9tay

Structure of the human inner kinetochore CCAN bound to a di-CENP-A nucleosome

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

Centromere protein H

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPH_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain H； PDBConstruct 1–247； UniProt 1–247

Centromere protein I

Homo sapiens

UniProt Q92674

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPI_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain I； PDBConstruct 1–756； UniProt 1–756

Centromere protein K

Homo sapiens

UniProt Q9BS16

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPK_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain K； PDBConstruct 1–269； UniProt 1–269

Centromere protein L

Homo sapiens

UniProt Q8N0S6

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPL_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain L； PDBConstruct 5–348； UniProt 1–344

Centromere protein M

Homo sapiens

UniProt Q9NSP4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPM_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain M； PDBConstruct 1–180； UniProt 1–180

Centromere protein N

Homo sapiens

UniProt Q96H22

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPN_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain N； PDBConstruct 1–339； UniProt 1–339

Centromere protein O

Homo sapiens

UniProt Q9BU64

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPO_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain O； PDBConstruct 89–300； UniProt 89–300

Centromere protein Q

Homo sapiens

UniProt Q7L2Z9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPQ_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain Q； PDBConstruct 2–215； UniProt 55–268

Centromere protein U

Homo sapiens

UniProt Q71F23

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPU_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain U； PDBConstruct 1–176； UniProt 243–418

Centromere protein P

Homo sapiens

UniProt Q6IPU0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPP_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain P； PDBConstruct 1–288； UniProt 1–288

Centromere protein R

Homo sapiens

UniProt Q13352

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPR_HUMAN
Isoform	—
PDB entities	11
Chains and sequence ranges	Author chain R； PDBConstruct 1–177； UniProt 1–177

Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T

Homo sapiens

UniProt P16455

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MGMT_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain T； PDBConstruct 25–206； UniProt 1–182

Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T

Homo sapiens

UniProt Q96BT3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPT_HUMAN
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain T； PDBConstruct 217–777； UniProt 1–561

Centromere protein W

Homo sapiens

UniProt Q5EE01

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPW_HUMAN
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain W； PDBConstruct 1–88； UniProt 1–88

Centromere protein S

Homo sapiens

UniProt Q8N2Z9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPS_HUMAN
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain S； PDBConstruct 1–138； UniProt 1–138

Centromere protein X

Homo sapiens

UniProt A8MT69

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPX_HUMAN
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain X； PDBConstruct 1–81； UniProt 1–81

Histone H3-like centromeric protein A

Homo sapiens

UniProt P49450

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CENPA_HUMAN
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain A； PDBConstruct 1–140； UniProt 1–140 Author chain E； PDBConstruct 1–140； UniProt 1–140 Author chain c； PDBConstruct 1–140； UniProt 1–140 Author chain g； PDBConstruct 1–140； UniProt 1–140

Histone H4

Homo sapiens

UniProt P62805

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H2A type 1-C × 4 （Q93077） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	H4_HUMAN
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain B； PDBConstruct 1–103； UniProt 1–103 Author chain F； PDBConstruct 1–103； UniProt 1–103 Author chain d； PDBConstruct 1–103； UniProt 1–103 Author chain h； PDBConstruct 1–103； UniProt 1–103

Histone H2A type 1-C

Homo sapiens

UniProt Q93077

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2B type 1-C/E/F/G/I × 4 （P62807） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	H2A1C_HUMAN
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain C； PDBConstruct 24–153； UniProt 1–130 Author chain G； PDBConstruct 24–153； UniProt 1–130 Author chain e； PDBConstruct 24–153； UniProt 1–130 Author chain i； PDBConstruct 24–153； UniProt 1–130

