8rgh

Structure of dynein-2 intermediate chain DYNC2I1 (WDR60) in complex with the dynein-2 heavy chain DYNC2H1.

Method: ELECTRON MICROSCOPY
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1. Protein Identity and Related Structures Protein Identity & Related Structures

Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1

Homo sapiens

UniProt P16455

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 6 Cytoplasmic dynein 2 intermediate chain 1 × 1 (Q8WVS4) Cytoplasmic dynein 2 intermediate chain 2 × 1 (Q96EX3) Cytoplasmic dynein 2 light intermediate chain 1 × 1 (Q8TCX1) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name MGMT_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 2–184; UniProt 2–184

Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1

Homo sapiens

UniProt Q8NCM8

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 6 Cytoplasmic dynein 2 intermediate chain 1 × 1 (Q8WVS4) Cytoplasmic dynein 2 intermediate chain 2 × 1 (Q96EX3) Cytoplasmic dynein 2 light intermediate chain 1 × 1 (Q8TCX1) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name DYHC2_HUMAN
Isoform —
PDB entities 1
Chains and sequence ranges Author chain A; PDBConstruct 208–4513; UniProt 2–4307

Cytoplasmic dynein 2 intermediate chain 1

Homo sapiens

UniProt Q8WVS4

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 6 Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1 × 1 (P16455,Q8NCM8) Cytoplasmic dynein 2 intermediate chain 2 × 1 (Q96EX3) Cytoplasmic dynein 2 light intermediate chain 1 × 1 (Q8TCX1) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name DC2I1_HUMAN
Isoform —
PDB entities 2
Chains and sequence ranges Author chain C; PDBConstruct 1–1066; UniProt 1–1066

Cytoplasmic dynein 2 intermediate chain 2

Homo sapiens

UniProt Q96EX3

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 6 Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1 × 1 (P16455,Q8NCM8) Cytoplasmic dynein 2 intermediate chain 1 × 1 (Q8WVS4) Cytoplasmic dynein 2 light intermediate chain 1 × 1 (Q8TCX1) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name DC2I2_HUMAN
Isoform —
PDB entities 3
Chains and sequence ranges Author chain D; PDBConstruct 1–536; UniProt 1–536

Cytoplasmic dynein 2 light intermediate chain 1

Homo sapiens

UniProt Q8TCX1

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 6 Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1 × 1 (P16455,Q8NCM8) Cytoplasmic dynein 2 intermediate chain 1 × 1 (Q8WVS4) Cytoplasmic dynein 2 intermediate chain 2 × 1 (Q96EX3) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name DC2L1_HUMAN
Isoform —
PDB entities 4
Chains and sequence ranges Author chain E; PDBConstruct 1–351; UniProt 1–351

Dynein light chain roadblock-type 1

Homo sapiens

UniProt Q9NP97

State in the Current Structure

Assembly Physical composition Protein state Molecular copy count Associated components Data consistency
1 Insufficient information Heteromer Protein 6 Methylated-DNA--protein-cysteine methyltransferase,Cytoplasmic dynein 2 heavy chain 1 × 1 (P16455,Q8NCM8) Cytoplasmic dynein 2 intermediate chain 1 × 1 (Q8WVS4) Cytoplasmic dynein 2 intermediate chain 2 × 1 (Q96EX3) Cytoplasmic dynein 2 light intermediate chain 1 × 1 (Q8TCX1) Consistent with protein count

Other States of the Same Protein in the Database

View Construct and Data Evidence
UniProt name DLRB1_HUMAN
Isoform —
PDB entities 5
Chains and sequence ranges Author chain G; PDBConstruct 1–96; UniProt 1–96 Author chain H; PDBConstruct 1–96; UniProt 1–96

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id8rgh
Deposition date deposition_date2023-12-13
Structure title titleStructure of dynein-2 intermediate chain DYNC2I1 (WDR60) in complex with the dynein-2 heavy chain DYNC2H1.
Keywords keywordsdynein, cilia, intraflagellar transport, complex, TRANSPORT PROTEIN; TRANSPORT PROTEIN
Experimental Method methodELECTRON MICROSCOPY
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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

8rgh__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

8rgh__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 q (1/Angstrom) I(q)
100 plotted points; both axes use logarithmic scales.

8rgh__assembly_1__model_1 | P(r) · Pending

The new assembly/model P(r) has not been calculated yet This placeholder does not display legacy data r (Angstrom) P(r)
P(r) will be calculated and displayed separately for the same assembly/model.
Rg(Guinier)37.88 Å
Rg (electron density)37.27 Å
Total Rg37.58 Å
Atom count9682
Residues1287
Excluded volume170740 ų
Maximum q0.500 Å⁻¹
Assembly Model Structure unit Oligomeric description Status CRYSOL Actions
1 1 8rgh__assembly_1__model_1 hexameric (6) Success 4.1.3-1-20251215 (887e7ef) View Download
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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (5)

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7. Citations (1)