当前蛋白身份:P63000 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
1FOE CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1 提交 2000-08-27 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–177(177 aa) 片段:RESIDUES 1 TO 177 FROM HUMAN RAC1
未记录 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;277 K;PEG 3350, Li2SO4, MES, glycerol, pH 6.0, VAPOR DIFFUSION, temperature 277.0K
分辨率 2.80 Å R-free 0.293
1FOE CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1 提交 2000-08-27 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 1–177(177 aa) 片段:RESIDUES 1 TO 177 FROM HUMAN RAC1
未记录 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;277 K;PEG 3350, Li2SO4, MES, glycerol, pH 6.0, VAPOR DIFFUSION, temperature 277.0K
分辨率 2.80 Å R-free 0.293
1FOE CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1 提交 2000-08-27 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 F 1–177(177 aa) 片段:RESIDUES 1 TO 177 FROM HUMAN RAC1
未记录 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;277 K;PEG 3350, Li2SO4, MES, glycerol, pH 6.0, VAPOR DIFFUSION, temperature 277.0K
分辨率 2.80 Å R-free 0.293
1FOE CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1 提交 2000-08-27 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 H 1–177(177 aa) 片段:RESIDUES 1 TO 177 FROM HUMAN RAC1
未记录 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;277 K;PEG 3350, Li2SO4, MES, glycerol, pH 6.0, VAPOR DIFFUSION, temperature 277.0K
分辨率 2.80 Å R-free 0.293
1FOE CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1 提交 2000-08-27 Assembly 5 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 B 1–177(177 aa) 片段:RESIDUES 1 TO 177 FROM HUMAN RAC1
链 D 1–177(177 aa) 片段:RESIDUES 1 TO 177 FROM HUMAN RAC1
链 F 1–177(177 aa) 片段:RESIDUES 1 TO 177 FROM HUMAN RAC1
链 H 1–177(177 aa) 片段:RESIDUES 1 TO 177 FROM HUMAN RAC1
未记录 SO4 SULFATE ION × 4 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;277 K;PEG 3350, Li2SO4, MES, glycerol, pH 6.0, VAPOR DIFFUSION, temperature 277.0K
分辨率 2.80 Å R-free 0.293
1FOE CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1 提交 2000-08-27 Assembly 6 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 B 1–177(177 aa) 片段:RESIDUES 1 TO 177 FROM HUMAN RAC1
链 H 1–177(177 aa) 片段:RESIDUES 1 TO 177 FROM HUMAN RAC1
未记录 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;277 K;PEG 3350, Li2SO4, MES, glycerol, pH 6.0, VAPOR DIFFUSION, temperature 277.0K
分辨率 2.80 Å R-free 0.293
1FOE CRYSTAL STRUCTURE OF RAC1 IN COMPLEX WITH THE GUANINE NUCLEOTIDE EXCHANGE REGION OF TIAM1 提交 2000-08-27 Assembly 7 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 D 1–177(177 aa) 片段:RESIDUES 1 TO 177 FROM HUMAN RAC1
链 F 1–177(177 aa) 片段:RESIDUES 1 TO 177 FROM HUMAN RAC1
未记录 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;277 K;PEG 3350, Li2SO4, MES, glycerol, pH 6.0, VAPOR DIFFUSION, temperature 277.0K
分辨率 2.80 Å R-free 0.293
1G4U CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP BOUND TO RAC1 提交 2000-10-28 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 R 1–184(184 aa) 片段:RAC1 RESIDUES 1-184
突变:F78S MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 AF3 ALUMINUM FLUORIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.7;18 %PEG 400, 0.1M MES, 15mM sodium flouride, 0.1mM aluminum chloride, 2mM DTT, 2mM magnesium chloride, pH 5.7, VAPOR DIFFUSION, HANGING DROP
分辨率 2.30 Å R-free 0.258
1I4D CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP COMPLEXED WITH ARFAPTIN (P21) 提交 2001-02-20 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 D 1–192(192 aa)
未记录 MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 9;291 K;Tris, Peg20K, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
分辨率 2.50 Å R-free 0.298
1I4L CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP IN COMPLEX WITH ARFAPTIN (P41) 提交 2001-02-22 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 D 1–192(192 aa)
未记录 MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 9;291 K;Tris, PEG20K, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
分辨率 2.70 Å R-free 0.301
1I4L CRYSTAL STRUCTURE ANALYSIS OF RAC1-GDP IN COMPLEX WITH ARFAPTIN (P41) 提交 2001-02-22 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 D 1–192(192 aa)
未记录 MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 9;291 K;Tris, PEG20K, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
分辨率 2.70 Å R-free 0.301
1I4T CRYSTAL STRUCTURE ANALYSIS OF RAC1-GMPPNP IN COMPLEX WITH ARFAPTIN 提交 2001-02-23 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 D 1–192(192 aa)
