8b9d

Human replisome bound by Pol Alpha

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA replication licensing factor MCM2

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM2_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain 2； PDBConstruct 1–904； UniProt 1–904

DNA replication licensing factor MCM3

Homo sapiens

UniProt P25205

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM3_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain 3； PDBConstruct 1–808； UniProt 1–808

DNA replication licensing factor MCM4

Homo sapiens

UniProt P33991

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM4_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain 4； PDBConstruct 1–863； UniProt 1–863

DNA replication licensing factor MCM5

Homo sapiens

UniProt P33992

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM5_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain 5； PDBConstruct 1–734； UniProt 1–734

DNA replication licensing factor MCM6

Homo sapiens

UniProt Q14566

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM6_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain 6； PDBConstruct 1–821； UniProt 1–821

DNA replication licensing factor MCM7

Homo sapiens

UniProt P33993

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MCM7_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain 7； PDBConstruct 1–719； UniProt 1–719

DNA polymerase alpha subunit B

Homo sapiens

UniProt Q14181

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	DPOA2_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain A； PDBConstruct 1–598； UniProt 1–598

Cell division control protein 45 homolog

Homo sapiens

UniProt O75419

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CDC45_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain C； PDBConstruct 1–160； UniProt 1–160 Author chain C； PDBConstruct 167–569； UniProt 164–566

DNA replication complex GINS protein PSF1

Homo sapiens

UniProt Q14691

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSF1_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain D； PDBConstruct 1–196； UniProt 1–196

DNA replication complex GINS protein PSF2

Homo sapiens

UniProt Q9Y248

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSF2_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain E； PDBConstruct 1–185； UniProt 1–185

DNA replication complex GINS protein PSF3

Homo sapiens

UniProt Q9BRX5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PSF3_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain F； PDBConstruct 1–216； UniProt 1–216

DNA replication complex GINS protein SLD5

Homo sapiens

UniProt Q9BRT9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	SLD5_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain G； PDBConstruct 39–261； UniProt 1–223

Protein timeless homolog

Homo sapiens

UniProt Q9UNS1

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TIM_HUMAN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain K； PDBConstruct 2–1209； UniProt 1–1208

TIMELESS-interacting protein

Homo sapiens

UniProt Q9BVW5

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TIPIN_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain L； PDBConstruct 1–301； UniProt 1–301

DNA primase large subunit

Homo sapiens

UniProt P49643

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRI2_HUMAN
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain P； PDBConstruct 1–509； UniProt 1–509

Claspin

Homo sapiens

UniProt Q9HAW4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CLSPN_HUMAN
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain Q； PDBConstruct 1–1339； UniProt 1–1339

DNA primase small subunit

Homo sapiens

UniProt P49642

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	PRI1_HUMAN
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain O； PDBConstruct 43–462； UniProt 1–420

WD repeat and HMG-box DNA-binding protein 1

Homo sapiens

UniProt O75717

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） DNA polymerase alpha catalytic subunit × 1 （P09884） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	WDHD1_HUMAN
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain H； PDBConstruct 32–1160； UniProt 1–1129 Author chain I； PDBConstruct 32–1160； UniProt 1–1129 Author chain J； PDBConstruct 32–1160； UniProt 1–1129

DNA polymerase alpha catalytic subunit

Homo sapiens

UniProt P09884

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 21 DNA 2	DNA replication licensing factor MCM2 × 1 （P49736） DNA replication licensing factor MCM3 × 1 （P25205） DNA replication licensing factor MCM4 × 1 （P33991） DNA replication licensing factor MCM5 × 1 （P33992） DNA replication licensing factor MCM6 × 1 （Q14566） DNA replication licensing factor MCM7 × 1 （P33993） DNA polymerase alpha subunit B × 1 （Q14181） Cell division control protein 45 homolog × 1 （O75419） DNA replication complex GINS protein PSF1 × 1 （Q14691） DNA replication complex GINS protein PSF2 × 1 （Q9Y248） DNA replication complex GINS protein PSF3 × 1 （Q9BRX5） DNA replication complex GINS protein SLD5 × 1 （Q9BRT9） Protein timeless homolog × 1 （Q9UNS1） TIMELESS-interacting protein × 1 （Q9BVW5） Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 （P49643） Claspin × 1 （Q9HAW4） DNA primase small subunit × 1 （P49642） WD repeat and HMG-box DNA-binding protein 1 × 3 （O75717） PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	DPOLA_HUMAN
Isoform	—
PDB entities	21
Chains and sequence ranges	Author chain B； PDBConstruct 43–1504； UniProt 1–1462

