当前蛋白身份:Q12306 重新检索
本组结构的主要差异维度
构建体不同 突变/修饰不同 组装状态不同 配体/离子不同 实验方法不同 实验环境不同 结构质量指标不同

差异标签只比较当前检索结果;所有PDB和assembly原始记录仍分别保留。

相关结构差异明细

一行代表一个 PDB 条目中的一个 biological assembly;同一蛋白的多个单体会分别列出。

PDB 条目 Assembly / 聚集状态 构建体 突变与修饰 配体、离子与非聚合物 实验方法 实验环境 结构质量
11HK SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to the VN01H1 Fab (Fab local refinement) 提交 2026-02-24 Assembly 1 信息不足 异源复合物;蛋白 × 9 PDB 声明:nonameric(9) 与蛋白数一致
链 A 1–94(94 aa)
链 D 1–94(94 aa)
链 G 1–94(94 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.70 Å
11HL SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to the VN01H1 Fab (S2 local refinement) 提交 2026-02-24 Assembly 1 信息不足 同源多聚体;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–94(94 aa)
链 B 1–94(94 aa)
链 C 1–94(94 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.80 Å
11HN SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to C77G12 (S2 local refinement) 提交 2026-02-24 Assembly 1 信息不足 同源多聚体;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–94(94 aa)
链 B 1–94(94 aa)
链 C 1–94(94 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 12 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.70 Å
11HW SARS-CoV-2 spike S2 trimer stabilized in the early fusion intermediate conformation (E-FICs-v3) bound to C77G12 (Fab local refinement) 提交 2026-02-25 Assembly 1 信息不足 异源复合物;蛋白 × 9 PDB 声明:nonameric(9) 与蛋白数一致
链 A 1–94(94 aa)
链 B 1–94(94 aa)
链 G 1–94(94 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.80 Å
1EUV X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO. 提交 2000-04-17 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 13–98(86 aa) 片段:SMT3 RESIDUES 13-98
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;294 K;0.1M MES pH6.5, 10% w/v polyethylene glycol 20000, 3% w/v 1,6-hexandiol, VAPOR DIFFUSION, HANGING DROP, temperature 294K
分辨率 1.60 Å R-free 0.251
1L2N Smt3 Solution Structure 提交 2002-02-22 Assembly 1 蛋白单体 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–101(101 aa)
未记录 未记录非水小分子 SOLUTION NMR
NMR测量条件 pH 6.5;293 K;压力 1
NMR样品组成 1 mM C13 and 15N Labelled | 90% H2O/10% D2O
分辨率未提供
2EKE Structure of a SUMO-binding-motif mimic bound to Smt3p-Ubc9p: conservation of a noncovalent Ubiquitin-like protein-E2 complex as a platform for selective interactions within a SUMO pathway 提交 2007-03-23 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 13–98(86 aa)
突变:thrombin site, Ubiquitin-like 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.5;277 K;18% PEG 3350, 0.2M magnesium chloride, 0.1M Bis-Tris, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 1.90 Å R-free 0.250
2EKE Structure of a SUMO-binding-motif mimic bound to Smt3p-Ubc9p: conservation of a noncovalent Ubiquitin-like protein-E2 complex as a platform for selective interactions within a SUMO pathway 提交 2007-03-23 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 13–98(86 aa)
突变:thrombin site, Ubiquitin-like 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.5;277 K;18% PEG 3350, 0.2M magnesium chloride, 0.1M Bis-Tris, pH 5.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 1.90 Å R-free 0.250
3PGE Structure of sumoylated PCNA 提交 2010-11-01 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 1–98(98 aa) 片段:sumo-C fragment of PCNA
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 5.6;291 K;2.0M Ammonium Sulfate, 0.1M sodium Citrate, pH 5.6, VAPOR DIFFUSION, HANGING DROP, temperature 291K
分辨率 2.80 Å R-free 0.253
3QHT Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO 提交 2011-01-26 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 2–98(97 aa)
未记录 GOL GLYCEROL × 8 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 8;292 K;14% PEG8000, 16% glycerol, pH 8.0, VAPOR DIFFUSION, temperature 292K
分辨率 2.40 Å R-free 0.272
3QHT Crystal Structure of the Monobody ySMB-1 bound to yeast SUMO 提交 2011-01-26 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 2–98(97 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 8;292 K;14% PEG8000, 16% glycerol, pH 8.0, VAPOR DIFFUSION, temperature 292K
分辨率 2.40 Å R-free 0.272
3TIX Crystal structure of the Chp1-Tas3 complex core 提交 2011-08-22 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 3–98(96 aa) 片段:N-TERMINAL DOMAIN,N-TERMINAL DOMAIN
未记录 CL CHLORIDE ION × 4 K POTASSIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.2;290 K;microseeding in 0.95 M potassium sodium tartrate, 100 mM MES, 180 mM sodium thiocyanate, pH 6.2, VAPOR DIFFUSION, HANGING DROP, temperature 290K
分辨率 2.90 Å R-free 0.243
3TIX Crystal structure of the Chp1-Tas3 complex core 提交 2011-08-22 Assembly 2 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 3–98(96 aa) 片段:N-TERMINAL DOMAIN,N-TERMINAL DOMAIN
未记录 CL CHLORIDE ION × 4 K POTASSIUM ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.2;290 K;microseeding in 0.95 M potassium sodium tartrate, 100 mM MES, 180 mM sodium thiocyanate, pH 6.2, VAPOR DIFFUSION, HANGING DROP, temperature 290K
分辨率 2.90 Å R-free 0.243
3UF8 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with a G95A surface mutation from Burkholderia pseudomallei complexed with FK506 提交 2011-10-31 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
突变:G95A FK5 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;290 K;Internal tracking number 226425. JCSG well A8. 0.2M Ammonium Formate, 20.0% w/v PEG3500, PEG400 Cryo. BupsA.00130.a.D242 PD00198 21.4mg/ml, pH 7.0, VAPOR DIFFUSION, SITTING DROP, temperature 290K
分辨率 1.50 Å R-free 0.183
3UQA Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation A54E from Burkholderia pseudomallei complexed with FK506 提交 2011-11-19 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
突变:A54E FK5 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN × 1 PEG DI(HYDROXYETHYL)ETHER × 1 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;290 K;Internal tracking number 226422. JCSG well A9. 0.2M Ammonium Chloride, 20.0% w/v PEG3500, 30% PEG400 Cryo. BupsA.00130.a.D220 PD00197 19.3mg/ml., pH 7.00, vapor diffusion, sitting drop, temperature 290K
分辨率 1.55 Å R-free 0.193
3UQB Crystal structure of a SMT Fusion PEPTIDYL-PROLYL CIS-TRANS ISOMERASE with surface mutation D44G from Burkholderia pseudomallei complexed with FK506 提交 2011-11-19 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
突变:D44G FK5 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 9;290 K;Internal tracking number 226421. PACT well B6. 0.1M MIB Buffer pH 9.0, 25.0% w/v PEG1500, 30% PEG400 Cryo. BUPSA.00130.A.D214 PD00190/6 23.7mg/ml, vapor diffusion, sitting drop, temperature 290K, VAPOR DIFFUSION, SITTING DROP
分辨率 1.90 Å R-free 0.228
3V60 Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164 提交 2011-12-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 20–98(79 aa) 片段:unp resicues 20-98
未记录 SO4 SULFATE ION × 18 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 4.5;291 K;4% PEG 8000, 500 mM LiSO4, pH 4.5, VAPOR DIFFUSION, HANGING DROP, temperature 291K
分辨率 2.60 Å R-free 0.249
3V61 Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164 提交 2011-12-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 20–98(79 aa) 片段:unp residues 20-98
未记录 BA BARIUM ION × 13 NEQ N-ETHYLMALEIMIDE × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;277 K;21% MPD, 100 mM BaCl2, 100 mM Bis-Tris, pH 6.5, VAPOR DIFFUSION, HANGING DROP, temperature 277K
分辨率 2.80 Å R-free 0.254
