTD-dimer interface mutant, T78A 提交 2010-05-26	构建体不同突变/修饰不同聚集状态不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 27–400（374 aa）片段：N-terminal domain 链 D 27–400（374 aa）片段：N-terminal domain	突变：T78A 突变：T78A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；100mM Tris, 200mM MgCl2, 20% PEG 8000, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K	分辨率 3.20 Å R-free 0.265
3N6V Structure of the GluA2 NTD-dimer interface mutant, T78A 提交 2010-05-26	构建体不同突变/修饰不同聚集状态不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 E 27–400（374 aa）片段：N-terminal domain 链 F 27–400（374 aa）片段：N-terminal domain	突变：T78A 突变：T78A	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 8.5；291 K；100mM Tris, 200mM MgCl2, 20% PEG 8000, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K	分辨率 3.20 Å R-free 0.265
3O28 Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 提交 2010-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, UNP residues 413 to 527 and 653 to 796 链 A 653–795（143 aa）片段：Ligand binding domain, UNP residues 413 to 527 and 653 to 796	未记录	O28 2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 6 DMS DIMETHYL SULFOXIDE × 2 GOL GLYCEROL × 12	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；277 K；16% PEG 8000, 100mM Sodium Cacodylate pH 4.5, 50mM Lithium Sulphate, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.00 Å R-free 0.234
3O29 Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 提交 2010-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, UNP residues 413 to 527 and 653 to 796 链 A 653–795（143 aa）片段：Ligand binding domain, UNP residues 413 to 527 and 653 to 796	未记录	GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 8 O29 N-[2-(dimethylamino)ethyl]-2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；277 K；12% PEG 4000, 100mM Sodium Cacodylate pH 4.5, 50mM Lithium Sulphate, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.02 Å R-free 0.250
3O2A Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 提交 2010-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, UNP residues 413 to 527 and 653 to 796 链 A 653–795（143 aa）片段：Ligand binding domain, UNP residues 413 to 527 and 653 to 796	未记录	O30 N-(3-aminopropyl)-2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；277 K；18% PEG 4000, 100mM Sodium Cacodylate pH 4.5, 50mM Lithium Sulphate, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.90 Å R-free 0.217
3O2J Structure of the GluA2 NTD-dimer interface mutant, N54A 提交 2010-07-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 22–400（379 aa）片段：N-terminal domain 链 B 22–400（379 aa）片段：N-terminal domain	突变：N54A 突变：N54A	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5.5；291 K；18% PEG 3350, 100mM sodium citrate, pH 5.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K	分辨率 1.95 Å R-free 0.247
3O6G Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 提交 2010-07-29	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, UNP residues 413 to 527 and 653 to 796 链 A 653–795（143 aa）片段：Ligand binding domain, UNP residues 413 to 527 and 653 to 796	未记录	GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 6 O27 N-[(3R)-pyrrolidin-3-yl]-2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 EDO 1,2-ETHANEDIOL × 8	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；17% PEG 4000, 100mM Sodium Cacodylate pH 4.0, 50mM Lithium Sulphate, 2.5% Glycerol, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.80 Å R-free 0.223
3O6H Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 提交 2010-07-29	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, UNP residues 413 to 527 and 653 to 796 链 A 653–795（143 aa）片段：Ligand binding domain, UNP residues 413 to 527 and 653 to 796	未记录	GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 6 O25 2-[({4-[(ethylamino)methyl]-3-(trifluoromethyl)-1H-pyrazol-1-yl}acetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 DMS DIMETHYL SULFOXIDE × 2 EDO 1,2-ETHANEDIOL × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；18% PEG 4000, 100mM Sodium Cacodylate pH 4.0, 50mM Lithium Sulphate, 5% Glycerol, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.10 Å R-free 0.263
3O6I Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 提交 2010-07-29	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, UNP residues 413 to 527 and 653 to 796 链 A 653–795（143 aa）片段：Ligand binding domain, UNP residues 413 to 527 and 653 to 796	未记录	GLU GLUTAMIC ACID × 2 O26 2-[({3-tert-butyl-4-[(methylamino)methyl]-1H-pyrazol-1-yl}acetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 SO4 SULFATE ION × 10	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.3；277 K；18% PEG 4000, 50mM Lithium sulphate, 2.5% Glycerol, 100mM Sodium Cacodylate pH 4.3, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.80 Å R-free 0.247
3PD8 X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution 提交 2010-10-22	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：UNP residues 413-527, 653-795 链 A 653–795（143 aa）片段：UNP residues 413-527, 653-795 链 B 413–527（115 aa）片段：UNP residues 413-527, 653-795 链 B 653–795（143 aa）片段：UNP residues 413-527, 653-795	未记录	ZN ZINC ION × 3 HA7 (7S)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-7-carboxylic acid × 2 GOL GLYCEROL × 1 ACY ACETIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；280 K；PEG4000, zinc acetate, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.48 Å R-free 0.261
3PD8 X-ray structure of the ligand-binding core of GluA2 in complex with (S)-7-HPCA at 2.5 A resolution 提交 2010-10-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 413–527（115 aa）片段：UNP residues 413-527, 653-795 链 C 653–795（143 aa）片段：UNP residues 413-527, 653-795	未记录	ZN ZINC ION × 4 HA7 (7S)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-7-carboxylic acid × 2 CAC CACODYLATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；280 K；PEG4000, zinc acetate, cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.48 Å R-free 0.261
3PD9 X-ray structure of the ligand-binding core of GluA2 in complex with (R)-5-HPCA at 2.1 A resolution 提交 2010-10-22	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：UNP residues 413-527, 653-795 链 A 653–795（143 aa）片段：UNP residues 413-527, 653-795 链 B 413–527（115 aa）片段：UNP residues 413-527, 653-795 链 B 653–795（143 aa）片段：UNP residues 413-527, 653-795	未记录	HA5 (5R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 5 CL CHLORIDE ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；PEG4000, ammonium sulfate, acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.10 Å R-free 0.233
3PMV Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 提交 2010-11-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, residues 413 to 527 and 653 to 796 链 A 653–796（144 aa）片段：Ligand binding domain, residues 413 to 527 and 653 to 796	未记录	GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 10 557 N-[(2S)-2-{4-[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}propyl]propane-2-sulfonamide × 2 GOL GLYCEROL × 8	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；18% PEG 4000, 50mM Lithium Sulphate, 2.5% Glycerol, 100mM Sodium Cacodylate pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.80 Å R-free 0.252
3PMW Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 提交 2010-11-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, residues 413 to 527 and 653 to 796 链 A 653–796（144 aa）片段：Ligand binding domain, residues 413 to 527 and 653 to 796	突变：S1-S2 fusion in which Gly118 and Thr119 replace a membrane-spanning region 突变：S1-S2 fusion in which Gly118 and Thr119 replace a membrane-spanning region	GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 14 GOL GLYCEROL × 4 DMS DIMETHYL SULFOXIDE × 2 G69 N-[(2S)-5-{[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-2,3-dihydro-1H-inden-2-yl]propane-2-sulfonami de × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；18% PEG 4000, 50mM Lithium Sulphate, 2.5% Glycerol, 100mM Sodium Cacodylate pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.20 Å R-free 0.313
3PMX Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 提交 2010-11-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, residues 413 to 527 and 653 to 796 链 A 653–796（144 aa）片段：Ligand binding domain, residues 413 to 527 and 653 to 796	未记录	GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 8 GOL GLYCEROL × 4 DMS DIMETHYL SULFOXIDE × 4 EDO 1,2-ETHANEDIOL × 8 808 N-[(2S)-5-{[5-(trifluoromethyl)furan-2-yl]methyl}-2,3-dihydro-1H-inden-2-yl]propane-2-sulfonamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4；277 K；18% PEG 4000, 50mM Lithium Sulphate, 2.5% Glycerol, 100mM Sodium Cacodylate pH 4.0, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.87 Å R-free 0.281
3RTF Chlorowillardiine bound to the ligand binding domain of GluA2 提交 2011-05-03	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）片段：SEE REMARK 999 链 B 653–794（142 aa）片段：SEE REMARK 999 链 D 414–527（114 aa）片段：SEE REMARK 999 链 D 653–794（142 aa）片段：SEE REMARK 999	未记录	CWD 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, 0.1 M sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.70 Å R-free 0.203
3RTF Chlorowillardiine bound to the ligand binding domain of GluA2 提交 2011-05-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 F 414–527（114 aa）片段：SEE REMARK 999 链 F 653–794（142 aa）片段：SEE REMARK 999	未记录	CWD 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, 0.1 M sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.70 Å R-free 0.203
3RTW Nitrowillardiine bound to the ligand binding domain of GluA2 提交 2011-05-04	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）片段：SEE REMARK 999 链 B 653–794（142 aa）片段：SEE REMARK 999 链 D 414–527（114 aa）片段：SEE REMARK 999 链 D 653–794（142 aa）片段：SEE REMARK 999	未记录	NWD 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 2 ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, 0.1 M sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.10 Å R-free 0.259
3RTW Nitrowillardiine bound to the ligand binding domain of GluA2 提交 2011-05-04	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 F 414–527（114 aa）片段：SEE REMARK 999 链 F 653–794（142 aa）片段：SEE REMARK 999	未记录	NWD 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, 0.1 M sodium cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.10 Å R-free 0.259
3T93 Glutamate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 提交 2011-08-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）片段：SEE REMARK 999 链 B 653–794（142 aa）片段：SEE REMARK 999 链 D 414–527（114 aa）片段：SEE REMARK 999 链 D 653–794（142 aa）片段：SEE REMARK 999	突变：A473C/S673C 突变：A473C/S673C 突变：A473C/S673C 突变：A473C/S673C	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.91 Å R-free 0.229
3T93 Glutamate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 提交 2011-08-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 F 414–527（114 aa）片段：SEE REMARK 999 链 F 653–794（142 aa）片段：SEE REMARK 999	突变：A473C/S673C 突变：A473C/S673C	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.91 Å R-free 0.229
3T96 Iodowillardiine bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 提交 2011-08-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）片段：SEE REMARK 999 链 B 653–794（142 aa）片段：SEE REMARK 999 链 D 414–527（114 aa）片段：SEE REMARK 999 链 D 653–794（142 aa）片段：SEE REMARK 999	突变：A473C/S673C 突变：A473C/S673C 突变：A473C/S673C 突变：A473C/S673C	IWD 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.87 Å R-free 0.219
3T96 Iodowillardiine bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 提交 2011-08-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 F 414–527（114 aa）片段：SEE REMARK 999 链 F 653–794（142 aa）片段：SEE REMARK 999	突变：A473C/S673C 突变：A473C/S673C	IWD 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.87 Å R-free 0.219
3T9H Kainate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 提交 2011-08-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）片段：SEE REMARK 999 链 B 653–794（142 aa）片段：SEE REMARK 999 链 D 414–527（114 aa）片段：SEE REMARK 999 链 D 653–794（142 aa）片段：SEE REMARK 999	突变：A473C/S673C 突变：A473C/S673C 突变：A473C/S673C 突变：A473C/S673C	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.02 Å R-free 0.235
3T9H Kainate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 提交 2011-08-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 F 414–527（114 aa）片段：SEE REMARK 999 链 F 653–794（142 aa）片段：SEE REMARK 999	突变：A473C/S673C 突变：A473C/S673C	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.02 Å R-free 0.235
3T9U CNQX bound to an oxidized double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 提交 2011-08-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 414–527（114 aa）片段：SEE REMARK 999 链 A 653–794（142 aa）片段：SEE REMARK 999 链 B 414–527（114 aa）片段：SEE REMARK 999 链 B 653–794（142 aa）片段：SEE REMARK 999	突变：A473C/S673C 突变：A473C/S673C 突变：A473C/S673C 突变：A473C/S673C	CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2 ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.97 Å R-free 0.219
3T9U CNQX bound to an oxidized double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 提交 2011-08-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 414–527（114 aa）片段：SEE REMARK 999 链 C 653–794（142 aa）片段：SEE REMARK 999	突变：A473C/S673C 突变：A473C/S673C	CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.97 Å R-free 0.219
3T9V CNQX bound to a reduced double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2 提交 2011-08-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 414–527（114 aa）片段：SEE REMARK 999 链 A 653–794（142 aa）片段：SEE REMARK 999 链 B 414–527（114 aa）片段：SEE REMARK 999 链 B 653–794（142 aa）片段：SEE REMARK 999	突变：A473C/S673C 突变：A473C/S673C 突变：A473C/S673C 突变：A473C/S673C	CNI 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.98 Å R-free 0.238
3T9X Glutamate bound to a double cysteine mutant (V484C/E657C) of the ligand binding domain of GluA2 提交 2011-08-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）片段：SEE REMARK 999 链 B 653–794（142 aa）片段：SEE REMARK 999 链 F 414–527（114 aa）片段：SEE REMARK 999 链 F 653–794（142 aa）片段：SEE REMARK 999	突变：V505C/E678C 突变：V505C/E678C 突变：V505C/E678C 突变：V505C/E678C	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.82 Å R-free 0.240
3T9X Glutamate bound to a double cysteine mutant (V484C/E657C) of the ligand binding domain of GluA2 提交 2011-08-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 D 414–527（114 aa）片段：SEE REMARK 999 链 D 653–794（142 aa）片段：SEE REMARK 999	突变：V505C/E678C 突变：V505C/E678C	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；14-15% PEG8000, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.82 Å R-free 0.240
3TDJ Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-97 at 1.95 A resolution 提交 2011-08-11	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, UNP residues 413-527 and 653-796 链 A 653–796（144 aa）片段：Ligand binding domain, UNP residues 413-527 and 653-796 链 B 413–527（115 aa）片段：Ligand binding domain, UNP residues 413-527 and 653-796 链 B 653–796（144 aa）片段：Ligand binding domain, UNP residues 413-527 and 653-796	突变：L483Y, N754S 突变：L483Y, N754S 突变：L483Y, N754S 突变：L483Y, N754S	GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 3 CL CHLORIDE ION × 5 GOL GLYCEROL × 11 3TJ 4-ethyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；15.2% PEG4000, 0.3 M lithium sulfate and 0.1 M phosphate-citrate., pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.95 Å R-free 0.215
3TKD Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and cyclothiazide at 1.45 A resolution 提交 2011-08-26	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain 链 A 653–795（143 aa）片段：Ligand binding domain 链 B 413–527（115 aa）片段：Ligand binding domain 链 B 653–795（143 aa）片段：Ligand binding domain	突变：L483Y, N754S 突变：L483Y, N754S 突变：L483Y, N754S 突变：L483Y, N754S	GLU GLUTAMIC ACID × 2 CYZ CYCLOTHIAZIDE × 2 SO4 SULFATE ION × 8 GOL GLYCEROL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；20% PEG4000, 0.3M ammonium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.45 Å R-free 0.180
3TZA Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid at 1.9A resolution 提交 2011-09-27	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, UNP resiudes 413-527,UNP residues 653-796 链 A 653–796（144 aa）片段：Ligand binding domain, UNP resiudes 413-527,UNP residues 653-796 链 B 413–527（115 aa）片段：Ligand binding domain, UNP resiudes 413-527,UNP residues 653-796 链 B 653–796（144 aa）片段：Ligand binding domain, UNP resiudes 413-527,UNP residues 653-796	未记录	TZG (S)-2-amino-3-(2-(2-carboxyethyl)-5-chloro-4-nitrophenyl)propionic acid × 2 SO4 SULFATE ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；15.2% PEG4000, 0.1M ammonium sulfate, 0.1M sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.90 Å R-free 0.230
4FAT Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator 提交 2012-05-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：ligand binding domain 链 A 653–796（144 aa）片段：ligand binding domain	突变：delta 528-652 突变：delta 528-652	GLU GLUTAMIC ACID × 2 496 2-({[4-(hydroxymethyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide × 2 SO4 SULFATE ION × 6 GOL GLYCEROL × 8 LI LITHIUM ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.1；298 K；18% PEG 4000, 50mM Lithium Sulphate, 100mM Sodium Cacodylate, pH 4.1, VAPOR DIFFUSION, HANGING DROP, temperature 298K	分辨率 1.40 Å R-free 0.209
4G8M Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist CBG-IV at 2.05A resolution 提交 2012-07-23	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：UNP residues 413-527, 653-796 链 A 653–796（144 aa）片段：UNP residues 413-527, 653-796 链 B 413–527（115 aa）片段：UNP residues 413-527, 653-796 链 B 653–796（144 aa）片段：UNP residues 413-527, 653-796	未记录	G8M (1S,2R)-2-[(S)-amino(carboxy)methyl]cyclobutanecarboxylic acid × 2 SO4 SULFATE ION × 7 CL CHLORIDE ION × 3 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；24.4% PEG4000, 0.3M lithium sulfate, 0.1M phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.05 Å R-free 0.228
4G8M Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist CBG-IV at 2.05A resolution 提交 2012-07-23	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：UNP residues 413-527, 653-796 链 A 653–796（144 aa）片段：UNP residues 413-527, 653-796 链 B 413–527（115 aa）片段：UNP residues 413-527, 653-796 链 B 653–796（144 aa）片段：UNP residues 413-527, 653-796	未记录	G8M (1S,2R)-2-[(S)-amino(carboxy)methyl]cyclobutanecarboxylic acid × 2 SO4 SULFATE ION × 7 CL CHLORIDE ION × 3 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；24.4% PEG4000, 0.3M lithium sulfate, 0.1M phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.05 Å R-free 0.228