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	8b9d
Deposition date deposition_date	2022-10-05
Structure title title	Human replisome bound by Pol Alpha
Keywords keywords	human, replication, priming, polymerase; REPLICATION
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8b9d__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8b9d__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

8b9d__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	77.50 Å
Rg (electron density)	77.50 Å
Total Rg	77.40 Å
Atom count	131961
Residues	8161
Excluded volume	1176400 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`8b9d__assembly_1__model_1`	23-meric （23）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (24)

Entity 1 Entity 1 polymer

Description description	DNA replication licensing factor MCM2
Molecular weight formula_weight	102034.1 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	2
Atom count atom_count	131961

MAESSESFTMASSPAQRRRGNDPLTSSPGRSSRRTDALTSSPGRDLPPFEDESEGLLGTEGPLEEEEDGEELIGDGMERDYRAIPELDAYEAEGLALDDEDVEELTASQREAAERAMRQRDREAGRGLGRMRRGLLYDSDEEDEERPARKRRQVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCNKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEVNMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATVILANHVAKKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDILCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDYVIEDDVNMAIRVMLESFIDTQKFSVMRSMRKTFARYLSFRRDNNELLLFILKQLVAEQVTYQRNRFGAQQDTIEVPEKDLVDKARQINIHNLSAFYDSELFRMNKFSHDLKRKMILQQF

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 2 Entity 2 polymer

Description description	DNA replication licensing factor MCM3
Molecular weight formula_weight	91110.9 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3

MAGTVVLDDVELREAQRDYLDFLDDEEDQGIYQSKVRELISDNQYRLIVNVNDLRRKNEKRANRLLNNAFEELVAFQRALKDFVASIDATYAKQYEEFYVGLEGSFGSKHVSPRTLTSCFLSCVVCVEGIVTKCSLVRPKVVRSVHYCPATKKTIERRYSDLTTLVAFPSSSVYPTKDEENNPLETEYGLSVYKDHQTITIQEMPEKAPAGQLPRSVDVILDDDLVDKAKPGDRVQVVGTYRCLPGKKGGYTSGTFRTVLIACNVKQMSKDAQPSFSAEDIAKIKKFSKTRSKDIFDQLAKSLAPSIHGHDYVKKAILCLLLGGVERDLENGSHIRGDINILLIGDPSVAKSQLLRYVLCTAPRAIPTTGRGSSGVGLTAAVTTDQETGERRLEAGAMVLADRGVVCIDEFDKMSDMDRTAIHEVMEQGRVTIAKAGIHARLNARCSVLAAANPVYGRYDQYKTPMENIGLQDSLLSRFDLLFIMLDQMDPEQDREISDHVLRMHRYRAPGEQDGDAMPLGSAVDILATDDPNFSQEDQQDTQIYEKHDNLLHGTKKKKEKMVSAAFMKKYIHVAKIIKPVLTQESATYIAEEYSRLRSQDSMSSDTARTSPVTARTLETLIRLATAHAKARMSKTVDLQDAEEAVELVQYAYFKKVLEKEKKRKKRSEDESETEDEEEKSQEDQEQKRKRRKTRQPDAKDGDSYDPYDFSDTEEEMPQVHTPKTADSQETKESQKVELSESRLKAFKVALLDVFREAHAQSIGMNRLTESINRDSEEPFSSVEIQAALSKMQDDNQVMVSEGIIFLI

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 3 Entity 3 polymer

Description description	DNA replication licensing factor MCM4
Molecular weight formula_weight	96684.9 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4

MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQSPAAQDVLFSSPPQMHSSAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSAQKGLQVDLQSDGAAAEDIVASEQSLGQKLVIWGTDVNVAACKENFQRFLQRFIDPLAKEEENVGIDITEPLYMQRLGEINVIGEPFLNVNCEHIKSFDKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKNMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEMDRGRIAEPSVCGRCHTTHSMALIHNRSLFSDKQMIKLQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVELLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLLLDPQDEAYDRRLAHHLVALYYQSEEQAEEELLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVDMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRLSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALKKLILSKGKTPALKYQQLFEDIRGQSDIAITKDMFEEALRALADDDFLTVTGKTVRLL

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 4 Entity 4 polymer

Description description	DNA replication licensing factor MCM5
Molecular weight formula_weight	82406.6 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	5

MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRVGTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEAAKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASAVRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDKCKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGLTTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEVISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLKFVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKMREDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMPTILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYCRVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALSKMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGVEGFTSQEDQEMLSRIEKQLKRRFAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGEIQHRMQRKVLYRLK

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 5 Entity 5 polymer

Description description	DNA replication licensing factor MCM6
Molecular weight formula_weight	93010.3 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	6

MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEYCRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 6 Entity 6 polymer

Description description	DNA replication licensing factor MCM7
Molecular weight formula_weight	81411.9 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	7

MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVRSPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 7 Entity 7 polymer

Description description	DNA polymerase alpha subunit B
Molecular weight formula_weight	66015.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A

MSASAQQLAEELQIFGLDCEEALIEKLVELCVQYGQNEEGMVGELIAFCTSTHKVGLTSEILNSFEHEFLSKRLSKARHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPVDLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPLLDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVKDVLGCVCVNPGRLTKGQVGGTFARLYLRRPAADGAERQSPCIAVQVVRI

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 8 Entity 8 polymer

Description description	Cell division control protein 45 homolog
Molecular weight formula_weight	66016.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MFVSDFRKEFYEVVQSQRVLLFVASDVDALCACKILQALFQCDHVQYTLVPVSGWQELETAFLEHKEQFHYFILINCGANVDLLDILQPDEDTIFFVCDTHRPVNVVNVYNDTQIKLLIKQDDDLEVPAYEDIFRDEEEDEEHSGNDSDGSEPSEKRTRLDYKDDDIVEQTMRRRQRREWEARRRDILFDYEQYEYHGTSSAMVMFELAWMLSKDLNDMLWWAIVGLTDQWVQDKITQMKYVTDVGVLQRHVSRHNHRNEDEENTLSVDCTRISFEYDLRLVLYQHWSLHDSLCNTSYTAARFKLWSVHGQKRLQEFLADMGLPLKQVKQKFQAMDISLKENLREMIEESANKFGMKDMRVQTFSIHFGFKHKFLASDVVFATMSLMESPEKDGSGTDHFIQALDSLSRSNLDKLYHGLELAKKQLRATQQTIASCLCTNLVISQGPFLYCSLMEGTPDVMLFSRPASLSLLSKHLLKSFVCSTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFLDALISLLS

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 9 Entity 9 polymer

Description description	DNA replication complex GINS protein PSF1
Molecular weight formula_weight	23022.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MFCEKAMELIRELHRAPEGQLPAFNEDGLRQVLEEMKALYEQNQSDVNEAKSGGRSDLIPTIKFRHCSLLRNRRCTVAYLYDRLLRIRALRWEYGSVLPNALRFHMAAEEMEWFNNYKRSLATYMRSLGGDEGLDITQDMKPPKSLYIEVRCLKDYGEFEVDDGTSVLLKKNSQHFLPRWKCEQLIRQGVLEHILS

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 10 Entity 10 polymer

Description description	DNA replication complex GINS protein PSF2
Molecular weight formula_weight	21453.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVEVPLWLAINLKQRQKCRLLPPEWMDVEKLEKMRDHERKEETFTPMPSPYYMELTKLLLNHASDNIPKADEIRTLVKDMWDTRIAKLRVSADSFVRQQEAHAKLDNLTLMEINTSGTFLTQALNHMYKLRTNLQPLESTQSQDF

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 11 Entity 11 polymer

Description description	DNA replication complex GINS protein PSF3
Molecular weight formula_weight	24562.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MSEAYFRVESGALGPEENFLSLDDILMSHEKLPVRTETAMPRLGAFFLERSAGAETDNAVPQGSKLELPLWLAKGLFDNKRRILSVELPKIYQEGWRTVFSADPNVVDLHKMGPHFYGFGSQLLHFDSPENADISQSLLQTFIGRFRRIMDSSQNAYNEDTSALVARLDEMERGLFQTGQKGLNDFQCWEKGQASQITASNLVQNYKKRKFTDMED

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 12 Entity 12 polymer

Description description	DNA replication complex GINS protein SLD5
Molecular weight formula_weight	29983.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

WSHPQFEKGGGSGGGSGGSAWSHPQFEKSGLEVLFQGPMTEEVDFLGQDSDGGSEEVVLTPAELIERLEQAWMNEKFAPELLESKPEIVECVMEQLEHMEENLRRAKREDLKVSIHQMEMERIRYVLSSYLRCRLMKIEKFFPHVLEKEKTRPEGEPSSLSPEELAFAREFMANTESYLKNVALKHMPPNLQKVDLFRAVPKPDLDSYVFLRVRERQENILVEPDTDEQRDYVIDLEKGSQHLIRYKTIAPLVASGAVQLI

