6zym

Human C Complex Spliceosome - High-resolution CORE

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Corepressor interacting with RBPJ 1

物种未注明

UniProt Q86X95

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CIR1_HUMAN
Isoform —
PDB实体 4
链与序列区间 作者链 9; PDB构建体 1–450; UniProt 1–450

Pre-mRNA-processing-splicing factor 8

物种未注明

UniProt Q6P2Q9

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PRP8_HUMAN
Isoform —
PDB实体 5
链与序列区间 作者链 A; PDB构建体 1–1755; UniProt 1–1755

116 kDa U5 small nuclear ribonucleoprotein component

物种未注明

UniProt Q15029

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 U5S1_HUMAN
Isoform —
PDB实体 6
链与序列区间 作者链 B; PDB构建体 1–952; UniProt 1–952

SNW domain-containing protein 1

物种未注明

UniProt Q13573

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SNW1_HUMAN
Isoform —
PDB实体 7
链与序列区间 作者链 C; PDB构建体 1–536; UniProt 1–536

Pleiotropic regulator 1

物种未注明

UniProt O43660

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PLRG1_HUMAN
Isoform —
PDB实体 8
链与序列区间 作者链 D; PDB构建体 1–514; UniProt 1–514

Pre-mRNA-processing factor 17

物种未注明

UniProt O60508

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PRP17_HUMAN
Isoform —
PDB实体 9
链与序列区间 作者链 E; PDB构建体 1–579; UniProt 1–579

U5 small nuclear ribonucleoprotein 40 kDa protein

物种未注明

UniProt Q96DI7

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SNR40_HUMAN
Isoform —
PDB实体 10
链与序列区间 作者链 F; PDB构建体 1–357; UniProt 1–357

Cell division cycle 5-like protein

物种未注明

UniProt Q99459

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CDC5L_HUMAN
Isoform —
PDB实体 11
链与序列区间 作者链 L; PDB构建体 1–802; UniProt 1–802

Crooked neck-like protein 1

物种未注明

UniProt Q9BZJ0

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CRNL1_HUMAN
Isoform —
PDB实体 12
链与序列区间 作者链 O; PDB构建体 1–848; UniProt 1–848

Pre-mRNA-splicing factor RBM22

物种未注明

UniProt Q9NW64

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RBM22_HUMAN
Isoform —
PDB实体 13
链与序列区间 作者链 P; PDB构建体 1–218; UniProt 1–218

Protein BUD31 homolog

物种未注明

UniProt P41223

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 BUD31_HUMAN
Isoform —
PDB实体 14
链与序列区间 作者链 Q; PDB构建体 1–144; UniProt 1–144

Spliceosome-associated protein CWC15 homolog

物种未注明

UniProt Q9P013

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CWC15_HUMAN
Isoform —
PDB实体 15
链与序列区间 作者链 R; PDB构建体 1–229; UniProt 1–229

Serine/arginine repetitive matrix protein 2

物种未注明

UniProt Q9UQ35

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SRRM2_HUMAN
Isoform —
PDB实体 16
链与序列区间 作者链 S; PDB构建体 1–2752; UniProt 1–2752

Pre-mRNA-splicing factor CWC22 homolog

物种未注明

UniProt Q9HCG8

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CWC22_HUMAN
Isoform —
PDB实体 17
链与序列区间 作者链 T; PDB构建体 1–908; UniProt 1–908

Peptidyl-prolyl cis-trans isomerase-like 1

物种未注明

UniProt Q9Y3C6

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PPIL1_HUMAN
Isoform —
PDB实体 18
链与序列区间 作者链 V; PDB构建体 1–166; UniProt 1–166

WD repeat-containing protein 70

物种未注明

UniProt Q9NW82

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 WDR70_HUMAN
Isoform —
PDB实体 20
链与序列区间 作者链 p; PDB构建体 1–654; UniProt 1–654

Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

物种未注明

UniProt Q92620

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PRP16_HUMAN
Isoform —
PDB实体 21
链与序列区间 作者链 r; PDB构建体 1–1227; UniProt 1–1227

Pre-mRNA-splicing factor ISY1 homolog

物种未注明

UniProt Q9ULR0

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ISY1_HUMAN
Isoform —
PDB实体 22
链与序列区间 作者链 s; PDB构建体 1–285; UniProt 1–285

Pre-mRNA-splicing factor CWC25 homolog

物种未注明

UniProt Q9NXE8

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Splicing factor YJU2 × 1 (Q9BW85) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CWC25_HUMAN
Isoform —
PDB实体 23
链与序列区间 作者链 t; PDB构建体 1–425; UniProt 1–425

Splicing factor YJU2

物种未注明

UniProt Q9BW85

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Protein FRG1 × 1 (Q14331) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 YJU2_HUMAN
Isoform —
PDB实体 24
链与序列区间 作者链 u; PDB构建体 1–178; UniProt 1–178

Protein FRG1

物种未注明

UniProt Q14331

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 21 RNA 5 U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Corepressor interacting with RBPJ 1 × 1 (Q86X95) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) SNW domain-containing protein 1 × 1 (Q13573) Pleiotropic regulator 1 × 1 (O43660) Pre-mRNA-processing factor 17 × 1 (O60508) U5 small nuclear ribonucleoprotein 40 kDa protein × 1 (Q96DI7) Cell division cycle 5-like protein × 1 (Q99459) Crooked neck-like protein 1 × 1 (Q9BZJ0) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Serine/arginine repetitive matrix protein 2 × 1 (Q9UQ35) Pre-mRNA-splicing factor CWC22 homolog × 1 (Q9HCG8) Peptidyl-prolyl cis-trans isomerase-like 1 × 1 (Q9Y3C6) pre-mRNA × 2 WD repeat-containing protein 70 × 1 (Q9NW82) Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 × 1 (Q92620) Pre-mRNA-splicing factor ISY1 homolog × 1 (Q9ULR0) Pre-mRNA-splicing factor CWC25 homolog × 1 (Q9NXE8) Splicing factor YJU2 × 1 (Q9BW85) MAGNESIUM ION × 5 INOSITOL HEXAKISPHOSPHATE × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 ZINC ION × 7 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 FRG1_HUMAN
Isoform —
PDB实体 25
链与序列区间 作者链 x; PDB构建体 1–258; UniProt 1–258

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id6zym
沉积日期 deposition_date2020-08-02
结构标题 titleHuman C Complex Spliceosome - High-resolution CORE
关键词 keywordshuman C complex, spliceosome, hC, human step 1 spliceosome, SPLICING; SPLICING
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

6zym__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

6zym__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

6zym__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)58.37 Å
Rg(电子密度)58.70 Å
总 Rg58.60 Å
原子数48271
残基数5678
排除体积839310 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 6zym__assembly_1__model_1 26-meric (26) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (29)

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6. 折叠分类 (SCOP + CATH) 1 domains

CATH v4.4 (1 domains)

结构域编号 domain_id6zymA01
类 Class class3 — Alpha Beta
架构 Architecture architecture90 — Alpha-Beta Complex
拓扑 Topology topology1570 — tt1808, chain A
同源超家族 H-superfamily homologous superfamily40 — Pre-mRNA-processing-splicing factor 8 (Prp8), endonuclease domain
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7. 引用文献 (1)