4GXS Ligand binding domain of GluA2 (AMPA/glutamate receptor) bound to (-)-kaitocephalin 提交 2012-09-04	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）片段：UNP Residues 652-794 链 B 653–794（142 aa）片段：UNP Residues 652-794 链 D 414–527（114 aa）片段：UNP Residues 652-794 链 D 653–794（142 aa）片段：UNP Residues 652-794	未记录	0YS (5R)-2-[(1S,2R)-2-amino-2-carboxy-1-hydroxyethyl]-5-{(2S)-2-carboxy-2-[(3,5-dichloro-4-hydroxybenzoyl)amino]ethyl}-L-proline × 2 ZN ZINC ION × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16-18% PEG 8K, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.96 Å R-free 0.225
4H8J Structure of GluA2-LBD in complex with MES 提交 2012-09-22	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：SEE REMARK 999 链 A 653–797（145 aa）片段：SEE REMARK 999 链 B 413–527（115 aa）片段：SEE REMARK 999 链 B 653–797（145 aa）片段：SEE REMARK 999	未记录	MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 6 EDO 1,2-ETHANEDIOL × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；23-27% w/v PEG3350, 0.2 M lithium sulfate, MES sodium, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K	分辨率 1.80 Å R-free 0.221
4H8J Structure of GluA2-LBD in complex with MES 提交 2012-09-22	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 413–527（115 aa）片段：SEE REMARK 999 链 C 653–797（145 aa）片段：SEE REMARK 999 链 D 413–527（115 aa）片段：SEE REMARK 999 链 D 653–797（145 aa）片段：SEE REMARK 999	未记录	MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1 SO4 SULFATE ION × 6 EDO 1,2-ETHANEDIOL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6；293 K；23-27% w/v PEG3350, 0.2 M lithium sulfate, MES sodium, pH 6.0, VAPOR DIFFUSION, HANGING DROP, temperature 293K	分辨率 1.80 Å R-free 0.221
4IGT Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist ZA302 at 1.24A resolution 提交 2012-12-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand-binding domain, UNP RESIDUES 413-527, 653-796 链 A 653–796（144 aa）片段：Ligand-binding domain, UNP RESIDUES 413-527, 653-796	未记录	3ZA (4R)-4-{3-[hydroxy(methyl)amino]-3-oxopropyl}-L-glutamic acid × 2 SO4 SULFATE ION × 6 LI LITHIUM ION × 2 GOL GLYCEROL × 8	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；15.2% PEG 4000, 0.1M Li2SO4, 0.1M phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 1.24 Å R-free 0.155
4ISU Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution. 提交 2013-01-17	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand-binding domain 链 A 653–796（144 aa）片段：Ligand-binding domain 链 C 413–527（115 aa）片段：Ligand-binding domain 链 C 653–796（144 aa）片段：Ligand-binding domain	未记录	IKM (4aS,5aR,6R,8aS,8bS)-5a-(carboxymethyl)-8-oxo-2,4a,5a,6,7,8,8a,8b-octahydro-1H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6-carboxylic acid × 1 SO4 SULFATE ION × 3 CL CHLORIDE ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；20% PEG4000, 0.1M Lithium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.30 Å R-free 0.258
4ISU Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution. 提交 2013-01-17	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：Ligand-binding domain 链 B 653–796（144 aa）片段：Ligand-binding domain 链 D 413–527（115 aa）片段：Ligand-binding domain 链 D 653–796（144 aa）片段：Ligand-binding domain	未记录	IKM (4aS,5aR,6R,8aS,8bS)-5a-(carboxymethyl)-8-oxo-2,4a,5a,6,7,8,8a,8b-octahydro-1H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6-carboxylic acid × 1 SO4 SULFATE ION × 3 CL CHLORIDE ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；20% PEG4000, 0.1M Lithium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.30 Å R-free 0.258
4ISU Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution. 提交 2013-01-17	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）片段：Ligand-binding domain 链 A 653–796（144 aa）片段：Ligand-binding domain	未记录	IKM (4aS,5aR,6R,8aS,8bS)-5a-(carboxymethyl)-8-oxo-2,4a,5a,6,7,8,8a,8b-octahydro-1H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6-carboxylic acid × 1 SO4 SULFATE ION × 1 CL CHLORIDE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；20% PEG4000, 0.1M Lithium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.30 Å R-free 0.258
4ISU Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution. 提交 2013-01-17	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 D 413–527（115 aa）片段：Ligand-binding domain 链 D 653–796（144 aa）片段：Ligand-binding domain	未记录	SO4 SULFATE ION × 1 CL CHLORIDE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；20% PEG4000, 0.1M Lithium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.30 Å R-free 0.258
4ISU Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution. 提交 2013-01-17	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 5 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 C 413–527（115 aa）片段：Ligand-binding domain 链 C 653–796（144 aa）片段：Ligand-binding domain	未记录	SO4 SULFATE ION × 2 CL CHLORIDE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；20% PEG4000, 0.1M Lithium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.30 Å R-free 0.258
4ISU Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution. 提交 2013-01-17	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 6 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）片段：Ligand-binding domain 链 B 653–796（144 aa）片段：Ligand-binding domain	未记录	IKM (4aS,5aR,6R,8aS,8bS)-5a-(carboxymethyl)-8-oxo-2,4a,5a,6,7,8,8a,8b-octahydro-1H-pyrrolo[3',4':4,5]furo[3,2-b]pyridine-6-carboxylic acid × 1 SO4 SULFATE ION × 2 CL CHLORIDE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；20% PEG4000, 0.1M Lithium sulfate, 0.1M phosphate-citrate pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 280K	分辨率 2.30 Å R-free 0.258
4IY5 Crystal structure of the glua2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and CX516 at 2.0 A resolution 提交 2013-01-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, UNP RESIDUES 413-527, 653-796 链 A 653–796（144 aa）片段：Ligand binding domain, UNP RESIDUES 413-527, 653-796 链 B 413–527（115 aa）片段：Ligand binding domain, UNP RESIDUES 413-527, 653-796 链 B 653–796（144 aa）片段：Ligand binding domain, UNP RESIDUES 413-527, 653-796	突变：L94Y, N242S 突变：L94Y, N242S 突变：L94Y, N242S 突变：L94Y, N242S	GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 5 GOL GLYCEROL × 3 CL CHLORIDE ION × 3 CX5 piperidin-1-yl(quinoxalin-6-yl)methanone × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；24.4% PEG 4000, 0.3M lithium sulfate, 0.1M phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 2.00 Å R-free 0.200
4IY6 Crystal structure of the GLUA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and ME-CX516 at 1.72 A resolution 提交 2013-01-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, UNP RESIDUES 413-527, 653-796 链 A 653–796（144 aa）片段：Ligand binding domain, UNP RESIDUES 413-527, 653-796	突变：L94Y, N242S 突变：L94Y, N242S	MQR [(3R)-3-methylpiperidin-1-yl](quinoxalin-6-yl)methanone × 2 MQS [(3S)-3-methylpiperidin-1-yl](quinoxalin-6-yl)methanone × 4 GLU GLUTAMIC ACID × 2 GOL GLYCEROL × 2 SO4 SULFATE ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；15.2% PEG 4000, 0.3M lithium sulfate, 0.1M sodium acetate, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.72 Å R-free 0.168
4L17 GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX 提交 2013-06-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain (UNP residues 413-527, 653-796) 链 A 653–796（144 aa）片段：Ligand binding domain (UNP residues 413-527, 653-796) 链 C 413–527（115 aa）片段：Ligand binding domain (UNP residues 413-527, 653-796) 链 C 653–796（144 aa）片段：Ligand binding domain (UNP residues 413-527, 653-796)	突变：L94Y, A153C 突变：L94Y, A153C 突变：L94Y, A153C 突变：L94Y, A153C	DNQ 6,7-DINITROQUINOXALINE-2,3-DIONE × 2 SO4 SULFATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；19% PEG 1450, 0.3M lithium sulfate, 0.1M cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K	分辨率 2.80 Å R-free 0.244
4L17 GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX 提交 2013-06-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 E 413–527（115 aa）片段：Ligand binding domain (UNP residues 413-527, 653-796) 链 E 653–796（144 aa）片段：Ligand binding domain (UNP residues 413-527, 653-796)	突变：L94Y, A153C 突变：L94Y, A153C	DNQ 6,7-DINITROQUINOXALINE-2,3-DIONE × 2 SO4 SULFATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；19% PEG 1450, 0.3M lithium sulfate, 0.1M cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K	分辨率 2.80 Å R-free 0.244
4L17 GluA2-L483Y-A665C ligand-binding domain in complex with the antagonist DNQX 提交 2013-06-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 G 413–527（115 aa）片段：Ligand binding domain (UNP residues 413-527, 653-796) 链 G 653–796（144 aa）片段：Ligand binding domain (UNP residues 413-527, 653-796)	突变：L94Y, A153C 突变：L94Y, A153C	DNQ 6,7-DINITROQUINOXALINE-2,3-DIONE × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277.15 K；19% PEG 1450, 0.3M lithium sulfate, 0.1M cacodylate, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277.15K	分辨率 2.80 Å R-free 0.244
4LZ5 Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators 提交 2013-07-31	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 404–527（124 aa）片段：SEE REMARK 999 链 A 653–796（144 aa）片段：SEE REMARK 999 链 C 404–527（124 aa）片段：SEE REMARK 999 链 C 653–796（144 aa）片段：SEE REMARK 999	突变：G389R,L390G,E391A 突变：G389R,L390G,E391A 突变：G389R,L390G,E391A 突变：G389R,L390G,E391A	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 2 1YV N-[(2R)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；1 uL 7 mg/mL protein in 10 mM (S)-Glu, 10 mM HEPES, pH 7.5, 20 mM sodium chloride, 1 mM EDTA, 150 uM ligand (from 30 mM DMSO stock) + 1 uL reservoir (10% PEG8000, 0.1 M zinc acetate, 0.1 M sodium acetate, pH 5.5), crystals appeared in 3-5 days, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.50 Å R-free 0.203
4LZ5 Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators 提交 2013-07-31	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 404–527（124 aa）片段：SEE REMARK 999 链 B 653–796（144 aa）片段：SEE REMARK 999	突变：G389R,L390G,E391A 突变：G389R,L390G,E391A	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 6 1YV N-[(2R)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；1 uL 7 mg/mL protein in 10 mM (S)-Glu, 10 mM HEPES, pH 7.5, 20 mM sodium chloride, 1 mM EDTA, 150 uM ligand (from 30 mM DMSO stock) + 1 uL reservoir (10% PEG8000, 0.1 M zinc acetate, 0.1 M sodium acetate, pH 5.5), crystals appeared in 3-5 days, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.50 Å R-free 0.203
4LZ7 Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators 提交 2013-07-31	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 404–527（124 aa）片段：SEE REMARK 999 链 A 653–796（144 aa）片段：SEE REMARK 999 链 C 404–527（124 aa）片段：SEE REMARK 999 链 C 653–796（144 aa）片段：SEE REMARK 999	突变：G389R,L390G,E391A 突变：G389R,L390G,E391A 突变：G389R,L390G,E391A 突变：G389R,L390G,E391A	ZN ZINC ION × 3 GLU GLUTAMIC ACID × 2 1YW N-({(5S)-3-[3-fluoro-4-(pyrrolidin-1-yl)phenyl]-4,5-dihydro-1,2-oxazol-5-yl}methyl)acetamide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；1 uL 7 mg/mL protein in 10 mM (S)-Glu, 10 mM HEPES, pH 7.5, 20 mM sodium chloride, 1 mM EDTA, 150 uM ligand (from 30 mM DMSO stock) + 1 uL reservoir (10% PEG8000, 0.1 M zinc acetate, 0.1 M sodium acetate, pH 5.5), crystals appeared in 3-5 days, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.10 Å R-free 0.240
4LZ7 Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators 提交 2013-07-31	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 404–527（124 aa）片段：SEE REMARK 999 链 B 653–796（144 aa）片段：SEE REMARK 999	突变：G389R,L390G,E391A 突变：G389R,L390G,E391A	ZN ZINC ION × 4 GLU GLUTAMIC ACID × 2 1YW N-({(5S)-3-[3-fluoro-4-(pyrrolidin-1-yl)phenyl]-4,5-dihydro-1,2-oxazol-5-yl}methyl)acetamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；1 uL 7 mg/mL protein in 10 mM (S)-Glu, 10 mM HEPES, pH 7.5, 20 mM sodium chloride, 1 mM EDTA, 150 uM ligand (from 30 mM DMSO stock) + 1 uL reservoir (10% PEG8000, 0.1 M zinc acetate, 0.1 M sodium acetate, pH 5.5), crystals appeared in 3-5 days, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.10 Å R-free 0.240
4LZ8 Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators 提交 2013-07-31	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 404–527（124 aa）片段：SEE REMARK 999 链 A 653–796（144 aa）片段：SEE REMARK 999 链 C 404–527（124 aa）片段：SEE REMARK 999 链 C 653–796（144 aa）片段：SEE REMARK 999	突变：G389R,L390G,E391A 突变：G389R,L390G,E391A 突变：G389R,L390G,E391A 突变：G389R,L390G,E391A	GLU GLUTAMIC ACID × 2 1YX N-[(3S)-1-{2-fluoro-4-[(5S)-5-{[(propan-2-ylsulfonyl)amino]methyl}-4,5-dihydro-1,2-oxazol-3-yl]phenyl}pyrrolidin-3-yl]acetamide × 1 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；1 uL 7 mg/mL protein in 10 mM (S)-Glu, 10 mM HEPES, pH 7.5, 20 mM sodium chloride, 1 mM EDTA, 150 uM ligand (from 30 mM DMSO stock) + 1 uL reservoir (10% PEG8000, 0.1 M zinc acetate, 0.1 M sodium acetate, pH 5.5), crystals appeared in 3-5 days, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.85 Å R-free 0.232
4LZ8 Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators 提交 2013-07-31	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 404–527（124 aa）片段：SEE REMARK 999 链 B 653–796（144 aa）片段：SEE REMARK 999	突变：G389R,L390G,E391A 突变：G389R,L390G,E391A	GLU GLUTAMIC ACID × 2 1YX N-[(3S)-1-{2-fluoro-4-[(5S)-5-{[(propan-2-ylsulfonyl)amino]methyl}-4,5-dihydro-1,2-oxazol-3-yl]phenyl}pyrrolidin-3-yl]acetamide × 2 ZN ZINC ION × 6	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；1 uL 7 mg/mL protein in 10 mM (S)-Glu, 10 mM HEPES, pH 7.5, 20 mM sodium chloride, 1 mM EDTA, 150 uM ligand (from 30 mM DMSO stock) + 1 uL reservoir (10% PEG8000, 0.1 M zinc acetate, 0.1 M sodium acetate, pH 5.5), crystals appeared in 3-5 days, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.85 Å R-free 0.232
4N07 Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-344 at 1.87 A resolution 提交 2013-10-01	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：unp residues 413-527, unp reisdues 653-796 链 A 653–796（144 aa）片段：unp residues 413-527, unp reisdues 653-796	突变：L504Y, N755S 突变：L504Y, N755S	2J9 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 GLU GLUTAMIC ACID × 2 ACT ACETATE ION × 12 ZN ZINC ION × 8 CAC CACODYLATE ION × 2 GOL GLYCEROL × 8	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16.5% PEG4000, 0.15 M zinc acetate, 0.1 M cacodylate, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.87 Å R-free 0.211
4N07 Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM-344 at 1.87 A resolution 提交 2013-10-01	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：unp residues 413-527, unp reisdues 653-796 链 B 653–796（144 aa）片段：unp residues 413-527, unp reisdues 653-796 链 C 413–527（115 aa）片段：unp residues 413-527, unp reisdues 653-796 链 C 653–796（144 aa）片段：unp residues 413-527, unp reisdues 653-796	突变：L504Y, N755S 突变：L504Y, N755S 突变：L504Y, N755S 突变：L504Y, N755S	2J9 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 GLU GLUTAMIC ACID × 2 ACT ACETATE ION × 7 ZN ZINC ION × 6 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；277 K；16.5% PEG4000, 0.15 M zinc acetate, 0.1 M cacodylate, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 1.87 Å R-free 0.211
4O3A Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution 提交 2013-12-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain (unp residues 413-527 and unp residues 653-736) 链 A 653–796（144 aa）片段：Ligand binding domain (unp residues 413-527 and unp residues 653-736)	未记录	GOL GLYCEROL × 12 ASP ASPARTIC ACID × 2 ZN ZINC ION × 6 ACT ACETATE ION × 6	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；24.4 % PEG 4000, 0.1 M zinc acetate and 0.1 M sodium acetate., pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.80 Å R-free 0.188
4O3A Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution 提交 2013-12-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）片段：Ligand binding domain (unp residues 413-527 and unp residues 653-736) 链 B 653–796（144 aa）片段：Ligand binding domain (unp residues 413-527 and unp residues 653-736)	未记录	GOL GLYCEROL × 4 ASP ASPARTIC ACID × 1 ZN ZINC ION × 2 ACT ACETATE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 3 CL CHLORIDE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；24.4 % PEG 4000, 0.1 M zinc acetate and 0.1 M sodium acetate., pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.80 Å R-free 0.188
4O3A Crystal structure of the glua2 ligand-binding domain in complex with L-aspartate at 1.80 a resolution 提交 2013-12-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 C 413–527（115 aa）片段：Ligand binding domain (unp residues 413-527 and unp residues 653-736) 链 C 653–796（144 aa）片段：Ligand binding domain (unp residues 413-527 and unp residues 653-736)	未记录	GOL GLYCEROL × 2 ASP ASPARTIC ACID × 1 ZN ZINC ION × 4 ACT ACETATE ION × 6 PEG DI(HYDROXYETHYL)ETHER × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；24.4 % PEG 4000, 0.1 M zinc acetate and 0.1 M sodium acetate., pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.80 Å R-free 0.188
4O3B Crystal structure of an open/closed glua2 ligand-binding domain dimer at 1.91 A resolution 提交 2013-12-18	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain (unp residues 413-527 and unp residues 653-736) 链 A 653–796（144 aa）片段：Ligand binding domain (unp residues 413-527 and unp residues 653-736) 链 B 413–527（115 aa）片段：Ligand binding domain (unp residues 413-527 and unp residues 653-736) 链 B 653–796（144 aa）片段：Ligand binding domain (unp residues 413-527 and unp residues 653-736)	未记录	SO4 SULFATE ION × 4 GOL GLYCEROL × 6 CL CHLORIDE ION × 1 PEG DI(HYDROXYETHYL)ETHER × 1 ACT ACETATE ION × 1 GLU GLUTAMIC ACID × 1 PG4 TETRAETHYLENE GLYCOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；20% PEG 4000, 0.1 M lithium sulfate and 0.1 M phosphate-citrate, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.91 Å R-free 0.178
4O3C Crystal structure of the GLUA2 ligand-binding domain in complex with L-aspartate at 1.50 A resolution 提交 2013-12-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain (unp residues 413-527 and unp residues 653-796) 链 A 653–796（144 aa）片段：Ligand binding domain (unp residues 413-527 and unp residues 653-796)	未记录	ASP ASPARTIC ACID × 2 CL CHLORIDE ION × 2 GOL GLYCEROL × 2 ACT ACETATE ION × 2 LI LITHIUM ION × 2 SO4 SULFATE ION × 8	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；20% PEG 4000, 0.1 M lithium sulfate and 0.1 M phosphate-citrate., pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K	分辨率 1.50 Å R-free 0.158
4Q30 Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5 提交 2014-04-10	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 414–527（114 aa）链 B 653–794（142 aa）链 D 414–527（114 aa）链 D 653–794（142 aa）	未记录	NWD 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 3.5；277 K；14-15% PEG 8K, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 3.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.03 Å R-free 0.230