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 13 Entity 13 polymer

Description description	Protein timeless homolog
Molecular weight formula_weight	138903.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

GMDLHMMNCELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRHEDETRDVRQQLGAAQILQSDLLPILTQHHQDKPLFDAVIRLMVNLTQPALLCFGNLPKEPSFRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEERQEEDNLLIERILLLVRNILHVPADLDQEKKIDDDASAHDQLLWAIHLSGLDDLLLFLASSSAEEQWSLHVLEIVSLMFRDQNPEQLAGVGQGRLAQERSADFAELEVLRQREMAEKKTRALQRGNRHSRFGGSYIVQGLKSIGERDLIFHKGLHNLRNYSSDLGKQPKKVPKRRQAARELSIQRRSALNVRLFLRDFCSEFLENCYNRLMGSVKDHLLREKAQQHDETYYMWALAFFMAFNRAASFRPGLVSETLSVRTFHFIEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATVNEMDISPDEAVRESSRIIKNNIFYVMEYRELFLALFRKFDERCQPRSFLRDLVETTHLFLKMLERFCRSRGNLVVQNKQKKRRKKKKKVLDQAIVSGNVPSSPEEVEAVWPALAEQLQCCAQNSELSMDSVVPFDAASEVPVEEQRAEAMVRIQDCLLAGQAPQALTLLRSAREVWPEGDVFGSQDISPEEEIQLLKQILSAPLPRQQGPEERGAEEEEEEEEEEEEELQVVQVSEKEFNFLDYLKRFACSTVVRAYVLLLRSYQQNSAHTNHCIVKMLHRLAHDLKMEALLFQLSVFCLFNRLLSDPAAGAYKELVTFAKYILGKFFALAAVNQKAFVELLFWKNTAVVREMTEGYGSLDDRSSSRRAPTWSPEEEAHLRELYLANKDVEGQDVVEAILAHLNTVPRTRKQIIHHLVQMGLADSVKDFQRKGTHIVLWTGDQELELQRLFEEFRDSDDVLGHIMKNITAKRSRARIVDKLLALGLVAERRELYKKRQKKLASSILPNGAESLKDFCQEDLEEEENLPEEDSEEEEEGGSEAEQVQGSLVLSNENLGQSLHQEGFSIPLLWLQNCLIRAADDREEDGCSQAVPLVPLTEENEEAMENEQFQQLLRKLGVRPPASGQETFWRIPAKLSPTQLRRAAASLSQPEEEQKLQPELQPKVPGEQGSDEEHCKEHRAQALRALLLAHKKKAGLASPEEEDAVGKEPLKAAPKKRQLLDSDEEQEEDEGRNRAPELGAPGIQKKKRYQIEDDEDD

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 14 Entity 14 polymer

Description description	TIMELESS-interacting protein
Molecular weight formula_weight	34600.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MLEPQENGVIDLPDYEHVEDETFPPFPPPASPERQDGEGTEPDEESGNGAPVRVPPKRTVKRNIPKLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKMLIRHMEHWAHRLFPKLQFEDFIDRVEYLGSKKEVQTCLKRIRLDLPILHEDFVSNNDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 15 Entity 15 polymer

Description description	Leading strand DNA
Molecular weight formula_weight	26092.6 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	M

TAGAGTAGGAAGTGAGGTAAGTGATTAGAGAATTGGAGAGTGTGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT

Entity 16 Entity 16 polymer

Description description	DNA Molecule
Molecular weight formula_weight	26402.9 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	N

GGCAGGCAGGCAGGCAGGCAGGCAGGCAGGCAGGCAGGCAACACACTCTCCAATTCTCTAATCACTTACCATCACTTCCTACTCTA

Entity 17 Entity 17 polymer

Description description	DNA primase large subunit
Molecular weight formula_weight	58890.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MEFSGRKWRKLRLAGDQRNASYPHCLQFYLQPPSENISLIEFENLAIDRVKLLKSVENLGVSYVKGTEQYQSKLESELRKLKFSYRENLEDEYEPRRRDHISHFILRLAYCQSEELRRWFIQQEMDLLRFRFSILPKDKIQDFLKDSQLQFEAISDEEKTLREQEIVASSPSLSGLKLGFESIYKIPFADALDLFRGRKVYLEDGFAYVPLKDIVAIILNEFRAKLSKALALTARSLPAVQSDERLQPLLNHLSHSYTGQDYSTQGNVGKISLDQIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTLEQALQFWKQEFIKGKMDPDKFDKGYSYNIRHSFGKEGKRTDYTPFSCLKIILSNPPSQGDYHGCPFRHSDPELLKQKLQSYKISPGGISQILDLVKGTHYQVACQKYFEMIHNVDDCGFSLNHPNQFFCESQRILNGGKDIKKEPIQPETPQPKPSVQKTKDASSALASLNSSLEMDMEGLEDYFSEDS