Histone H2B type 1-C/E/F/G/I

Homo sapiens

UniProt P62807

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Insufficient information	Heteromer	Protein 35 DNA 2	Centromere protein H × 1 （Q9H3R5） Centromere protein I × 1 （Q92674） Centromere protein K × 1 （Q9BS16） Centromere protein L × 1 （Q8N0S6） Centromere protein M × 1 （Q9NSP4） Centromere protein N × 1 （Q96H22） Centromere protein O × 1 （Q9BU64） Centromere protein Q × 1 （Q7L2Z9） Centromere protein U × 1 （Q71F23） Centromere protein P × 1 （Q6IPU0） Centromere protein R × 1 （Q13352） Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T × 1 （P16455,Q96BT3） Centromere protein W × 1 （Q5EE01） Centromere protein S × 1 （Q8N2Z9） Centromere protein X × 1 （A8MT69） Histone H3-like centromeric protein A × 4 （P49450） Histone H4 × 4 （P62805） Histone H2A type 1-C × 4 （Q93077） DNA (318-MER) × 1 DNA (318-MER) × 1 scFv × 4	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	H2B1C_HUMAN
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain D； PDBConstruct 1–126； UniProt 1–126 Author chain J； PDBConstruct 1–126； UniProt 1–126 Author chain f； PDBConstruct 1–126； UniProt 1–126 Author chain j； PDBConstruct 1–126； UniProt 1–126

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	9tay
Deposition date deposition_date	2025-11-18
Structure title title	Structure of the human inner kinetochore CCAN bound to a di-CENP-A nucleosome
Keywords keywords	Centromeres, Kinetochores, CELL CYCLE; CELL CYCLE
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

9tay__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

9tay__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

9tay__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	0.00 Å
Rg (electron density)	104.80 Å
Total Rg	105.10 Å
Atom count	57462
Residues	6201
Excluded volume	986940 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`9tay__assembly_1__model_1`	37-meric （37）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (22)

Entity 1 Entity 1 polymer

Description description	Centromere protein H
Molecular weight formula_weight	28520.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H
Atom count atom_count	57462

MEEQPQMQDADEPADSGGEGRAGGPPQVAGAQAACSEDRMTLLLRLRAQTKQQLLEYKSMVDASEEKTPEQIMQEKQIEAKIEDLENEIEEVKVAFEIKKLALDRMRLSTALKKNLEKISRQSSVLMDNMKHLLELNKLIMKSQQESWDLEEKLLDIRKKRLQLKQASESKLLEIQTEKNKQKIDLDSMENSERIKIIRQNLQMEIKITTVIQHVFQNLILGSKVNWAEDPALKEIVLQLEKNVDMM

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 2 Entity 2 polymer

Description description	Centromere protein I
Molecular weight formula_weight	87615.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MSPQKRVKNVQAQNRTSQGSSSFQTTLSAWKVKQDPSNSKNISKHGQNNPVGDYEHADDQAEEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKNGLASEEIDILLNIALSGKFGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGSTKVLFYRWLVAMFDFIDRKEQINLLYGFFFASLQDDALCPYVCHLLYLLTKKENVKPFRVRKLLDLQAKMGMQPHLQALLSLYKFFAPALISVSLPVRKKIYFKNSENLWKTALLAVKQRNRGPSPEPLKLMLGPANVRPLKRKWNSLSVIPVLNSSSYTKECGKKEMSLSDCLNRSGSFPLEQLQSFPQLLQNIHCLELPSQMGSVLNNSLLLHYINCVRDEPVLLRFYYWLSQTLQEECIWYKVNNYEHGKEFTNFLDTIIRAECFLQEGFYSCEAFLYKSLPLWDGLCCRSQFLQLVSWIPFSSFSEVKPLLFDHLAQLFFTSTIYFKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSMNSVSKLIHYVGWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHRYRKNLTAAKKNELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKGIYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSSIRGKKWSWYLDYLFSQGLQGLKLFIRSSVHHSSIPRAEGINCNNQYENLYFQ

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 3 Entity 3 polymer

Description description	Centromere protein K
Molecular weight formula_weight	31696.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MNQEDLDPDSTTDVGDVTNTEEELIRECEEMWKDMEECQNKLSLIGTETLTDSNAQLSLLIMQVKCLTAELSQWQKKTPETIPLTEDVLITLGKEEFQKLRQDLEMVLSTKESKNEKLKEDLEREQRWLDEQQQIMESLNVLHSELKNKVETFSESRIFNELKTKMLNIKEYKEKLLSTLGEFLEDHFPLPDRSVKKKKKNIQESSVNLITLHEMLEILINRLFDVPHDPYVKISDSFWPPYVELLLRNGIALRHPEDPTRIRLEAFHQ

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 4 Entity 4 polymer

Description description	Centromere protein L
Molecular weight formula_weight	39364.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

GPLGMDSYSAPESTPSASSRPEDYFIGATPLQKRLESVRKQSSFILTPPRRKIPQCSQLQEDVDPQKVAFLLHKQWTLYSLTPLYKFSYSNLKEYSRLLNAFIVAEKQKGLAVEVGEDFNIKVIFSTLLGMKGTQRDPEAFLVQIVSKSQLPSENREGKVLWTGWFCCVFGDSLLETVSEDFTCLPLFLANGAESNTAIIGTWFQKTFDCYFSPLAINAFNLSWMAAMWTACKMDHYVATTEFLWSVPCSPQSLDISFAIHPEDAKALWDSVHKTPGEVTQEEVDLFMDCLYSHFHRHFKIHLSATRLVRVSTSVASAHTDGKIKILCHKYLIGVLAYLTELAIFQIE

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 5 Entity 5 polymer

Description description	Centromere protein M
Molecular weight formula_weight	19761.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MSVLRPLDKLPGLNTATILLVGTEDALLQQLADSMLKEDCASELKVHLAKSLPLPSSVNRPRIDLIVFVVNLHSKYSLQNTEESLRHVDASFFLGKVCFLATGAGRESHCSIHRHTVVKLAHTYQSPLLYCDLEVEGFRATMAQRLVRVLQICAGHVPGVSALNLLSLLRSSEGPSLEDL

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 6 Entity 6 polymer

Description description	Centromere protein N
Molecular weight formula_weight	40541.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	N

MDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQFHQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSSMLRRNTPLLGQALTIASKHHQIVKMDLRSRYLDSLKAIVFKQYNQTFETHNSTTPLQERSLGLDINMDSRIIHENIVEKERVQRITQETFGDYPQPQLEFAQYKLETKFKSGLNGSILAERKEPLRCLIKFSSPHLLEALKSLAPAGIADAPLSPLLTCIPNKRMNYFKIRDKSDLEVLFQ

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 7 Entity 7 polymer

Description description	Centromere protein O
Molecular weight formula_weight	33830.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

MEQANPLRPDGESKGGVLAHLERLETQVSRSRKQSEELQSVQAQEGALGTKIHKLRRLRDELRAVVRHRRASVKACIANVEPNQTVEINEQEALEEKLENVKAILQAYHFTGLSGKLTSRGVCVCISTAFEGNLLDSYFVDLVIQKPLRIHHHSVPVFIPLEEIAAKYLQTNIQHFLFSLCEYLNAYSGRKYQADRLQSDFAALLTGPLQRNPLCNLLSFTYKLDPGGQSFPFCARLLYKDLTATLPTDVTVTCQGVEVLSTSWEEQRASHETLFCTKPLHQVFASFTRKGEKLDMSLVS

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 8 Entity 8 polymer

Description description	Centromere protein Q
Molecular weight formula_weight	24634.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MTKHTNLKHGKTAASKRKTWQPLSKSTRDHLQTMMESVIMTILSNSIKEKEEIQYHLNFLKKRLLQQCETLKVPPKKMEDLTNVSSLLNMERARDKANEEGLALLQEEIDKMVETTELMTGNIQSLKNKIQILASEVEEEEERVKQMHQINSSGVLSLPELSQKTLKAPTLQKEILALIPNQNALLKDLDILHNSSQMKSMSTFIEEAYKKLDAS

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 9 Entity 9 polymer

Description description	Centromere protein U
Molecular weight formula_weight	24484.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	U

MKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLTNLKRKNAKMISDIEKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSSLRNAAYFLSNLKQLYQDYSDVQAQEPNVKETYDSSSLPALLFKARTLLGAESHLRNINHQLEKLLDQGENLYFQSWSHPQFEKGGGSGGGSGGGSWSHPQFEK

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 10 Entity 10 polymer

Description description	Centromere protein P
Molecular weight formula_weight	33210.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	P