4Q30 Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5 提交 2014-04-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 F 414–527（114 aa）链 F 653–794（142 aa）	未记录	NWD 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 3.5；277 K；14-15% PEG 8K, 0.1 M sodium cacodylate, 0.1-0.15 M zinc acetate, 0.25 M ammonium sulfate, pH 3.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K	分辨率 2.03 Å R-free 0.230
4U1O GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form C 提交 2014-07-15	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）链 A 653–796（144 aa）	未记录	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 1 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Na cacodylate, pH 6.5, 1.26 M ammonium sulfate	分辨率 1.85 Å R-free 0.209
4U1W Full length GluA2-kainate-(R,R)-2b complex crystal form A 提交 2014-07-16	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES, pH 6.5, 6%PEG6K, 3% TMAO, 0.006M Taurine	分辨率 3.25 Å R-free 0.316
4U1X Full length GluA2-kainate-(R,R)-2b complex crystal form B 提交 2014-07-16	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES, pH 6.2, 5.25% PEG6K, 3% TMAO, 0.006 M Taurine, 20 mM MnCl2	分辨率 3.30 Å R-free 0.289
4U1Y Full length GluA2-FW-(R,R)-2b complex 提交 2014-07-16	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3 FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M imidazole pH 6.2, 9% PEG1450, 3% TMAO	分辨率 3.90 Å R-free 0.303
4U1Z GluA2flip sLBD complexed with kainate and (R,R)-2b crystal form D 提交 2014-07-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）链 A 653–796（144 aa）	未记录	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 1 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Na acetate, pH 4.5, 25% PEG3350	分辨率 1.94 Å R-free 0.208
4U21 GluA2flip sLBD complexed with FW and (R,R)-2b crystal form E 提交 2014-07-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 654–796（143 aa）链 B 413–527（115 aa）链 B 654–796（143 aa）	突变：A796S 突变：A796S 突变：A796S 突变：A796S	FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 2 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；293 K；phosphate-citrate, pH 4.2, 0.2 M Li sulfate, 20% PEG1K	分辨率 1.39 Å R-free 0.198
4U22 GluA2flip sLBD complexed with FW and (R,R)-2b crystal form D 提交 2014-07-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）链 A 653–796（144 aa）	突变：A796S 突变：A796S	FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 1 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M Na acetate, pH 4.5, 20% PEG3K	分辨率 1.44 Å R-free 0.217
4U23 GluA2flip sLBD complexed with FW and (R,R)-2b crystal form F 提交 2014-07-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）链 A 653–796（144 aa）	突变：A796S 突变：A796S	FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 1 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；293 K；0.1 M bicine/Trizma base, pH 8.5, 0.09 M Morpheus nitrate-phosphate-sulfate, 10% w/v PEG8K, 20% (v/v) ethylene glycol	分辨率 1.67 Å R-free 0.250
4U2P Full-length AMPA subtype ionotropic glutamate receptor GluA2 in the apo state 提交 2014-07-17	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 MES 2-(N-MORPHOLINO)-ETHANESULFONIC ACID × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277.15 K；0.1 M MES, 5.8-6.2% PEG6000, 5% TMAO, 0.1-0.3 M sodium acetate	分辨率 3.24 Å R-free 0.288
4U2Q Full-length AMPA subtype ionotropic glutamate receptor GluA2 in complex with partial agonist kainate 提交 2014-07-17	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277.15 K；0.1 M MES, 4.8-5.3% PEG6000, 3.5% TMAO, 6 mM taurine	分辨率 3.52 Å R-free 0.318
4U2R Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state 提交 2014-07-17	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 413–527（115 aa）链 A 653–796（144 aa）链 B 413–527（115 aa）链 B 653–796（144 aa）链 C 413–527（115 aa）链 C 653–796（144 aa）链 D 413–527（115 aa）链 D 653–796（144 aa）	突变：A796S,A796S 突变：A796S,A796S 突变：A796S,A796S 突变：A796S,A796S 突变：A796S,A796S 突变：A796S,A796S 突变：A796S,A796S 突变：A796S,A796S	SO4 SULFATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；297 K；17-20% PEG8000, 0.2M lithium sulfate, 0.1 M sodium acetate	分辨率 1.41 Å R-free 0.232
4U2R Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state 提交 2014-07-17	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）链 B 653–796（144 aa）	突变：A796S,A796S 突变：A796S,A796S	SO4 SULFATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；297 K；17-20% PEG8000, 0.2M lithium sulfate, 0.1 M sodium acetate	分辨率 1.41 Å R-free 0.232
4U2R Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state 提交 2014-07-17	构建体不同突变/修饰不同聚集状态不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）链 A 653–796（144 aa）	突变：A796S,A796S 突变：A796S,A796S	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；297 K；17-20% PEG8000, 0.2M lithium sulfate, 0.1 M sodium acetate	分辨率 1.41 Å R-free 0.232
4U2R Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state 提交 2014-07-17	构建体不同突变/修饰不同聚集状态不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 C 413–527（115 aa）链 C 653–796（144 aa）	突变：A796S,A796S 突变：A796S,A796S	未记录非水小分子	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；297 K；17-20% PEG8000, 0.2M lithium sulfate, 0.1 M sodium acetate	分辨率 1.41 Å R-free 0.232
4U2R Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state 提交 2014-07-17	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 5 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 D 413–527（115 aa）链 D 653–796（144 aa）	突变：A796S,A796S 突变：A796S,A796S	SO4 SULFATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；297 K；17-20% PEG8000, 0.2M lithium sulfate, 0.1 M sodium acetate	分辨率 1.41 Å R-free 0.232
4U4F Structure of GluA2* in complex with partial agonist (S)-5-Nitrowillardiine 提交 2014-07-23	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 其他组合同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	NWD 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；11-14% (w/v) PEG 3,000, 50 mM lithium sulfate, 0.1 M tricine	分辨率 4.79 Å R-free 0.262
4U4G Structure of GluA2* in complex with competitive antagonist ZK 200775 提交 2014-07-23	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 其他组合同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）片段：UNP residues 25-847 链 B 25–847（823 aa）片段：UNP residues 25-847 链 C 25–847（823 aa）片段：UNP residues 25-847 链 D 25–847（823 aa）片段：UNP residues 25-847	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4	X-RAY DIFFRACTION X-ray结晶条件 BATCH MODE；277 K；7-11% PEG 20,000, 0.1 M MES	分辨率 4.49 Å R-free 0.248
4U4S Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM25 at 1.90 A resolution. 提交 2014-07-24	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：Dimeric	链 A 413–527（115 aa）片段：UNP residues 413-527, UNP residues 653-796 链 A 653–796（144 aa）片段：UNP residues 413-527, UNP residues 653-796 链 B 413–527（115 aa）片段：UNP residues 413-527, UNP residues 653-796 链 B 653–796（144 aa）片段：UNP residues 413-527, UNP residues 653-796	突变：yes 突变：yes 突变：yes 突变：yes	3C1 4-ethyl-3,4-dihydro-2H-pyrido[4,3-e][1,2,4]thiadiazine 1,1-dioxide × 2 SO4 SULFATE ION × 3 GOL GLYCEROL × 4 ACT ACETATE ION × 8 CL CHLORIDE ION × 2 GLU GLUTAMIC ACID × 2 PEG DI(HYDROXYETHYL)ETHER × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；22% PEG4000, 0.2 M ammoniumsulfate, 0.1 M phosphate-citrate.	分辨率 1.90 Å R-free 0.208
4U4X Crystal structure of the GluA2 ligand-binding domain (S1S2J-L483Y-N754S) in complex with glutamate and BPAM37 at 1.56 A resolution. 提交 2014-07-24	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：Dimeric	链 A 413–527（115 aa）片段：UNP residues 413-527, UNP residues 653-796 链 A 653–796（144 aa）片段：UNP residues 413-527, UNP residues 653-796 链 B 413–527（115 aa）片段：UNP residues 413-527, UNP residues 653-796 链 B 653–796（144 aa）片段：UNP residues 413-527, UNP residues 653-796	突变：yes 突变：yes 突变：yes 突变：yes	3C2 4-ethyl-3,4-dihydro-2H-pyrido[3,2-e][1,2,4]thiadiazine 1,1-dioxide × 2 SO4 SULFATE ION × 5 GLU GLUTAMIC ACID × 2 ACT ACETATE ION × 4 GOL GLYCEROL × 3 PEG DI(HYDROXYETHYL)ETHER × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；24% PEG4000, 0.1 M ammoniumsulfate, 0.1 M phosphate-citrate	分辨率 1.56 Å R-free 0.175
4U5B Crystal structure of GluA2 A622T, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex 提交 2014-07-25	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 25–845（821 aa）链 B 25–845（821 aa）链 C 25–845（821 aa）链 D 25–845（821 aa）	未记录	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES pH 5.8-6.3, 0.1 M NaCl, 5%-6% PEG3350	分辨率 3.50 Å R-free 0.261
4U5C Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist FW and postitive modulator (R,R)-2b complex 提交 2014-07-25	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 25–845（821 aa）链 B 25–845（821 aa）链 C 25–845（821 aa）链 D 25–845（821 aa）	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES pH 5.8-6.3, 0.1 M NaCl, 5%-6% PEG3350	分辨率 3.69 Å R-free 0.254
4U5D Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex 提交 2014-07-25	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 25–845（821 aa）链 B 25–845（821 aa）链 C 25–845（821 aa）链 D 25–845（821 aa）	未记录	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES pH 5.8-6.3, 0.1 M NaCl, 5%-6% PEG3350	分辨率 3.58 Å R-free 0.297
4U5E Crystal structure of GluA2 T625G, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex 提交 2014-07-25	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 25–845（821 aa）链 B 25–845（821 aa）链 C 25–845（821 aa）链 D 25–845（821 aa）	未记录	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES pH 5.8-6.3, 0.1 M NaCl, 5%-6% PEG3350	分辨率 3.51 Å R-free 0.276
4U5F Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex, GluA2cryst2 construct 提交 2014-07-24	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 25–848（824 aa）链 B 25–848（824 aa）链 C 25–848（824 aa）链 D 25–848（824 aa）	未记录	KAI 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；0.1 M MES pH 5.8-6.3, 0.1 M NaCl, 5%-6% PEG3350	分辨率 3.70 Å R-free 0.286
4UQ6 Electron density map of GluA2em in complex with LY451646 and glutamate 提交 2014-06-20	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 22–847（826 aa）片段：RESIDUES 22-847 链 B 22–847（826 aa）片段：RESIDUES 22-847 链 C 22–847（826 aa）片段：RESIDUES 22-847 链 D 22–847（826 aa）片段：RESIDUES 22-847	未记录	GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；ETHANE	分辨率 12.80 Å
4UQJ Cryo-EM density map of GluA2em in complex with ZK200775 提交 2014-06-24	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 22–847（826 aa）片段：RESIDUES 22-847 链 B 22–847（826 aa）片段：RESIDUES 22-847 链 C 22–847（826 aa）片段：RESIDUES 22-847 链 D 22–847（826 aa）片段：RESIDUES 22-847	突变：YES 突变：YES 突变：YES 突变：YES	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 150 MM NACL, 20 MM TRIS, 0.75 MM DDM, 0.12 MM CHS, 0.3 MM ZK200775；pH 8；150 MM NACL, 20 MM TRIS, 0.75 MM DDM, 0.12 MM CHS, 0.3 MM ZK200775 cryo-EM玻璃化条件冷冻剂 ETHANE；ETHANE	分辨率 10.40 Å
4UQK Electron density map of GluA2em in complex with quisqualate and LY451646 提交 2014-06-24	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 22–847（826 aa）片段：RESIDUES 22-847 链 B 22–847（826 aa）片段：RESIDUES 22-847 链 C 22–847（826 aa）片段：RESIDUES 22-847 链 D 22–847（826 aa）片段：RESIDUES 22-847	未记录	QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；ETHANE	分辨率 16.40 Å
4X48 Crystal structure of GluR2 ligand-binding core 提交 2014-12-02	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：Ligand binding domain, engineered single chain 链 A 653–796（144 aa）片段：Ligand binding domain, engineered single chain 链 C 413–527（115 aa）片段：Ligand binding domain, engineered single chain 链 C 653–796（144 aa）片段：Ligand binding domain, engineered single chain	未记录	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 3 XPF N-{(3S,4S)-4-[4-(5-cyanothiophen-2-yl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；The protein solution contained 7 mg/ml GluR2-S1S2J, 10mM (S)-Glu, 10mM HEPES (pH 7.5), 20mM NaCl and 1mM EDTA. Compound was added to a final concentration of 150micromolar from a 30mM DMSO stock. To this solution, an equal amount of reservoir solution containing 10% PEG 8000, 0.1 M ZnAc and 0.1M NaAc, pH 5.5 was added, and 2microlitre drops of this mixture were allowed to equilibrate by vapor diffusion over a 1mL reservoir. Crystals appeared in the drops in 3-5 days.	分辨率 1.89 Å R-free 0.197
4X48 Crystal structure of GluR2 ligand-binding core 提交 2014-12-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：Ligand binding domain, engineered single chain 链 B 653–796（144 aa）片段：Ligand binding domain, engineered single chain	未记录	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 4 XPF N-{(3S,4S)-4-[4-(5-cyanothiophen-2-yl)phenoxy]tetrahydrofuran-3-yl}propane-2-sulfonamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；The protein solution contained 7 mg/ml GluR2-S1S2J, 10mM (S)-Glu, 10mM HEPES (pH 7.5), 20mM NaCl and 1mM EDTA. Compound was added to a final concentration of 150micromolar from a 30mM DMSO stock. To this solution, an equal amount of reservoir solution containing 10% PEG 8000, 0.1 M ZnAc and 0.1M NaAc, pH 5.5 was added, and 2microlitre drops of this mixture were allowed to equilibrate by vapor diffusion over a 1mL reservoir. Crystals appeared in the drops in 3-5 days.	分辨率 1.89 Å R-free 0.197
4YMA Structure of the ligand-binding domain of GluA2 in complex with the antagonist CNG10109 提交 2015-03-06	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	SO4 SULFATE ION × 6 GOL GLYCEROL × 2 4E5 (3R)-3-(3-carboxy-5-hydroxyphenyl)-L-proline × 2 EDO 1,2-ETHANEDIOL × 2 ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；PEG4000, lithium sulfate, phosphate citrate	分辨率 1.90 Å R-free 0.228
4YU0 Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution 提交 2015-03-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）链 A 653–796（144 aa）	突变：E713T, Y768R,E713T, Y768R 突变：E713T, Y768R,E713T, Y768R	GLU GLUTAMIC ACID × 1 PO4 PHOSPHATE ION × 3 PEG DI(HYDROXYETHYL)ETHER × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7；277.14 K；20% w/v PEG3350 and 200 mM (NH4)2HPO4	分辨率 1.26 Å R-free 0.157
4YU0 Crystal structure of a tetramer of GluA2 TR mutant ligand binding domains bound with glutamate at 1.26 Angstrom resolution 提交 2015-03-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）链 B 653–796（144 aa）	突变：E713T, Y768R,E713T, Y768R 突变：E713T, Y768R,E713T, Y768R	GLU GLUTAMIC ACID × 1 PO4 PHOSPHATE ION × 3 PEG DI(HYDROXYETHYL)ETHER × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7；277.14 K；20% w/v PEG3350 and 200 mM (NH4)2HPO4	分辨率 1.26 Å R-free 0.157
4Z0I Crystal structure of a tetramer of GluA2 ligand binding domains bound with glutamate at 1.45 Angstrom resolution 提交 2015-03-26	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–796（144 aa）	未记录	GLU GLUTAMIC ACID × 2 PO4 PHOSPHATE ION × 6 PG4 TETRAETHYLENE GLYCOL × 2 PEG DI(HYDROXYETHYL)ETHER × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7；277.14 K；20% PEG 3350 and 200 mM KNO3	分辨率 1.45 Å R-free 0.208
4Z0I Crystal structure of a tetramer of GluA2 ligand binding domains bound with glutamate at 1.45 Angstrom resolution 提交 2015-03-26	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）链 B 653–796（144 aa）	未记录	GLU GLUTAMIC ACID × 2 PO4 PHOSPHATE ION × 6	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 7；277.14 K；20% PEG 3350 and 200 mM KNO3	分辨率 1.45 Å R-free 0.208
5BUU Crystal structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM-321 at 2.07 A resolution 提交 2015-06-04	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：UNP residues 413-527,UNP residues 653-796 链 A 653–796（144 aa）片段：UNP residues 413-527,UNP residues 653-796 链 B 413–527（115 aa）片段：UNP residues 413-527,UNP residues 653-796 链 B 653–796（144 aa）片段：UNP residues 413-527,UNP residues 653-796	突变：L483Y, N754S,L483Y, N754S 突变：L483Y, N754S,L483Y, N754S 突变：L483Y, N754S,L483Y, N754S 突变：L483Y, N754S,L483Y, N754S	4V6 (3R)-7-chloro-2,3,4-trimethyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 5 EDO 1,2-ETHANEDIOL × 5	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；15.2 % PEG4000, 0.2 M ammonium-sulfate, 0.1 M phosphate-citrate	分辨率 2.07 Å R-free 0.250
5CBR Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (S)-2-amino-3-(3,4-dichloro-5-(5-hydroxypyridin-3-yl)phenyl)propanoic acid at 2.0A resolution 提交 2015-07-01	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）	未记录	4ZK 3,4-dichloro-5-(5-hydroxypyridin-3-yl)-L-phenylalanine × 2 GOL GLYCEROL × 6 SO4 SULFATE ION × 12 ACT ACETATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；PEG4000, lithium sulfate and phosphate-citrate buffer pH 4.5	分辨率 2.00 Å R-free 0.238
5CBS Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution 提交 2015-07-01	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：UNP residues 413-527,UNP residues 653-797 链 A 653–797（145 aa）片段：UNP residues 413-527,UNP residues 653-797 链 C 413–527（115 aa）片段：UNP residues 413-527,UNP residues 653-797 链 C 653–797（145 aa）片段：UNP residues 413-527,UNP residues 653-797	未记录	E42 (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid × 2 SO4 SULFATE ION × 5 EDO 1,2-ETHANEDIOL × 4 GOL GLYCEROL × 3 CL CHLORIDE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；PEG2000, lithium sulfate and phosphate-citrate buffer pH 4.5	分辨率 1.80 Å R-free 0.219
5CBS Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid at 1.8A resolution 提交 2015-07-01	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）片段：UNP residues 413-527,UNP residues 653-797 链 B 653–797（145 aa）片段：UNP residues 413-527,UNP residues 653-797 链 D 413–527（115 aa）片段：UNP residues 413-527,UNP residues 653-797 链 D 653–797（145 aa）片段：UNP residues 413-527,UNP residues 653-797	未记录	E42 (R)-2-amino-3-(3'-hydroxybiphenyl-3-yl)propanoic acid × 2 SO4 SULFATE ION × 5 EDO 1,2-ETHANEDIOL × 10 GOL GLYCEROL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；PEG2000, lithium sulfate and phosphate-citrate buffer pH 4.5	分辨率 1.80 Å R-free 0.219
5ELV Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504-N775) in complex with glutamate and BPAM-521 at 1.92 A resolution 提交 2015-11-05	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）片段：UNP residues, 413-527,UNP residue, 653-797 链 A 653–797（145 aa）片段：UNP residues, 413-527,UNP residue, 653-797 链 B 413–527（115 aa）片段：UNP residues, 413-527,UNP residue, 653-797 链 B 653–797（145 aa）片段：UNP residues, 413-527,UNP residue, 653-797	突变：L504Y and N775S 突变：L504Y and N775S 突变：L504Y and N775S 突变：L504Y and N775S	SO4 SULFATE ION × 4 GOL GLYCEROL × 4 CL CHLORIDE ION × 3 ACT ACETATE ION × 9 5PX 4-Cyclopropyl-3,4-dihydro-7-hydroxy-2H-1,2,4-benzothiadiazine 1,1-dioxide × 2 GLU GLUTAMIC ACID × 2 PEG DI(HYDROXYETHYL)ETHER × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；20% PEG4000, 0.3 M lithium sulfate and 0.1 M phosphate-citrate	分辨率 1.92 Å R-free 0.209
