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8era

RMC-5552 in complex with mTORC1 and FKBP12

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Serine/threonine-protein kinase mTOR

Homo sapiens

UniProt P42345

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Peptidyl-prolyl cis-trans isomerase FKBP1A × 1 （P62942） Target of rapamycin complex subunit LST8 × 1 （Q9BVC4） Regulatory-associated protein of mTOR × 1 （Q8N122） ;1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one ; × 1 ;(3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone ; × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1aue 1aue 2gaq 2npu 3jbz 5wbh 5wbh 5wbh 5wbh

9 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1fap 1nsg 2fap 2rse 3fap 4drh 4drh 4dri 4drj 4fap 4jsn 4jsn

76 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MTOR_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A； PDBConstruct 1–2549； UniProt 1–2549

Peptidyl-prolyl cis-trans isomerase FKBP1A

Homo sapiens

UniProt P62942

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Serine/threonine-protein kinase mTOR × 1 （P42345） Target of rapamycin complex subunit LST8 × 1 （Q9BVC4） Regulatory-associated protein of mTOR × 1 （Q8N122） ;1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one ; × 1 ;(3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone ; × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1d6o 1d6o 1d7h 1d7h 1d7i 1d7i 1d7j 1d7j 1f40 1fkb 1fkg 1fkh

79 assemblies; showing the first 12

Homodimer
1a7x 1bkf 1d6o 1d6o 1d7h 1d7h 1d7i 1d7i 1d7j 1d7j 1eym 1fkd

22 assemblies; showing the first 12

Homotetramer
1fkd 1fkj 1qpf 2fke

4 assemblies

Other homooligomers

None

Heteromeric or nucleic-acid complex
1b6c 1b6c 1b6c 1b6c 1b6c 1bl4 1fap 1nsg 1tco 21kr 21ks 21kt

67 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name FKB1A_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain B； PDBConstruct 2–108； UniProt 2–108

Target of rapamycin complex subunit LST8

Homo sapiens

UniProt Q9BVC4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Serine/threonine-protein kinase mTOR × 1 （P42345） Peptidyl-prolyl cis-trans isomerase FKBP1A × 1 （P62942） Regulatory-associated protein of mTOR × 1 （Q8N122） ;1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one ; × 1 ;(3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone ; × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
4jsn 4jsn 4jsp 4jsp 4jsv 4jsv 4jsx 4jsx 4jt5 4jt5 4jt6 4jt6

53 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name LST8_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain C； PDBConstruct 1–326； UniProt 1–326

Regulatory-associated protein of mTOR

Homo sapiens

UniProt Q8N122

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Protein heterocomplex Heteromer Protein 4 Serine/threonine-protein kinase mTOR × 1 （P42345） Peptidyl-prolyl cis-trans isomerase FKBP1A × 1 （P62942） Target of rapamycin complex subunit LST8 × 1 （Q9BVC4） ;1-[6-{[(3M)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1H)-yl]-3-hydroxypropan-1-one ; × 1 ;(3S,5R,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30R,34aS)-5,9,27-trihydroxy-3-{(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4H,31H)-tetrone ; × 1 Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
5h64 6bcu 6bcx 6sb0 6sb2 6u62 7owg 7pea 7peb 7pec 7ux2 7uxc

22 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name RPTOR_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain Y； PDBConstruct 1–1335； UniProt 1–1335

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8era
Deposition date deposition_date2022-10-11
Structure title titleRMC-5552 in complex with mTORC1 and FKBP12
Keywords keywordsAntitumor, mTORC1, COMPLEX (ISOMERASE-KINASE) complex; COMPLEX (ISOMERASE/KINASE)
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8era__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8era__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8era__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）72.50 Å
Rg (electron density)72.78 Å
Total Rg72.56 Å
Atom count29054
Residues3644
Excluded volume519770 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8era__assembly_1__model_1 tetrameric （4） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (6)

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6. Fold Classification (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

Domain ID domain_id8eraB01
Class class3 — Alpha Beta
Architecture architecture10 — Roll
Topology topology50 — Chitinase A; domain 3
Homologous superfamily homologous superfamily40 —
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7. Citations (2)