6f3a

Cryo-EM structure of a single dynein tail domain bound to dynactin and BICD2N

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

ARP1 actin related protein 1 homolog A

物种未注明

UniProt F2Z5G5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 36 Actin, cytoplasmic 1 × 1 (Q6QAQ1) Actin related protein 10 homolog × 1 (I3LHK5) Capping protein (Actin filament) muscle Z-line, alpha 1 × 1 (A0PFK5) F-actin capping protein beta subunit × 1 (A9XFX6) Dynactin Subunit 2 × 1 Dynactin Subunit 2 × 1 Dynactin Subunit 3 × 2 Dynactin Subunit 2 × 2 Dynactin 6 × 1 (D0G6S1) Dynactin subunit 5 × 1 (A0A286ZK88) Dynactin Subunit 4 × 1 Dynactin Subunit 1 × 1 Dynactin subunit 2 × 1 (F1SKF9) Dynactin subunit 2 × 3 (F1SKF9) Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Cytoplasmic dynein 1 light intermediate chain 2 × 1 (O43237) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Dynactin Subunit 1 × 1 BICD2N × 2 ADENOSINE-5'-DIPHOSPHATE × 9 ADENOSINE-5'-TRIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 F2Z5G5_PIG
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–376; UniProt 1–376 作者链 B; PDB构建体 1–376; UniProt 1–376 作者链 C; PDB构建体 1–376; UniProt 1–376 作者链 D; PDB构建体 1–376; UniProt 1–376 作者链 E; PDB构建体 1–376; UniProt 1–376 作者链 F; PDB构建体 1–376; UniProt 1–376 作者链 G; PDB构建体 1–376; UniProt 1–376 作者链 I; PDB构建体 1–376; UniProt 1–376

Actin, cytoplasmic 1

物种未注明

UniProt Q6QAQ1

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 36 ARP1 actin related protein 1 homolog A × 8 (F2Z5G5) Actin related protein 10 homolog × 1 (I3LHK5) Capping protein (Actin filament) muscle Z-line, alpha 1 × 1 (A0PFK5) F-actin capping protein beta subunit × 1 (A9XFX6) Dynactin Subunit 2 × 1 Dynactin Subunit 2 × 1 Dynactin Subunit 3 × 2 Dynactin Subunit 2 × 2 Dynactin 6 × 1 (D0G6S1) Dynactin subunit 5 × 1 (A0A286ZK88) Dynactin Subunit 4 × 1 Dynactin Subunit 1 × 1 Dynactin subunit 2 × 1 (F1SKF9) Dynactin subunit 2 × 3 (F1SKF9) Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Cytoplasmic dynein 1 light intermediate chain 2 × 1 (O43237) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Dynactin Subunit 1 × 1 BICD2N × 2 ADENOSINE-5'-DIPHOSPHATE × 9 ADENOSINE-5'-TRIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ACTB_PIG
Isoform —
PDB实体 2
链与序列区间 作者链 H; PDB构建体 1–375; UniProt 1–375

Actin related protein 10 homolog

物种未注明

UniProt I3LHK5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 36 ARP1 actin related protein 1 homolog A × 8 (F2Z5G5) Actin, cytoplasmic 1 × 1 (Q6QAQ1) Capping protein (Actin filament) muscle Z-line, alpha 1 × 1 (A0PFK5) F-actin capping protein beta subunit × 1 (A9XFX6) Dynactin Subunit 2 × 1 Dynactin Subunit 2 × 1 Dynactin Subunit 3 × 2 Dynactin Subunit 2 × 2 Dynactin 6 × 1 (D0G6S1) Dynactin subunit 5 × 1 (A0A286ZK88) Dynactin Subunit 4 × 1 Dynactin Subunit 1 × 1 Dynactin subunit 2 × 1 (F1SKF9) Dynactin subunit 2 × 3 (F1SKF9) Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Cytoplasmic dynein 1 light intermediate chain 2 × 1 (O43237) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Dynactin Subunit 1 × 1 BICD2N × 2 ADENOSINE-5'-DIPHOSPHATE × 9 ADENOSINE-5'-TRIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 I3LHK5_PIG
Isoform —
PDB实体 3
链与序列区间 作者链 J; PDB构建体 1–390; UniProt 1–390