突变:Q61L MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 9;291 K;Tris, PEG20K, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
分辨率 2.60 Å R-free 0.304
1I4T CRYSTAL STRUCTURE ANALYSIS OF RAC1-GMPPNP IN COMPLEX WITH ARFAPTIN 提交 2001-02-23 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 D 1–192(192 aa)
突变:Q61L MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 9;291 K;Tris, PEG20K, pH 9.0, VAPOR DIFFUSION, HANGING DROP, temperature 291K
分辨率 2.60 Å R-free 0.304
1MH1 SMALL G-PROTEIN 提交 1997-01-21 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 2–184(183 aa) 片段:RESIDUES 1 - 184
突变:M1P, F78S MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.8;pH 6.8
分辨率 1.38 Å R-free 0.205
1RYF Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase 提交 2003-12-22 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–201(201 aa) 片段:residues 1-201
未记录 MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.75 Å R-free 0.223
1RYF Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase 提交 2003-12-22 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 1–201(201 aa) 片段:residues 1-201
未记录 MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.75 Å R-free 0.223
1RYH Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase 提交 2003-12-22 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–201(201 aa) 片段:residues 1-201
未记录 MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.75 Å R-free 0.219
1RYH Alternative Splicing of Rac1 Generates Rac1b, a Self-activating GTPase 提交 2003-12-22 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 1–201(201 aa) 片段:residues 1-201
未记录 MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 1.75 Å R-free 0.219
2FJU Activated Rac1 bound to its effector phospholipase C beta 2 提交 2006-01-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa) 片段:residues 1-189
未记录 MG MAGNESIUM ION × 1 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;291 K;8% PEG 3350, pH 8.5, VAPOR DIFFUSION, SITTING DROP, temperature 291K
分辨率 2.20 Å R-free 0.226
2H7V Co-crystal structure of YpkA-Rac1 提交 2006-06-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–184(184 aa)
突变:F78S MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;295 K;100mM HEPES pH 6.5-7.5, 5%-8% PEGMME2000 micro seeding, VAPOR DIFFUSION, SITTING DROP, temperature 295K
分辨率 2.60 Å R-free 0.257
2H7V Co-crystal structure of YpkA-Rac1 提交 2006-06-04 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–184(184 aa)
突变:F78S MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;295 K;100mM HEPES pH 6.5-7.5, 5%-8% PEGMME2000 micro seeding, VAPOR DIFFUSION, SITTING DROP, temperature 295K
分辨率 2.60 Å R-free 0.257
2NZ8 N-terminal DHPH cassette of Trio in complex with nucleotide-free Rac1 提交 2006-11-22 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa) 片段:soluble part (residues 1-177)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 6;291 K;100 mM sodium cacodylate pH 5.5 to 6.5, 14 to 18% (w/v) PEG 8000, and 300-500 mM calcium acetate, pH 6.0, VAPOR DIFFUSION, temperature 291K
分辨率 2.00 Å R-free 0.249
2P2L Rac1-GDP-Zinc Complex 提交 2007-03-07 Assembly 1 蛋白同源多聚体 同源多聚体;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–184(184 aa)
链 B 1–184(184 aa)
链 C 1–184(184 aa)
未记录 ZN ZINC ION × 8 GDP GUANOSINE-5'-DIPHOSPHATE × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6;277 K;100mM MES pH6.0, 15mM ZnSO4, 10% PEGMME 550., VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 1.90 Å R-free 0.208
2P2L Rac1-GDP-Zinc Complex 提交 2007-03-07 Assembly 2 蛋白同源多聚体 同源多聚体;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 1–184(184 aa)
链 B 1–184(184 aa)
链 C 1–184(184 aa)
未记录 ZN ZINC ION × 16 GDP GUANOSINE-5'-DIPHOSPHATE × 6 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6;277 K;100mM MES pH6.0, 15mM ZnSO4, 10% PEGMME 550., VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 1.90 Å R-free 0.208
2RMK Rac1/PRK1 Complex 提交 2007-10-25 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–192(192 aa)
突变:Q61L MG MAGNESIUM ION × 1 GCP PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER × 1 SOLUTION NMR
NMR测量条件 pH 7.4;298 K;离子强度(mmCIF原始值)0.225;压力 ambient
NMR样品组成 0.6mM [U-13C; U-15N; U-2H] Rac1; 0.6mM PRK1 HR1b; 0.7mM PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER; 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR样品组成 0.6mM [U-100% 13C; U-100% 15N] Rac1; 0.6mM PRK1 HR1b; 0.7mM PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER; 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR样品组成 0.6mM [U-100% 15N] Rac1; 0.6mM PRK1 HR1b; 0.7mM PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER; 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR样品组成 0.6mM [U-100% 13C; U-100% 15N] Rac1; 0.6mM PRK1 Rac1; 0.7mM PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER; 90% H2O, 10% D2O | 90% H2O/10% D2O