3V62 Structure of the S. cerevisiae Srs2 C-terminal domain in complex with PCNA conjugated to SUMO on lysine 164 提交 2011-12-18 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 20–98(79 aa) 片段:unp residues 20-98
突变:GSH from N-tag after thrombin cleavage, K19R 非标准单体:是(mmCIF未提供具体位点) NEQ N-ETHYLMALEIMIDE × 2 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;279 K;1.9 M AMMONIUM SULFATE 4% PEG 400 100 mM HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
分辨率 2.90 Å R-free 0.237
3V62 Structure of the S. cerevisiae Srs2 C-terminal domain in complex with PCNA conjugated to SUMO on lysine 164 提交 2011-12-18 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 D 20–98(79 aa) 片段:unp residues 20-98
突变:GSH from N-tag after thrombin cleavage, K19R 非标准单体:是(mmCIF未提供具体位点) NEQ N-ETHYLMALEIMIDE × 2 SO4 SULFATE ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;279 K;1.9 M AMMONIUM SULFATE 4% PEG 400 100 mM HEPES, pH 7.5, VAPOR DIFFUSION, HANGING DROP, temperature 279K
分辨率 2.90 Å R-free 0.237
3VAW Crystal structure of a smt fusion peptidyl-prolyl cis-trans isomerase with surface mutation v3i from burkholderia pseudomallei complexed with fk506 提交 2011-12-29 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–99(87 aa) 片段:Q12306 RESIDUES 13-99, Q3JK38 RESIDUES 2-113
突变:V3I,V3I FK5 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;290 K;Internal tracking number 226593. PACT well H3. 0.2M Sodium Iodide, 0.1M Bis-Tris Propane, pH 8.5, 20.0% w/v PEG3350, 30% PEG400 Cryo. BupsA.00130.a.D24 PD00194 19.6mg/ml., vapor diffusion, sitting drop, temperature 290K
分辨率 1.55 Å R-free 0.194
4FN2 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ37 提交 2012-06-19 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
突变:D44G 854 ethyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;295 K;Internal tracking number 233926b1. Puck VKT6-6, Morpheus well B1. 10% PEG 20,000, 20% PEG MME550, 0.03M Halides (NaF, NaBr, NaI), 0.1M MES/Imidazole pH 6.5, Direct Cryo. BupsA.00130.a.D214, 20.00 mg/ml, CJ37 (EBSI2854), vapor diffusion, sitting drop, temperature 295K
分辨率 1.95 Å R-free 0.224
4FN2 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ37 提交 2012-06-19 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
突变:D44G 854 ethyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;295 K;Internal tracking number 233926b1. Puck VKT6-6, Morpheus well B1. 10% PEG 20,000, 20% PEG MME550, 0.03M Halides (NaF, NaBr, NaI), 0.1M MES/Imidazole pH 6.5, Direct Cryo. BupsA.00130.a.D214, 20.00 mg/ml, CJ37 (EBSI2854), vapor diffusion, sitting drop, temperature 295K
分辨率 1.95 Å R-free 0.224
4G50 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ168 提交 2012-07-17 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
突变:D44G 861 3-(3,4,5-trimethoxyphenyl)propyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate × 1 FMT FORMIC ACID × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;295 K;Internal tracking number 233897a9. Puck VKT6-9, JCSG_A8 optimization. 50mM Ammonium formate, 24.55% PEG 3,350, 10% ethylene glycol. BupsA.00130.a.D214, 20.00 mg/ml, CJ168 (EBSI2861), pH 7.5, vapor diffusion, sitting drop, temperature 295K
分辨率 1.75 Å R-free 0.219
4G50 Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ168 提交 2012-07-17 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
突变:D44G 861 3-(3,4,5-trimethoxyphenyl)propyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate × 1 FMT FORMIC ACID × 2 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;295 K;Internal tracking number 233897a9. Puck VKT6-9, JCSG_A8 optimization. 50mM Ammonium formate, 24.55% PEG 3,350, 10% ethylene glycol. BupsA.00130.a.D214, 20.00 mg/ml, CJ168 (EBSI2861), pH 7.5, vapor diffusion, sitting drop, temperature 295K
分辨率 1.75 Å R-free 0.219
4GGQ Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with CJ40 提交 2012-08-07 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
未记录 CA CALCIUM ION × 1 861 3-(3,4,5-trimethoxyphenyl)propyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;295 K;Internal tracking number 235051a1. Puck IBH5-4, Morpheus well A1. 10% PEG 20,000, 20% PEG MME550, 0.03M Divalent Catios (MgCl2, CaCl2), 0.1M MES/Imidazole pH 6.5, Direct Cryo. BupsA.00130.a.D21, 20.00 mg/ml, CJ40 (EBSI2855), vapor diffusion, sitting drop, temperature 295K
分辨率 1.95 Å R-free 0.220
4GGQ Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with CJ40 提交 2012-08-07 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
未记录 CA CALCIUM ION × 1 861 3-(3,4,5-trimethoxyphenyl)propyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate × 1 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;295 K;Internal tracking number 235051a1. Puck IBH5-4, Morpheus well A1. 10% PEG 20,000, 20% PEG MME550, 0.03M Divalent Catios (MgCl2, CaCl2), 0.1M MES/Imidazole pH 6.5, Direct Cryo. BupsA.00130.a.D21, 20.00 mg/ml, CJ40 (EBSI2855), vapor diffusion, sitting drop, temperature 295K
分辨率 1.95 Å R-free 0.220
4GGQ Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with CJ40 提交 2012-08-07 Assembly 3 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
未记录 861 3-(3,4,5-trimethoxyphenyl)propyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;295 K;Internal tracking number 235051a1. Puck IBH5-4, Morpheus well A1. 10% PEG 20,000, 20% PEG MME550, 0.03M Divalent Catios (MgCl2, CaCl2), 0.1M MES/Imidazole pH 6.5, Direct Cryo. BupsA.00130.a.D21, 20.00 mg/ml, CJ40 (EBSI2855), vapor diffusion, sitting drop, temperature 295K
分辨率 1.95 Å R-free 0.220
4GGQ Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with CJ40 提交 2012-08-07 Assembly 4 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 D 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
未记录 861 3-(3,4,5-trimethoxyphenyl)propyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;295 K;Internal tracking number 235051a1. Puck IBH5-4, Morpheus well A1. 10% PEG 20,000, 20% PEG MME550, 0.03M Divalent Catios (MgCl2, CaCl2), 0.1M MES/Imidazole pH 6.5, Direct Cryo. BupsA.00130.a.D21, 20.00 mg/ml, CJ40 (EBSI2855), vapor diffusion, sitting drop, temperature 295K
分辨率 1.95 Å R-free 0.220
4GIV Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183 提交 2012-08-09 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
突变:D44G 4GI 3-(pyridin-3-yl)propyl (2S)-1-[(3-nitrophenyl)sulfonyl]piperidine-2-carboxylate × 1 FMT FORMIC ACID × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;295 K;Internal tracking number 232625a12. Puck IBH5-9, JCSG_A8 optimization screen. 50mM Ammonium Formate, 30% PEG3,350, 25% ethylene glycol cryo-protected. BupsA.00130.a.D214, 20.00 mg/ml, CJ183 (EBSI2864), pH 7.5, vapor diffusion, sitting drop, temperature 295K
分辨率 2.45 Å R-free 0.262
4GIV Crystal structure of a SMT fusion Peptidyl-prolyl cis-trans isomerase with surface mutation D44G from Burkholderia pseudomallei complexed with CJ183 提交 2012-08-09 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 13–98(86 aa) 片段:Q12306 residues 13-98, Q3JK38 residues 2-113
突变:D44G 4GI 3-(pyridin-3-yl)propyl (2S)-1-[(3-nitrophenyl)sulfonyl]piperidine-2-carboxylate × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;295 K;Internal tracking number 232625a12. Puck IBH5-9, JCSG_A8 optimization screen. 50mM Ammonium Formate, 30% PEG3,350, 25% ethylene glycol cryo-protected. BupsA.00130.a.D214, 20.00 mg/ml, CJ183 (EBSI2864), pH 7.5, vapor diffusion, sitting drop, temperature 295K