Capping protein (Actin filament) muscle Z-line, alpha 1

物种未注明

UniProt A0PFK5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 36 ARP1 actin related protein 1 homolog A × 8 (F2Z5G5) Actin, cytoplasmic 1 × 1 (Q6QAQ1) Actin related protein 10 homolog × 1 (I3LHK5) F-actin capping protein beta subunit × 1 (A9XFX6) Dynactin Subunit 2 × 1 Dynactin Subunit 2 × 1 Dynactin Subunit 3 × 2 Dynactin Subunit 2 × 2 Dynactin 6 × 1 (D0G6S1) Dynactin subunit 5 × 1 (A0A286ZK88) Dynactin Subunit 4 × 1 Dynactin Subunit 1 × 1 Dynactin subunit 2 × 1 (F1SKF9) Dynactin subunit 2 × 3 (F1SKF9) Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Cytoplasmic dynein 1 light intermediate chain 2 × 1 (O43237) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Dynactin Subunit 1 × 1 BICD2N × 2 ADENOSINE-5'-DIPHOSPHATE × 9 ADENOSINE-5'-TRIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A0PFK5_PIG
Isoform —
PDB实体 4
链与序列区间 作者链 K; PDB构建体 1–286; UniProt 1–286

F-actin capping protein beta subunit

物种未注明

UniProt A9XFX6

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 36 ARP1 actin related protein 1 homolog A × 8 (F2Z5G5) Actin, cytoplasmic 1 × 1 (Q6QAQ1) Actin related protein 10 homolog × 1 (I3LHK5) Capping protein (Actin filament) muscle Z-line, alpha 1 × 1 (A0PFK5) Dynactin Subunit 2 × 1 Dynactin Subunit 2 × 1 Dynactin Subunit 3 × 2 Dynactin Subunit 2 × 2 Dynactin 6 × 1 (D0G6S1) Dynactin subunit 5 × 1 (A0A286ZK88) Dynactin Subunit 4 × 1 Dynactin Subunit 1 × 1 Dynactin subunit 2 × 1 (F1SKF9) Dynactin subunit 2 × 3 (F1SKF9) Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Cytoplasmic dynein 1 light intermediate chain 2 × 1 (O43237) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Dynactin Subunit 1 × 1 BICD2N × 2 ADENOSINE-5'-DIPHOSPHATE × 9 ADENOSINE-5'-TRIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A9XFX6_PIG
Isoform —
PDB实体 5
链与序列区间 作者链 L; PDB构建体 1–272; UniProt 1–272

Dynactin 6

物种未注明

UniProt D0G6S1

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 36 ARP1 actin related protein 1 homolog A × 8 (F2Z5G5) Actin, cytoplasmic 1 × 1 (Q6QAQ1) Actin related protein 10 homolog × 1 (I3LHK5) Capping protein (Actin filament) muscle Z-line, alpha 1 × 1 (A0PFK5) F-actin capping protein beta subunit × 1 (A9XFX6) Dynactin Subunit 2 × 1 Dynactin Subunit 2 × 1 Dynactin Subunit 3 × 2 Dynactin Subunit 2 × 2 Dynactin subunit 5 × 1 (A0A286ZK88) Dynactin Subunit 4 × 1 Dynactin Subunit 1 × 1 Dynactin subunit 2 × 1 (F1SKF9) Dynactin subunit 2 × 3 (F1SKF9) Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Cytoplasmic dynein 1 light intermediate chain 2 × 1 (O43237) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Dynactin Subunit 1 × 1 BICD2N × 2 ADENOSINE-5'-DIPHOSPHATE × 9 ADENOSINE-5'-TRIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 D0G6S1_PIG
Isoform —
PDB实体 10
链与序列区间 作者链 U; PDB构建体 1–190; UniProt 1–190

Dynactin subunit 5

物种未注明

UniProt A0A286ZK88

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 36 ARP1 actin related protein 1 homolog A × 8 (F2Z5G5) Actin, cytoplasmic 1 × 1 (Q6QAQ1) Actin related protein 10 homolog × 1 (I3LHK5) Capping protein (Actin filament) muscle Z-line, alpha 1 × 1 (A0PFK5) F-actin capping protein beta subunit × 1 (A9XFX6) Dynactin Subunit 2 × 1 Dynactin Subunit 2 × 1 Dynactin Subunit 3 × 2 Dynactin Subunit 2 × 2 Dynactin 6 × 1 (D0G6S1) Dynactin Subunit 4 × 1 Dynactin Subunit 1 × 1 Dynactin subunit 2 × 1 (F1SKF9) Dynactin subunit 2 × 3 (F1SKF9) Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Cytoplasmic dynein 1 light intermediate chain 2 × 1 (O43237) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Dynactin Subunit 1 × 1 BICD2N × 2 ADENOSINE-5'-DIPHOSPHATE × 9 ADENOSINE-5'-TRIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 A0A286ZK88_PIG
Isoform —
PDB实体 11
链与序列区间 作者链 V; PDB构建体 1–182; UniProt 1–182

Dynactin subunit 2

物种未注明

UniProt F1SKF9

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 36 ARP1 actin related protein 1 homolog A × 8 (F2Z5G5) Actin, cytoplasmic 1 × 1 (Q6QAQ1) Actin related protein 10 homolog × 1 (I3LHK5) Capping protein (Actin filament) muscle Z-line, alpha 1 × 1 (A0PFK5) F-actin capping protein beta subunit × 1 (A9XFX6) Dynactin Subunit 2 × 1 Dynactin Subunit 2 × 1 Dynactin Subunit 3 × 2 Dynactin Subunit 2 × 2 Dynactin 6 × 1 (D0G6S1) Dynactin subunit 5 × 1 (A0A286ZK88) Dynactin Subunit 4 × 1 Dynactin Subunit 1 × 1 Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Cytoplasmic dynein 1 light intermediate chain 2 × 1 (O43237) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Dynactin Subunit 1 × 1 BICD2N × 2 ADENOSINE-5'-DIPHOSPHATE × 9 ADENOSINE-5'-TRIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 F1SKF9_PIG
Isoform —
PDB实体 14, 15
链与序列区间 作者链 a; PDB构建体 1–68; UniProt 1–68 作者链 b; PDB构建体 1–89; UniProt 1–89 作者链 c; PDB构建体 1–89; UniProt 1–89 作者链 d; PDB构建体 1–89; UniProt 1–89

Cytoplasmic dynein 1 heavy chain 1

Homo sapiens

UniProt Q14204

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 36 ARP1 actin related protein 1 homolog A × 8 (F2Z5G5) Actin, cytoplasmic 1 × 1 (Q6QAQ1) Actin related protein 10 homolog × 1 (I3LHK5) Capping protein (Actin filament) muscle Z-line, alpha 1 × 1 (A0PFK5) F-actin capping protein beta subunit × 1 (A9XFX6) Dynactin Subunit 2 × 1 Dynactin Subunit 2 × 1 Dynactin Subunit 3 × 2 Dynactin Subunit 2 × 2 Dynactin 6 × 1 (D0G6S1) Dynactin subunit 5 × 1 (A0A286ZK88) Dynactin Subunit 4 × 1 Dynactin Subunit 1 × 1 Dynactin subunit 2 × 1 (F1SKF9) Dynactin subunit 2 × 3 (F1SKF9) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Cytoplasmic dynein 1 light intermediate chain 2 × 1 (O43237) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Dynactin Subunit 1 × 1 BICD2N × 2 ADENOSINE-5'-DIPHOSPHATE × 9 ADENOSINE-5'-TRIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DYHC1_HUMAN
Isoform —
PDB实体 16
链与序列区间 作者链 e; PDB构建体 1–1455; UniProt 1–1455 作者链 f; PDB构建体 1–1455; UniProt 1–1455

Cytoplasmic dynein 1 intermediate chain 2

Homo sapiens

UniProt Q13409

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 36 ARP1 actin related protein 1 homolog A × 8 (F2Z5G5) Actin, cytoplasmic 1 × 1 (Q6QAQ1) Actin related protein 10 homolog × 1 (I3LHK5) Capping protein (Actin filament) muscle Z-line, alpha 1 × 1 (A0PFK5) F-actin capping protein beta subunit × 1 (A9XFX6) Dynactin Subunit 2 × 1 Dynactin Subunit 2 × 1 Dynactin Subunit 3 × 2 Dynactin Subunit 2 × 2 Dynactin 6 × 1 (D0G6S1) Dynactin subunit 5 × 1 (A0A286ZK88) Dynactin Subunit 4 × 1 Dynactin Subunit 1 × 1 Dynactin subunit 2 × 1 (F1SKF9) Dynactin subunit 2 × 3 (F1SKF9) Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 light intermediate chain 2 × 1 (O43237) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Dynactin Subunit 1 × 1 BICD2N × 2 ADENOSINE-5'-DIPHOSPHATE × 9 ADENOSINE-5'-TRIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DC1I2_HUMAN
Isoform Q13409-3
PDB实体 17
链与序列区间 作者链 g; PDB构建体 1–612; UniProt 1–612 作者链 h; PDB构建体 1–612; UniProt 1–612

Cytoplasmic dynein 1 light intermediate chain 2

Homo sapiens

UniProt O43237

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 36 ARP1 actin related protein 1 homolog A × 8 (F2Z5G5) Actin, cytoplasmic 1 × 1 (Q6QAQ1) Actin related protein 10 homolog × 1 (I3LHK5) Capping protein (Actin filament) muscle Z-line, alpha 1 × 1 (A0PFK5) F-actin capping protein beta subunit × 1 (A9XFX6) Dynactin Subunit 2 × 1 Dynactin Subunit 2 × 1 Dynactin Subunit 3 × 2 Dynactin Subunit 2 × 2 Dynactin 6 × 1 (D0G6S1) Dynactin subunit 5 × 1 (A0A286ZK88) Dynactin Subunit 4 × 1 Dynactin Subunit 1 × 1 Dynactin subunit 2 × 1 (F1SKF9) Dynactin subunit 2 × 3 (F1SKF9) Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Dynein light chain roadblock-type 1 × 2 (Q9NP97) Dynactin Subunit 1 × 1 BICD2N × 2 ADENOSINE-5'-DIPHOSPHATE × 9 ADENOSINE-5'-TRIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DC1L2_HUMAN
Isoform —
PDB实体 18
链与序列区间 作者链 j; PDB构建体 1–492; UniProt 1–492

Dynein light chain roadblock-type 1

Homo sapiens

UniProt Q9NP97

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白异源复合物 异源复合物 蛋白 36 ARP1 actin related protein 1 homolog A × 8 (F2Z5G5) Actin, cytoplasmic 1 × 1 (Q6QAQ1) Actin related protein 10 homolog × 1 (I3LHK5) Capping protein (Actin filament) muscle Z-line, alpha 1 × 1 (A0PFK5) F-actin capping protein beta subunit × 1 (A9XFX6) Dynactin Subunit 2 × 1 Dynactin Subunit 2 × 1 Dynactin Subunit 3 × 2 Dynactin Subunit 2 × 2 Dynactin 6 × 1 (D0G6S1) Dynactin subunit 5 × 1 (A0A286ZK88) Dynactin Subunit 4 × 1 Dynactin Subunit 1 × 1 Dynactin subunit 2 × 1 (F1SKF9) Dynactin subunit 2 × 3 (F1SKF9) Cytoplasmic dynein 1 heavy chain 1 × 2 (Q14204) Cytoplasmic dynein 1 intermediate chain 2 × 2 (Q13409) Cytoplasmic dynein 1 light intermediate chain 2 × 1 (O43237) Dynactin Subunit 1 × 1 BICD2N × 2 ADENOSINE-5'-DIPHOSPHATE × 9 ADENOSINE-5'-TRIPHOSPHATE × 1 与蛋白数一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 DLRB1_HUMAN
Isoform —
PDB实体 19
链与序列区间 作者链 k; PDB构建体 1–96; UniProt 1–96 作者链 l; PDB构建体 1–96; UniProt 1–96

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id6f3a
沉积日期 deposition_date2017-11-28
结构标题 titleCryo-EM structure of a single dynein tail domain bound to dynactin and BICD2N
关键词 keywordsTDB, dynein/dynactin/BICD2, complex, MOTOR PROTEIN; MOTOR PROTEIN
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

6f3a__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

6f3a__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

6f3a__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)97.74 Å
Rg(电子密度)99.40 Å
总 Rg99.14 Å
原子数48864
残基数9811
排除体积787700 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 6f3a__assembly_1__model_1 36-meric (36) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (23)

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7. 引用文献 (1)