5FHM Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-(aminomethyl)benzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at resolution 1.55 A resolution 提交 2015-12-22	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	SO4 SULFATE ION × 6 5XP (2~{S})-3-[5-[2-[[3-(aminomethyl)phenyl]methyl]-1,2,3,4-tetrazol-5-yl]-3-oxidanyl-1,2-oxazol-4-yl]-2-azanyl-propanoic acid × 1 GOL GLYCEROL × 2 ACT ACETATE ION × 4 EDO 1,2-ETHANEDIOL × 7 LI LITHIUM ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；PEG4000 lithium sulfate sodium acetate buffer pH 5.5	分辨率 1.55 Å R-free 0.159
5FHN Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-methylbenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 1.6 A resolution 提交 2015-12-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）链 A 653–797（145 aa）	未记录	SO4 SULFATE ION × 1 GOL GLYCEROL × 2 ACT ACETATE ION × 1 5XO (S)-2-Amino-3-(5-(2-(3-methylbenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid × 1 EDO 1,2-ETHANEDIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；18% PEG4000 0.1 M ammonium sulfate 0.1 M phosphate-citrate buffer pH 4.5	分辨率 1.60 Å R-free 0.186
5FHO Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-chlorobenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 2.3 A resolution 提交 2015-12-22	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 D 413–527（115 aa）链 D 653–797（145 aa）	未记录	5XN (1S)-1-carboxy-2-(5-{2-[(3-chlorophenyl)methyl]-2H-tetrazol-5-yl}-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)ethan-1-aminium × 2 SO4 SULFATE ION × 6 GOL GLYCEROL × 2 CL CHLORIDE ION × 5 EDO 1,2-ETHANEDIOL × 8	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；PEG4000 ammonium sulfate acetate buffer pH 5.5	分辨率 2.30 Å R-free 0.216
5FHO Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-chlorobenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 2.3 A resolution 提交 2015-12-22	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）链 B 653–797（145 aa）链 C 413–527（115 aa）链 C 653–797（145 aa）	未记录	5XN (1S)-1-carboxy-2-(5-{2-[(3-chlorophenyl)methyl]-2H-tetrazol-5-yl}-3-oxo-2,3-dihydro-1,2-oxazol-4-yl)ethan-1-aminium × 2 SO4 SULFATE ION × 6 GOL GLYCEROL × 4 CL CHLORIDE ION × 4 EDO 1,2-ETHANEDIOL × 6 PG4 TETRAETHYLENE GLYCOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；280 K；PEG4000 ammonium sulfate acetate buffer pH 5.5	分辨率 2.30 Å R-free 0.216
5FTH Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (zinc form) 提交 2016-01-13	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 404–527（124 aa）片段：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796 链 A 653–796（144 aa）片段：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796 链 B 404–527（124 aa）片段：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796 链 B 653–796（144 aa）片段：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796	突变：YES 突变：YES 突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 4	X-RAY DIFFRACTION X-ray结晶条件 pH 6；15% PEG 8,000, 200 MM ZN ACETATE, 100MM MES PH 6.0	分辨率 2.90 Å R-free 0.283
5FTH Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (zinc form) 提交 2016-01-13	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 404–527（124 aa）片段：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796 链 C 653–796（144 aa）片段：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796	突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 6；15% PEG 8,000, 200 MM ZN ACETATE, 100MM MES PH 6.0	分辨率 2.90 Å R-free 0.283
5FTI Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (lithium form) 提交 2016-01-13	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 404–527（124 aa）片段：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796 链 A 653–796（144 aa）片段：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796	突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 LI LITHIUM ION × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 5；22% PEG 4,000, 200 MM LI SULPHATE, 100MM ACETATE PH 5.0	分辨率 1.35 Å R-free 0.177
5FTI Crystal structure of the GluA2 K738M-T744K LBD in complex with glutamate (lithium form) 提交 2016-01-13	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 404–527（124 aa）片段：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796 链 B 653–796（144 aa）片段：LIGAND BINDING DOMAIN, UNP RESIDUES 404-527,653-796	突变：YES 突变：YES	GLU GLUTAMIC ACID × 2 LI LITHIUM ION × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 pH 5；22% PEG 4,000, 200 MM LI SULPHATE, 100MM ACETATE PH 5.0	分辨率 1.35 Å R-free 0.177
5FWX Crystal structure of the AMPA receptor GluA2/A4 N-terminal domain heterodimer 提交 2016-02-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 25–400（376 aa）片段：RESIDUES 25-400	未记录	SO4 SULFATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2	X-RAY DIFFRACTION X-ray结晶条件 17% PEG 3350 WITH 0.1-0.35 M AMMONIUM SULPHATE	分辨率 2.50 Å R-free 0.238
5FWX Crystal structure of the AMPA receptor GluA2/A4 N-terminal domain heterodimer 提交 2016-02-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 25–400（376 aa）片段：RESIDUES 25-400	未记录	SO4 SULFATE ION × 2 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	X-RAY DIFFRACTION X-ray结晶条件 17% PEG 3350 WITH 0.1-0.35 M AMMONIUM SULPHATE	分辨率 2.50 Å R-free 0.238
5FWY Crystal structure of the AMPA receptor GluA2/A3 N-terminal domain heterodimer 提交 2016-02-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 A 25–400（376 aa）片段：RESIDUES 25-400	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 SO4 SULFATE ION × 5 GOL GLYCEROL × 1	X-RAY DIFFRACTION X-ray结晶条件 14-16 % PEG 3350, 0.27 M AMMONIUM SULPHATE AND 0.1 M BICINE PH 9	分辨率 2.12 Å R-free 0.231
5FWY Crystal structure of the AMPA receptor GluA2/A3 N-terminal domain heterodimer 提交 2016-02-21	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白异源复合物异源复合物；蛋白 × 2 PDB 声明：dimeric	链 C 25–400（376 aa）片段：RESIDUES 25-400	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 5 SO4 SULFATE ION × 3	X-RAY DIFFRACTION X-ray结晶条件 14-16 % PEG 3350, 0.27 M AMMONIUM SULPHATE AND 0.1 M BICINE PH 9	分辨率 2.12 Å R-free 0.231
5IDE Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model I) 提交 2016-02-24	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 A 23–883（861 aa）链 C 23–883（861 aa）	突变：N292C 突变：N292C	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4；25 mM Tris pH 7.4, 0.25 % DDM, 150 mM NaCl cryo-EM玻璃化条件冷冻剂 ETHANE；Incubated for 1 minute, blotted for 3 seconds	分辨率 8.25 Å
5IDF Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model II) 提交 2016-02-24	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 A 23–883（861 aa）链 C 23–883（861 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 7.4；25 mM Tris pH 7.4, 0.25 % DDM, 150 mM NaCl cryo-EM玻璃化条件冷冻剂 ETHANE；Incubated for 1 minute, blotted for 3 seconds	分辨率 10.31 Å
5JEI Crystal structure of the GluA2 LBD in complex with FW 提交 2016-04-18	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 413–527（115 aa）链 A 653–797（145 aa）	突变：V154C,V154C 突变：V154C,V154C	FWD 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID × 4 PO4 PHOSPHATE ION × 8 PG4 TETRAETHYLENE GLYCOL × 8 PEG DI(HYDROXYETHYL)ETHER × 12 TOE 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL × 4 PG0 2-(2-METHOXYETHOXY)ETHANOL × 4 ETE 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL × 8 EDO 1,2-ETHANEDIOL × 4 NA SODIUM ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 6.2；277 K；50.0 % v/v PEG 200, 200 mM Sodium Chloride, 100 mM Sodium/Potassium Phosphate pH 6.2	分辨率 1.23 Å R-free 0.147
5KBS Cryo-EM structure of GluA2-0xSTZ at 8.7 Angstrom resolution 提交 2016-06-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	突变：N241E, V382L, G384E, N385D, V758L,N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L,N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L,N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L,N241E, V382L, G384E, N385D, V758L	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；3 blot force, 8.0 s blot time	分辨率 8.70 Å
5KBT Cryo-EM structure of GluA2-1xSTZ complex at 6.4 Angstrom resolution 提交 2016-06-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；3 blot force, 8.0 s blot time	分辨率 6.40 Å
5KBU Cryo-EM structure of GluA2-2xSTZ complex at 7.8 Angstrom resolution 提交 2016-06-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；3 blot force, 8.0 s blot time	分辨率 7.80 Å
5KBV Cryo-EM structure of GluA2 bound to antagonist ZK200775 at 6.8 Angstrom resolution 提交 2016-06-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	突变：N241E, V382L,G384E, N385D, V758L 突变：N241E, V382L,G384E, N385D, V758L 突变：N241E, V382L,G384E, N385D, V758L 突变：N241E, V382L,G384E, N385D, V758L	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；Blot force 3, 8.0 s blot time	分辨率 6.80 Å
5KK2 Architecture of fully occupied GluA2 AMPA receptor - TARP complex elucidated by single particle cryo-electron microscopy 提交 2016-06-20	实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 7.30 Å
5L1B AMPA subtype ionotropic glutamate receptor GluA2 in Apo state 提交 2016-07-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 A 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 B 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 B 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 C 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 C 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 D 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 D 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587,UNP residues 25-847, with deletions of 397-398, 402-405, 566-587	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；8-11% (w/v) PEG 8,000, 0.2 M magnesium acetate and 0.1 M sodium cacodylate (pH 6.3-6.7)	分辨率 4.00 Å R-free 0.292
5L1E AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor CP465022 提交 2016-07-29	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 A 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 B 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 B 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 C 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 C 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 D 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 D 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 6ZQ 3-(2-chlorophenyl)-2-(2-{6-[(diethylamino)methyl]pyridin-2-yl}ethyl)-6-fluoroquinazolin-4(3H)-one × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；11-14% (w/v) PEG 6,000, 0.1 M ammonium phosphate and 0.1 M TRIS (pH 7.9-8.0)	分辨率 4.37 Å R-free 0.292
5L1F AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor Perampanel 提交 2016-07-29	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 A 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 B 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 B 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 C 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 C 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 D 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 D 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 6ZP 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；11-14% (w/v) PEG 6,000, 0.1 M ammonium phosphate and 0.1 M TRIS (pH 7.9-8.0)	分辨率 4.00 Å R-free 0.272
5L1G AMPA subtype ionotropic glutamate receptor GluA2 in complex with GYKI-Br 提交 2016-07-29	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 A 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 B 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 B 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 C 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 C 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 D 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 D 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 GYB (8R)-5-(4-amino-3-bromophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide × 5	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；sodium acetate	分辨率 4.51 Å R-free 0.295
5L1H AMPA subtype ionotropic glutamate receptor GluA2 in complex with noncompetitive inhibitor GYKI53655 提交 2016-07-29	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 A 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 B 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 B 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 C 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 C 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 D 25–565（541 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587 链 D 588–847（260 aa）片段：UNP residues 25-847, with deletions of 397-398, 402-405, 566-587	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 GYK (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；277 K；11-14% (w/v) PEG 6,000, 0.1 M ammonium phosphate and 0.1 M TRIS (pH 7.9-8.0)	分辨率 3.80 Å R-free 0.292
5N6P AMPA receptor NTD mutant 提交 2017-02-15	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 25–400（376 aa）	突变：K73C D134C	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.6；291 K；16-20% PEG3350, 200 mM sodium formate	分辨率 2.80 Å R-free 0.249
5NG9 Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist CIP-AS at 1.15 A resolution. 提交 2017-03-17	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）	未记录	FLC CITRATE ANION × 4 LI LITHIUM ION × 2 8VN (3~{a}~{S},4~{S},6~{a}~{R})-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-d][1,2]oxazole-3,4-dicarboxylic acid × 2 8WQ (2~{S},3~{R},4~{R})-3-(carboxycarbonyl)-4-oxidanyl-pyrrolidine-2-carboxylic acid × 2 SO4 SULFATE ION × 6 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；15.2% PEG4000, 0.1 M lithium sulfate, 0.1 M phosphate-citrate buffer	分辨率 1.15 Å R-free 0.133
5NIH Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist LM-12b at 1.3 A resolution. 提交 2017-03-24	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 A 413–527（115 aa）链 A 653–797（145 aa）	未记录	SO4 SULFATE ION × 3 8VE (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid × 1 GOL GLYCEROL × 3 CL CHLORIDE ION × 1 ACT ACETATE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；24.4% PEG4000, 0.3 M ammonium sulfate, 0.1 M phosphate-citrate buffer	分辨率 1.30 Å R-free 0.158
5NIH Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with agonist LM-12b at 1.3 A resolution. 提交 2017-03-24	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白单体单体；蛋白 × 1 PDB 声明：monomeric	链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	SO4 SULFATE ION × 2 8VE (3~{a}~{R},4~{S},6~{a}~{R})-1-methyl-4,5,6,6~{a}-tetrahydro-3~{a}~{H}-pyrrolo[3,4-c]pyrazole-3,4-dicarboxylic acid × 1 GOL GLYCEROL × 1 CL CHLORIDE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；24.4% PEG4000, 0.3 M ammonium sulfate, 0.1 M phosphate-citrate buffer	分辨率 1.30 Å R-free 0.158
5NS9 Crystal structure of the GluA2 LBD (L483Y-N754S-L758V) in complex with glutamate 提交 2017-04-25	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	1PE PENTAETHYLENE GLYCOL × 2 PG0 2-(2-METHOXYETHOXY)ETHANOL × 1 SO4 SULFATE ION × 6 NA SODIUM ION × 5 GLU GLUTAMIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 7；277.15 K；20% w/v PEG3350, 200mM Li2SO4	分辨率 1.44 Å R-free 0.205
5O9A Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504Y-N775S) in complex with glutamate and BPAM121 at 1.78 A resolution 提交 2017-06-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	突变：L504Y,N775S 突变：L504Y,N775S 突变：L504Y,N775S 突变：L504Y,N775S	SO4 SULFATE ION × 6 7M6 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide × 2 CL CHLORIDE ION × 4 GOL GLYCEROL × 3 GLU GLUTAMIC ACID × 2 EDO 1,2-ETHANEDIOL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；18% PEG4000, 0.23 M lithium sulfate, 0.1 M phosphate citrate pH 4.5	分辨率 1.78 Å R-free 0.179
5O9A Crystal structure of the GluA2 ligand-binding domain (S1S2J-L504Y-N775S) in complex with glutamate and BPAM121 at 1.78 A resolution 提交 2017-06-16	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 413–527（115 aa）链 C 653–797（145 aa）链 D 413–527（115 aa）链 D 653–797（145 aa）	突变：L504Y,N775S 突变：L504Y,N775S 突变：L504Y,N775S 突变：L504Y,N775S	SO4 SULFATE ION × 10 7M6 7-chloro-4-(2-fluoroethyl)-2,3-dihydro-1,2,4-benzothiadiazine 1,1-dioxide × 2 CL CHLORIDE ION × 3 GOL GLYCEROL × 1 GLU GLUTAMIC ACID × 2 CIT CITRIC ACID × 1 PEG DI(HYDROXYETHYL)ETHER × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；18% PEG4000, 0.23 M lithium sulfate, 0.1 M phosphate citrate pH 4.5	分辨率 1.78 Å R-free 0.179
5OEW Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with glutamate and positive allosteric modulator BPAM538 提交 2017-07-10	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 9 ACT ACETATE ION × 2 9TE 4-cyclopropyl-7-(3-methoxyphenoxy)-2,3-dihydro-1$l^{6},2,4-benzothiadiazine 1,1-dioxide × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；18% PEG4000, 0.23M lithium-sulfate, 0.1M phosphate-citrate	分辨率 2.00 Å R-free 0.189
5OEW Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with glutamate and positive allosteric modulator BPAM538 提交 2017-07-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 413–527（115 aa）链 C 653–797（145 aa）	未记录	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 16 ACT ACETATE ION × 4 9TE 4-cyclopropyl-7-(3-methoxyphenoxy)-2,3-dihydro-1$l^{6},2,4-benzothiadiazine 1,1-dioxide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；18% PEG4000, 0.23M lithium-sulfate, 0.1M phosphate-citrate	分辨率 2.00 Å R-free 0.189
5VHW GluA2-0xGSG1L bound to ZK 提交 2017-04-13	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 7.80 Å
5VHX GluA2-1xGSG1L bound to ZK 提交 2017-04-13	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 5 PDB 声明：pentameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）链 E 25–847（823 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 8.30 Å
5VHY GluA2-2xGSG1L bound to ZK 提交 2017-04-13	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 6 PDB 声明：hexameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）链 E 25–847（823 aa）链 F 25–847（823 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.60 Å
5VHZ GluA2-2xGSG1L bound to L-Quisqualate 提交 2017-04-13	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 6 PDB 声明：hexameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）链 E 25–847（823 aa）链 F 25–847（823 aa）	未记录	QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 8.40 Å
5VOT Structure of AMPA receptor-TARP complex 提交 2017-05-03	实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.90 Å
5VOU Structure of AMPA receptor-TARP complex 提交 2017-05-03	实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 6.40 Å
5VOV Structure of AMPA receptor-TARP complex 提交 2017-05-03	实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 7.70 Å