NMR样品组成 0.6mM [U-100% 15N] HR1b; 0.6mM PRK1 Rac1; 0.7mM PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER; 90% H2O, 10% D2O | 90% H2O/10% D2O
分辨率未提供
2VRW Critical structural role for the PH and C1 domains of the Vav1 exchange factor 提交 2008-04-16 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–184(184 aa) 片段:RESIDUES 1-184
未记录 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 pH 9;100MM BICINE PH9.0 10% PEG 6000
分辨率 1.85 Å R-free 0.251
2WKP Structure of a photoactivatable Rac1 containing Lov2 Wildtype 提交 2009-06-16 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 4–180(177 aa) 片段:NPH1-1, RESIDUES 404-546 AND P21-RAC1, RESIDUES 4-180
突变:YES GTP GUANOSINE-5'-TRIPHOSPHATE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 MG MAGNESIUM ION × 1 CA CALCIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 100 MM CA ACETATE, 100 MM SODIUM CACODYLATE PH 5.5, 12 % (W/V) PEG 8000
分辨率 1.90 Å R-free 0.195
2WKQ Structure of a photoactivatable Rac1 containing the Lov2 C450A Mutant 提交 2009-06-16 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 4–180(177 aa) 片段:NPH1-1 RESIDUES 404-546 AND P21-RAC1, RESIDUES 4-180
突变:YES GTP GUANOSINE-5'-TRIPHOSPHATE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 MG MAGNESIUM ION × 1 CL CHLORIDE ION × 3 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 100 MM POTASSIUM CHLORIDE, 5% (W/V) PEG 4000
分辨率 1.60 Å R-free 0.186
2WKR Structure of a photoactivatable Rac1 containing the Lov2 C450M Mutant 提交 2009-06-16 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 4–180(177 aa) 片段:NPH1-1, RESIDUES 404-546 AND P21-RAC1, RESIDUES 4-180
突变:YES GTP GUANOSINE-5'-TRIPHOSPHATE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 MG MAGNESIUM ION × 1 CL CHLORIDE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 18 % (V/V) PEG 600
分辨率 2.20 Å R-free 0.226
2YIN STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1. 提交 2011-05-16 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 1–177(177 aa) 片段:RESIDUES 1-177
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.5;293 K;0.1 M MES PH 6.5, 12% (W/V) PEG 3350, 10% (V/V) GLYCEROL AND 150 MM NACL. AT 20 C
分辨率 2.70 Å R-free 0.255
2YIN STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1. 提交 2011-05-16 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–177(177 aa) 片段:RESIDUES 1-177
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 pH 6.5;293 K;0.1 M MES PH 6.5, 12% (W/V) PEG 3350, 10% (V/V) GLYCEROL AND 150 MM NACL. AT 20 C
分辨率 2.70 Å R-free 0.255
3B13 Crystal structure of the DHR-2 domain of DOCK2 in complex with Rac1 (T17N mutant) 提交 2011-06-24 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 B 1–177(177 aa) 片段:GTPase domain (UNP RESIDUES 1-177)
链 D 1–177(177 aa) 片段:GTPase domain (UNP RESIDUES 1-177)
突变:T17N 突变:T17N 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8;293 K;100mM sodium citrate, 15% PEG 6000, pH 8.0, VAPOR DIFFUSION, SITTING DROP, temperature 293K
分辨率 3.01 Å R-free 0.234
3BJI Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1 提交 2007-12-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 1–177(177 aa) 片段:Rac1
未记录 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;298 K;17% PEG-3350, 100 mM HEPES, pH 7.5, 200 mM ammonium chloride, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.60 Å R-free 0.293
3BJI Structural Basis of Promiscuous Guanine Nucleotide Exchange by the T-Cell Essential Vav1 提交 2007-12-04 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–177(177 aa) 片段:Rac1
未记录 ZN ZINC ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;298 K;17% PEG-3350, 100 mM HEPES, pH 7.5, 200 mM ammonium chloride, VAPOR DIFFUSION, SITTING DROP, temperature 298K
分辨率 2.60 Å R-free 0.293
3RYT The Plexin A1 intracellular region in complex with Rac1 提交 2011-05-11 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–177(177 aa) 片段:UNP residues 1-177
突变:Q61L MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7;298 K;15% PEG1500, 100 mM SPG buffer, pH 7.0, VAPOR DIFFUSION, HANGING DROP, temperature 298K
分辨率 3.58 Å R-free 0.340
3SBD Crystal structure of RAC1 P29S mutant 提交 2011-06-03 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 2–177(176 aa)
突变:P29S GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;294 K;20% PEG4000, 7% isopropanol, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
