8b9d

Human replisome bound by Pol Alpha

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

DNA replication licensing factor MCM2

Homo sapiens

UniProt P49736

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 MCM2_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 2; PDB构建体 1–904; UniProt 1–904

DNA replication licensing factor MCM3

Homo sapiens

UniProt P25205

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 MCM3_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 3; PDB构建体 1–808; UniProt 1–808

DNA replication licensing factor MCM4

Homo sapiens

UniProt P33991

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 MCM4_HUMAN
Isoform —
PDB实体 3
链与序列区间 作者链 4; PDB构建体 1–863; UniProt 1–863

DNA replication licensing factor MCM5

Homo sapiens

UniProt P33992

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 MCM5_HUMAN
Isoform —
PDB实体 4
链与序列区间 作者链 5; PDB构建体 1–734; UniProt 1–734

DNA replication licensing factor MCM6

Homo sapiens

UniProt Q14566

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 MCM6_HUMAN
Isoform —
PDB实体 5
链与序列区间 作者链 6; PDB构建体 1–821; UniProt 1–821

DNA replication licensing factor MCM7

Homo sapiens

UniProt P33993

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 MCM7_HUMAN
Isoform —
PDB实体 6
链与序列区间 作者链 7; PDB构建体 1–719; UniProt 1–719

DNA polymerase alpha subunit B

Homo sapiens

UniProt Q14181

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

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UniProt名称 DPOA2_HUMAN
Isoform —
PDB实体 7
链与序列区间 作者链 A; PDB构建体 1–598; UniProt 1–598

Cell division control protein 45 homolog

Homo sapiens

UniProt O75419

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

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UniProt名称 CDC45_HUMAN
Isoform —
PDB实体 8
链与序列区间 作者链 C; PDB构建体 1–160; UniProt 1–160 作者链 C; PDB构建体 167–569; UniProt 164–566

DNA replication complex GINS protein PSF1

Homo sapiens

UniProt Q14691

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PSF1_HUMAN
Isoform —
PDB实体 9
链与序列区间 作者链 D; PDB构建体 1–196; UniProt 1–196

DNA replication complex GINS protein PSF2

Homo sapiens

UniProt Q9Y248

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

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UniProt名称 PSF2_HUMAN
Isoform —
PDB实体 10
链与序列区间 作者链 E; PDB构建体 1–185; UniProt 1–185

DNA replication complex GINS protein PSF3

Homo sapiens

UniProt Q9BRX5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

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UniProt名称 PSF3_HUMAN
Isoform —
PDB实体 11
链与序列区间 作者链 F; PDB构建体 1–216; UniProt 1–216

DNA replication complex GINS protein SLD5

Homo sapiens

UniProt Q9BRT9

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

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UniProt名称 SLD5_HUMAN
Isoform —
PDB实体 12
链与序列区间 作者链 G; PDB构建体 39–261; UniProt 1–223

Protein timeless homolog

Homo sapiens

UniProt Q9UNS1

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

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UniProt名称 TIM_HUMAN
Isoform —
PDB实体 13
链与序列区间 作者链 K; PDB构建体 2–1209; UniProt 1–1208

TIMELESS-interacting protein

Homo sapiens

UniProt Q9BVW5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

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UniProt名称 TIPIN_HUMAN
Isoform —
PDB实体 14
链与序列区间 作者链 L; PDB构建体 1–301; UniProt 1–301

DNA primase large subunit

Homo sapiens

UniProt P49643

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

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UniProt名称 PRI2_HUMAN
Isoform —
PDB实体 17
链与序列区间 作者链 P; PDB构建体 1–509; UniProt 1–509

Claspin

Homo sapiens

UniProt Q9HAW4

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CLSPN_HUMAN
Isoform —
PDB实体 18
链与序列区间 作者链 Q; PDB构建体 1–1339; UniProt 1–1339

DNA primase small subunit

Homo sapiens

UniProt P49642

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PRI1_HUMAN
Isoform —
PDB实体 19
链与序列区间 作者链 O; PDB构建体 43–462; UniProt 1–420

WD repeat and HMG-box DNA-binding protein 1

Homo sapiens

UniProt O75717

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) DNA polymerase alpha catalytic subunit × 1 (P09884) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 WDHD1_HUMAN
Isoform —
PDB实体 20
链与序列区间 作者链 H; PDB构建体 32–1160; UniProt 1–1129 作者链 I; PDB构建体 32–1160; UniProt 1–1129 作者链 J; PDB构建体 32–1160; UniProt 1–1129

DNA polymerase alpha catalytic subunit

Homo sapiens

UniProt P09884

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 21 DNA 2 DNA replication licensing factor MCM2 × 1 (P49736) DNA replication licensing factor MCM3 × 1 (P25205) DNA replication licensing factor MCM4 × 1 (P33991) DNA replication licensing factor MCM5 × 1 (P33992) DNA replication licensing factor MCM6 × 1 (Q14566) DNA replication licensing factor MCM7 × 1 (P33993) DNA polymerase alpha subunit B × 1 (Q14181) Cell division control protein 45 homolog × 1 (O75419) DNA replication complex GINS protein PSF1 × 1 (Q14691) DNA replication complex GINS protein PSF2 × 1 (Q9Y248) DNA replication complex GINS protein PSF3 × 1 (Q9BRX5) DNA replication complex GINS protein SLD5 × 1 (Q9BRT9) Protein timeless homolog × 1 (Q9UNS1) TIMELESS-interacting protein × 1 (Q9BVW5) Leading strand DNA × 1 DNA Molecule × 1 DNA primase large subunit × 1 (P49643) Claspin × 1 (Q9HAW4) DNA primase small subunit × 1 (P49642) WD repeat and HMG-box DNA-binding protein 1 × 3 (O75717) PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER × 3 MAGNESIUM ION × 3 ZINC ION × 4 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DPOLA_HUMAN
Isoform —
PDB实体 21
链与序列区间 作者链 B; PDB构建体 43–1504; UniProt 1–1462

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id8b9d
沉积日期 deposition_date2022-10-05
结构标题 titleHuman replisome bound by Pol Alpha
关键词 keywordshuman, replication, priming, polymerase; REPLICATION
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

8b9d__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

8b9d__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 1010 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

8b9d__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)77.50 Å
Rg(电子密度)77.50 Å
总 Rg77.40 Å
原子数131961
残基数8161
排除体积1176400 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 8b9d__assembly_1__model_1 23-meric (23) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (24)

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7. 引用文献 (1)