5WEK GluA2 bound to antagonist ZK and GSG1L in digitonin, state 1 提交 2017-07-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）片段：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG 链 B 25–847（823 aa）片段：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG 链 C 25–847（823 aa）片段：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG 链 D 25–847（823 aa）片段：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG	突变：N241E, V382L, G384E, N385D, N392Q, V1151L 突变：N241E, V382L, G384E, N385D, N392Q, V1151L 突变：N241E, V382L, G384E, N385D, N392Q, V1151L 突变：N241E, V382L, G384E, N385D, N392Q, V1151L	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.60 Å
5WEL GluA2 bound to antagonist ZK and GSG1L in digitonin, state 2 提交 2017-07-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）片段：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG 链 B 25–847（823 aa）片段：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG 链 C 25–847（823 aa）片段：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG 链 D 25–847（823 aa）片段：UNP P19491 residues 25-847, UNP D3Z7H4 residues 2-238 linked via LINKER GTG	突变：N241E, V382L, G384E, N385D, N392Q, V1151L 突变：N241E, V382L, G384E, N385D, N392Q, V1151L 突变：N241E, V382L, G384E, N385D, N392Q, V1151L 突变：N241E, V382L, G384E, N385D, N392Q, V1151L	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 AJP Digitonin × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.40 Å
5WEM GluA2 bound to GSG1L in digitonin, state 1 提交 2017-07-10	构建体不同突变/修饰不同聚集状态不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）片段：UNP P19491 residues 25-847 and UNP D3Z7H4 residues 2-238 linked via LINKER GTG 链 B 25–847（823 aa）片段：UNP P19491 residues 25-847 and UNP D3Z7H4 residues 2-238 linked via LINKER GTG 链 C 25–847（823 aa）片段：UNP P19491 residues 25-847 and UNP D3Z7H4 residues 2-238 linked via LINKER GTG 链 D 25–847（823 aa）片段：UNP P19491 residues 25-847 and UNP D3Z7H4 residues 2-238 linked via LINKER GTG	突变：N241E, V382L, G384E, N385D, N392Q, V1151L 突变：N241E, V382L, G384E, N385D, N392Q, V1151L 突变：N241E, V382L, G384E, N385D, N392Q, V1151L 突变：N241E, V382L, G384E, N385D, N392Q, V1151L	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 6.10 Å
5WEN GluA2 bound to GSG1L in digitonin, state 2 提交 2017-07-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）片段：UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG,UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG 链 B 25–847（823 aa）片段：UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG,UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG 链 C 25–847（823 aa）片段：UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG,UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG 链 D 25–847（823 aa）片段：UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG,UNP residues 25-847 and UNP residues 2-238 linked via LINKER GTG	突变：N241E, V382L, G384E, N385D, N392Q, V1151L,N241E, V382L, G384E, N385D, N392Q, V1151L 突变：N241E, V382L, G384E, N385D, N392Q, V1151L,N241E, V382L, G384E, N385D, N392Q, V1151L 突变：N241E, V382L, G384E, N385D, N392Q, V1151L,N241E, V382L, G384E, N385D, N392Q, V1151L 突变：N241E, V382L, G384E, N385D, N392Q, V1151L,N241E, V382L, G384E, N385D, N392Q, V1151L	AJP Digitonin × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 6.80 Å
5WEO Activated GluA2 complex bound to glutamate, cyclothiazide, and STZ in digitonin 提交 2017-07-10	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）片段：UNP P19491 residues 25-847, UNP O88602 2-208 linked via LINKER GT 链 B 25–847（823 aa）片段：UNP P19491 residues 25-847, UNP O88602 2-208 linked via LINKER GT 链 C 25–847（823 aa）片段：UNP P19491 residues 25-847, UNP O88602 2-208 linked via LINKER GT 链 D 25–847（823 aa）片段：UNP P19491 residues 25-847, UNP O88602 2-208 linked via LINKER GT	突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L 突变：N241E, V382L, G384E, N385D, V758L	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.20 Å
6DLZ Open state GluA2 in complex with STZ after micelle signal subtraction 提交 2018-06-04	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.90 Å
6DM0 Open state GluA2 in complex with STZ and blocked by IEM-1460, after micelle signal subtraction 提交 2018-06-04	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 GZD N,N,N-trimethyl-5-({[(3s,5s,7s)-tricyclo[3.3.1.1~3,7~]decan-1-yl]methyl}amino)pentan-1-aminium × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.40 Å
6DM1 Open state GluA2 in complex with STZ and blocked by NASPM, after micelle signal subtraction 提交 2018-06-04	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 GYY N-[3-({4-[(3-aminopropyl)amino]butyl}amino)propyl]-2-(naphthalen-1-yl)acetamide × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.20 Å
6FAZ Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the positive allosteric modulator TDPAM01 at 1.4 A resolution. 提交 2017-12-18	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	SO4 SULFATE ION × 5 PEG DI(HYDROXYETHYL)ETHER × 2 GOL GLYCEROL × 5 CL CHLORIDE ION × 5 ACT ACETATE ION × 3 GLU GLUTAMIC ACID × 2 EDO 1,2-ETHANEDIOL × 2 D45 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；280 K；15% PEG4000, 0.3 M ammonium sulfate, 0.1 M phosphate-citrate	分辨率 1.40 Å R-free 0.168
6FQG GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form A) at 2.34 Angstrom resolution 提交 2018-02-14	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	突变：S729C 突变：S729C 突变：S729C 突变：S729C	GLU GLUTAMIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 4；287 K；0.2M Ammonium chloride, 20% PEG 3350, 10uM ZK200775	分辨率 2.34 Å R-free 0.231
6FQH GluA2(flop) S729C ligand binding core dimer bound to NBQX at 1.76 Angstrom resolution 提交 2018-02-14	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 400–527（128 aa）链 A 653–797（145 aa）链 B 400–527（128 aa）链 B 653–797（145 aa）	突变：S729C,S729C 突变：S729C,S729C 突变：S729C,S729C 突变：S729C,S729C	E2Q 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 5.5；289 K；0.1M tri-sodium Citrate, 20% PEG 3000	分辨率 1.76 Å R-free 0.224
6FQI GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form B) at 2.91 Angstrom resolution 提交 2018-02-14	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	GLU GLUTAMIC ACID × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；pH 6.5；289 K；0.16 M Calcium acetate, 0.08 M Sodium Cacodylate, 14.4% (w/v) PEG 8000, 20% (v/v) Glycerol, 1 mM glutamate	分辨率 2.91 Å R-free 0.267
6FQJ GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution 提交 2018-02-14	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 H 413–527（115 aa）链 H 653–797（145 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；287 K；0.2M Ammonium Chloride, 20% PEG 3350, 10microM ZK200775.	分辨率 2.50 Å R-free 0.265
6FQJ GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution 提交 2018-02-14	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）链 B 653–797（145 aa）链 G 413–527（115 aa）链 G 653–797（145 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；287 K；0.2M Ammonium Chloride, 20% PEG 3350, 10microM ZK200775.	分辨率 2.50 Å R-free 0.265
6FQJ GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution 提交 2018-02-14	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 3 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 413–527（115 aa）链 C 653–797（145 aa）链 E 413–527（115 aa）链 E 653–797（145 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；287 K；0.2M Ammonium Chloride, 20% PEG 3350, 10microM ZK200775.	分辨率 2.50 Å R-free 0.265
6FQJ GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution 提交 2018-02-14	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 4 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 D 413–527（115 aa）链 D 653–797（145 aa）链 F 413–527（115 aa）链 F 653–797（145 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；287 K；0.2M Ammonium Chloride, 20% PEG 3350, 10microM ZK200775.	分辨率 2.50 Å R-free 0.265
6FQK GluA2(flop) S729C ligand binding core dimer bound to ZK200775 at 1.98 Angstrom resolution 提交 2018-02-14	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 400–527（128 aa）链 A 653–797（145 aa）链 B 400–527（128 aa）链 B 653–797（145 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP；287 K；0.2M Ammonium Chloride, 20% PEG 3350, 10microM ZK200775.	分辨率 1.98 Å R-free 0.256
6GIV Structure of GluA2-N775S ligand-binding domain (S1S2J) in complex with glutamate and Rubidium Bromide at 1.75 A resolution 提交 2018-05-15	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）	突变：N775S,N775S 突变：N775S,N775S	GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 2 GOL GLYCEROL × 6 BR BROMIDE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；18-24.4% PEG4000, 0.2-0.3 M Li2SO4, and 0.1 M cacodylate, pH 6.5	分辨率 1.75 Å R-free 0.190
6GL4 Structure of GluA2o ligand-binding domain (S1S2J) in complex with glutamate and sodium bromide at 1.95 A resolution 提交 2018-05-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 652–797（146 aa）	未记录	GLU GLUTAMIC ACID × 2 BR BROMIDE ION × 6 GOL GLYCEROL × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；25% PEG4000, 0.2M sodium sulfate, 0.1M sodium acetate pH 5.5	分辨率 1.95 Å R-free 0.199
6GL4 Structure of GluA2o ligand-binding domain (S1S2J) in complex with glutamate and sodium bromide at 1.95 A resolution 提交 2018-05-22	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）链 B 652–797（146 aa）	未记录	GLU GLUTAMIC ACID × 2 BR BROMIDE ION × 6 NA SODIUM ION × 4 ACT ACETATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；25% PEG4000, 0.2M sodium sulfate, 0.1M sodium acetate pH 5.5	分辨率 1.95 Å R-free 0.199
6HC9 STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM02 AT 2.4 A RESOLUTION. 提交 2018-08-14	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	GOL GLYCEROL × 1 CL CHLORIDE ION × 7 GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 8 PEG DI(HYDROXYETHYL)ETHER × 3 PGE TRIETHYLENE GLYCOL × 1 FXW 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE) × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；291 K；20% PEG4000, 0.3 M lithium sulfate, 0.1 M phosphate citrate	分辨率 2.40 Å R-free 0.239
6HCA STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S1J) IN COMPLEX WITH POSITIVE ALLOSTERIC MODULATOR TDPAM02 AT 1.8 A RESOLUTION 提交 2018-08-14	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	SO4 SULFATE ION × 10 GOL GLYCEROL × 7 CL CHLORIDE ION × 6 FXW 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE) × 1 PEG DI(HYDROXYETHYL)ETHER × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；291 K；24% PEG4000, 0.3 M lithium sulfate, 0.1 M phosphate citrate	分辨率 1.88 Å R-free 0.207
6HCB STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.9 A RESOLUTION. 提交 2018-08-14	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	SO4 SULFATE ION × 9 GLU GLUTAMIC ACID × 2 GOL GLYCEROL × 4 CL CHLORIDE ION × 4 PEG DI(HYDROXYETHYL)ETHER × 2 D45 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；15% PEG4000, 0.1 M ammonium sulphate, 0.1 M phosphate citrate	分辨率 1.90 Å R-free 0.192
6HCC STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM02 AT 1.6 A RESOLUTION. 提交 2018-08-14	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	FXW 6,6'-(ETHANE-1,2-DIYL)BIS(4-CYCLOPROPYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE) × 1 GLU GLUTAMIC ACID × 2 SO4 SULFATE ION × 5 GOL GLYCEROL × 7 PEG DI(HYDROXYETHYL)ETHER × 2 CL CHLORIDE ION × 3 ACT ACETATE ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；291 K；24% PEG4000, 0.3 M lithium sulfate, 0.1 M phosphate citrate	分辨率 1.62 Å R-free 0.182
6HCH STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.6 A RESOLUTION. 提交 2018-08-15	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 15 D45 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) × 1 ACT ACETATE ION × 5 GOL GLYCEROL × 1 CL CHLORIDE ION × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；15% PEG4000, 0.1 M zinc acetate, 0.1 M sodium acetate	分辨率 1.60 Å R-free 0.178
6HCH STRUCTURE OF GLUA2 LIGAND-BINDING DOMAIN (S1S2J-L504Y-N775S) IN COMPLEX WITH GLUTAMATE AND TDPAM01 AT 1.6 A RESOLUTION. 提交 2018-08-15	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 413–527（115 aa）链 C 653–797（145 aa）	未记录	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 16 D45 6,6'-(Ethane-1,2-diyl)bis(4-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) × 2 ACT ACETATE ION × 6 GOL GLYCEROL × 2 CL CHLORIDE ION × 4 SO4 SULFATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；15% PEG4000, 0.1 M zinc acetate, 0.1 M sodium acetate	分辨率 1.60 Å R-free 0.178
6NJL Architecture and subunit arrangement of native AMPA receptors 提交 2019-01-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 其他组合异源复合物；蛋白 × 14 PDB 声明：tetradecameric	链 B 1–883（883 aa）链 D 1–883（883 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 6.70 Å
6NJM Architecture and subunit arrangement of native AMPA receptors 提交 2019-01-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 其他组合异源复合物；蛋白 × 16 PDB 声明：hexadecameric	链 B 1–883（883 aa）链 D 1–883（883 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 6.50 Å
6NJN Architecture and subunit arrangement of native AMPA receptors 提交 2019-01-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 其他组合异源复合物；蛋白 × 15 PDB 声明：pentadecameric	链 B 1–883（883 aa）链 D 1–883（883 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 6.50 Å
6O9G Open state GluA2 in complex with STZ and blocked by AgTx-636, after micelle signal subtraction 提交 2019-03-13	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 LU7 N~1~-{5-[(3-{[3-(L-arginylamino)propyl]amino}propyl)amino]pentyl}-N~2~-[(2,4-dihydroxyphenyl)acetyl]-L-aspartamide × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.80 Å
6PEQ GluA2 in complex with its auxiliary subunit CNIH3 - map LBD-TMD-C3 - with antagonist ZK200775 -without NTD 提交 2019-06-20	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–868（868 aa）链 B 1–868（868 aa）链 C 1–868（868 aa）链 D 1–868（868 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 8 PAM PALMITOLEIC ACID × 14 CLR CHOLESTEROL × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.97 Å
6Q54 Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution 提交 2018-12-07	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	SO4 SULFATE ION × 10 HJ8 (2~{S})-2-azanyl-3-(3-ethyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid × 2 GOL GLYCEROL × 4 PGE TRIETHYLENE GLYCOL × 2 CL CHLORIDE ION × 3 CIT CITRIC ACID × 1 LI LITHIUM ION × 3 PEG DI(HYDROXYETHYL)ETHER × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；20% PEG4000, 0.3 M lithium sulfate, 0.1 M phosphate-citrate	分辨率 1.40 Å R-free 0.163
6Q60 Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(2-methyl-5-hydroxy-2H-1,2,3-triazol-4-yl)propanoic acid at 1.55 A resolution 提交 2018-12-10	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	未记录	HJH (2~{S})-2-azanyl-3-(2-methyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid × 2 SO4 SULFATE ION × 4 GOL GLYCEROL × 12 CL CHLORIDE ION × 3 LI LITHIUM ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；10% PEG4000, 0.1 M lithium sulfate, 0.1 M phosphate-citrate, pH 4.5	分辨率 1.55 Å R-free 0.175
6QKC GluA1/2 In complex with auxiliary subunit gamma-8 提交 2019-01-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 B 1–860（860 aa）链 D 1–860（860 aa）	未记录	E2Q 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 12	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；25 mM TRIS, pH 8, 150 mM NaCl and 0.1 % digitonin (w/v) cryo-EM玻璃化条件冷冻剂 ETHANE；3uL on grid, 60 sec incubation and 4sec blotting time	分辨率 4.40 Å
6QKZ Full length GluA1/2-gamma8 complex 提交 2019-01-30	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 其他组合异源复合物；蛋白 × 6 PDB 声明：hexameric	链 B 22–860（839 aa）链 D 22–860（839 aa）	未记录	E2Q 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；25 mM TRIS, pH 8, 150 mM NaCl and 0.1 % digitonin (w/v) cryo-EM玻璃化条件冷冻剂 ETHANE；3uL on grid, 60 sec incubation and 4sec blotting time	分辨率 6.30 Å
6RUQ Structure of GluA2cryst in complex the antagonist ZK200775 and the negative allosteric modulator GYKI53655 at 4.65 A resolution 提交 2019-05-28	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 其他组合同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	突变：N235E, N385D, N392Q, K410A, R586Q, C589A 突变：N235E, N385D, N392Q, K410A, R586Q, C589A 突变：N235E, N385D, N392Q, K410A, R586Q, C589A 突变：N235E, N385D, N392Q, K410A, R586Q, C589A	GYK (8R)-5-(4-aminophenyl)-N,8-dimethyl-8,9-dihydro-2H,7H-[1,3]dioxolo[4,5-h][2,3]benzodiazepine-7-carboxamide × 4 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4	X-RAY DIFFRACTION X-ray结晶条件 MICROBATCH；pH 6；279 K；0.1 M MES, 12 % PEG 20,000	分辨率 4.65 Å R-free 0.291
6U5S NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in pseudo-symmetric global conformation 提交 2019-08-28	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 1 其他组合同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–868（868 aa）链 B 1–868（868 aa）链 C 1–868（868 aa）链 D 1–868（868 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.07 Å
6U6I NTD of GluA2 in complex with CNIH3 - with antagonist ZK200775 - in asymmetric global conformation 提交 2019-08-29	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 其他组合同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–868（868 aa）链 B 1–868（868 aa）链 C 1–868（868 aa）链 D 1–868（868 aa）	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.12 Å
6UCB GluA2 in complex with its auxiliary subunit CNIH3 - with antagonist ZK200775, LBD, TMD, CNIH3, and lipids 提交 2019-09-15	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–868（868 aa）链 B 1–868（868 aa）链 C 1–868（868 aa）链 D 1–868（868 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 8 PAM PALMITOLEIC ACID × 14 CLR CHOLESTEROL × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.28 Å
6UD4 GluA2 in complex with its auxiliary subunit CNIH3 in AS map II - (LBD-TMD-C3(AS) II)- with antagonist ZK200775, without NTD 提交 2019-09-18	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–868（868 aa）链 B 1–868（868 aa）链 C 1–868（868 aa）链 D 1–868（868 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 CLR CHOLESTEROL × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.30 Å
6UD8 GluA2 in complex with its auxiliary subunit CNIH3 - with antagonist ZK200775 提交 2019-09-18	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–868（868 aa）链 B 1–868（868 aa）链 C 1–868（868 aa）链 D 1–868（868 aa）	未记录	OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 CLR CHOLESTEROL × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.20 Å
6XSR Crystal structure of GluA2 AMPA receptor in complex with trans-4-butylcyclohexane carboxylic acid (4-BCCA) inhibitor 提交 2020-07-16	构建体不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–838（814 aa）链 B 25–838（814 aa）链 C 25–838（814 aa）链 D 25–838（814 aa）	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 V8G trans-4-butylcyclohexane-1-carboxylic acid × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 8；277 K；8-11% (w/v) PEG 8,000, 0.2 M magnesium acetate and 0.1 M sodium cacodylate (pH 6.3-6.7) or 11-14% (w/v) PEG 6,000, 0.1 M ammonium phosphate and 0.1 M TRIS (pH 7.9-8.0)	分辨率 4.25 Å R-free 0.296