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 18 Entity 18 polymer

Description description	Claspin
Molecular weight formula_weight	155184.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MTGEVGSEVHLEINDPNVISQEEADSPSDSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASPEKTTYDSAEEENKENLYAGKNTKIKRIYKTVADSDESYMEKSLYQENLEAQVKPCLELSLQSGNSTDFTTDRKSSKKHIHDKEGTAGKAKVKSKRRLEKEERKMEKIRQLKKKETKNQEDDVEQPFNDSGCLLVDKDLFETGLEDENNSPLEDEESLESIRAAVKNKVKKHKKKEPSLESGVHSFEEGSELSKGTTRKERKAARLSKEALKQLHSETQRLIRESALNLPYHMPENKTIHDFFKRKPRPTCHGNAMALLKSSKYQSSHHKEIIDTANTTEMNSDHHSKGSEQTTGAENEVETNALPVVSKETQIITGSDESCRKDLVKNEELEIQEKQKQSDIRPSPGDSSVLQQESNFLGNNHSEECQVGGLVAFEPHALEGEGPQNPEETDEKVEEPEQQNKSSAVGPPEKVRRFTLDRLKQLGVDVSIKPRLGADEDSFVILEPETNRELEALKQRFWKHANPAAKPRAGQTVNVNVIVKDMGTDGKEELKADVVPVTLAPKKLDGASHTKPGEKLQVLKAKLQEAMKLRRFEERQKRQALFKLDNEDGFEEEEEEEEEMTDESEEDGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEFLLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPTEEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFFPTAGGFRSPSPGLFRASLVSSASKSSGKLSEPSLPIEDSQDLYNASPEPKTLFLGAGDFQFCLEDDTQSQLLDADGFLNVRNHRNQYQALKPRLPLASMDENAMDANMDELLDLCTGKFTSQAEKHLPRKSDKKENMEELLNLCSGKFTSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDNEFDSDEDEHSDSGNDLALEDHEDDDEEELLKRSEKLKRQMRLRKYLEDEAEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLYQERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQVKTGSLLNQPKAVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGPSFMTSPSPKHLKTDDSTSGLTRSIFKYLESLEVLFQGPDYKDDDDKDYKDDDDKDYKDDDDK

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 19 Entity 19 polymer

Description description	DNA primase small subunit
Molecular weight formula_weight	54242.6 kDa
EC 编号 ec_number	2.7.7.102
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

MASAWSHPQFEKGGGSGGGSGGSAWSHPQFEKSGLEVLFQGPMETFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSDLEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPKCWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLVKGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHDELQQSFQKSHNSLQRWEHLKKVASRYQNNIKNDKYGPWLEWEIMLQYCFPRLDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAISTNEEEKEENEAESDVKHRTRDYKKTSLAPYVKVFEHFLENLDKSRKGELLKKSDLQKDF

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 20 Entity 20 polymer

Description description	WD repeat and HMG-box DNA-binding protein 1
Molecular weight formula_weight	129967.0 kDa
Source method src_method	man
Copy count entity_count	3