分辨率 2.10 Å R-free 0.285
3SBD Crystal structure of RAC1 P29S mutant 提交 2011-06-03 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 2–177(176 aa)
突变:P29S GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;294 K;20% PEG4000, 7% isopropanol, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
分辨率 2.10 Å R-free 0.285
3SBE Crystal structure of RAC1 P29S mutant 提交 2011-06-03 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 2–177(176 aa)
突变:P29S GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;294 K;20% PEG4000, 7% isopropanol, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
分辨率 2.60 Å R-free 0.296
3SU8 Crystal structure of a truncated intracellular domain of Plexin-B1 in complex with Rac1 提交 2011-07-11 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa) 片段:UNP residues 1-177
未记录 MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 3.20 Å R-free 0.238
3SUA Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1 提交 2011-07-11 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa) 片段:UNP residues 1-177
未记录 MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 4.39 Å R-free 0.264
3SUA Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1 提交 2011-07-11 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–177(177 aa) 片段:UNP residues 1-177
未记录 MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 4.39 Å R-free 0.264
3SUA Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1 提交 2011-07-11 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–177(177 aa) 片段:UNP residues 1-177
未记录 MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 4.39 Å R-free 0.264
3SUA Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1 提交 2011-07-11 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 1–177(177 aa) 片段:UNP residues 1-177
链 B 1–177(177 aa) 片段:UNP residues 1-177
链 C 1–177(177 aa) 片段:UNP residues 1-177
未记录 MG MAGNESIUM ION × 3 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 3 X-RAY DIFFRACTION mmCIF 未提供已读取条件 分辨率 4.39 Å R-free 0.264
3TH5 Crystal structure of wild-type RAC1 提交 2011-08-18 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 2–177(176 aa) 片段:UNP residues 2-177
未记录 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;294 K;22% PEG4000, 7% isopropanol, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
分辨率 2.30 Å R-free 0.264
3TH5 Crystal structure of wild-type RAC1 提交 2011-08-18 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 2–177(176 aa) 片段:UNP residues 2-177
未记录 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;294 K;22% PEG4000, 7% isopropanol, 0.1M HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 294K
分辨率 2.30 Å R-free 0.264
4GZL Crystal structure of RAC1 Q61L mutant 提交 2012-09-06 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 2–177(176 aa) 片段:UNP residues 2-177
突变:Q61L GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 IPA ISOPROPYL ALCOHOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;296 K;16-18% PEG4000, 6% isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 296K
分辨率 2.00 Å R-free 0.250
4GZL Crystal structure of RAC1 Q61L mutant 提交 2012-09-06 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 2–177(176 aa) 片段:UNP residues 2-177
突变:Q61L GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;296 K;16-18% PEG4000, 6% isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 296K
分辨率 2.00 Å R-free 0.250
4GZM Crystal structure of RAC1 F28L mutant 提交 2012-09-06 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 2–177(176 aa) 片段:UNP residues 2-177
突变:F28L GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;296 K;16-18% PEG4000, 8% isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 296K
分辨率 2.80 Å R-free 0.288
4GZM Crystal structure of RAC1 F28L mutant 提交 2012-09-06 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 2–177(176 aa) 片段:UNP residues 2-177
突变:F28L GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;296 K;16-18% PEG4000, 8% isopropanol, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 296K
分辨率 2.80 Å R-free 0.288
4YON P-Rex1:Rac1 complex 提交 2015-03-11 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–177(177 aa) 片段:UNP residues 1-177
突变:G12V 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;293 K;0.1 sodium MES, pH 6.5, 0.2M sodium acetate, 15% (w/v) PEG 8000
分辨率 1.95 Å R-free 0.183
5FI0 Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 提交 2015-12-22 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–192(192 aa)