6YK2 Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydrothieno[3,4-d]pyrimidin- 2,4(1H,3H)-dione at resolution 1.60A 提交 2020-04-05	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）	未记录	SO4 SULFATE ION × 6 GOL GLYCEROL × 10 CGW (2~{S})-2-azanyl-3-[2,4-bis(oxidanylidene)-5,7-dihydrothieno[3,4-d]pyrimidin-1-yl]propanoic acid × 2 CL CHLORIDE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；15% PEG4000, 0.3M Lithium Sulfate, 0.1M acetate	分辨率 1.61 Å R-free 0.163
6YK3 Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound ( S) - 1- [2'-Amino-2'-carboxyethyl]-5 ,7- dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 1.20A 提交 2020-04-05	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）	未记录	GOL GLYCEROL × 8 SO4 SULFATE ION × 8 PVQ (S)-1-[2'-Amino-2'-carboxyethyl]-5,7-dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione × 2 NH4 AMMONIUM ION × 2 CL CHLORIDE ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；20% PEG4000, 0.3M ammonium sulfate, 0.1M acetate	分辨率 1.20 Å R-free 0.140
6YK4 Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound ( S) - 1- [2'-Amino-2'-carboxyethyl]-6-methyl-5 ,7- dihydropyrrolo[3,4-d]pyrimidin-2,4(1H,3H)-dione at resolution 1.00A 提交 2020-04-05	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）	未记录	SO4 SULFATE ION × 8 GOL GLYCEROL × 8 LI LITHIUM ION × 2 CG8 (2~{S})-2-azanyl-3-[6-methyl-2,4-bis(oxidanylidene)-5,7-dihydropyrrolo[3,4-d]pyrimidin-1-yl]propanoic acid × 2 CL CHLORIDE ION × 4	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；15.2% PEG4000, 0.3M lithium sulfate, 0.1M acetate	分辨率 1.00 Å R-free 0.120
6YK5 Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]- pyrimidine-2,4(1H,3H)-dione at resolution 1.15A 提交 2020-04-05	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）	未记录	GOL GLYCEROL × 8 SO4 SULFATE ION × 12 LI LITHIUM ION × 2 PVK (S)-1-(2'-Amino-2'-carboxyethyl)-5,7-dihydrofuro[3,4-d]-pyrimidine-2,4(1H,3H)-dione × 2 CL CHLORIDE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 5.5；279 K；PEG4000, lithium sulfate, acetate	分辨率 1.15 Å R-free 0.130
6YK6 Structure of the AMPA receptor GluA2o ligand-binding domain (S1S2J) in complex with the compound (S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimidin-2,4-dione at resolution 1.47A 提交 2020-04-05	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）	未记录	SO4 SULFATE ION × 8 GOL GLYCEROL × 6 LI LITHIUM ION × 2 CL CHLORIDE ION × 4 OUB (S)-1-(2'-Amino-2'-carboxyethyl)furo[3,4-d]pyrimidin-2,4-dione × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 4.5；279 K；24.4% PEG4000, 0.15M lithium sulfate, 0.1M phosphate-citrate	分辨率 1.47 Å R-free 0.172
6ZYU Structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM549 提交 2020-08-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）	突变：L483Y,N754S 突变：L483Y,N754S	ZN ZINC ION × 4 CAC CACODYLATE ION × 2 ACT ACETATE ION × 4 GLU GLUTAMIC ACID × 2 QSZ (4~{S})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide × 2 QSW (4~{R})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide × 2 GOL GLYCEROL × 6 CL CHLORIDE ION × 6	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；299 K；Zinc acetate, polyethylene glycol 4000, cacodylate	分辨率 1.90 Å R-free 0.187
6ZYU Structure of the GluA2 ligand-binding domain (L483Y-N754S) in complex with glutamate and BPAM549 提交 2020-08-03	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 B 413–527（115 aa）链 B 653–797（145 aa）链 C 413–527（115 aa）链 C 653–797（145 aa）	突变：L483Y,N754S 突变：L483Y,N754S 突变：L483Y,N754S 突变：L483Y,N754S	ZN ZINC ION × 6 ACT ACETATE ION × 3 GLU GLUTAMIC ACID × 2 QSZ (4~{S})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide × 2 QSW (4~{R})-4-cyclopropyl-7-fluoranyl-3,4-dihydro-2~{H}-thiochromene 1,1-dioxide × 2 GOL GLYCEROL × 3 CL CHLORIDE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；299 K；Zinc acetate, polyethylene glycol 4000, cacodylate	分辨率 1.90 Å R-free 0.187
7OCA Resting state full-length GluA1/A2 heterotertramer in complex with TARP gamma 8 and CNIH2 提交 2021-04-26	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 其他组合异源复合物；蛋白 × 8 PDB 声明：octameric	链 B 1–860（860 aa）链 D 1–860（860 aa）	未记录	E2Q 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 46 CLR CHOLESTEROL × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.40 Å
7OCC NTD of resting state GluA1/A2 heterotertramer 提交 2021-04-26	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 其他组合异源复合物；蛋白 × 2 PDB 声明：dimeric	链 D 1–860（860 aa）	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.40 Å
7OCC NTD of resting state GluA1/A2 heterotertramer 提交 2021-04-26	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 2 其他组合异源复合物；蛋白 × 2 PDB 声明：dimeric	链 B 1–860（860 aa）	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 3	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.40 Å
7OCD Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8 (LBD-TMD) 提交 2021-04-26	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 B 1–860（860 aa）链 D 1–860（860 aa）	未记录	E2Q 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 6	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.50 Å
7OCE Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) 提交 2021-04-26	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 B 1–860（860 aa）链 D 1–860（860 aa）	未记录	E2Q 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 46 CLR CHOLESTEROL × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.10 Å
7OCF Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD) 提交 2021-04-26	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 B 1–860（860 aa）链 D 1–860（860 aa）	未记录	CYZ CYCLOTHIAZIDE × 4 PC1 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 26 GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.60 Å
7QHB Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ 提交 2021-12-11	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 B 1–860（860 aa）链 D 1–860（860 aa）	未记录	PAM PALMITOLEIC ACID × 14 GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 2 79N (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；25 mM TRIS 150 mM NaCl 0.02 % GDN 87 uM CTZ 100 mM L-Glu cryo-EM玻璃化条件冷冻剂 ETHANE；3-4 second blots	分辨率 3.50 Å
7QHH Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD) 提交 2021-12-12	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 B 1–860（860 aa）链 D 1–860（860 aa）	未记录	GLU GLUTAMIC ACID × 4 PAM PALMITOLEIC ACID × 10 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 2 79N (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；25 mM TRIS 150 mM NaCl 0.02 % GDN 87 uM CTZ 100 mM L-Glu cryo-EM玻璃化条件冷冻剂 ETHANE；3-4 second blots	分辨率 3.60 Å
7RYY Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist glutamate 提交 2021-08-26	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；25 mM glutamate was added to the purified protein and incubated on ice for 30 min before sample preparation	分辨率 4.40 Å
7RYZ Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit GSG1L bound to agonist quisqualate 提交 2021-08-26	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；1mM Quisqualate was added to the purified protein and incubated on ice for 30 min before sample preparation	分辨率 4.15 Å
7RZ4 Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK 200775 提交 2021-08-27	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 24	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；0.1mM ZK was added to the purified protein and incubated on ice for 30 min before sample preparation	分辨率 3.60 Å
7RZ5 Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK 200775 提交 2021-08-27	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 24	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；0.1mM ZK was added to the purified protein and incubated on ice for 30 min before sample preparation	分辨率 3.30 Å
7RZ6 Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist glutamate 提交 2021-08-27	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 2 GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；25 mM glutamate was added to the purified protein and incubated on ice for 30 min before sample preparation	分辨率 4.40 Å
7RZ7 Structure of the complex of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist Quisqualate 提交 2021-08-27	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；1 mM Quisqualate was added to the purified protein and incubated on ice for 30 min before sample preparation	分辨率 4.20 Å
7RZ8 Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit TARP gamma-5 bound to agonist quisqualate 提交 2021-08-27	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 22 QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；1 mM Quisqualate was added to the purified protein and incubated on ice for 30 min before sample preparation	分辨率 4.10 Å
7RZ9 Structure of the complex of AMPA receptor GluA2 with auxiliary subunit GSG1L in the apo state 提交 2021-08-27	构建体不同聚集状态不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.15 Å
7RZA Structure of the complex of AMPA receptor GluA2 with auxiliary subunit GSG1L bound to agonist quisqualate 提交 2021-08-27	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；1mM Quisqualate was added to the purified protein and incubated on ice for 30 min before sample preparation	分辨率 4.26 Å
7TNK Complex GNNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM) 提交 2022-01-21	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	GLU GLUTAMIC ACID × 1 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.50 Å
7TNL Complex GNGN1 of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM) 提交 2022-01-21	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	GLU GLUTAMIC ACID × 2 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.59 Å
7TNM Complex GNGN2 of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM) 提交 2022-01-21	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	GLU GLUTAMIC ACID × 2 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.74 Å
7TNN Complex GGNN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM) 提交 2022-01-21	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	GLU GLUTAMIC ACID × 2 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.91 Å
7TNO Complex GGGN of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM) 提交 2022-01-21	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	GLU GLUTAMIC ACID × 3 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.02 Å
7TNP Complex GGGG of AMPA-subtype iGluR GluA2 in complex with auxiliary subunit gamma2 (Stargazin) at low glutamate concentration (20 uM) in the presence of cyclothiazide (100 uM) 提交 2022-01-21	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.96 Å
8AYL Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059 提交 2022-09-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 B 1–860（860 aa）链 D 1–860（860 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 PLM PALMITIC ACID × 8 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 6 OIJ 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.20 Å
8AYM Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118 提交 2022-09-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 B 1–860（860 aa）链 D 1–860（860 aa）	未记录	XVD 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol × 2 PLM PALMITIC ACID × 14 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 6 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.30 Å
8AYN Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand LY3130481 提交 2022-09-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 B 1–860（860 aa）链 D 1–860（860 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 PLM PALMITIC ACID × 14 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 4 OLR 6-[(1~{S})-1-[1-[5-(2-hydroxyethyloxy)pyridin-2-yl]pyrazol-3-yl]ethyl]-3~{H}-1,3-benzothiazol-2-one × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.80 Å
8AYO Open state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059 提交 2022-09-02	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 6 PDB 声明：hexameric	链 B 1–860（860 aa）链 D 1–860（860 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 PLM PALMITIC ACID × 10 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 2 OIJ 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.30 Å
8C1R Resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma-2 提交 2022-12-21	配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PLM PALMITIC ACID × 7 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 5	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.20 Å
8C1S Transmembrane domain of resting state homomeric GluA2 F231A mutant AMPA receptor in complex with TARP gamma 2 提交 2022-12-21	配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	PLM PALMITIC ACID × 6 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.00 Å
8FP4 GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 500mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na610) 提交 2023-01-04	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 B 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 C 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 D 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification	未记录	CL CHLORIDE ION × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.40 Å
8FP9 GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) 提交 2023-01-04	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion	CA CALCIUM ION × 1 CL CHLORIDE ION × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100 mM) and cyclothiazide (CTZ, 0.33 mM) were added before freezing. The 1 M L-glutamic acid stock solution was adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.44 Å
8FPC Conformation 1 of the ligand binding domain (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) 提交 2023-01-04	突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100 mM) and cyclothiazide (CTZ, 0.33 mM) were added before freezing. The 1 M L-glutamic acid stock solution was adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.78 Å
8FPG GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg) 提交 2023-01-04	突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion	CL CHLORIDE ION × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 0.1 mM) and cyclothiazide (CTZ, 0.33 mM) were added before freezing. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.32 Å
8FPH Conformation 2 of the ligand binding domain (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) 提交 2023-01-04	突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100 mM) and cyclothiazide (CTZ, 330 uM) were added before freezing. The 1 M L-glutamic acid stock solution was adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.14 Å
8FPK LBD conformation 1 of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg) 提交 2023-01-04	突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion	Y4Y 6-(aminomethyl)-7-nitro-1,4-dihydroquinoxaline-2,3-dione × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, 0.1 mM) and cyclothiazide (CTZ, 0.33 mM) were added before freezing. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.76 Å
8FPL LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg) 提交 2023-01-04	突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion 突变：FLAG epitope tag (DYKDDDDK) insertion	Y4Y 6-(aminomethyl)-7-nitro-1,4-dihydroquinoxaline-2,3-dione × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, final conc. 0.1mM) and cyclothiazide (CTZ, final conc. 0.33mM) was added before freezing. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.81 Å
8FPS GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K) 提交 2023-01-05	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 B 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 C 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 D 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification	突变：N619K 突变：N619K 突变：N619K 突变：N619K	CL CHLORIDE ION × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.38 Å
8FPV LBD conformation 1 (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 500mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na610) 提交 2023-01-05	聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.08 Å
8FPY LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 500mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na610) 提交 2023-01-05	聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.98 Å
8FPZ LBD conformation 3 (LBDconf3) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 500mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na610) 提交 2023-01-05	聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.01 Å
8FQ1 GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 150mM CaCl2, 330uM CTZ, and 100mM L-glutamate (Open-Ca150) 提交 2023-01-05	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 B 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 C 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 D 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification	非标准单体：是（mmCIF未提供具体位点）非标准单体：是（mmCIF未提供具体位点）非标准单体：是（mmCIF未提供具体位点）非标准单体：是（mmCIF未提供具体位点）	CA CALCIUM ION × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 5.59 Å
8FQ2 LBD conformation 1 (LBDconf1) of GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K) 提交 2023-01-05	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 B 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 C 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 D 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification	突变：N619K 突变：N619K 突变：N619K 突变：N619K	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.14 Å
8FQ3 LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K) 提交 2023-01-05	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 B 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 C 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 D 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification	突变：N619K 突变：N619K 突变：N619K 突变：N619K	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.17 Å
8FQ5 GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Na110) 提交 2023-01-05	配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	CL CHLORIDE ION × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.34 Å
8FQ6 LBD of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 150mM CaCl2, 330uM CTZ, and 100mM L-glutamate (Open-Ca150) 提交 2023-01-05	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 B 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 C 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 D 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.14 Å