分辨率 2.45 Å R-free 0.262
5D6J Crystal structure of a mycobacterial protein 提交 2015-08-12 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 21–94(74 aa) 片段:UNP RESIDUES 21-94
未记录 MG MAGNESIUM ION × 1 ATP ADENOSINE-5'-TRIPHOSPHATE × 1 X-RAY DIFFRACTION
X-ray结晶条件 EVAPORATION;281 K;0.2 M sodium malonate, 20% PEG 3350
分辨率 2.25 Å R-free 0.206
5JNE E2-SUMO-Siz1 E3-SUMO-PCNA complex 提交 2016-04-29 Assembly 1 信息不足 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 20–98(79 aa) 片段:unp residues 167-445
链 C 19–98(80 aa)
突变:Siz1 C361D, Smt3 Delta N-terminus 1-18 突变:N-terminal 1-18 delete, K19R ZN ZINC ION × 1 GOL GLYCEROL × 6 6LN ethane-1,2-dithiol × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8.5;291 K;0.1 M Tris-HCl (pH 8.5), 5% PEG 10,000, 0.2 M NaCl, 10% glycerol, 3% dioxane
分辨率 2.85 Å R-free 0.250
5JNE E2-SUMO-Siz1 E3-SUMO-PCNA complex 提交 2016-04-29 Assembly 2 信息不足 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 E 20–98(79 aa) 片段:unp residues 167-445
链 G 19–98(80 aa)
突变:Siz1 C361D, Smt3 Delta N-terminus 1-18 突变:N-terminal 1-18 delete, K19R ZN ZINC ION × 1 GOL GLYCEROL × 4 6LN ethane-1,2-dithiol × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8.5;291 K;0.1 M Tris-HCl (pH 8.5), 5% PEG 10,000, 0.2 M NaCl, 10% glycerol, 3% dioxane
分辨率 2.85 Å R-free 0.250
5KLX Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110 提交 2016-06-26 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa) 片段:UNP Q12306 residues 13-98,UNP Q3JK38 residues 2-113
未记录 6UO 2-[(2~{S})-1-(phenylmethyl)sulfonylpiperidin-2-yl]carbonyloxyethyl pyridine-3-carboxylate × 1 MG MAGNESIUM ION × 1 IMD IMIDAZOLE × 1 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;289 K;BUPSA.00130.A.D21 (CID4597, SMT TAG ON, BATCH 1264062) AT 10.37MG/ML (IN 25MM TRIS, PH8.0, 200MM NACL, 1% GLYCEROL, 1MM TCEP BUFFER) WAS INCUBATED WITH 2MM SF110_S (BSI5665). CRYSTALS WERE PRODUCED BY SITTING DROP VAPOR IFFUSION WITH AN EQUAL VOLUME COMBINATION OF THE PROTEIN/LIGAND COMPLEX AND A SOLUTION CONTAINING 10% W/V PEG20,000, 20% V/V PEG MME 550, 0.03M MGCL2, 0.03M CACL2, 0.1M MES/IMIDAZOLE, PH6.5 (MORPHEUS A1). CRYSTAL TRACKING ID 273103A1, RVA0-10, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 289K
分辨率 2.45 Å R-free 0.256
5KLX Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110 提交 2016-06-26 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 13–98(86 aa) 片段:UNP Q12306 residues 13-98,UNP Q3JK38 residues 2-113
未记录 6UO 2-[(2~{S})-1-(phenylmethyl)sulfonylpiperidin-2-yl]carbonyloxyethyl pyridine-3-carboxylate × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;289 K;BUPSA.00130.A.D21 (CID4597, SMT TAG ON, BATCH 1264062) AT 10.37MG/ML (IN 25MM TRIS, PH8.0, 200MM NACL, 1% GLYCEROL, 1MM TCEP BUFFER) WAS INCUBATED WITH 2MM SF110_S (BSI5665). CRYSTALS WERE PRODUCED BY SITTING DROP VAPOR IFFUSION WITH AN EQUAL VOLUME COMBINATION OF THE PROTEIN/LIGAND COMPLEX AND A SOLUTION CONTAINING 10% W/V PEG20,000, 20% V/V PEG MME 550, 0.03M MGCL2, 0.03M CACL2, 0.1M MES/IMIDAZOLE, PH6.5 (MORPHEUS A1). CRYSTAL TRACKING ID 273103A1, RVA0-10, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 289K
分辨率 2.45 Å R-free 0.256
5KLX Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110 提交 2016-06-26 Assembly 3 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 13–98(86 aa) 片段:UNP Q12306 residues 13-98,UNP Q3JK38 residues 2-113
未记录 6UO 2-[(2~{S})-1-(phenylmethyl)sulfonylpiperidin-2-yl]carbonyloxyethyl pyridine-3-carboxylate × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;289 K;BUPSA.00130.A.D21 (CID4597, SMT TAG ON, BATCH 1264062) AT 10.37MG/ML (IN 25MM TRIS, PH8.0, 200MM NACL, 1% GLYCEROL, 1MM TCEP BUFFER) WAS INCUBATED WITH 2MM SF110_S (BSI5665). CRYSTALS WERE PRODUCED BY SITTING DROP VAPOR IFFUSION WITH AN EQUAL VOLUME COMBINATION OF THE PROTEIN/LIGAND COMPLEX AND A SOLUTION CONTAINING 10% W/V PEG20,000, 20% V/V PEG MME 550, 0.03M MGCL2, 0.03M CACL2, 0.1M MES/IMIDAZOLE, PH6.5 (MORPHEUS A1). CRYSTAL TRACKING ID 273103A1, RVA0-10, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 289K
分辨率 2.45 Å R-free 0.256
5KLX Crystal Structure of SMT Fusion Peptidyl-Prolyl Cis-Trans Isomerase from Burkholderia Pseudomallei Complexed with SF110 提交 2016-06-26 Assembly 4 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 D 13–98(86 aa) 片段:UNP Q12306 residues 13-98,UNP Q3JK38 residues 2-113
未记录 6UO 2-[(2~{S})-1-(phenylmethyl)sulfonylpiperidin-2-yl]carbonyloxyethyl pyridine-3-carboxylate × 1 MG MAGNESIUM ION × 1 IMD IMIDAZOLE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;289 K;BUPSA.00130.A.D21 (CID4597, SMT TAG ON, BATCH 1264062) AT 10.37MG/ML (IN 25MM TRIS, PH8.0, 200MM NACL, 1% GLYCEROL, 1MM TCEP BUFFER) WAS INCUBATED WITH 2MM SF110_S (BSI5665). CRYSTALS WERE PRODUCED BY SITTING DROP VAPOR IFFUSION WITH AN EQUAL VOLUME COMBINATION OF THE PROTEIN/LIGAND COMPLEX AND A SOLUTION CONTAINING 10% W/V PEG20,000, 20% V/V PEG MME 550, 0.03M MGCL2, 0.03M CACL2, 0.1M MES/IMIDAZOLE, PH6.5 (MORPHEUS A1). CRYSTAL TRACKING ID 273103A1, RVA0-10, VAPOR DIFFUSION, SITTING DROP, TEMPERATURE 289K
分辨率 2.45 Å R-free 0.256
5V8T Crystal structure of SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with SF354 提交 2017-03-22 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–97(85 aa) 片段:unp residues 13-97; unp residues 2-113
未记录 8ZV 2-{[3,5-bis(2-methoxyethoxy)benzene-1-carbonyl]amino}ethyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate × 1 FMT FORMIC ACID × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8;289 K;BupsA.00130.a.D21 (CID4597, SMT tag on, Batch 776103) at 10.37mg/ml (in 25mM Tris, pH8.0, 200mM NaCl, 1% glycerol, 1mM TCEP buffer) was incubated with 2mM SF354 (BSI5672). Crystals were produced by sitting drop vapor diffusion with an equal volume combination of the protein/ligand complex and a solution containing 24.55% (w/v) PEG-3350, 50 mM ammonium formate (JCSG_A8 opt screen d7) and cryoprotected with 15% ethylene glycol. Crystal Tracking ID 274545d7, uxe3-7
分辨率 2.10 Å R-free 0.221
5V8T Crystal structure of SMT fusion Peptidyl-prolyl cis-trans isomerase from Burkholderia pseudomallei complexed with SF354 提交 2017-03-22 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 13–97(85 aa) 片段:unp residues 13-97; unp residues 2-113
未记录 8ZV 2-{[3,5-bis(2-methoxyethoxy)benzene-1-carbonyl]amino}ethyl (2S)-1-(benzylsulfonyl)piperidine-2-carboxylate × 1 MG MAGNESIUM ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8;289 K;BupsA.00130.a.D21 (CID4597, SMT tag on, Batch 776103) at 10.37mg/ml (in 25mM Tris, pH8.0, 200mM NaCl, 1% glycerol, 1mM TCEP buffer) was incubated with 2mM SF354 (BSI5672). Crystals were produced by sitting drop vapor diffusion with an equal volume combination of the protein/ligand complex and a solution containing 24.55% (w/v) PEG-3350, 50 mM ammonium formate (JCSG_A8 opt screen d7) and cryoprotected with 15% ethylene glycol. Crystal Tracking ID 274545d7, uxe3-7
分辨率 2.10 Å R-free 0.221
5YC2 Crystal structure of inner membrane protein Bqt4 in complex with telomeric protein Rap1 提交 2017-09-06 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 20–92(73 aa)
突变:Q61E 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;277 K;0.1M HEPES sodium pH 7.5, 10% v/v 2-Propanol, 20% w/v Polyethyleneglycol 4000.
