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8rgg

Structure of dynein-2 intermediate chain DYNC2I2 (WDR34) in complex with dynein-2 heavy chain DYNC2H1.

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1

Homo sapiens

UniProt P16455

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 7 Cytoplasmic dynein 2 intermediate chain 1 × 1 （Q8WVS4） Cytoplasmic dynein 2 intermediate chain 2 × 1 （Q96EX3） Dynein light chain roadblock-type 1 × 2 （Q9NP97） Dynein light chain 1, cytoplasmic × 2 （P63167） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
1eh6 1eh7 1eh8 1qnt 1yfh

5 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1t38 1t39 1t39 1yfh 1yfh 28op 8rgg 8rgh 8rty 8ru2 9hhl 9qey

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name MGMT_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain B； PDBConstruct 2–184； UniProt 2–184

Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1

Homo sapiens

UniProt Q8NCM8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 7 Cytoplasmic dynein 2 intermediate chain 1 × 1 （Q8WVS4） Cytoplasmic dynein 2 intermediate chain 2 × 1 （Q96EX3） Dynein light chain roadblock-type 1 × 2 （Q9NP97） Dynein light chain 1, cytoplasmic × 2 （P63167） Consistent with protein count

Other States of the Same Protein in the Database

Monomer
4rh7

1 assemblies

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
8rgg 8rgh

2 assemblies

View Construct and Data Evidence
UniProt name DYHC2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain B； PDBConstruct 208–4513； UniProt 2–4307

Cytoplasmic dynein 2 intermediate chain 1

Homo sapiens

UniProt Q8WVS4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 7 Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1 × 1 （P16455,Q8NCM8） Cytoplasmic dynein 2 intermediate chain 2 × 1 （Q96EX3） Dynein light chain roadblock-type 1 × 2 （Q9NP97） Dynein light chain 1, cytoplasmic × 2 （P63167） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6rlb 6sc2 8rgg 8rgh

4 assemblies

View Construct and Data Evidence
UniProt name DC2I1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C； PDBConstruct 1–1066； UniProt 1–1066

Cytoplasmic dynein 2 intermediate chain 2

Homo sapiens

UniProt Q96EX3

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 7 Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1 × 1 （P16455,Q8NCM8） Cytoplasmic dynein 2 intermediate chain 1 × 1 （Q8WVS4） Dynein light chain roadblock-type 1 × 2 （Q9NP97） Dynein light chain 1, cytoplasmic × 2 （P63167） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer

None

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6rlb 6sc2 8rgg 8rgh

4 assemblies

View Construct and Data Evidence
UniProt name DC2I2_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain D； PDBConstruct 1–536； UniProt 1–536

Dynein light chain roadblock-type 1

Homo sapiens

UniProt Q9NP97

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 7 Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1 × 1 （P16455,Q8NCM8） Cytoplasmic dynein 2 intermediate chain 1 × 1 （Q8WVS4） Cytoplasmic dynein 2 intermediate chain 2 × 1 （Q96EX3） Dynein light chain 1, cytoplasmic × 2 （P63167） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
1z09 2b95 2e8j 2hz5 2hz5

5 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
6f1t 6f1z 6f38 6f3a 6rlb 6sc2 7z8f 8j07 8pr1 8ptk 8rgg 8rgh

20 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name DLRB1_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain G； PDBConstruct 1–96； UniProt 1–96 Author chain H； PDBConstruct 1–96； UniProt 1–96

Dynein light chain 1, cytoplasmic

Homo sapiens

UniProt P63167

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 7 Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1 × 1 （P16455,Q8NCM8） Cytoplasmic dynein 2 intermediate chain 1 × 1 （Q8WVS4） Cytoplasmic dynein 2 intermediate chain 2 × 1 （Q96EX3） Dynein light chain roadblock-type 1 × 2 （Q9NP97） Consistent with protein count

Other States of the Same Protein in the Database

Monomer

None

Homodimer
9nz7 9nz7

2 assemblies

Homotetramer

None

Other homooligomers

None

Heteromeric or nucleic-acid complex
1cmi 1cmi 3zke 3zke 3zke 3zkf 3zkf 3zkf 6gzj 6gzl 6rlb 6sc2

25 assemblies; showing the first 12

View Construct and Data Evidence
UniProt name DYL1_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain I； PDBConstruct 1–89； UniProt 1–89 Author chain J； PDBConstruct 1–89； UniProt 1–89

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8rgg
Deposition date deposition_date2023-12-13
Structure title titleStructure of dynein-2 intermediate chain DYNC2I2 (WDR34) in complex with dynein-2 heavy chain DYNC2H1.
Keywords keywordsdynein, cilia, intraflagellar transport, complex, TRANSPORT PROTEIN; TRANSPORT PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8rgg__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8rgg__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8rgg__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg（Guinier）34.84 Å
Rg (electron density)33.77 Å
Total Rg34.25 Å
Atom count7679
Residues1156
Excluded volume132930 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8rgg__assembly_1__model_1 heptameric （7） Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)