8FQ8 LBD conformation 1 (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Na110) 提交 2023-01-05	聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) were added before freezing. The 1 M L-glutamic acid stock solution was adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.11 Å
8FQA LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Na110) 提交 2023-01-05	聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.35 Å
8FQB GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 10mM CaCl2, 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Ca10) 提交 2023-01-05	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 B 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 C 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification 链 D 1–883（883 aa）片段：DYKDDDDK near the C-terminal is a FLAG epitope tag used for purification	未记录	CA CALCIUM ION × 1 CL CHLORIDE ION × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.36 Å
8FQD LBD conformation 1 (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 10mM CaCl2, 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Ca10) 提交 2023-01-06	聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.01 Å
8FQE LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma2, with 10mM CaCl2, 140mM NMDG, 330uM CTZ, and 100mM L-glutamate (Open-Ca10) 提交 2023-01-06	聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.14 Å
8FQF GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na260) 提交 2023-01-06	配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	CL CHLORIDE ION × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.29 Å
8FQG LBD conformation 1 (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na260) 提交 2023-01-06	聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.01 Å
8FQH LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na260) 提交 2023-01-06	聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.43 Å
8FR0 LBD conformation 3 (LBDconf3) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na260) 提交 2023-01-06	聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；L-glutamic acid (100mM) and cyclothiazide (CTZ, 0.33mM) was added before freezing. The 1M L-glutamic acid stock solution is adjusted to pH 7.4 using NaOH. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.04 Å
8P3Q Homomeric GluA2 flip R/G-unedited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 3 提交 2023-05-18	配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	PLM PALMITIC ACID × 7 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 5	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.95 Å
8P3S Homomeric GluA2 flip R/G-unedited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 2 提交 2023-05-18	配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	PLM PALMITIC ACID × 7 OLC (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 5	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.95 Å
8P3X Homomeric GluA2 flip R/G-edited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 1 提交 2023-05-18	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	突变：F231A 突变：F231A 突变：F231A 突变：F231A	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.36 Å
8P3Y Homomeric GluA2 flip R/G-edited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 3 提交 2023-05-18	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	突变：F231A 突变：F231A 突变：F231A 突变：F231A	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.55 Å
8P3Z Homomeric GluA2 flip R/G-edited Q/R-edited F231A mutant in tandem with TARP gamma-2, desensitized conformation 2 提交 2023-05-18	突变/修饰不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	突变：F231A 突变：F231A 突变：F231A 突变：F231A	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.46 Å
8QEZ Crystal structure of the AMPA receptor GluA2-L504Y-N775S ligand binding domain in complex with L-glutamate and positive allosteric modulator BPAM395 at 1.55A resolution 提交 2023-09-01	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 A 413–527（115 aa）链 A 653–797（145 aa）链 B 413–527（115 aa）链 B 653–797（145 aa）	突变：L504Y,N775S 突变：L504Y,N775S 突变：L504Y,N775S 突变：L504Y,N775S	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 5 ACT ACETATE ION × 7 UF5 6-chloranyl-4-cyclopropyl-2,3-dihydrothieno[3,2-e][1,2,4]thiadiazine 1,1-dioxide × 2 CL CHLORIDE ION × 2 GOL GLYCEROL × 1	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；15.2% PEG4000, 0.1M Zn Acetate, 0.1M Cacodylate pH 6.5	分辨率 1.55 Å R-free 0.195
8QEZ Crystal structure of the AMPA receptor GluA2-L504Y-N775S ligand binding domain in complex with L-glutamate and positive allosteric modulator BPAM395 at 1.55A resolution 提交 2023-09-01	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验方法不同实验环境不同结构质量不同	Assembly 2 蛋白同源多聚体同源多聚体；蛋白 × 2 PDB 声明：dimeric	链 C 413–527（115 aa）链 C 653–797（145 aa）	突变：L504Y,N775S 突变：L504Y,N775S	GLU GLUTAMIC ACID × 2 ZN ZINC ION × 4 ACT ACETATE ION × 2 UF5 6-chloranyl-4-cyclopropyl-2,3-dihydrothieno[3,2-e][1,2,4]thiadiazine 1,1-dioxide × 2 CL CHLORIDE ION × 2 GOL GLYCEROL × 6 CAC CACODYLATE ION × 2	X-RAY DIFFRACTION X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP；pH 6.5；279 K；15.2% PEG4000, 0.1M Zn Acetate, 0.1M Cacodylate pH 6.5	分辨率 1.55 Å R-free 0.195
8SS2 Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state) 提交 2023-05-08	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 26 CLR CHOLESTEROL × 2 AJP Digitonin × 2 SPD SPERMIDINE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；vitrification carried out in nitrogen atmosphere	分辨率 3.58 Å
8SS3 Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state) 提交 2023-05-08	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 50 CLR CHOLESTEROL × 4 AJP Digitonin × 6 SPD SPERMIDINE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；vitrification carried out in nitrogen atmosphere	分辨率 3.21 Å
8SS4 Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 (apo state) 提交 2023-05-08	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	SPD SPERMIDINE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；vitrification carried out in nitrogen atmosphere	分辨率 3.30 Å
8SS5 Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 (apo state) 提交 2023-05-08	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	NA SODIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；vitrification carried out in nitrogen atmosphere	分辨率 3.56 Å
8SS6 Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state) 提交 2023-05-08	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	6ZP 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile × 4 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 28 CLR CHOLESTEROL × 8 NA SODIUM ION × 1 SPD SPERMIDINE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；vitrification carried out in nitrogen atmosphere	分辨率 3.01 Å
8SS7 Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state) 提交 2023-05-08	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	6ZP 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile × 4 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 28 CLR CHOLESTEROL × 8 NA SODIUM ION × 1 SPD SPERMIDINE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；vitrification carried out in nitrogen atmosphere	分辨率 2.76 Å
8SS8 Structure of AMPA receptor GluA2 complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state) 提交 2023-05-08	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	6ZP 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile × 4 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 NA SODIUM ION × 2 CLR CHOLESTEROL × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；vitrification carried out in nitrogen atmosphere	分辨率 2.81 Å
8SS9 Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state) 提交 2023-05-08	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	6ZP 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile × 4 ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 14 CLR CHOLESTEROL × 2 NA SODIUM ION × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；vitrification carried out in nitrogen atmosphere	分辨率 2.72 Å
8SSA Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state) 提交 2023-05-08	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 12 GLU GLUTAMIC ACID × 4 SPD SPERMIDINE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；vitrification carried out in nitrogen atmosphere	分辨率 3.88 Å
8SSB Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state) 提交 2023-05-08	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足异源复合物；蛋白 × 6 PDB 声明：hexameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	PCW 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE × 28 GLU GLUTAMIC ACID × 4 SPD SPERMIDINE × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE；vitrification carried out in nitrogen atmosphere	分辨率 3.66 Å
8VJ6 GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 1 提交 2024-01-05	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–842（818 aa）链 B 25–842（818 aa）链 C 25–842（818 aa）链 D 25–842（818 aa）	未记录	A1AB5 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.50 Å
8VJ7 GluA2 bound to GYKI-52466 and Glutamate, Inhibited State 2 提交 2024-01-05	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白同源多聚体同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–842（818 aa）链 B 25–842（818 aa）链 C 25–842（818 aa）链 D 25–842（818 aa）	未记录	GLU GLUTAMIC ACID × 4 A1AB5 4-[(5S,8R)-8-methyl-6,7,8,9-tetrahydro-2H,5H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl]aniline × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.85 Å
9B5Z GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of LBD-TMD-TARPgamma2 提交 2024-03-23	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.71 Å
9B61 GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of LBD-TMD-TARPgamma2 提交 2024-03-23	实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl. 4 micro litter of protein in buffer was mixed with 1 micro litter of 50mM citric acid buffer (the 50mM citric acid buffer was prepared by diluting 0.5M citric acid/sodium citrate buffer at pH4.0) immediately before applying the sample to the grid. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.81 Å
9B63 GluA2 flip Q in complex with TARPgamma2 at pH5, consensus structure of TMD-TARPgamma2 提交 2024-03-23	实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl. 4 micro litter of protein in buffer was mixed with 1 micro litter of 50mM citric acid buffer (the 50mM citric acid buffer was prepared by diluting 0.5M citric acid/sodium citrate buffer at pH4.0) immediately before applying the sample to the grid. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 2.76 Å
9B64 GluA2 flip Q in complex with TARPgamma2 at pH5, class23, structure of LBD-TMD-TARPgamma2 提交 2024-03-23	实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl. 4 micro litter of protein in buffer was mixed with 1 micro litter of 50mM citric acid buffer (the 50mM citric acid buffer was prepared by diluting 0.5M citric acid/sodium citrate buffer at pH4.0) immediately before applying the sample to the grid. cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.56 Å
9B67 GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of LBD-TMD-TARPgamma2 提交 2024-03-23	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.39 Å
9B68 GluA2 flip Q in complex with TARPgamma2 at pH8, class1, structure of NTD 提交 2024-03-23	聚集状态不同配体/离子不同结构质量不同	Assembly 1 其他组合同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.60 Å
9B69 GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of NTD 提交 2024-03-23	聚集状态不同配体/离子不同结构质量不同	Assembly 1 其他组合同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.69 Å
9B6A GluA2 flip Q in complex with TARPgamma2 at pH8, class12, structure of LBD-TMD-TARPgamma2 提交 2024-03-23	结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 1–883（883 aa）链 B 1–883（883 aa）链 C 1–883（883 aa）链 D 1–883（883 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；Tris adjusted to pH 8 using HCl cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.35 Å
9DHP Resting state 1 of the GluA2-gamma2 complex 提交 2024-09-04	构建体不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 412–841（430 aa）链 B 412–841（430 aa）链 C 412–841（430 aa）链 D 412–841（430 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.18 Å
9DHQ Resting state 2 of the GluA2-gamma2 complex 提交 2024-09-04	构建体不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 412–841（430 aa）链 B 412–841（430 aa）链 C 412–841（430 aa）链 D 412–841（430 aa）	未记录	未记录非水小分子	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.78 Å
9DHR Glutamate activated state of the GluA2-gamma2 complex 提交 2024-09-04	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 412–841（430 aa）链 B 412–841（430 aa）链 C 412–841（430 aa）链 D 412–841（430 aa）	未记录	GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.54 Å
9DHS Desensitized state 1 of the GluA2-gamma2 complex 提交 2024-09-04	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 412–841（430 aa）链 B 412–841（430 aa）链 C 412–841（430 aa）链 D 412–841（430 aa）	未记录	GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.48 Å
9DHT Desensitized state 2 of the GluA2-gamma2 complex 提交 2024-09-04	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 412–841（430 aa）链 B 412–841（430 aa）链 C 412–841（430 aa）链 D 412–841（430 aa）	未记录	GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.31 Å
9E4Y GluA2-gamma2 complex bound to memantine, glutamate, and cyclothiazide 提交 2024-10-25	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 25–841（817 aa）链 B 25–841（817 aa）链 C 25–841（817 aa）链 D 25–841（817 aa）	未记录	377 Memantine × 1 GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.30 Å
9E4Z GluA2-gamma2 complex bound glutamate and cyclothiazide 提交 2024-10-25	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 25–841（817 aa）链 B 25–841（817 aa）链 C 25–841（817 aa）链 D 25–841（817 aa）	未记录	GLU GLUTAMIC ACID × 4 CYZ CYCLOTHIAZIDE × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.70 Å
9E9D Structure of full length AMPA receptor GluA2 and auxiliary subunit TARP gamma-2 in complex with anti-miR 17 oligonucleotide RGLS4326 提交 2024-11-08	构建体不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	未记录	A1BX3 O-{[(1S,3S,4R,6S,7R)-7-{[(R)-{[(1R,3R,4R,6S,7R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-1-yl]methoxy}(sulfanyl)phosphoryl]oxy}-3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-1-yl]methyl} O-[(2R,3S,4R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxy-2-methyloxolan-3-yl] hydrogen (R)-phosphorothioate × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.24 Å
9E9E Structure of AMPA receptor GluA2 and auxiliary subunit TARP gamma-2 (LBD-TMD) in complex with anti-miR 17 oligonucleotide RGLS4326 提交 2024-11-08	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 信息不足同源多聚体；蛋白 × 4 PDB 声明：tetrameric	链 A 25–847（823 aa）链 B 25–847（823 aa）链 C 25–847（823 aa）链 D 25–847（823 aa）	突变：N48D 突变：N48D 突变：N48D 突变：N48D	A1BX3 O-{[(1S,3S,4R,6S,7R)-7-{[(R)-{[(1R,3R,4R,6S,7R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-7-hydroxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-1-yl]methoxy}(sulfanyl)phosphoryl]oxy}-3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-1-yl]methyl} O-[(2R,3S,4R,5S)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-methoxy-2-methyloxolan-3-yl] hydrogen (R)-phosphorothioate × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.24 Å
9MRK Glutamate activated state of the GluA2-gamma2 complex prepared at 37 degrees C 提交 2025-01-08	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 412–841（430 aa）链 B 412–841（430 aa）链 C 412–841（430 aa）链 D 412–841（430 aa）	未记录	GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.62 Å
9MRL Desensitized state 1 of the GluA2-gamma2 complex prepared at 37 degrees C 提交 2025-01-08	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 412–841（430 aa）链 B 412–841（430 aa）链 C 412–841（430 aa）链 D 412–841（430 aa）	未记录	GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.17 Å
9MRM Desensitized state 2 of the GluA2-gamma2 complex prepared at 37 degrees C 提交 2025-01-08	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 412–841（430 aa）链 B 412–841（430 aa）链 C 412–841（430 aa）链 D 412–841（430 aa）	未记录	GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.52 Å
9MRN Consensus glutamate activated state of the GluA2-gamma2 complex 提交 2025-01-08	构建体不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 A 412–841（430 aa）链 B 412–841（430 aa）链 C 412–841（430 aa）链 D 412–841（430 aa）	未记录	GLU GLUTAMIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.46 Å
9OVT Heteromeric GluA1/A2 in the inactive state, composite map of LBD-TMD 提交 2025-05-31	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 B 413–841（429 aa）链 D 413–841（429 aa）	未记录	ZK1 {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid × 4 NA SODIUM ION × 3	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；150 mM NaCl, 20 mM Tris-HCl pH 8.0, and 0.05% digitonin, 100 uM ZK-200775 cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.43 Å
9OVU Composite map of GluA1/A2 in the activated state, in complex with positive allosteric modulator (R,R)-2b and agonist glutamate (ATD-LBD-TMD) 提交 2025-05-31	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 其他组合异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 B 1–847（847 aa）链 D 1–847（847 aa）	未记录	GLU GLUTAMIC ACID × 4 NA SODIUM ION × 1 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；150 mM NaCl, 20 mM Tris-HCl pH 8.0, and 0.05% digitonin, 500 uM (R,R)-2b, 1 mM glutamate cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.20 Å
9OVV Heteromeric GluA1/A2-CNIH1 in the activated state, composite map of LBD-TMD 提交 2025-05-31	构建体不同突变/修饰不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 8 PDB 声明：octameric	链 B 413–840（428 aa）链 D 413–840（428 aa）	未记录	GLU GLUTAMIC ACID × 4 POV (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate × 16 FWF N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide × 2 NA SODIUM ION × 1	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；150 mM NaCl, 20 mM Tris-HCl pH 8.0, and 0.05% digitonin, 500 uM (R,R)-2b, 1 mM glutamate cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 3.76 Å
9OVW Heteromeric GluA1/A2 in the desensitized state, composite map of ATD-LBD-TMD 提交 2025-05-31	构建体不同突变/修饰不同聚集状态不同配体/离子不同实验环境不同结构质量不同	Assembly 1 蛋白异源复合物异源复合物；蛋白 × 4 PDB 声明：tetrameric	链 B 25–841（817 aa）链 D 25–841（817 aa）	未记录	QUS (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID × 4	ELECTRON MICROSCOPY cryo-EM缓冲液 pH 8；150 mM NaCl, 20 mM Tris-HCl pH 8.0, and 0.05% digitonin, 1 mM quiqualate cryo-EM玻璃化条件冷冻剂 ETHANE	分辨率 4.91 Å

共 333 个其他 PDB 条目、482 个 assembly。打开独立比较页并筛选聚集状态

查看构建体与数据证据

UniProt名称	GRIA2_RAT
Isoform	P19491-2
PDB实体	2
链与序列区间	作者链 A； PDB构建体 1–889； UniProt 1–883 作者链 B； PDB构建体 1–889； UniProt 1–883 作者链 C； PDB构建体 1–889； UniProt 1–883 作者链 D； PDB构建体 1–889； UniProt 1–883

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。链映射与序列区间收在“数据证据”中；数据库内部编号、导入时间和 assembly 操作表达式仅用于维护，因此不在读者页面展示。

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

下载 Download SAXS (.dat) P(r) (.pr.out) CIF

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id	9b60
沉积日期 deposition_date	2024-03-23
结构标题 title	GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of TMD-TARPgamma2
关键词 keywords	AMPA receptor, ionotropic glutamate receptor, ion channel, auxiliary subunit, TRANSPORT PROTEIN; TRANSPORT PROTEIN
实验方法 method	ELECTRON MICROSCOPY

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3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

回转半径 Rg (Guinier) rg_guinier	36.43 Å
回转半径 Rg (电子) rg_electron	35.07 Å
零角强度 I(0) i0	287055000.00
分子量 molecular_weight	147860.0 kDa
排除体积 excluded_volume	189220 Å³
包络体积 envelope_volume	246760 Å³
水化壳体积 shell_volume	56286 Å³
包络直径 envelope_diameter	114.9 Å
壳层 Rg shell_rg	43.11 Å
包络 Rg envelope_rg	35.46 Å
形状 Rg shape_rg	35.03 Å
总 Rg total_rg	35.80 Å
总原子数 total_atoms	10439
残基数 n_residues	1348
球谐函数阶数 n_harmonics	20
q 范围 q_range	— – 0.5000 Å⁻¹
数据点数 n_points	101
壳层类型 shell_type	directional
溶剂电子密度 solvent_density	0.3340 e/Å³
壳层衬度 contrast_shell	0.0300 e/Å³
CRYSOL 版本 crysol_version	4.1.3

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4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

最大尺寸 Dmax dmax	111.9 Å
Rg (实空间) rg_real	36.19 Å
Rg 误差 (实空间) rg_real_error	0.56 Å
I(0) (实空间) i0_real	2.8710e+08
I(0) 误差 (实空间) i0_real_error	4.2730e+06
Rg (倒空间) rg_reciprocal	36.34 Å
I(0) (倒空间) i0_reciprocal	287100000.0000
解质量估计 total_estimate	0.8907
解质量评级 solution_quality	GOOD a GOOD solution
P(r) 峰数 n_peaks	1
主峰位置 r_peak_primary	49.4 Å
偏度 Skewness skewness	0.085
峰度 Kurtosis kurtosis	-0.421
角度范围 angular_range	— – 0.2150 Å⁻¹
当前正则化参数 α current_alpha	0.0001
最高正则化参数 α highest_alpha	22160000.0000
实空间数据点数 n_real_points	44
GNOM 版本 gnom_version	4.1.3
质量判据 quality_criteria	AN1: 0.000; Oscil: 0.897; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.978; Smooth: 0.906

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5. 晶体学与实验 5. Crystallography & Experiment

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6. 实体与聚合物信息 Entities & Polymers (2)

实体 1 Entity 1 polymer

描述 description	Voltage-dependent calcium channel gamma-2 subunit
分子量 formula_weight	35938.7 kDa
来源方法 src_method	man
拷贝数 entity_count	4

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	H,F,E,G
原子数 atom_count	10461

MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTDYWLYSRGVCKTKSVSENETSKKNEEVMTHSGLWRTCCLEGNFKGLCKQIDHFPEDADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPSKSDSKKNSYSYGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQASAITRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGVKGFNTLPSTEISMYTLSRDPLKAATTPTATYNSDRDNSFLQVHNCIQKDSKDSLHANTANRRTTPV

来源 Source

来源生物 organism	Mus musculus
通用名 common_name	house mouse
NCBI 分类编号 ncbi_taxonomy_id	10090
宿主生物 host_organism	Homo sapiens

实体 2 Entity 2 polymer

描述 description	Isoform Flip of Glutamate receptor 2
分子量 formula_weight	99617.5 kDa
来源方法 src_method	man
拷贝数 entity_count	4

聚合物 Polymer

聚合物类型 type	polypeptide(L)
链编号 strand_id	C,B,A,D

MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYDIATPKGSSLGTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSSQNSQNFATDYKDDDDKEGYNVYGIESVKI

来源 Source

来源生物 organism	Rattus norvegicus
通用名 common_name	Norway rat
NCBI 分类编号 ncbi_taxonomy_id	10116
宿主生物 host_organism	Homo sapiens

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8. 引用文献 (1)

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晶胞边长 a length_a	1.000 Å
晶胞边长 b length_b	1.000 Å
晶胞边长 c length_c	1.000 Å
晶胞夹角 α angle_alpha	90.00 °
晶胞夹角 β angle_beta	90.00 °
晶胞夹角 γ angle_gamma	90.00 °
晶胞分子数 Z z_pdb	—

空间群 space_group	P 1
空间群编号 int_tables_number	1
晶系 crystal_system	—

分辨率 resolution	2.57 Å
分辨率测定方法 resolution_method	—
颗粒数 num_particles	1108462

fit	/app/data/saxs_computation/b6/9b60/9b60.fit
pddf	/app/data/pr_computation/b6/9b60/9b60.pr.out
profile	/app/data/saxs_computation/b6/9b60/9b60.dat

GluA2 flip Q in complex with TARPgamma2 at pH8, consensus structure of TMD-TARPgamma2

1. 蛋白身份与相关结构 Protein Identity & Related Structures

Voltage-dependent calcium channel gamma-2 subunit

当前结构中的状态

数据库中的同蛋白其他状态

Isoform Flip of Glutamate receptor 2

当前结构中的状态

数据库中的同蛋白其他状态

SAXS 散射曲线 SAXS Profile

P(r) 距离分布 P(r) Distribution

2. 结构基本信息 2. Structure Basics

3. SAXS 参数 (CRYSOL 理论计算) 3. SAXS Parameters (CRYSOL)

4. P(r) 距离分布 (GNOM 反演) 4. P(r) Analysis (GNOM)

5. 晶体学与实验 5. Crystallography & Experiment

晶胞参数 Unit Cell

对称性 Symmetry

冷冻电镜 EM 3D

6. 实体与聚合物信息 Entities & Polymers (2)

实体 1 Entity 1 polymer

聚合物 Polymer

来源 Source

实体 2 Entity 2 polymer

聚合物 Polymer

来源 Source

8. 引用文献 (1)

9. 文件与曲线 (10)

Files (7)

Curves (3)