分辨率 2.70 Å R-free 0.249
5YC2 Crystal structure of inner membrane protein Bqt4 in complex with telomeric protein Rap1 提交 2017-09-06 Assembly 2 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 20–92(73 aa)
突变:Q61E 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7.5;277 K;0.1M HEPES sodium pH 7.5, 10% v/v 2-Propanol, 20% w/v Polyethyleneglycol 4000.
分辨率 2.70 Å R-free 0.249
5YCA Crystal structure of inner membrane protein Bqt4 in complex with LEM2 提交 2017-09-07 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 20–92(73 aa)
突变:Q61E 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 5.6;289 K;1600 mM Sodium citrate tribasic
分辨率 1.57 Å R-free 0.214
6CFP CRYSTAL STRUCTURE OF POLYMERASE ACID PROTEIN (PA) FROM INFLUENZA A VIRUS, WILSON-SMITH/1933 (H1N1) BOUND TO FRAGMENT HIT BSI-70565 1-{1-[4-FLUOROPHENYL)METHYL]-2-METHYL-1H-IMIDAZOL-4-YL}ETHAN-1-ONE 提交 2018-02-15 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa)
未记录 EZS 1-{1-[(4-fluorophenyl)methyl]-2-methyl-1H-imidazol-4-yl}ethan-1-one × 1 DMS DIMETHYL SULFOXIDE × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;289 K;MOLECULAR DIMENSIONS MORPHEUS SCREEN D10: 10% PEG 8000, 20% ETHYLENE GLYCOL; 20MM OF EACH 1, 6-HEXANEDIOL, 1-BUTANOL, 1,2-PROPANEDIOL, 2-PROPANOL, 1,4- BUTANEDIOL, 1,3-PROPANEDIOL; 100MM TRIS/BICINE PH 8.5; INVAA.07057.A.D15. AT 20.0 MG/ML, OVERNIGHT SOAK WITH 7 MM BSI70565, DIRECT CRYO; tray 297881d10, puck WXU6-7
分辨率 2.45 Å R-free 0.231
6O49 CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF339 提交 2019-02-28 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa)
未记录 LL7 (2~{S})-~{N}-[3-oxidanylidene-3-[(3,4,5-trimethoxyphenyl)amino]propyl]-1-(phenylmethyl)sulfonyl-piperidine-2-carboxamide × 1 CA CALCIUM ION × 1 EDO 1,2-ETHANEDIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;289 K;BupsA.00130.a.D21 (CID4597, SMT tag on, Batch 1264062) at 10.37mg/ml (in 25mM Tris, pH8.0, 200mM NaCl, 1% glycerol, 1mM TCEP buffer) was incubated with 2mM SF339_S (BSI5671). Crystals were produced by sitting drop vapor diffusion with an equal volume combination of the protein/ligand complex and a solution containing 100 mM MES pH 6.0, 200 mM Calcium chloride dehydrate, 20% PEG6000 (PACT B11). Crystal Tracking ID 297348b11, izs6-2
分辨率 1.85 Å R-free 0.211
6O49 CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF339 提交 2019-02-28 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 13–98(86 aa)
未记录 LL7 (2~{S})-~{N}-[3-oxidanylidene-3-[(3,4,5-trimethoxyphenyl)amino]propyl]-1-(phenylmethyl)sulfonyl-piperidine-2-carboxamide × 1 CA CALCIUM ION × 1 EDO 1,2-ETHANEDIOL × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6;289 K;BupsA.00130.a.D21 (CID4597, SMT tag on, Batch 1264062) at 10.37mg/ml (in 25mM Tris, pH8.0, 200mM NaCl, 1% glycerol, 1mM TCEP buffer) was incubated with 2mM SF339_S (BSI5671). Crystals were produced by sitting drop vapor diffusion with an equal volume combination of the protein/ligand complex and a solution containing 100 mM MES pH 6.0, 200 mM Calcium chloride dehydrate, 20% PEG6000 (PACT B11). Crystal Tracking ID 297348b11, izs6-2
分辨率 1.85 Å R-free 0.211
6O4A CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF355 提交 2019-02-28 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa)
未记录 CA CALCIUM ION × 1 LLD 2-(pyridin-3-ylcarbonylamino)ethyl (2~{S})-1-(phenylmethyl)sulfonylpiperidine-2-carboxylate × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;289 K;BupsA.00130.a.D21 (CID4597, SMT tag on, Batch 1264062) at 10.37mg/ml (in 25mM Tris, pH8.0, 200mM NaCl, 1% glycerol, 1mM TCEP buffer) was incubated with 2mM SF355 (BSI5667). Crystals were produced by sitting drop vapor diffusion with an equal volume combination of the protein/ligand complex and a solution containing HamptonResearch PACT screen (B4): 25% PEG 1500, 100m MIB pH 7.0. The sample was cryoprotected with 15% ethylene glycol: Crystal tray ID 290655b4, puck ID PWP0-3
分辨率 2.10 Å R-free 0.208
6O4A CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF355 提交 2019-02-28 Assembly 2 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 B 13–98(86 aa)
未记录 LLD 2-(pyridin-3-ylcarbonylamino)ethyl (2~{S})-1-(phenylmethyl)sulfonylpiperidine-2-carboxylate × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;289 K;BupsA.00130.a.D21 (CID4597, SMT tag on, Batch 1264062) at 10.37mg/ml (in 25mM Tris, pH8.0, 200mM NaCl, 1% glycerol, 1mM TCEP buffer) was incubated with 2mM SF355 (BSI5667). Crystals were produced by sitting drop vapor diffusion with an equal volume combination of the protein/ligand complex and a solution containing HamptonResearch PACT screen (B4): 25% PEG 1500, 100m MIB pH 7.0. The sample was cryoprotected with 15% ethylene glycol: Crystal tray ID 290655b4, puck ID PWP0-3
分辨率 2.10 Å R-free 0.208
6O4A CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF355 提交 2019-02-28 Assembly 3 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 C 13–98(86 aa)
未记录 CA CALCIUM ION × 1 LLD 2-(pyridin-3-ylcarbonylamino)ethyl (2~{S})-1-(phenylmethyl)sulfonylpiperidine-2-carboxylate × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;289 K;BupsA.00130.a.D21 (CID4597, SMT tag on, Batch 1264062) at 10.37mg/ml (in 25mM Tris, pH8.0, 200mM NaCl, 1% glycerol, 1mM TCEP buffer) was incubated with 2mM SF355 (BSI5667). Crystals were produced by sitting drop vapor diffusion with an equal volume combination of the protein/ligand complex and a solution containing HamptonResearch PACT screen (B4): 25% PEG 1500, 100m MIB pH 7.0. The sample was cryoprotected with 15% ethylene glycol: Crystal tray ID 290655b4, puck ID PWP0-3
分辨率 2.10 Å R-free 0.208
6O4A CRYSTAL STRUCTURE OF SMT FUSION PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FROM BURKHOLDERIA PSEUDOMALLEI COMPLEXED WITH SF355 提交 2019-02-28 Assembly 4 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 D 13–98(86 aa)
未记录 LLD 2-(pyridin-3-ylcarbonylamino)ethyl (2~{S})-1-(phenylmethyl)sulfonylpiperidine-2-carboxylate × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 6.5;289 K;BupsA.00130.a.D21 (CID4597, SMT tag on, Batch 1264062) at 10.37mg/ml (in 25mM Tris, pH8.0, 200mM NaCl, 1% glycerol, 1mM TCEP buffer) was incubated with 2mM SF355 (BSI5667). Crystals were produced by sitting drop vapor diffusion with an equal volume combination of the protein/ligand complex and a solution containing HamptonResearch PACT screen (B4): 25% PEG 1500, 100m MIB pH 7.0. The sample was cryoprotected with 15% ethylene glycol: Crystal tray ID 290655b4, puck ID PWP0-3
分辨率 2.10 Å R-free 0.208
6P81 Structure of DNA polymerase III, beta subunit/ beta sliding clamp from Klebsiella pneumoniae, expressed with an N-terminal His-Smt3 fusion tag, in complex with Griselimycin 提交 2019-06-06 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 13–98(86 aa) 片段:KlpnA.17987.a.EN11
未记录 CA CALCIUM ION × 1 PG5 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE × 1 ACT ACETATE ION × 1 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 4.5;290 K;Microlytic MCSG-2, condition D4: 30% (V/V) PEG 300, 200mM Calcium acetate, 100mM sodium acetate / acetic acid pH 4.5: KlpnA.17987.a.EN11.PD383542 at 20.95mg/ml + 2mM griselimycin: tray 309729 D4: cryo: direct: puck ECJ6-1.