未记录 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;294 K;Sodium dihydrogen phosphate, PEG 8000
分辨率 3.28 Å R-free 0.235
5FI0 Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 提交 2015-12-22 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 1–192(192 aa)
未记录 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;294 K;Sodium dihydrogen phosphate, PEG 8000
分辨率 3.28 Å R-free 0.235
5FI0 Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 提交 2015-12-22 Assembly 3 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 F 1–192(192 aa)
未记录 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;294 K;Sodium dihydrogen phosphate, PEG 8000
分辨率 3.28 Å R-free 0.235
5FI0 Crystal Structure of the P-Rex1 DH/PH tandem in complex with Rac1 提交 2015-12-22 Assembly 4 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 H 1–192(192 aa)
未记录 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;294 K;Sodium dihydrogen phosphate, PEG 8000
分辨率 3.28 Å R-free 0.235
5HZH Crystal structure of photoinhibitable Rac1 containing C450A mutant LOV2 domain 提交 2016-02-02 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–47(47 aa)
链 A 48–180(133 aa)
突变:Q61L,Q61L,Q61L,Q61L,Q61L,Q61L,Q61L,Q61L,Q61L 突变:Q61L,Q61L,Q61L,Q61L,Q61L,Q61L,Q61L,Q61L,Q61L GTP GUANOSINE-5'-TRIPHOSPHATE × 1 FMN FLAVIN MONONUCLEOTIDE × 1 MG MAGNESIUM ION × 1 CA CALCIUM ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;293 K;0.2 M calcium acetate, 26% (w/v) PEG 3350
分辨率 2.60 Å R-free 0.255
5N6O Wild type human Rac1-GDP 提交 2017-02-15 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 2–177(176 aa)
未记录 GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;291.15 K;0,1 mM MES ph 6.5 PEG 3350 20%
分辨率 2.59 Å R-free 0.252
5N6O Wild type human Rac1-GDP 提交 2017-02-15 Assembly 2 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 2–177(176 aa)
未记录 GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;291.15 K;0,1 mM MES ph 6.5 PEG 3350 20%
分辨率 2.59 Å R-free 0.252
5O33 A structure of the GEF Kalirin DH1 domain in complex with the small GTPase Rac1 提交 2017-05-23 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 6 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.2;293 K;0.1M citrate pH4.2, 0.2M sodium chloride, 18% (W/V) PEG 8000
分辨率 1.64 Å R-free 0.240
5QQD PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with Z56880342 提交 2019-05-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 1 JGA N-ethyl-N'-(5-methyl-1,2-oxazol-3-yl)urea × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293.15 K;0.1M bis-tris pH 5.5 24% PEG 3350
分辨率 1.91 Å R-free 0.259
5QQE PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-531-494 提交 2019-05-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 1 N5S N-(5-methyl-1,2-oxazol-3-yl)-N'-[(3S)-4,4,4-trifluoro-3-hydroxy-3-(5-methylfuran-2-yl)butyl]urea × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293.15 K;0.1M bis-tris pH 5.5 24% PEG 3350
分辨率 1.95 Å R-free 0.284
5QQF PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-004-412-710 提交 2019-05-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 1 N5V N-ethyl-N'-1,3-thiazol-2-ylurea × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293.15 K;0.1M bis-tris pH 5.5 24% PEG 3350
分辨率 2.26 Å R-free 0.270
5QQG PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-541-216 提交 2019-05-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 1 N64 N-(5-methyl-1,2-oxazol-3-yl)-N'-[3-(4-phenylpiperazin-1-yl)propyl]urea × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293.15 K;0.1M bis-tris pH 5.5 24% PEG 3350
分辨率 2.23 Å R-free 0.274
5QQH PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-020-096-465 提交 2019-05-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 1 N67 N-methyl-5-({[(5-methyl-1,2-oxazol-3-yl)carbamoyl]amino}methyl)thiophene-2-sulfonamide × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293.15 K;0.1M bis-tris pH 5.5 24% PEG 3350
分辨率 2.09 Å R-free 0.263
5QQI PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-178-994 提交 2019-05-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 1 N6D N-[3-(methoxymethyl)phenyl]-N'-(5-methyl-1,2-oxazol-3-yl)urea × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293.15 K;0.1M bis-tris pH 5.5 24% PEG 3350
分辨率 2.08 Å R-free 0.277
5QQJ PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-587-558 提交 2019-05-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 1 N6J N-{1-[(imidazo[1,2-a]pyridin-2-yl)methyl]-1H-pyrazol-4-yl}-N'-(5-methyl-1,2-oxazol-3-yl)urea × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293.15 K;0.1M bis-tris pH 5.5 24% PEG 3350
分辨率 1.90 Å R-free 0.269
5QQK PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-359-835 提交 2019-05-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 1 N6V N-{1-[2-(diethylamino)ethyl]-1H-indol-5-yl}-N'-(5-methyl-1,2-oxazol-3-yl)urea × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293.15 K;0.1M bis-tris pH 5.5 24% PEG 3350
分辨率 2.24 Å R-free 0.266
5QQL PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-565-301 提交 2019-05-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 1 N71 N-(5-methyl-1,2-oxazol-3-yl)-N'-[2-(phenylsulfonyl)ethyl]urea × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293.15 K;0.1M bis-tris pH 5.5 24% PEG 3350
分辨率 2.25 Å R-free 0.270
5QQM PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-009-565-325 提交 2019-05-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 1 N74 N-(1-benzyl-1H-pyrazol-4-yl)-N'-(5-methyl-1,2-oxazol-3-yl)urea × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293.15 K;0.1M bis-tris pH 5.5 24% PEG 3350
分辨率 2.02 Å R-free 0.273
5QQN PanDDA analysis group deposition -- Crystal Structure of Kalirin/Rac1 in complex with MolPort-010-382-606 提交 2019-05-03 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 1 N5D N-cyclopropyl-2-(4-{[(5-methyl-1,2-oxazol-3-yl)carbamoyl]amino}-1H-pyrazol-1-yl)acetamide × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293.15 K;0.1M bis-tris pH 5.5 24% PEG 3350
分辨率 2.26 Å R-free 0.279
5QU9 PanDDA analysis group deposition of ground-state model of Kalirin/Rac1 screened against a customized urea fragment library by X-ray Crystallography at the XChem facility of Diamond Light Source beamline I04-1 提交 2019-12-13 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.5;293.15 K;0.1M bis-tris pH 5.5 24% PEG 3350
分辨率 2.00 Å R-free 0.231
6AGP Structure of Rac1 in the low-affinity state for Mg2+ 提交 2018-08-13 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–181(181 aa)
突变:E31C, D63C, Q74C, L160C GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 SOLUTION NMR
NMR测量条件 pH 7;313 K;离子强度(mmCIF原始值)0;压力 1
NMR样品组成 20 mM HEPES, 5 mM MgCl2, 0.5 mM GDP, 0.1 mM DSS, 90% H2O/10% D2O | 90% H2O/10% D2O
分辨率未提供
6BC1 A Complex between PH Domain of p190RhoGEF and Activated Rac1 Bound to a GTP Analog 提交 2017-10-20 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 2–177(176 aa)
未记录 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;293 K;22% PEG 3350, 100mM NaHEPES
分辨率 2.90 Å R-free 0.323
6BC1 A Complex between PH Domain of p190RhoGEF and Activated Rac1 Bound to a GTP Analog 提交 2017-10-20 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 2–177(176 aa)
未记录 GSP 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;293 K;22% PEG 3350, 100mM NaHEPES
分辨率 2.90 Å R-free 0.323
6TGC CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex. 提交 2019-11-15 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 C 1–192(192 aa)
链 F 1–192(192 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.10 Å
6X1G Crystal structure of a GEF domain from the Orientia tsutsugamushi protein OtDUB in complex with Rac1 提交 2020-05-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–177(177 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 MICROBATCH;pH 9.5;293 K;25 mM CHES pH 9.5, 25% (w/v) PEG 8000
分辨率 1.60 Å R-free 0.218
6X1G Crystal structure of a GEF domain from the Orientia tsutsugamushi protein OtDUB in complex with Rac1 提交 2020-05-18 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 1–177(177 aa)
未记录 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 MICROBATCH;pH 9.5;293 K;25 mM CHES pH 9.5, 25% (w/v) PEG 8000
分辨率 1.60 Å R-free 0.218
7AJK Crystal structure of CRYI-B Rac1 complex 提交 2020-09-29 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 BBB 2–177(176 aa)
未记录 MG MAGNESIUM ION × 1 GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;279 K;8% v/v PEG4,000 0.1M Tris pH 8.5 0.2M Sodium acetate
分辨率 3.10 Å R-free 0.282
7DPA Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex 提交 2020-12-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 B 1–177(177 aa)
链 E 1–177(177 aa)
突变:G15A 突变:G15A 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.80 Å
7SJ4 Human Trio residues 1284-1959 in complex with Rac1 提交 2021-10-15 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–192(192 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE;Blot force 10
分辨率 2.86 Å
7USD Cryo-EM structure of D-site Rac1-bound WAVE Regulatory Complex 提交 2022-04-25 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 F 1–188(188 aa)
突变:P29S, Q61L GTP GUANOSINE-5'-TRIPHOSPHATE × 1 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.00 Å
7USE Cryo-EM structure of WAVE regulatory complex with Rac1 bound on both A and D site 提交 2022-04-25 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 7 PDB 声明:heptameric(7) 与蛋白数一致
链 F 1–188(188 aa)
链 G 1–188(188 aa)
突变:P29S 突变:P29S, Q61L GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 2 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.00 Å
8I5V DOCK10 mutant L1903Y complexed with Rac1 提交 2023-01-26 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–177(177 aa)
未记录 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;293 K;ammonium sulfate, sodium cacodylate, PEG 8000, glycerol
分辨率 1.73 Å R-free 0.208
8I5W Crystal structure of the DHR-2 domain of DOCK10 in complex with Rac1 提交 2023-01-26 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–177(177 aa)
未记录 SO4 SULFATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;293 K;ammonium sulfate, sodium cacodylate, PEG 8000, glycerol
分辨率 2.43 Å R-free 0.280
8Q0N HACE1 in complex with RAC1 Q61L 提交 2023-07-28 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 1–192(192 aa)
突变:Q61L 04E iodoacetic acid × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.20 Å
8S1N Crystal structure of human Rac1-GDP 提交 2024-02-15 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–177(177 aa)
未记录 MG MAGNESIUM ION × 1 GDP GUANOSINE-5'-DIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;291.5 K;100 mM HEPES 7.0, 200 mM Calcium chloride, 20% PEG 6000
分辨率 1.80 Å R-free 0.258
8S1O Crystal structure of human Rac1-GDP-Pi 提交 2024-02-15 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–177(177 aa)
未记录 GDP GUANOSINE-5'-DIPHOSPHATE × 1 MG MAGNESIUM ION × 1 PO4 PHOSPHATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;292.15 K;100 mM SPG buffer pH 5 and 25% PEG 1500
分辨率 2.27 Å R-free 0.266
8ZJ2 Cryo-EM structure of the RhoG/DOCK5/ELMO1/Rac1 complex 提交 2024-05-14 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 7 PDB 声明:heptameric(7) 与蛋白数一致
链 C 1–177(177 aa)
链 G 1–177(177 aa)
突变:G15A 突变:G15A MG MAGNESIUM ION × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.66 Å
8ZJI Structure of DOCK5/ELMO1/Rac1 core (RhoG/DOCK5/ELMO1/Rac1 dataset, class 1) 提交 2024-05-15 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 C 1–177(177 aa)
链 F 1–177(177 aa)
突变:G15A 突变:G15A 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.23 Å
8ZJJ Structure of DOCK5/ELMO1/Rac1 core (RhoG/DOCK5/ELMO1/Rac1 dataset, class 2) 提交 2024-05-15 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 C 1–177(177 aa)
链 F 1–177(177 aa)
突变:G15A 突变:G15A 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.23 Å
8ZJK Structure of DOCK5/ELMO1/Rac1 core (RhoG/DOCK5/ELMO1/Rac1 dataset, class 3) 提交 2024-05-15 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 C 1–177(177 aa)
链 F 1–177(177 aa)
突变:G15A 突变:G15A 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.23 Å
8ZJL Structure of DOCK5/ELMO1/Rac1 core (RhoG/DOCK5/ELMO1/Rac1 dataset, class 4) 提交 2024-05-15 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 C 1–177(177 aa)
链 F 1–177(177 aa)
突变:G15A 突变:G15A 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.31 Å
8ZJM Structure of DOCK5/ELMO1/Rac1 core (RhoG/DOCK5/ELMO1/Rac1 dataset, class 5) 提交 2024-05-15 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 C 1–177(177 aa)
链 F 1–177(177 aa)
突变:G15A 突变:G15A 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.52 Å
9HU8 Crystal structure of Kalirin/Rac1 in complex with MC-278. 提交 2024-12-20 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 A1IXV 2-chloranyl-~{N}-(2-oxidanylidene-5,6,7,8-tetrahydro-1~{H}-1,8-naphthyridin-4-yl)ethanamide × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;293 K;0.1 M citrate pH 4.2, 0.2 M NaCl and 18 % PEG 8K
分辨率 1.48 Å R-free 0.231
9I1L Crystal structure of Kalirin/Rac1 in complex with RS-009 提交 2025-01-16 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 A1IZQ 2-chloranyl-~{N}-(6-oxidanylidene-1,7-dihydropyrrolo[2,3-b]pyridin-4-yl)ethanamide × 1 DMS DIMETHYL SULFOXIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;277 K;0.1 M bis-tris pH 5.5, 0.1 M NaCl, 27% PEG 3350
分辨率 1.68 Å R-free 0.269
9IFK Crystal structure of Kalirin/Rac1 in complex with DK-2 提交 2025-02-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 A1I32 2-chloranyl-~{N}-(2-oxidanylidene-1~{H}-quinolin-4-yl)ethanamide × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;277 K;0.1 M citrate pH 4.7, 0.8 M LiCl and 25% PEG 6K.
分辨率 1.34 Å R-free 0.235
9IG1 Crystal structure of Kalirin/Rac1 in complex with DK-652 提交 2025-02-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
未记录 A1I33 2-chloranyl-~{N}-(1-oxidanylidene-2~{H}-isoquinolin-7-yl)ethanamide × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;277 K;0.1 M bis-tris pH 5.5, 0.2 M NaCl and 25% PEG 3350
分辨率 1.65 Å R-free 0.293
9LX0 DOCK5/ELMO1 complex with RhoG and Rac1 on lipid membrane 提交 2025-02-17 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 D 1–188(188 aa)
链 H 1–188(188 aa)
突变:G15A, C189S 突变:G15A, C189S 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 6.98 Å
9RFB Crystal Structure of Human Rac1 in Complex with the Scaffold Protein POSH (residues 321-348) 提交 2025-06-04 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–177(177 aa)
非标准单体:是(mmCIF未提供具体位点) GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8;277 K;0.05 M phosphate, 20% (w/v) PEG 8000. RAC1 6 mg/mL , GMPPNP 1mM, POSH 3 mM
分辨率 1.85 Å R-free 0.226
9RFB Crystal Structure of Human Rac1 in Complex with the Scaffold Protein POSH (residues 321-348) 提交 2025-06-04 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–177(177 aa)
非标准单体:是(mmCIF未提供具体位点) GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 PO4 PHOSPHATE ION × 2 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8;277 K;0.05 M phosphate, 20% (w/v) PEG 8000. RAC1 6 mg/mL , GMPPNP 1mM, POSH 3 mM
分辨率 1.85 Å R-free 0.226
9RFF Crystal Structure of Human Rac1 Fused with the Scaffold Protein POSH (residues 319-371) 提交 2025-06-04 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–177(177 aa)
非标准单体:是(mmCIF未提供具体位点) GNP PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER × 1 MG MAGNESIUM ION × 1 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;277 K;0.12 M ethylene glycol, 0.1 M imidazole-MES pH 6.5, 37% (v/v) 2-methyl-2,4-pentanediol (MPD)-PEG 1000-PEG 3500 2 mg/mL Rac1-POSH
分辨率 1.25 Å R-free 0.164
9VM4 Structure of DOCK6-Rac1 complex protomer 提交 2025-06-27 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–177(177 aa)
突变:G15A 未记录非水小分子 ELECTRON MICROSCOPY mmCIF 未提供已读取条件 分辨率 4.20 Å
9VM5 Structure of DOCK6-Rac1 complex 提交 2025-06-27 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 B 1–177(177 aa)
链 D 1–177(177 aa)
突变:G15A 突变:G15A 未记录非水小分子 ELECTRON MICROSCOPY mmCIF 未提供已读取条件 分辨率 5.32 Å
9VM7 Structure of DOCK6 tetramer complexed with Rac1 提交 2025-06-27 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 B 1–177(177 aa)
链 D 1–177(177 aa)
链 F 1–177(177 aa)
链 H 1–177(177 aa)
突变:G15A 突变:G15A 突变:G15A 突变:G15A 未记录非水小分子 ELECTRON MICROSCOPY mmCIF 未提供已读取条件 分辨率 6.85 Å