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H,J,I

DYKDDDDKDYKDDDDKDYKDDDDKENLYFQGMPATRKPMRYGHTEGHTEVCFDDSGSFIVTCGSDGDVRIWEDLDDDDPKFINVGEKAYSCALKSGKLVTAVSNNTIQVHTFPEGVPDGILTRFTTNANHVVFNGDGTKIAAGSSDFLVKIVDVMDSSQQKTFRGHDAPVLSLSFDPKDIFLASASCDGSVRVWQISDQTCAISWPLLQKCNDVINAKSICRLAWQPKSGKLLAIPVEKSVKLYRRESWSHQFDLSDNFISQTLNIVTWSPCGQYLAAGSINGLIIVWNVETKDCMERVKHEKGYAICGLAWHPTCGRISYTDAEGNLGLLENVCDPSGKTSSSKVSSRVEKDYNDLFDGDDMSNAGDFLNDNAVEIPSFSKGIINDDEDDEDLMMASGRPRQRSHILEDDENSVDISMLKTGSSLLKEEEEDGQEGSIHNLPLVTSQRPFYDGPMPTPRQKPFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQDNAIDVEFHDTSIHHATHLSNTLNYTIADLSHEAILLACESTDELASKLHCLHFSSWDSSKEWIIDLPQNEDIEAICLGQGWAAAATSALLLRLFTIGGVQKEVFSLAGPVVSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGDPLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNTWTPICNTREHCKGKSDHYWVVGIHENPQQLRCIPCKGSRFPPTLPRPAVAILSFKLPYCQIATEKGQMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAVNLAIKYASRSRKLILAQKLSELAVEKAAELTATQVEEEEEEEDFRKKLNAGYSNTATEWSQPRFRNQVEEDAEDSGEADDEEKPEIHKPGQNSFSKSTNSSDVSAKSGAVTFSSQGRVNPFKVSASSKEPAMSMNSARSTNILDNMGKSSKKSTALSRTTNNEKSPIIKPLIPKPKPKQASAASYFQKRNSQTNKTEEVKEENLKNVLSETPAICPPQNTENQRPKTGFQMWLEENRSNILSDNPDFSDEADIIKEGMIRFRVLSTEERKVWANKAKGETASEGTEAKKRKRVVDESDETENQEEKAKENLNLSKKQKPLDFSTNQKLSAFAFKQE

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 21 Entity 21 polymer

Description description	DNA polymerase alpha catalytic subunit
Molecular weight formula_weight	170392.7 kDa
EC 编号 ec_number	2.7.7.7
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MASAWSHPQFEKGGGSGGGSGGSAWSHPQFEKSGLEVLFQGPMAPVHGDDSLSDSGSFVSSRARREKKSKKGRQEALERLKKAKAGEKYKYEVEDFTGVYEEVDEEQYSKLVQARQDDDWIVDDDGIGYVEDGREIFDDDLEDDALDADEKGKDGKARNKDKRNVKKLAVTKPNNIKSMFIACAGKKTADKAVDLSKDGLLGDILQDLNTETPQITPPPVMILKKKRSIGASPNPFSVHTATAVPSGKIASPVSRKEPPLTPVPLKRAEFAGDDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEADSGKGTVSYLGSFLPDVSCWDIDQEGDSSFSVQEVQVDSSHLPLVKGADEEQVFHFYWLDAYEDQYNQPGVVFLFGKVWIESAETHVSCCVMVKNIERTLYFLPREMKIDLNTGKETGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQLPQDLKGETFSHVFGTNTSSLELFLMNRKIKGPCWLEVKSPQLLNQPVSWCKVEAMALKPDLVNVIKDVSPPPLVVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAAPKPPFQSHFCVVSKPKDCIFPYAFKEVIEKKNVKVEVAATERTLLGFFLAKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRLKRSNMPKLGGRSGFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQNMYSESSQLLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNEFLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYDKFILLLDFNSLYPSIIQEFNICFTTVQRVASEAQKVTEDGEQEQIPELPDPSLEMGILPREIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVTYKGREILMHTKEMVQKMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEVNKLYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIGQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWINSQGGRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEPIDGIDAVLIATWLGLDPTQFRVHHYHKDEENDALLGGPAQLTDEEKYRDCERFKCPCPTCGTENIYDNVFDGSGTDMEPSLYRCSNIDCKASPLTFTVQLSNKLIMDIRRFIKKYYDGWLICEEPTCRNRTRHLPLQFSRTGPLCPACMKATLQPEYSDKSLYTQLCFYRYIFDAECALEKLTTDHEKDKLKKQFFTPKVLQDYRKLKNTAEQFLSRSGYSEVNLSKLFAGCAVKS

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 22 Entity 22 non-polymer

Description description	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Molecular weight formula_weight	506.2 kDa
Source method src_method	syn
Copy count entity_count	3

Entity 23 Entity 23 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	3

Entity 24 Entity 24 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	4

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	3.40 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	174696

Human replisome bound by Pol Alpha

1. Protein Identity and Related Structures Protein Identity & Related Structures

DNA replication licensing factor MCM2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM6

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication licensing factor MCM7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA polymerase alpha subunit B

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Cell division control protein 45 homolog

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication complex GINS protein PSF1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

DNA replication complex GINS protein PSF2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer