7aav

Human pre-Bact-2 spliceosome core structure

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

116 kDa U5 small nuclear ribonucleoprotein component

物种未注明

UniProt Q15029

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 Protein BUD31 homolog × 1 (P41223) Cell division cycle 5-like protein × 1 (Q99459) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Microfibrillar-associated protein 1 × 1 (P55081) Pleiotropic regulator 1 × 1 (O43660) MINX M3 pre-mRNA × 1 Pre-mRNA-processing factor 17 × 1 (O60508) Pre-mRNA-splicing factor 38A × 1 (Q8NAV1) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) SNW domain-containing protein 1 × 1 (Q13573) Zinc finger matrin-type protein 2 × 1 (Q96NC0) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Ubiquitin-like protein 5 × 1 (Q9BZL1) GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 U5S1_HUMAN
Isoform —
PDB实体 1
链与序列区间 作者链 r; PDB构建体 1–972; UniProt 1–972

Protein BUD31 homolog

物种未注明

UniProt P41223

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Cell division cycle 5-like protein × 1 (Q99459) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Microfibrillar-associated protein 1 × 1 (P55081) Pleiotropic regulator 1 × 1 (O43660) MINX M3 pre-mRNA × 1 Pre-mRNA-processing factor 17 × 1 (O60508) Pre-mRNA-splicing factor 38A × 1 (Q8NAV1) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) SNW domain-containing protein 1 × 1 (Q13573) Zinc finger matrin-type protein 2 × 1 (Q96NC0) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Ubiquitin-like protein 5 × 1 (Q9BZL1) GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 BUD31_HUMAN
Isoform —
PDB实体 2
链与序列区间 作者链 Q; PDB构建体 1–144; UniProt 1–144

Cell division cycle 5-like protein

物种未注明

UniProt Q99459

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Protein BUD31 homolog × 1 (P41223) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Microfibrillar-associated protein 1 × 1 (P55081) Pleiotropic regulator 1 × 1 (O43660) MINX M3 pre-mRNA × 1 Pre-mRNA-processing factor 17 × 1 (O60508) Pre-mRNA-splicing factor 38A × 1 (Q8NAV1) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) SNW domain-containing protein 1 × 1 (Q13573) Zinc finger matrin-type protein 2 × 1 (Q96NC0) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Ubiquitin-like protein 5 × 1 (Q9BZL1) GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CDC5L_HUMAN
Isoform —
PDB实体 3
链与序列区间 作者链 L; PDB构建体 1–802; UniProt 1–802

Spliceosome-associated protein CWC15 homolog

物种未注明

UniProt Q9P013

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Protein BUD31 homolog × 1 (P41223) Cell division cycle 5-like protein × 1 (Q99459) Microfibrillar-associated protein 1 × 1 (P55081) Pleiotropic regulator 1 × 1 (O43660) MINX M3 pre-mRNA × 1 Pre-mRNA-processing factor 17 × 1 (O60508) Pre-mRNA-splicing factor 38A × 1 (Q8NAV1) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) SNW domain-containing protein 1 × 1 (Q13573) Zinc finger matrin-type protein 2 × 1 (Q96NC0) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Ubiquitin-like protein 5 × 1 (Q9BZL1) GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 CWC15_HUMAN
Isoform —
PDB实体 4
链与序列区间 作者链 R; PDB构建体 1–229; UniProt 1–229

Microfibrillar-associated protein 1

物种未注明

UniProt P55081

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Protein BUD31 homolog × 1 (P41223) Cell division cycle 5-like protein × 1 (Q99459) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Pleiotropic regulator 1 × 1 (O43660) MINX M3 pre-mRNA × 1 Pre-mRNA-processing factor 17 × 1 (O60508) Pre-mRNA-splicing factor 38A × 1 (Q8NAV1) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) SNW domain-containing protein 1 × 1 (Q13573) Zinc finger matrin-type protein 2 × 1 (Q96NC0) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Ubiquitin-like protein 5 × 1 (Q9BZL1) GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 MFAP1_HUMAN
Isoform —
PDB实体 5
链与序列区间 作者链 K; PDB构建体 1–439; UniProt 1–439

Pleiotropic regulator 1

物种未注明

UniProt O43660

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Protein BUD31 homolog × 1 (P41223) Cell division cycle 5-like protein × 1 (Q99459) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Microfibrillar-associated protein 1 × 1 (P55081) MINX M3 pre-mRNA × 1 Pre-mRNA-processing factor 17 × 1 (O60508) Pre-mRNA-splicing factor 38A × 1 (Q8NAV1) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) SNW domain-containing protein 1 × 1 (Q13573) Zinc finger matrin-type protein 2 × 1 (Q96NC0) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Ubiquitin-like protein 5 × 1 (Q9BZL1) GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PLRG1_HUMAN
Isoform —
PDB实体 6
链与序列区间 作者链 G; PDB构建体 1–514; UniProt 1–514

Pre-mRNA-processing factor 17

物种未注明

UniProt O60508

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Protein BUD31 homolog × 1 (P41223) Cell division cycle 5-like protein × 1 (Q99459) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Microfibrillar-associated protein 1 × 1 (P55081) Pleiotropic regulator 1 × 1 (O43660) MINX M3 pre-mRNA × 1 Pre-mRNA-splicing factor 38A × 1 (Q8NAV1) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) SNW domain-containing protein 1 × 1 (Q13573) Zinc finger matrin-type protein 2 × 1 (Q96NC0) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Ubiquitin-like protein 5 × 1 (Q9BZL1) GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PRP17_HUMAN
Isoform —
PDB实体 8
链与序列区间 作者链 8; PDB构建体 1–579; UniProt 1–579

Pre-mRNA-splicing factor 38A

物种未注明

UniProt Q8NAV1

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Protein BUD31 homolog × 1 (P41223) Cell division cycle 5-like protein × 1 (Q99459) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Microfibrillar-associated protein 1 × 1 (P55081) Pleiotropic regulator 1 × 1 (O43660) MINX M3 pre-mRNA × 1 Pre-mRNA-processing factor 17 × 1 (O60508) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) SNW domain-containing protein 1 × 1 (Q13573) Zinc finger matrin-type protein 2 × 1 (Q96NC0) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Ubiquitin-like protein 5 × 1 (Q9BZL1) GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PR38A_HUMAN
Isoform —
PDB实体 9
链与序列区间 作者链 I; PDB构建体 1–312; UniProt 1–312

Pre-mRNA-processing-splicing factor 8

物种未注明

UniProt Q6P2Q9

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Protein BUD31 homolog × 1 (P41223) Cell division cycle 5-like protein × 1 (Q99459) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Microfibrillar-associated protein 1 × 1 (P55081) Pleiotropic regulator 1 × 1 (O43660) MINX M3 pre-mRNA × 1 Pre-mRNA-processing factor 17 × 1 (O60508) Pre-mRNA-splicing factor 38A × 1 (Q8NAV1) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) SNW domain-containing protein 1 × 1 (Q13573) Zinc finger matrin-type protein 2 × 1 (Q96NC0) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Ubiquitin-like protein 5 × 1 (Q9BZL1) GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 PRP8_HUMAN
Isoform —
PDB实体 10
链与序列区间 作者链 A; PDB构建体 1–2335; UniProt 1–2335

Pre-mRNA-splicing factor RBM22

物种未注明

UniProt Q9NW64

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Protein BUD31 homolog × 1 (P41223) Cell division cycle 5-like protein × 1 (Q99459) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Microfibrillar-associated protein 1 × 1 (P55081) Pleiotropic regulator 1 × 1 (O43660) MINX M3 pre-mRNA × 1 Pre-mRNA-processing factor 17 × 1 (O60508) Pre-mRNA-splicing factor 38A × 1 (Q8NAV1) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) SNW domain-containing protein 1 × 1 (Q13573) Zinc finger matrin-type protein 2 × 1 (Q96NC0) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Ubiquitin-like protein 5 × 1 (Q9BZL1) GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 RBM22_HUMAN
Isoform —
PDB实体 11
链与序列区间 作者链 P; PDB构建体 1–420; UniProt 1–420

SNW domain-containing protein 1

物种未注明

UniProt Q13573

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Protein BUD31 homolog × 1 (P41223) Cell division cycle 5-like protein × 1 (Q99459) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Microfibrillar-associated protein 1 × 1 (P55081) Pleiotropic regulator 1 × 1 (O43660) MINX M3 pre-mRNA × 1 Pre-mRNA-processing factor 17 × 1 (O60508) Pre-mRNA-splicing factor 38A × 1 (Q8NAV1) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) Zinc finger matrin-type protein 2 × 1 (Q96NC0) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Ubiquitin-like protein 5 × 1 (Q9BZL1) GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SNW1_HUMAN
Isoform —
PDB实体 12
链与序列区间 作者链 v; PDB构建体 1–536; UniProt 1–536

Zinc finger matrin-type protein 2

物种未注明

UniProt Q96NC0

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Protein BUD31 homolog × 1 (P41223) Cell division cycle 5-like protein × 1 (Q99459) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Microfibrillar-associated protein 1 × 1 (P55081) Pleiotropic regulator 1 × 1 (O43660) MINX M3 pre-mRNA × 1 Pre-mRNA-processing factor 17 × 1 (O60508) Pre-mRNA-splicing factor 38A × 1 (Q8NAV1) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) SNW domain-containing protein 1 × 1 (Q13573) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 Ubiquitin-like protein 5 × 1 (Q9BZL1) GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ZMAT2_HUMAN
Isoform —
PDB实体 13
链与序列区间 作者链 N; PDB构建体 1–199; UniProt 1–199

Ubiquitin-like protein 5

物种未注明

UniProt Q9BZL1

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–RNA 异源复合物 蛋白 13 RNA 4 116 kDa U5 small nuclear ribonucleoprotein component × 1 (Q15029) Protein BUD31 homolog × 1 (P41223) Cell division cycle 5-like protein × 1 (Q99459) Spliceosome-associated protein CWC15 homolog × 1 (Q9P013) Microfibrillar-associated protein 1 × 1 (P55081) Pleiotropic regulator 1 × 1 (O43660) MINX M3 pre-mRNA × 1 Pre-mRNA-processing factor 17 × 1 (O60508) Pre-mRNA-splicing factor 38A × 1 (Q8NAV1) Pre-mRNA-processing-splicing factor 8 × 1 (Q6P2Q9) Pre-mRNA-splicing factor RBM22 × 1 (Q9NW64) SNW domain-containing protein 1 × 1 (Q13573) Zinc finger matrin-type protein 2 × 1 (Q96NC0) U2 snRNA × 1 U5 snRNA × 1 U6 snRNA × 1 GUANOSINE-5'-TRIPHOSPHATE × 1 MAGNESIUM ION × 1 D-chiro inositol hexakisphosphate × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 UBL5_HUMAN
Isoform —
PDB实体 17
链与序列区间 作者链 q; PDB构建体 1–73; UniProt 1–73

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id7aav
沉积日期 deposition_date2020-09-04
结构标题 titleHuman pre-Bact-2 spliceosome core structure
关键词 keywordsComplex, spliceosome, catalytic activation, splicing; SPLICING
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

7aav__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

7aav__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

7aav__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)53.74 Å
Rg(电子密度)53.62 Å
总 Rg53.62 Å
原子数25867
残基数4151
排除体积421440 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 7aav__assembly_1__model_1 heptadecameric (17) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (20)

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7. 引用文献 (1)