分辨率 1.75 Å R-free 0.213
6Q2S Cryo-EM structure of RET/GFRa3/ARTN extracellular complex. The 3D refinement was applied with C2 symmetry. 提交 2019-08-08 Assembly 1 信息不足 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 A 1–98(98 aa)
链 B 1–98(98 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 14 CA CALCIUM ION × 8 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.80 Å
6RPQ Crystal structure of PhoCDC21-1 intein 提交 2019-05-14 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 2–98(97 aa)
突变:A101T, C112A 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;293 K;tri-ammonium citrate
分辨率 2.65 Å R-free 0.235
6UKM STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound MSA-2 提交 2019-10-05 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 2–98(97 aa)
突变:G230A,R293Q QAD 4-(5,6-dimethoxy-1-benzothiophen-2-yl)-4-oxobutanoic acid × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 8.5;298 K;25% PEG 6000, 100 mM Tris, 200 mM NaCl, 2 mM DTT
分辨率 1.74 Å R-free 0.192
6UKU STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 3 提交 2019-10-06 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 2–98(97 aa)
突变:G230A,R293Q QAV 4,4'-[propane-1,3-diylbis(6-methoxy-1-benzothiene-5,2-diyl)]bis(4-oxobutanoic acid) × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 8.5;298 K;25% PEG 6000, 100 mM Tris, 200 mM NaCl, 2 mM DTT
分辨率 1.68 Å R-free 0.221
6UKV STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 9 提交 2019-10-06 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 2–98(97 aa)
链 B 2–98(97 aa)
突变:G230A,R293Q 突变:G230A,R293Q QB1 4-[6-(3-{[2-(3-carboxypropanoyl)-6-methoxy-1-benzothiophen-5-yl]oxy}propoxy)-5-methoxy-1-benzothiophen-2-yl]-4-oxobutanoic acid × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 8.5;298 K;25% PEG 6000, 100 mM Tris, 200 mM NaCl, 2 mM DTT
分辨率 1.83 Å R-free 0.208
6UKW STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 10 提交 2019-10-06 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 2–98(97 aa)
链 B 2–98(97 aa)
突变:G230A,R293Q 突变:G230A,R293Q QB7 4-[6-(3-{[2-(3-carboxypropanoyl)-4-fluoro-6-methoxy-1-benzothiophen-5-yl]oxy}propoxy)-5-methoxy-1-benzothiophen-2-yl]-4-oxobutanoic acid × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 8.5;298 K;25% PEG 6000, 100 mM Tris, 200 mM NaCl, 2 mM DTT
分辨率 1.97 Å R-free 0.241
6UKX STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 11 提交 2019-10-06 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 2–98(97 aa)
链 B 2–98(97 aa)
突变:G230A,R293Q 突变:G230A,R293Q QBA 4,4'-{propane-1,3-diylbis[oxy(5-methoxy-1-benzothiene-6,2-diyl)]}bis(4-oxobutanoic acid) × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 8.5;298 K;25% PEG 6000, 100 mM Tris, 200 mM NaCl, 2 mM DTT
分辨率 1.93 Å R-free 0.217
6UKY STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 12 提交 2019-10-06 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 2–98(97 aa)
突变:G230A,R293Q QBD 4-(6-{3-[2-(3-carboxypropanoyl)-6-methoxy-1-benzothiophen-4-yl]propyl}-5-methoxy-1-benzothiophen-2-yl)-4-oxobutanoic acid × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 8.5;298 K;25% PEG 6000, 100 mM Tris, 200 mM NaCl, 2 mM DTT
分辨率 1.95 Å R-free 0.227
6UKZ STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 6 提交 2019-10-06 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 2–98(97 aa)
链 B 2–98(97 aa)
突变:G230A,R293Q 突变:G230A,R293Q QBG 4-[5-(2-{[2-(3-carboxypropanoyl)-4-fluoro-6-methoxy-1-benzothiophen-5-yl]oxy}ethoxy)-6-methoxy-1-benzothiophen-2-yl]-4-oxobutanoic acid × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 8.5;298 K;25% PEG 6000, 100 mM Tris, 200 mM NaCl, 2 mM DTT
分辨率 1.52 Å R-free 0.213
6UL0 STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 4 提交 2019-10-06 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 2–98(97 aa)
突变:G230A,R293Q QBJ 4-{5-[(1Z)-3-{[2-(3-carboxypropanoyl)-6-methoxy-1-benzothiophen-5-yl]oxy}prop-1-en-1-yl]-6-methoxy-1-benzothiophen-2-yl}-4-oxobutanoic acid × 2 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION;pH 8.5;298 K;25% PEG 6000, 100 mM Tris, 200 mM NaCl, 2 mM DTT
分辨率 1.76 Å R-free 0.242
6VEL Crystal Structure of Human E-cadherin bound by mouse monoclonal antibody 66E8Fab 提交 2020-01-02 Assembly 1 信息不足 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 C 1–98(98 aa)
未记录 SO4 SULFATE ION × 6 CA CALCIUM ION × 3 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;290 K;A complex of HosaA.19747.a.KW2, MumuA.20194.a.LG23, and MumuA.20195.a.LH23 was crystallized at 10.4 mg/ml at 14C and mixed 1:1 with 12.5% (w/v) PEG 4000, 20% (v/v) 1,2,6-hexanetriol, 0.1M GlyGly/AMPD pH 8.5, 0.03M of each Lithium sulfate, Sodium sulfate, and Potassium sulfate. Tray 307437a10: puck ckt8-9.
分辨率 2.65 Å R-free 0.236
6VW2 Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils 提交 2020-02-18 Assembly 1 信息不足 同源多聚体;蛋白 × 10 PDB 声明:decameric(10) 与蛋白数一致
链 A 1–97(97 aa)
链 B 1–97(97 aa)
链 C 1–97(97 aa)
链 D 1–97(97 aa)
链 E 1–97(97 aa)
链 F 1–97(97 aa)
链 G 1–97(97 aa)
链 H 1–97(97 aa)
链 I 1–97(97 aa)
链 J 1–97(97 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
7LTO Nse5-6 complex 提交 2021-02-19 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–98(98 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.20 Å
7O2W Structure of the C9orf72-SMCR8 complex 提交 2021-03-31 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 2–96(95 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.80 Å
7P47 Structure of the E3 ligase Smc5/Nse2 in complex with Ubc9-SUMO thioester mimetic 提交 2021-07-09 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 5 PDB 声明:pentameric(5) 与蛋白数一致
链 D 1–98(98 aa)
链 E 1–98(98 aa)
未记录 ZN ZINC ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;311 K;12% PEG8000, 0.2M dimethyl-2-hydroxyethylammoniumpropane sulfonate (NDSB 211), 8% ethylene glycol, 0.1M MES pH 6.5
分辨率 3.31 Å R-free 0.293
7P7I Native structure of N-acetylglucosamine kinase from Plesiomonas shigelloides 提交 2021-07-19 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 AAA 2–96(95 aa)
链 BBB 2–96(95 aa)
未记录 PEG DI(HYDROXYETHYL)ETHER × 3 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 ZN ZINC ION × 2 PGE TRIETHYLENE GLYCOL × 2 EDO 1,2-ETHANEDIOL × 8 CL CHLORIDE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 MICROBATCH;291 K;60 mM divalent cations; 0.1 M Tris/bicine pH 8.5; 12.5% each MPD, PEG 1K, PEG 3350. condition A12 from Morpheus screen (Molecular Dimensions)
分辨率 1.70 Å R-free 0.210
7P7W N-acetylglucosamine kinase from Plesiomonas shigelloides compexed with alpha-N-acetylglucosamine and ADP 提交 2021-07-20 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 AAA 2–96(95 aa)
链 BBB 2–96(95 aa)
未记录 ADP ADENOSINE-5'-DIPHOSPHATE × 2 GOL GLYCEROL × 3 IMD IMIDAZOLE × 4 NDG 2-acetamido-2-deoxy-alpha-D-glucopyranose × 2 ZN ZINC ION × 4 EDO 1,2-ETHANEDIOL × 17 PEG DI(HYDROXYETHYL)ETHER × 1 K POTASSIUM ION × 2 IPA ISOPROPYL ALCOHOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 MICROBATCH;291 K;120 mM alcohols; ; 0.1 M imidazole/MES pH 6.5; 30% each glycerol and PEG 4K Condition A3 of Morpheus screen (Molecular dimensions). Crystal was soaked for 60 seconds in cryoprotectant containing 10 mM ADP
分辨率 1.57 Å R-free 0.211
7P9L N-acetylglucosamine kinase from Plesiomonas shigelloides compexed with alpha-N-acetylglucosamine-6-phosphate 提交 2021-07-27 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 AAA 2–96(95 aa)
链 BBB 2–96(95 aa)
未记录 EDO 1,2-ETHANEDIOL × 22 PEG DI(HYDROXYETHYL)ETHER × 7 4QY 2-acetamido-2-deoxy-6-O-phosphono-beta-D-glucopyranose × 2 ZN ZINC ION × 4 K POTASSIUM ION × 2 PO4 PHOSPHATE ION × 2 CL CHLORIDE ION × 1 TRS 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL × 1 X-RAY DIFFRACTION
X-ray结晶条件 MICROBATCH;291 K;90 mM halogens; 0.1 M Tris/bicine pH 8.5; 30% each PEG 550 MME and PEG 20K, condition B9 from Morpheus screen (Molecular Dimensions)
分辨率 1.75 Å R-free 0.223
7P9P N-acetylglucosamine kinase from Plesiomonas shigelloides compexed with alpha-N-acetylglucosamine and AMP-PNP inhibitor 提交 2021-07-27 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 AAA 2–96(95 aa)
链 BBB 2–96(95 aa)
未记录 ZN ZINC ION × 4 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 PEG DI(HYDROXYETHYL)ETHER × 3 PGE TRIETHYLENE GLYCOL × 2 NDG 2-acetamido-2-deoxy-alpha-D-glucopyranose × 2 EDO 1,2-ETHANEDIOL × 15 K POTASSIUM ION × 2 X-RAY DIFFRACTION
X-ray结晶条件 MICROBATCH;291 K;60 mM divalent cations; 0.1 M imidazole/MES pH 6.5; 30% each glycerol and PEG 4K. Condition A3 from Morpheus screen (Molecular Dimensions)
分辨率 2.11 Å R-free 0.233
7P9Y N-acetylglucosamine kinase from Plesiomonas shigelloides compexed with alpha-N-acetylglucosamine 提交 2021-07-28 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 AAA 2–96(95 aa)
链 BBB 2–96(95 aa)
未记录 MPD (4S)-2-METHYL-2,4-PENTANEDIOL × 3 EDO 1,2-ETHANEDIOL × 16 PGE TRIETHYLENE GLYCOL × 1 NDG 2-acetamido-2-deoxy-alpha-D-glucopyranose × 2 ZN ZINC ION × 4 K POTASSIUM ION × 2 CL CHLORIDE ION × 2 PEG DI(HYDROXYETHYL)ETHER × 1 X-RAY DIFFRACTION
X-ray结晶条件 MICROBATCH;291 K;90 mM halogens; 0.1 M Na-HEPES/MOPS pH 7.5; 12.5% each MPD, PEG 1K, PEG 3350 Condition B8 of Morpheus screen (Molecular Dimensions)
分辨率 1.94 Å R-free 0.250
7PA1 Structure of N-acetylglucosamine kinase from Plesiomonas shigelloides in complex with AMP-PNP in the absence of N-acetylglucoseamine substrate 提交 2021-07-28 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 AAA 2–96(95 aa)
链 BBB 2–96(95 aa)
未记录 PEG DI(HYDROXYETHYL)ETHER × 2 ANP PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 2 ZN ZINC ION × 2 PGE TRIETHYLENE GLYCOL × 4 EDO 1,2-ETHANEDIOL × 9 X-RAY DIFFRACTION
X-ray结晶条件 MICROBATCH;291 K;0.09M NPS; 0.1 M Tris/bicine pH 8.5; 30% each PEG 550 MME and PEG 20K, condition C9 from Morpheus crystallisation screen (Molecular Dimensions).
分辨率 2.20 Å R-free 0.252
7SDE Cryo-EM structure of Nse5/6 heterodimer 提交 2021-09-29 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 1–98(98 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.20 Å
7ZHS 3D reconstruction of the cylindrical assembly of DnaJA2 delta G/F by imposing D5 symmetry 提交 2022-04-07 Assembly 1 信息不足 同源多聚体;蛋白 × 40 PDB 声明:40-meric(40) 与蛋白数一致
链 A 3–98(96 aa)
链 B 3–98(96 aa)
链 C 3–98(96 aa)
链 D 3–98(96 aa)
链 E 3–98(96 aa)
链 F 3–98(96 aa)
链 G 3–98(96 aa)
链 H 3–98(96 aa)
链 I 3–98(96 aa)
链 J 3–98(96 aa)
链 K 3–98(96 aa)
链 L 3–98(96 aa)
链 M 3–98(96 aa)
链 N 3–98(96 aa)
链 O 3–98(96 aa)
链 P 3–98(96 aa)
链 Q 3–98(96 aa)
链 R 3–98(96 aa)
链 S 3–98(96 aa)
链 T 3–98(96 aa)
链 U 3–98(96 aa)
链 V 3–98(96 aa)
链 W 3–98(96 aa)
链 X 3–98(96 aa)
链 Y 3–98(96 aa)
链 Z 3–98(96 aa)
链 a 3–98(96 aa)
链 b 3–98(96 aa)
链 c 3–98(96 aa)
链 d 3–98(96 aa)
链 e 3–98(96 aa)
链 f 3–98(96 aa)
链 g 3–98(96 aa)
链 h 3–98(96 aa)
链 i 3–98(96 aa)
链 j 3–98(96 aa)
链 k 3–98(96 aa)
链 l 3–98(96 aa)
链 m 3–98(96 aa)
链 n 3–98(96 aa)
未记录 ZN ZINC ION × 80 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 6.90 Å
7ZWL Crystal structure of human STING in complex with 3',3'-c-di-(2'F,2'd<carba>AMP) 提交 2022-05-19 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 C 2–98(97 aa)
未记录 K43 9-[(1~{R},6~{R},8~{R},9~{S},10~{R},15~{R},17~{R},18~{S})-17-(6-aminopurin-9-yl)-9,18-bis(fluoranyl)-3,12-bis(oxidanyl)-3,12-bis(oxidanylidene)-2,4,11,13-tetraoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.3.0.0^{6,10}]octadecan-8-yl]purin-6-amine × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;291 K;0.2 M Lithium acetate, 20% (w/v) PEG 3350
分辨率 2.00 Å R-free 0.249
8B7F Nuclease from C. glutamicum 提交 2022-09-29 Assembly 1 信息不足 同源多聚体;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 A 2–98(97 aa)
链 B 2–98(97 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;291 K;10% (w/v) PEG 6K, 30% (v/v) ethanol and 10 mM sodium acetate
分辨率 4.60 Å R-free 0.311
8DMB Structure of Desulfovirgula thermocuniculi IsrB (DtIsrB) in complex with omega RNA and target DNA 提交 2022-07-08 Assembly 1 其他组合 单体;蛋白 × 1 PDB 声明:tetrameric(4) 与全部聚合物一致
链 P 1–98(98 aa)
突变:H584L MG MAGNESIUM ION × 2 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.10 Å
8R1F Monomeric E6AP-E6-p53 ternary complex 提交 2023-11-01 Assembly 1 信息不足 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 B 1–98(98 aa)
突变:C80S,C97S,C111S,C140S ZN ZINC ION × 3 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.67 Å
8R1G Dimeric ternary structure of E6AP-E6-p53 提交 2023-11-01 Assembly 1 信息不足 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 B 1–98(98 aa)
链 E 1–98(98 aa)
突变:C80S,C97S,C111S,C140S 突变:C80S,C97S,C111S,C140S ZN ZINC ION × 6 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.99 Å
8UZH SUMO fused Trehalose Synthase (TreS) of Mycobacterium tuberculosis 提交 2023-11-15 Assembly 1 信息不足 同源多聚体;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 2–98(97 aa)
链 B 2–98(97 aa)
未记录 CA CALCIUM ION × 6 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;289 K;0.8 M Ammonium sulfate, 0.1 M Sodium Citrate pH 5.0
分辨率 2.80 Å R-free 0.290
8VQH CryoEM structure of BchN-BchB electron acceptor component protein of DPOR 提交 2024-01-18 Assembly 1 信息不足 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 B 1–96(96 aa)
链 D 1–96(96 aa)
未记录 SF4 IRON/SULFUR CLUSTER × 2 CU COPPER (II) ION × 2 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.70 Å
8X7V Structure of human SCMC ternary complex 提交 2023-11-26 Assembly 1 信息不足 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 C 1–98(98 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.01 Å
8X7W Structure of dimeric human SCMC complex 提交 2023-11-26 Assembly 1 信息不足 异源复合物;蛋白 × 6 PDB 声明:hexameric(6) 与蛋白数一致
链 C 1–98(98 aa)
链 F 1–98(98 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.36 Å
9E7U Cryo-EM structure of NOT1:NOT8:PieF 提交 2024-11-04 Assembly 1 信息不足 异源复合物;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 C 1–95(95 aa)
未记录 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.50 Å
9E7V Off-pathway Mycobacterium tuberculosis transcription initiation promoter complex (RNA Polymerase with Sigma-A, CarD, and RbpA) 提交 2024-11-04 Assembly 1 信息不足 异源复合物;蛋白 × 8 PDB 声明:decameric(10) 与全部聚合物一致
链 M 1–98(98 aa)
未记录 POP PYROPHOSPHATE 2- × 1 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
9E7Y De Novo Mycobacterium tuberculosis transcription initiation promoter complex with 7-mer RNA and disordered Beta' Lid element (RNA Polymerase with Sigma-A, CarD, and RbpA) 提交 2024-11-04 Assembly 1 信息不足 异源复合物;蛋白 × 8 PDB 声明:undecameric(11) 与全部聚合物一致
链 M 1–98(98 aa)
未记录 POP PYROPHOSPHATE 2- × 1 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 4.20 Å
9E84 De Novo Mycobacterium tuberculosis transcription initiation promoter complex with 6-mer RNA and disordered Sigma-A region 4 domain (RNA Polymerase with Sigma-A, CarD, and RbpA) 提交 2024-11-05 Assembly 1 信息不足 异源复合物;蛋白 × 8 PDB 声明:11-meric(11) 与全部聚合物一致
链 M 1–98(98 aa)
未记录 POP PYROPHOSPHATE 2- × 1 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.60 Å
9E85 De Novo Mycobacterium tuberculosis transcription initiation promoter complex with 6-mer RNA and closed Beta' clamp (RNA Polymerase with Sigma-A, CarD, and RbpA) 提交 2024-11-05 Assembly 1 信息不足 异源复合物;蛋白 × 8 PDB 声明:11-meric(11) 与全部聚合物一致
链 M 1–98(98 aa)
未记录 POP PYROPHOSPHATE 2- × 1 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.10 Å
9E86 De Novo Mycobacterium tuberculosis transcription initiation promoter complex with 5-mer RNA and open Beta' clamp (RNA Polymerase with Sigma-A, CarD, and RbpA) 提交 2024-11-05 Assembly 1 信息不足 异源复合物;蛋白 × 8 PDB 声明:11-meric(11) 与全部聚合物一致
链 M 1–98(98 aa)
未记录 POP PYROPHOSPHATE 2- × 1 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.80 Å
9E87 De Novo Mycobacterium tuberculosis transcription initiation pre-RPO promoter complex with open Beta' clamp (RNA Polymerase with Sigma-A, CarD, and RbpA) 提交 2024-11-05 Assembly 1 信息不足 异源复合物;蛋白 × 8 PDB 声明:decameric(10) 与全部聚合物一致
链 M 1–98(98 aa)
未记录 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.60 Å
9E88 De novo backtracked transcription elongation complex of Mycobacterium tuberculosis RNA polymerase on a linear DNA fragment (TEC-Backtracked) 提交 2024-11-05 Assembly 1 信息不足 异源复合物;蛋白 × 6 PDB 声明:nonameric(9) 与全部聚合物一致
链 M 1–98(98 aa)
未记录 ZN ZINC ION × 2 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.40 Å
9G8I Sumo-Darpin-A10-complex 提交 2024-07-23 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 C 21–95(75 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;293 K;Bis-Tris pH 6.5, 23% (v/v) PEG 3350
分辨率 2.51 Å R-free 0.301
9G8I Sumo-Darpin-A10-complex 提交 2024-07-23 Assembly 2 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 D 21–95(75 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;293 K;Bis-Tris pH 6.5, 23% (v/v) PEG 3350
分辨率 2.51 Å R-free 0.301
9GAU Sumo-Darpin-C10-complex 提交 2024-07-29 Assembly 1 蛋白异源复合物 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 21–96(76 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 6.5;293 K;0.1M Bis-Tris. 16% (v/v)PEG 3350
分辨率 2.64 Å R-free 0.288
9HDO The Human LINE-1 ORF2p target-primed reverse transcription complex 提交 2024-11-12 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:heptameric(7) 与全部聚合物一致
链 A 2–98(97 aa)
未记录 MG MAGNESIUM ION × 1 ZN ZINC ION × 1 D3T 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.30 Å
9HDP The Human LINE-1 ORF2p target-primed reverse transcription complex with the fingers domain in a closed conformation 提交 2024-11-12 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:heptameric(7) 与全部聚合物一致
链 A 2–98(97 aa)
未记录 MG MAGNESIUM ION × 1 ZN ZINC ION × 1 D3T 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.50 Å
9HDQ The Human LINE-1 ORF2p target-primed reverse transcription complex with the fingers domain in an open conformation 提交 2024-11-12 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:heptameric(7) 与全部聚合物一致
链 A 2–98(97 aa)
未记录 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.45 Å
9HDR Human LINE-1 ORF2p target-primed reverse transcription complex with EN domain resolved 提交 2024-11-12 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:heptameric(7) 与全部聚合物一致
链 A 2–98(97 aa)
未记录 MG MAGNESIUM ION × 1 ZN ZINC ION × 1 D3T 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.10 Å
9HX5 Apo structure of SRSF6 RRM2 WT 提交 2025-01-07 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 8.5;277 K;0.1 M Bis-Tris propane pH 8.5, 0.2 M Sodium sulfate, 20 % PEG 3350, 10 % Ethylene glycol
分辨率 2.10 Å R-free 0.258
9HX7 Structure of SRSF6 RRM2 WT with "GGA"-RNA 提交 2025-01-07 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:dimeric(2) 与全部聚合物一致
链 A 13–98(86 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, SITTING DROP;pH 7;277 K;0.1 M HEPES pH 7.0, 0.1 M NH4SO4, 0.1 M Na-Form, 25 % Smear Broad
分辨率 2.30 Å R-free 0.250
9HX8 Apo structure of SRSF6 RRM2 W123A 提交 2025-01-07 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 13–98(86 aa)
突变:W123A 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 8;277 K;0.1 M Na-Citrate, 20 % PEG 3350
分辨率 2.00 Å R-free 0.259
9IIS GDP-fucose pyrophosphorylase part of FKP with a SUMO tag 提交 2024-06-21 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:monomeric(1) 与蛋白数一致
链 A 1–98(98 aa)
未记录 EPE 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID × 1 ACT ACETATE ION × 1 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;pH 7.5;295 K;PEG 3350, ammonium acetate, HEPES
分辨率 2.36 Å R-free 0.254
9KPZ Structure of TolQRA complex at pH 5.4 from E.coli 提交 2024-11-24 Assembly 1 信息不足 异源复合物;蛋白 × 12 PDB 声明:dodecameric(12) 与蛋白数一致
链 H 3–99(97 aa)
链 I 3–99(97 aa)
链 J 3–99(97 aa)
链 K 3–99(97 aa)
链 L 3–99(97 aa)
未记录 3PE 1,2-Distearoyl-sn-glycerophosphoethanolamine × 7 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 5.4
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.18 Å
9KQ0 Structure of TolQRA complex at pH 8.0 from E.coli 提交 2024-11-24 Assembly 1 信息不足 异源复合物;蛋白 × 12 PDB 声明:dodecameric(12) 与蛋白数一致
链 H 3–99(97 aa)
链 I 3–99(97 aa)
链 J 3–99(97 aa)
链 K 3–99(97 aa)
链 L 3–99(97 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 8
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.60 Å
9MB6 Cryo-EM structure of wild-type SaCas9-guide RNA-mismatched target DNA complex 提交 2025-03-15 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:tetrameric(4) 与全部聚合物一致
链 A 3–98(96 aa)
未记录 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.01 Å
9MB7 Cryo-EM structure of eSaCas9-NNG-guide RNA-mismatched target DNA complex 提交 2025-03-15 Assembly 1 信息不足 单体;蛋白 × 1 PDB 声明:tetrameric(4) 与全部聚合物一致
链 A 3–98(96 aa)
未记录 MG MAGNESIUM ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.6
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.88 Å
9OIK Structure of S. Typhimurium 14028 Gifsy-1 prophage HepS bound to bacteriophage lambda J Tail Tip 提交 2025-05-06 Assembly 1 信息不足 异源复合物;蛋白 × 8 PDB 声明:octameric(8) 与蛋白数一致
链 C 1–98(98 aa)
链 D 1–98(98 aa)
未记录 未记录非水小分子 X-RAY DIFFRACTION
X-ray结晶条件 VAPOR DIFFUSION, HANGING DROP;291 K;0.2 M Sodium Acetate, 16% PEG 4000, 0.1 M Tris pH 8.5
分辨率 1.86 Å R-free 0.209
9OPR TMPRSS2 S441A in complex with the H1H7 Fab and anti-kappa light chain nanobody 提交 2025-05-19 Assembly 1 信息不足 异源复合物;蛋白 × 4 PDB 声明:tetrameric(4) 与蛋白数一致
链 A 1–94(94 aa)
突变:S441A 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.20 Å
9SMX CM1-activated gTuRC in complex with nascent alpha-E254D mutant microtubules 提交 2025-09-09 Assembly 1 信息不足 异源复合物;蛋白 × 73 PDB 声明:73-meric(73) 与蛋白数一致
链 AC 2–99(98 aa)
链 CC 2–99(98 aa)
链 Cc 2–99(98 aa)
链 EC 2–99(98 aa)
链 Ec 2–99(98 aa)
链 GC 2–99(98 aa)
链 Gc 2–99(98 aa)
链 MC 2–99(98 aa)
链 Mc 2–99(98 aa)
未记录 GTP GUANOSINE-5'-TRIPHOSPHATE × 11 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 6.9
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.67 Å
9SYR Human quaternary complex of a translating 80S ribosome, NAC, MetAP1 and NatD 提交 2025-10-13 Assembly 1 信息不足 异源复合物;蛋白 × 80 PDB 声明:86-meric(86) 与全部聚合物一致
链 Nd 4–98(95 aa)
未记录 ZN ZINC ION × 10 COA COENZYME A × 1 GTP GUANOSINE-5'-TRIPHOSPHATE × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.4
cryo-EM玻璃化条件 冷冻剂 ETHANE-PROPANE
分辨率 3.55 Å
9UT1 The helicase-primase complex from HHV1 bound with ssDNA and amenamevir 提交 2025-05-02 Assembly 1 信息不足 异源复合物;蛋白 × 3 PDB 声明:tetrameric(4) 与全部聚合物一致
链 B 3–98(96 aa)
链 C 3–98(96 aa)
突变:R64T/R71E 突变:R64T/R71E A1BXD Amenamevir × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.14 Å
9UT3 The helicase module of the helicase-primase complex from HHV1 bound with ssDNA and amenamevir 提交 2025-05-02 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:trimeric(3) 与全部聚合物一致
链 B 3–98(96 aa)
突变:R64T/R71E A1BXD Amenamevir × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.88 Å
9UT4 The primase module of the helicase-primase complex from HHV1 bound with ssDNA and amenamevir 提交 2025-05-02 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 3–98(96 aa)
链 C 3–98(96 aa)
突变:R64T/R71E 突变:R64T/R71E 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 2.91 Å
9UT5 The helicase-primase complex from HHV1 bound with ssDNA and pritelivir 提交 2025-05-02 Assembly 1 信息不足 异源复合物;蛋白 × 3 PDB 声明:tetrameric(4) 与全部聚合物一致
链 B 3–98(96 aa)
链 C 3–98(96 aa)
突变:R64T/R71E 突变:R64T/R71E A1BXB Pritelivir × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.32 Å
9UT6 The helicase module of the helicase-primase complex from HHV1 bound with ssDNA and pritelivir 提交 2025-05-02 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:trimeric(3) 与全部聚合物一致
链 B 3–98(96 aa)
突变:R64T/R71E A1BXB Pritelivir × 1 ZN ZINC ION × 1 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.12 Å
9UT7 The Primase module of the helicase-primase complex from HHV1 bound with ssDNA and pritelivir 提交 2025-05-02 Assembly 1 信息不足 异源复合物;蛋白 × 2 PDB 声明:dimeric(2) 与蛋白数一致
链 B 3–98(96 aa)
链 C 3–98(96 aa)
突变:R64T/R71E 突变:R64T/R71E 未记录非水小分子 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.08 Å
9Z3K SARS-CoV-2 S2 trimer stabilized in the early fusion intermediate conformation by circular permutation and clamping by gp41 (E-FICs-v1) 提交 2025-11-07 Assembly 1 信息不足 同源多聚体;蛋白 × 3 PDB 声明:trimeric(3) 与蛋白数一致
链 A 1–94(94 aa)
链 B 1–94(94 aa)
链 C 1–94(94 aa)
未记录 NAG 2-acetamido-2-deoxy-beta-D-glucopyranose × 18 ELECTRON MICROSCOPY
cryo-EM缓冲液 pH 7.5
cryo-EM玻璃化条件 冷冻剂 ETHANE
分辨率 3.30 Å