MDAELAEVRALQAEIAALRRACEDPPAPWEEKSRVQKSFQAIHQFNLEGWKSSKDLKNQLGHLESELSFLSTLTGINIRNHSKQTEDLTSTEMTEKSIRKVLQRHRLSGNCHMVTFQLEFQILEIQNKERLSSAVTDLNIIMEPTECSELSEFVSRAEERKDLFMFFRSLHFFVEWFEYRKRTFKHLKEKYPDAVYLSEGPSSCSMGIRSASRPGFELVIVWRIQIDEDGKVFPKLDLLTKVPQRALELDKNRAIETAPLSFRTLVGLLGIEAALESLIKSLCAEENN

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 11 Entity 11 polymer

Description description	Centromere protein R
Molecular weight formula_weight	20228.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R

MPVKRSLKLDGLLEENSFDPSKITRKKSVITYSPTTGTCQMSLFASPTSSEEQKHRNGLSNEKRKKLNHPSLTESKESTTKDNDEFMMLLSKVEKLSEEIMEIMQNLSSIQALEGSRELENLIGISCASHFLKREMQKTKELMTKVNKQKLFEKSTGLPHKASRHLDSYEFLKAILN

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 12 Entity 12 polymer

Description description	Methylated-DNA--protein-cysteine methyltransferase,Centromere protein T
Molecular weight formula_weight	84067.7 kDa
EC 编号 ec_number	2.1.1.63
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	T

MSYYHHHHHHDYDIPTTENLYFQGMDKDCEMKRTTLDSPLGKLELSGCEQGLHRIIFLGKGTSAADAVEVPAPAAVLGGPEPLMQATAWLNAYFHQPEAIEEFPVPALHHPVFQQESFTRQVLWKLLKVVKFGEVISYSHLAALAGNPAATAAVKTALSGNPVPILIPCHRVVQGDLDVGGYEGGLAVKEWLLAHEGHRLGKPGLGSDLEVLFQGPMADHNPDSDSTPRTLLRRVLDTADPRTPRRPRSARAGARRALLETASPRKLSGQTRTIARGRSHGARSVGRSAHIQASGHLEEQTPRTLLKNILLTAPESSILMPESVVKPVPAPQAVQPSRQESSCGSLELQLPELEPPTTLAPGLLAPGRRKQRLRLSVFQQGVDQGLSLSQEPQGNADASSLTRSLNLTFATPLQPQSVQRPGLARRPPARRAVDVGAFLRDLRDTSLAPPNIVLEDTQPFSQPMVGSPNVYHSLPCTPHTGAEDAEQAAGRKTQSSGPGLQKNSPGKPAQFLAGEAEEVNAFALGFLSTSSGVSGEDEVEPLHDGVEEAEKKMEEEGVSVSEMEATGAQGPSRVEEAEGHTEVTEAEGSQGTAEADGPGASSGDEDASGRAASPESASSTPESLQARRHHQFLEPAPAPGAAVLSSEPAEPLLVRHPPRPRTTGPRPRQDPHKAGLSHYVKLFSFYAKMPMERKALEMVEKCLDKYFQHLCDDLEVFAAHAGRKTVKPEDLELLMRRQGLVTDQVSLHVLVERHLPLEYRQLLIPCAYSGNSVFPAQ

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 13 Entity 13 polymer

Description description	Centromere protein W
Molecular weight formula_weight	10087.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	W

MALSTIVSQRKQIKRKAPRGFLKRVFKRKKPQLRLEKSGDLLVHLNCLLFVHRLAEESRTNACASKCRVINKEHVLAAAKVILKKSRG

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 14 Entity 14 polymer

Description description	Centromere protein S
Molecular weight formula_weight	15917.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	S

MEEEAETEEQQRFSYQQRLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAISELTFRQCENFAKDLEMFARHAKRTTINTEDVKLLARRSNSLLKYITDKSEEIAQINLERKAQKKKKSEDGSKNSRQPAEAGVVESEN

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 15 Entity 15 polymer

Description description	Centromere protein X
Molecular weight formula_weight	8972.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X

MEGAGAGSGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 16 Entity 16 polymer

Description description	Histone H3-like centromeric protein A
Molecular weight formula_weight	16023.6 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A,E,c,g

MGPRRRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRRQGWLKEIRKLQKSTHLLIRKLPFSRLAREICVKFTRGVDFNWQAQALLALQEAAEAFLVHLFEDAYLLTLHAGRVTLFPKDVQLARRIRGLEEGLG

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 17 Entity 17 polymer

Description description	Histone H4
Molecular weight formula_weight	11394.4 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B,F,d,h

MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISGLIYEETRGVLKVFLENVIRDAVTYTEHAKRKTVTAMDVVYALKRQGRTLYGFGG

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 18 Entity 18 polymer

Description description	Histone H2A type 1-C
Molecular weight formula_weight	16666.3 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C,G,e,i

MGSSHHHHHHSPGLEVLFQGPRGMSGRGKQGGKARAKAKSRSSRAGLQFPVGRVHRLLRKGNYAERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 19 Entity 19 polymer

Description description	Histone H2B type 1-C/E/F/G/I
Molecular weight formula_weight	13937.2 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D,J,f,j

MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSVYVYKVLKQVHPDTGISSKAMGIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK

Source Source

Source organism organism	Homo sapiens
Common name common_name	human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 20 Entity 20 polymer

Description description	DNA (318-MER)
Molecular weight formula_weight	99810.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	V

ATCAGGAAATATCTTCACATAAAAACTAGACAATTGGTCGTAGACAGCTCTAGCACCGCTTAAACGCACGTACGCGCTGTCCCCCGCGTTTTAACCGCCAAGGGGATTACTCCCTAGTCTCCTTGTAGTATCTGCAAGTGGACATTCGGAGCACTTTGTGGCCTTCGTTGGAAACGGGAATATGTTCACATAAAAACTAGACAATTGGTCGTAGACAGCTCTAGCACCGCTTAAACGCACGTACGCGCTGTCCCCCGCGTTTTAACCGCCAAGGGGATTACTCCCTAGTCTCCTTGTAGTATCTGGAATTGGACATTTGGAGAT

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 21 Entity 21 polymer

Description description	DNA (318-MER)
Molecular weight formula_weight	100290.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	Y

ATCTCCAAATGTCCAATTCCAGATACTACAAGGAGACTAGGGAGTAATCCCCTTGGCGGTTAAAACGCGGGGGACAGCGCGTACGTGCGTTTAAGCGGTGCTAGAGCTGTCTACGACCAATTGTCTAGTTTTTATGTGAACATATTCCCGTTTCCAACGAAGGCCACAAAGTGCTCCGAATGTCCACTTGCAGATACTACAAGGAGACTAGGGAGTAATCCCCTTGGCGGTTAAAACGCGGGGGACAGCGCGTACGTGCGTTTAAGCGGTGCTAGAGCTGTCTACGACCAATTGTCTAGTTTTTATGTGAAGATATTTCCTGAT

Source Source

Source organism organism	Homo sapiens
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 22 Entity 22 polymer

Description description	scFv
Molecular weight formula_weight	29161.3 kDa
Source method src_method	man
Copy count entity_count	4

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Z,a,m,n

MMKSSHHHHHHENLYFQSNAMEVQLQQSGPELVEPGTSVKMPCKASGYTFTSYTIQWVKQTPRQGLEWIGYIYPYNAGTKYNEKFKGKATLTSDKSSSTVYMELSSLTSEDSAVYYCARKSSRLRSTLDYWGQGTSVTVSSGGGGSGGGGSGGGGSMDIKMTQSPSSMHASLGERVTITCKASQDIRSYLSWYQQKPWKSPKTLIYYATSLADGVPSRFSGSGSGQDFSLTINNLESDDTATYYCLQHGESPYTFGSGTKLEIKRA

Source Source

Source organism organism	Mus musculus
NCBI taxonomy ID ncbi_taxonomy_id	10090
Host organism host_organism	Escherichia coli

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Resolution resolution	15.500 Å
Low-resolution limit resolution_low	— Å
R factor r_factor	—
R_work r_work	—
R_free r_free	—

Resolution resolution	15.50 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	15057

Structure of the human inner kinetochore CCAN bound to a di-CENP-A nucleosome

1. Protein Identity and Related Structures Protein Identity & Related Structures

Centromere protein H

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Centromere protein I

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Centromere protein K

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Centromere protein L

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Centromere protein M

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Centromere protein N

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Centromere protein O

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Centromere protein Q

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Centromere protein U

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Centromere protein P

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer