7nvr

Human Mediator with RNA Polymerase II Pre-initiation complex

Method: ELECTRON MICROSCOPY

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1. Protein Identity and Related Structures Protein Identity & Related Structures

TFIIH basal transcription factor complex helicase XPD subunit

Homo sapiens

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	ERCC2_HUMAN
Isoform	—
PDB entities	1
Chains and sequence ranges	Author chain 0； PDBConstruct 1–760； UniProt 1–760

General transcription factor IIH subunit 1

Homo sapiens

UniProt P32780

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TF2H1_HUMAN
Isoform	—
PDB entities	2
Chains and sequence ranges	Author chain 1； PDBConstruct 1–548； UniProt 1–548

General transcription factor IIH subunit 4

Homo sapiens

UniProt Q92759

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TF2H4_HUMAN
Isoform	—
PDB entities	3
Chains and sequence ranges	Author chain 2； PDBConstruct 1–462； UniProt 1–462

CDK-activating kinase assembly factor MAT1

Homo sapiens

UniProt P51948

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MAT1_HUMAN
Isoform	—
PDB entities	4
Chains and sequence ranges	Author chain 3； PDBConstruct 1–309； UniProt 1–309

General transcription factor IIH subunit 3

Homo sapiens

UniProt Q13889

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TF2H3_HUMAN
Isoform	—
PDB entities	5
Chains and sequence ranges	Author chain 4； PDBConstruct 1–308； UniProt 1–308

General transcription factor IIH subunit 5

Homo sapiens

UniProt Q6ZYL4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TF2H5_HUMAN
Isoform	—
PDB entities	6
Chains and sequence ranges	Author chain 5； PDBConstruct 1–71； UniProt 1–71

General transcription factor IIH subunit 2

Homo sapiens

UniProt Q13888

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TF2H2_HUMAN
Isoform	—
PDB entities	7
Chains and sequence ranges	Author chain 6； PDBConstruct 1–395； UniProt 1–395

General transcription and DNA repair factor IIH helicase subunit XPB

Homo sapiens

UniProt P19447

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	ERCC3_HUMAN
Isoform	—
PDB entities	8
Chains and sequence ranges	Author chain 7； PDBConstruct 1–782； UniProt 1–782

Cyclin-dependent kinase 7

Homo sapiens

UniProt P50613

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CDK7_HUMAN
Isoform	—
PDB entities	9
Chains and sequence ranges	Author chain 8； PDBConstruct 1–346； UniProt 1–346

Cyclin-H

Homo sapiens

UniProt P51946

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	CCNH_HUMAN
Isoform	—
PDB entities	10
Chains and sequence ranges	Author chain 9； PDBConstruct 1–323； UniProt 1–323

DNA-directed RNA polymerase subunit beta

OrganismNot specified

UniProt I3LGP4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	I3LGP4_PIG
Isoform	—
PDB entities	12
Chains and sequence ranges	Author chain B； PDBConstruct 1–1174； UniProt 78–1251

DNA-directed RNA polymerase II subunit RPB3

OrganismNot specified

UniProt I3LCH3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	I3LCH3_PIG
Isoform	—
PDB entities	13
Chains and sequence ranges	Author chain C； PDBConstruct 1–275； UniProt 1–275

RPOL4c domain-containing protein

OrganismNot specified

UniProt A0A287ADR4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A287ADR4_PIG
Isoform	—
PDB entities	14
Chains and sequence ranges	Author chain D； PDBConstruct 1–142； UniProt 43–184

DNA-directed RNA polymerase II subunit E

OrganismNot specified

UniProt I3LSI7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	I3LSI7_PIG
Isoform	—
PDB entities	15
Chains and sequence ranges	Author chain E； PDBConstruct 1–210； UniProt 1–210

DNA-directed RNA polymerase II subunit F

OrganismNot specified

UniProt F1SKN8

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	F1SKN8_PIG
Isoform	—
PDB entities	16
Chains and sequence ranges	Author chain F； PDBConstruct 1–127； UniProt 1–127

DNA-directed RNA polymerase II subunit RPB7

OrganismNot specified

UniProt I3LJZ9

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	I3LJZ9_PIG
Isoform	—
PDB entities	17
Chains and sequence ranges	Author chain G； PDBConstruct 1–172； UniProt 1–172

DNA-directed RNA polymerases I, II, and III subunit RPABC3

OrganismNot specified

UniProt A0A4X1ULF2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A4X1ULF2_PIG
Isoform	—
PDB entities	18
Chains and sequence ranges	Author chain H； PDBConstruct 1–150； UniProt 1–150

DNA-directed RNA polymerase II subunit RPB9

OrganismNot specified

UniProt P60899

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	RPB9_PIG
Isoform	—
PDB entities	19
Chains and sequence ranges	Author chain I； PDBConstruct 1–125； UniProt 1–125

DNA-directed RNA polymerases I, II, and III subunit RPABC5

OrganismNot specified

UniProt A0A4X1VYD0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A4X1VYD0_PIG
Isoform	—
PDB entities	20
Chains and sequence ranges	Author chain J； PDBConstruct 1–67； UniProt 1–67

RNA_pol_L_2 domain-containing protein

OrganismNot specified

UniProt A0A4X1UK25

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	A0A4X1UK25_PIG
Isoform	—
PDB entities	21
Chains and sequence ranges	Author chain K； PDBConstruct 1–117； UniProt 1–117

RNA polymerase II subunit K

OrganismNot specified

UniProt I3LN51

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	I3LN51_PIG
Isoform	—
PDB entities	22
Chains and sequence ranges	Author chain L； PDBConstruct 1–58； UniProt 1–58

Transcription initiation factor IIB

Homo sapiens

UniProt Q00403

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TF2B_HUMAN
Isoform	—
PDB entities	23
Chains and sequence ranges	Author chain M； PDBConstruct 1–316； UniProt 1–316

TATA-box-binding protein

Homo sapiens

UniProt P20226

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TBP_HUMAN
Isoform	—
PDB entities	25
Chains and sequence ranges	Author chain O； PDBConstruct 1–339； UniProt 1–339

General transcription factor IIF subunit 1

Homo sapiens

UniProt P35269

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	T2FA_HUMAN
Isoform	—
PDB entities	26
Chains and sequence ranges	Author chain Q； PDBConstruct 1–517； UniProt 1–517

General transcription factor IIF subunit 2

Homo sapiens

UniProt P13984

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	T2FB_HUMAN
Isoform	—
PDB entities	27
Chains and sequence ranges	Author chain R； PDBConstruct 1–249； UniProt 1–249

Transcription initiation factor IIA subunit 1

Homo sapiens

UniProt P52655

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	TF2AA_HUMAN
Isoform	—
PDB entities	29
Chains and sequence ranges	Author chain U； PDBConstruct 1–376； UniProt 1–376

Transcription initiation factor IIA subunit 2

Homo sapiens

UniProt P52657

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	T2AG_HUMAN
Isoform	—
PDB entities	30
Chains and sequence ranges	Author chain V； PDBConstruct 1–109； UniProt 1–109

General transcription factor IIE subunit 1

Homo sapiens

UniProt P29083

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	T2EA_HUMAN
Isoform	—
PDB entities	31
Chains and sequence ranges	Author chain W； PDBConstruct 1–439； UniProt 1–439

Transcription initiation factor IIE subunit beta

Homo sapiens

UniProt P29084

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	T2EB_HUMAN
Isoform	—
PDB entities	32
Chains and sequence ranges	Author chain X； PDBConstruct 1–291； UniProt 1–291

Mediator of RNA polymerase II transcription subunit 6

Homo sapiens

UniProt O75586

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED6_HUMAN
Isoform	—
PDB entities	35
Chains and sequence ranges	Author chain a； PDBConstruct 1–246； UniProt 1–246

Mediator of RNA polymerase II transcription subunit 8

Homo sapiens

UniProt Q96G25

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED8_HUMAN
Isoform	—
PDB entities	36
Chains and sequence ranges	Author chain b； PDBConstruct 1–268； UniProt 1–268

Mediator of RNA polymerase II transcription subunit 11

Homo sapiens

UniProt Q9P086

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED11_HUMAN
Isoform	—
PDB entities	37
Chains and sequence ranges	Author chain c； PDBConstruct 1–117； UniProt 1–117

Mediator of RNA polymerase II transcription subunit 17

Homo sapiens

UniProt Q9NVC6

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED17_HUMAN
Isoform	—
PDB entities	38
Chains and sequence ranges	Author chain d； PDBConstruct 1–651； UniProt 1–651

Mediator of RNA polymerase II transcription subunit 18

Homo sapiens

UniProt Q9BUE0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED18_HUMAN
Isoform	—
PDB entities	39
Chains and sequence ranges	Author chain e； PDBConstruct 1–208； UniProt 1–208

Mediator of RNA polymerase II transcription subunit 20

Homo sapiens

UniProt Q9H944

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED20_HUMAN
Isoform	—
PDB entities	40
Chains and sequence ranges	Author chain f； PDBConstruct 1–212； UniProt 1–212

Mediator of RNA polymerase II transcription subunit 22

Homo sapiens

UniProt Q15528

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED22_HUMAN
Isoform	—
PDB entities	41
Chains and sequence ranges	Author chain g； PDBConstruct 1–200； UniProt 1–200

Mediator of RNA polymerase II transcription subunit 4

Homo sapiens

UniProt Q9NPJ6

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED4_HUMAN
Isoform	—
PDB entities	42
Chains and sequence ranges	Author chain h； PDBConstruct 1–270； UniProt 1–270

Mediator of RNA polymerase II transcription subunit 7

Homo sapiens

UniProt O43513

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED7_HUMAN
Isoform	—
PDB entities	43
Chains and sequence ranges	Author chain i； PDBConstruct 1–233； UniProt 1–233

Mediator of RNA polymerase II transcription subunit 9

Homo sapiens

UniProt Q9NWA0

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED9_HUMAN
Isoform	—
PDB entities	44
Chains and sequence ranges	Author chain j； PDBConstruct 1–146； UniProt 1–146

Mediator of RNA polymerase II transcription subunit 10

Homo sapiens

UniProt Q9BTT4

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED10_HUMAN
Isoform	—
PDB entities	45
Chains and sequence ranges	Author chain k； PDBConstruct 1–135； UniProt 1–135

Mediator of RNA polymerase II transcription subunit 14

Homo sapiens

UniProt O60244

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED14_HUMAN
Isoform	—
PDB entities	46
Chains and sequence ranges	Author chain l； PDBConstruct 1–1454； UniProt 1–1454

Mediator of RNA polymerase II transcription subunit 19

Homo sapiens

UniProt A0JLT2

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED19_HUMAN
Isoform	—
PDB entities	47
Chains and sequence ranges	Author chain m； PDBConstruct 1–244； UniProt 1–244

Mediator of RNA polymerase II transcription subunit 21

Homo sapiens

UniProt Q13503

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED21_HUMAN
Isoform	—
PDB entities	48
Chains and sequence ranges	Author chain n； PDBConstruct 1–144； UniProt 1–144

Mediator of RNA polymerase II transcription subunit 31

Homo sapiens

UniProt Q9Y3C7

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED31_HUMAN
Isoform	—
PDB entities	49
Chains and sequence ranges	Author chain o； PDBConstruct 1–131； UniProt 1–131

Mediator of RNA polymerase II transcription subunit 27

Homo sapiens

UniProt Q6P2C8

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED27_HUMAN
Isoform	—
PDB entities	50
Chains and sequence ranges	Author chain p； PDBConstruct 1–311； UniProt 1–311

Mediator of RNA polymerase II transcription subunit 28

Homo sapiens

UniProt Q9H204

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） unassigned peptide (MED29 or MED30) × 1 Mediator of RNA polymerase II transcription subunit 30 × 1 （Q96HR3） unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED28_HUMAN
Isoform	—
PDB entities	51
Chains and sequence ranges	Author chain q； PDBConstruct 1–178； UniProt 1–178

Mediator of RNA polymerase II transcription subunit 30

Homo sapiens

UniProt Q96HR3

State in the Current Structure

Assembly	Physical composition	Protein state	Molecular copy count	Associated components	Data consistency
1	Protein–DNA	Heteromer	Protein 56 DNA 2	TFIIH basal transcription factor complex helicase XPD subunit × 1 （P18074） General transcription factor IIH subunit 1 × 1 （P32780） General transcription factor IIH subunit 4 × 1 （Q92759） CDK-activating kinase assembly factor MAT1 × 1 （P51948） General transcription factor IIH subunit 3 × 1 （Q13889） General transcription factor IIH subunit 5 × 1 （Q6ZYL4） General transcription factor IIH subunit 2 × 1 （Q13888） General transcription and DNA repair factor IIH helicase subunit XPB × 1 （P19447） Cyclin-dependent kinase 7 × 1 （P50613） Cyclin-H × 1 （P51946） DNA-directed RNA polymerase subunit × 1 DNA-directed RNA polymerase subunit beta × 1 （I3LGP4） DNA-directed RNA polymerase II subunit RPB3 × 1 （I3LCH3） RPOL4c domain-containing protein × 1 （A0A287ADR4） DNA-directed RNA polymerase II subunit E × 1 （I3LSI7） DNA-directed RNA polymerase II subunit F × 1 （F1SKN8） DNA-directed RNA polymerase II subunit RPB7 × 1 （I3LJZ9） DNA-directed RNA polymerases I, II, and III subunit RPABC3 × 1 （A0A4X1ULF2） DNA-directed RNA polymerase II subunit RPB9 × 1 （P60899） DNA-directed RNA polymerases I, II, and III subunit RPABC5 × 1 （A0A4X1VYD0） RNA_pol_L_2 domain-containing protein × 1 （A0A4X1UK25） RNA polymerase II subunit K × 1 （I3LN51） Transcription initiation factor IIB × 1 （Q00403） NT × 1 TATA-box-binding protein × 1 （P20226） General transcription factor IIF subunit 1 × 1 （P35269） General transcription factor IIF subunit 2 × 1 （P13984） TEMPLATE × 1 Transcription initiation factor IIA subunit 1 × 1 （P52655） Transcription initiation factor IIA subunit 2 × 1 （P52657） General transcription factor IIE subunit 1 × 1 （P29083） Transcription initiation factor IIE subunit beta × 1 （P29084） Unassigned peptide, likely TFIIE-beta × 1 Unassigned peptide, likely XPB × 1 Mediator of RNA polymerase II transcription subunit 6 × 1 （O75586） Mediator of RNA polymerase II transcription subunit 8 × 1 （Q96G25） Mediator of RNA polymerase II transcription subunit 11 × 1 （Q9P086） Mediator of RNA polymerase II transcription subunit 17 × 1 （Q9NVC6） Mediator of RNA polymerase II transcription subunit 18 × 1 （Q9BUE0） Mediator of RNA polymerase II transcription subunit 20 × 1 （Q9H944） Mediator of RNA polymerase II transcription subunit 22 × 1 （Q15528） Mediator of RNA polymerase II transcription subunit 4 × 1 （Q9NPJ6） Mediator of RNA polymerase II transcription subunit 7 × 1 （O43513） Mediator of RNA polymerase II transcription subunit 9 × 1 （Q9NWA0） Mediator of RNA polymerase II transcription subunit 10 × 1 （Q9BTT4） Mediator of RNA polymerase II transcription subunit 14 × 1 （O60244） Mediator of RNA polymerase II transcription subunit 19 × 1 （A0JLT2） Mediator of RNA polymerase II transcription subunit 21 × 1 （Q13503） Mediator of RNA polymerase II transcription subunit 31 × 1 （Q9Y3C7） Mediator of RNA polymerase II transcription subunit 27 × 1 （Q6P2C8） Mediator of RNA polymerase II transcription subunit 28 × 1 （Q9H204） unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED14) × 1 unassigned peptide (MED6) × 1 unassigned peptide (MED17) × 1 unassigned peptide (MED29 or MED30) × 1 unassigned peptide (MED29 or MED30) × 1 IRON/SULFUR CLUSTER × 1 ZINC ION × 18 MAGNESIUM ION × 1	Consistent with all polymers

Other States of the Same Protein in the Database

View Construct and Data Evidence

UniProt name	MED30_HUMAN
Isoform	—
PDB entities	53
Chains and sequence ranges	Author chain s； PDBConstruct 1–178； UniProt 1–178

The page prioritizes protein identity, the current assembly, associated components, oligomeric state and cross-PDB links. Chain mapping and sequence ranges are retained as data evidence. Internal IDs, import timestamps and assembly operation expressions are maintenance fields and are not shown here.

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2. Structure Basics 2. Structure Basics

Entry ID entry_id	7nvr
Deposition date deposition_date	2021-03-15
Structure title title	Human Mediator with RNA Polymerase II Pre-initiation complex
Keywords keywords	Mediator complex, RNA polymerase II, TFIIH, Pre-initiation complex, TRANSCRIPTION; TRANSCRIPTION
Experimental Method method	ELECTRON MICROSCOPY

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3. Official assembly/model SAXS Official SAXS Profiles

This page reads only the latest assembly calculations. Every curve maps to an explicit PDB entry, official biological assembly and coordinate model.

7nvr__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

Download this curve (.dat)

7nvr__assembly_1__model_1 | I(q)

100 plotted points; both axes use logarithmic scales.

7nvr__assembly_1__model_1 | P(r) · Pending

P(r) will be calculated and displayed separately for the same assembly/model.

Rg（Guinier）	91.54 Å
Rg (electron density)	91.84 Å
Total Rg	91.67 Å
Atom count	96126
Residues	11812
Excluded volume	1710100 Å³
Maximum q	0.500 Å⁻¹

Assembly	Model	Structure unit	Oligomeric description	Status	CRYSOL	Actions
1	1	`7nvr__assembly_1__model_1`	58-meric （58）	Success	4.1.3-1-20251215 (887e7ef)	View Download

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4. Crystallography and Experiment 4. Crystallography & Experiment

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5. Entities and Polymers Entities & Polymers (61)

Entity 1 Entity 1 polymer

Description description	TFIIH basal transcription factor complex helicase XPD subunit
Molecular weight formula_weight	87021.1 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	0
Atom count atom_count	96126

MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 2 Entity 2 polymer

Description description	General transcription factor IIH subunit 1
Molecular weight formula_weight	62116.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	1

MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEYEDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQSRRLMKKT

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 3 Entity 3 polymer

Description description	General transcription factor IIH subunit 4
Molecular weight formula_weight	52245.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	2

MESTPSRGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRMLFLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRIALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLSQAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQLSFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGTVHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGITAQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFELLLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 4 Entity 4 polymer

Description description	CDK-activating kinase assembly factor MAT1
Molecular weight formula_weight	35874.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	3

MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPS

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 5 Entity 5 polymer

Description description	General transcription factor IIH subunit 3
Molecular weight formula_weight	34416.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	4

MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVIASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMTKSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQLILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAKKKKLKVSA

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 6 Entity 6 polymer

Description description	General transcription factor IIH subunit 5
Molecular weight formula_weight	8060.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	5

MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERVGELMDQNAFSLTQK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 7 Entity 7 polymer

Description description	General transcription factor IIH subunit 2
Molecular weight formula_weight	44482.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	6

MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHVSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVCAVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 8 Entity 8 polymer

Description description	General transcription and DNA repair factor IIH helicase subunit XPB
Molecular weight formula_weight	89404.7 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	7

MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQVDESGTKVDEYGAKDYRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVESCHPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAISKTAESSGGPSTSRVTDPQGKSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRNDSVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYMEYHSSRSKAPSKHVHPLFKRFRK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 9 Entity 9 polymer

Description description	Cyclin-dependent kinase 7
Molecular weight formula_weight	39090.3 kDa
EC 编号 ec_number	2.7.11.22,2.7.11.23
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	8

MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 10 Entity 10 polymer

Description description	Cyclin-H
Molecular weight formula_weight	37695.5 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	9

MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 11 Entity 11 polymer

Description description	DNA-directed RNA polymerase subunit
Molecular weight formula_weight	217450.1 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	A

MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDPRQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKGHGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

Entity 12 Entity 12 polymer

Description description	DNA-directed RNA polymerase subunit beta
Molecular weight formula_weight	134041.4 kDa
EC 编号 ec_number	2.7.7.6
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	B

MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVEDAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTYSAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLDPGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSMLARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEMVKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETKKAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQKFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLSHLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSPILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSEVSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASGVVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIVAIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGMRHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELEGTNRRYTKRDCSTFLRTSETGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEGITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSRDGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGCRNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

Entity 13 Entity 13 polymer

Description description	DNA-directed RNA polymerase II subunit RPB3
Molecular weight formula_weight	31439.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	C

MPYANQPTVRITELTDENVKFIIENTDLAVANSIRRVFIAEVPIIAIDWVQIDANSSVLHDEFIAHRLGLIPLTSDDIVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDLISNSPRVIPVTSRNRDNDPSDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPTAGVAFEYDPDNALRHTVYPKPEEWPKSEYSELDEDESQAPYDPNGKPERFYYNVESCGSLRPETIVLSALSGLKKKLSDLQTQLSHEIQSDVLTIN

Entity 14 Entity 14 polymer

Description description	RPOL4c domain-containing protein
Molecular weight formula_weight	16331.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	D

MAAGGSDPRAGDVEEDASQLIFPKEFETAETLLNSEVHMLLEHRKQQNESAEDEQELSEVFMKTLNYTARFSRFKNRETIASVRSLLLQKKLHKFELACLANLCPETAEESKALIPSLEGRFEDEELQQILDDIQTKRSFQY

Entity 15 Entity 15 polymer

Description description	DNA-directed RNA polymerase II subunit E
Molecular weight formula_weight	24644.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	E

MDDEEETYRLWKIRKTIMQLCHDRGYLVTQDELDQTLEEFKAQFGDKPSEGRPRRTDLTVLVAHNDDPTDQMFVFFPEEPKVGIKTIKVYCQRMQEENITRALIVVQQGMTPSAKQSLVDMAPKYILEQFLQQELLINITEHELVPEHVVMTKEEVTELLARYKLRENQLPRIQAGDPVARYFGIKRGQVVKIIRPSETAGRYITYRLVQ

Entity 16 Entity 16 polymer

Description description	DNA-directed RNA polymerase II subunit F
Molecular weight formula_weight	14477.0 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	F

MSDNEDNFDGDDFDDVEEDEGLDDLENAEEEGQENVEILPSGERPQANQKRITTPYMTKYERARVLGTRALQIAMCAPVMVELEGETDPLLIAMKELKARKIPIIIRRYLPDGSYEDWGVDELIISD

Entity 17 Entity 17 polymer

Description description	DNA-directed RNA polymerase II subunit RPB7
Molecular weight formula_weight	19314.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	G

MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQPGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS

Entity 18 Entity 18 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC3
Molecular weight formula_weight	17162.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	H

MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVIASTLYEDGTLDDGEYNPTDDRPSRADQFEYVMYGKVYRIEGDETSTEAATRLSAYVSYGGLLMRLQGDANNLHGFEVDSRVYLLMKKLAF

Entity 19 Entity 19 polymer

Description description	DNA-directed RNA polymerase II subunit RPB9
Molecular weight formula_weight	14541.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	I

MEPDGTYEPGFVGIRFCQECNNMLYPKEDKENRILLYACRNCDYQQEADNSCIYVNKITHEVDELTQIIADVSQDPTLPRTEDHPCQKCGHKEAVFFQSHSARAEDAMRLYYVCTAPHCGHRWTE

Entity 20 Entity 20 polymer

Description description	DNA-directed RNA polymerases I, II, and III subunit RPABC5
Molecular weight formula_weight	7655.1 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	J

MIIPVRCFTCGKIVGNKWEAYLGLLQAEYTEGDALDALGLKRYCCRRMLLAHVDLIEKLLNYAPLEK

Entity 21 Entity 21 polymer

Description description	RNA_pol_L_2 domain-containing protein
Molecular weight formula_weight	13310.3 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	K

MNAPPAFESFLLFEGEKKITINKDTKVPNACLFTINKEDHTLGNIIKSQLLKDPQVLFAGYKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRVAIKDKQEGIE

Entity 22 Entity 22 polymer

Description description	RNA polymerase II subunit K
Molecular weight formula_weight	7018.2 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	L

MDTQKDVQPPKQQPMIYICGECHTENEIKSRDPIRCRECGYRIMYKKRTKRLVVFDAR

Entity 23 Entity 23 polymer

Description description	Transcription initiation factor IIB
Molecular weight formula_weight	34877.9 kDa
EC 编号 ec_number	2.3.1.48
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	M

MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPTDFKFDTPVDKLPQL

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 24 Entity 24 polymer

Description description	NT
Molecular weight formula_weight	32911.9 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	N

CGGGTGTTCCTGAAGGGGGGCTATAAAAGGGGGTGGGGGCGCGTTCGTCCTCACTCTCTTCCGCATCGCTGTCTGCGAGGGCCAGCTGTTGGGGTGAGTACTCCCT

Entity 25 Entity 25 polymer

Description description	TATA-box-binding protein
Molecular weight formula_weight	37729.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	O

MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQNTNSLSILEEQQRQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQAVAAAAVQQSTSQQATQGTSGQAPQLFHSQTLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTIALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVVQKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPRIVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 26 Entity 26 polymer

Description description	General transcription factor IIF subunit 1
Molecular weight formula_weight	58343.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Q

MAALGPSSQNVTEYVVRVPKNTTKKYNIMAFNAADKVNFATWNQARLERDLSNKKIYQEEEMPESGAGSEFNRKLREEARRKKYGIVLKEFRPEDQPWLLRVNGKSGRKFKGIKKGGVTENTSYYIFTQCPDGAFEAFPVHNWYNFTPLARHRTLTAEEAEEEWERRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEGGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKSTPQPPSGKTTPNSGDVQVTEDAVRRYLTRKPMTTKDLLKKFQTKKTGLSSEQTVNVLAQILKRLNPERKMINDKMHFSLKE

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 27 Entity 27 polymer

Description description	General transcription factor IIF subunit 2
Molecular weight formula_weight	28427.3 kDa
EC 编号 ec_number	3.6.4.12
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	R

MAERGELDLTGAKQNTGVWLVKVPKYLSQQWAKASGRGEVGKLRIAKTQGRTEVSFTLNEDLANIHDIGGKPASVSAPREHPFVLQSVGGQTLTVFTESSSDKLSLEGIVVQRAECRPAASENYMRLKRLQIEESSKPVRLSQQLDKVVTTNYKPVANHQYNIEYERKKKEDGKRARADKQHVLDMLFSAFEKHQYYNLKDLVDITKQPVVYLKEILKEIGVQNVKGIHKNTWELKPEYRHYQGEEKSD

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 28 Entity 28 polymer

Description description	TEMPLATE
Molecular weight formula_weight	32508.8 kDa
Source method src_method	syn
Copy count entity_count	1

Polymer Polymer

Polymer type type	polydeoxyribonucleotide
Chain IDs strand_id	T

AGGGAGTACTCACCCCAACAGCTGGCCCTCGCAGACAGCGATGCGGAAGAGAGTGAGGACGAACGCGCCCCCACCCCCTTTTATAGCCCCCCTTCAGGAACACCCG

Entity 29 Entity 29 polymer

Description description	Transcription initiation factor IIA subunit 1
Molecular weight formula_weight	41544.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	U

MANSANTNTVPKLYRSVIEDVINDVRDIFLDDGVDEQVLMELKTLWENKLMQSRAVDGFHSEEQQLLLQVQQQHQPQQQQHHHHHHHQQAQPQQTVPQQAQTQQVLIPASQQATAPQVIVPDSKLIQHMNASNMSAAATAATLALPAGVTPVQQILTNSGQLLQVVRAANGAQYIFQPQQSVVLQQQVIPQMQPGGVQAPVIQQVLAPLPGGISPQTGVIIQPQQILFTGNKTQVIPTTVAAPTPAQAQITATGQQQPQAQPAQTQAPLVLQVDGTGDTSSEEDEDEEEDYDDDEEEDKEKDGAEDGQVEEEPLNSEDDVSDEEGQELFDTENVVVCQYDKIHRSKNKWKFHLKDGIMNLNGRDYIFSKAIGDAEW

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 30 Entity 30 polymer

Description description	Transcription initiation factor IIA subunit 2
Molecular weight formula_weight	12469.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	V

MAYQLYRNTTLGNSLQESLDELIQSQQITPQLALQVLLQFDKAINAALAQRVRNRVNFRGSLNTYRFCDNVWTFVLNDVEFREVTELIKVDKVKIVACDGKNTGSNTTE

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 31 Entity 31 polymer

Description description	General transcription factor IIE subunit 1
Molecular weight formula_weight	49516.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	W

MADPDVLTEVPAALKRLAKYVIRGFYGIEHALALDILIRNSCVKEEDMLELLKFDRKQLRSVLNNLKGDKFIKCRMRVETAADGKTTRHNYYFINYRTLVNVVKYKLDHMRRRIETDERDSTNRASFKCPVCSSTFTDLEANQLFDPMTGTFRCTFCHTEVEEDESAMPKKDARTLLARFNEQIEPIYALLRETEDVNLAYEILEPEPTEIPALKQSKDHAATTAGAASLAGGHHREAWATKGPSYEDLYTQNVVINMDDQEDLHRASLEGKSAKERPIWLRESTVQGAYGSEDMKEGGIDMDAFQEREEGHAGPDDNEEVMRALLIHEKKTSSAMAGSVGAAAPVTAANGSDSESETSESDDDSPPRPAAVAVHKREEDEEEDDEFEEVADDPIVMVAGRPFSYSEVSQRPELVAQMTPEEKEAYIAMGQRMFEDLFE

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 32 Entity 32 polymer

Description description	Transcription initiation factor IIE subunit beta
Molecular weight formula_weight	33106.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	X

MDPSLLRERELFKKRALSTPVVEKRSASSESSSSSSKKKKTKVEHGGSSGSKQNSDHSNGSFNLKALSGSSGYKFGVLAKIVNYMKTRHQRGDTHPLTLDEILDETQHLDIGLKQKQWLMTEALVNNPKIEVIDGKYAFKPKYNVRDKKALLRLLDQHDQRGLGGILLEDIEEALPNSQKAVKALGDQILFVNRPDKKKILFFNDKSCQFSVDEEFQKLWRSVTVDSMDEEKIEEYLKRQGISSMQESGPKKVAPIQRRKKPASQKKRRFKTHNEHLAGVLKDYSDITSSK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 33 Entity 33 polymer

Description description	Unassigned peptide, likely TFIIE-beta
Molecular weight formula_weight	1635.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Y

XXXXXXXXXXXXXXXXXXX

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Escherichia coli

Entity 34 Entity 34 polymer

Description description	Unassigned peptide, likely XPB
Molecular weight formula_weight	698.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	Z

XXXXXXXX

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 35 Entity 35 polymer

Description description	Mediator of RNA polymerase II transcription subunit 6
Molecular weight formula_weight	28464.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	a

MAAVDIRDNLLGISWVDSSWIPILNSGSVLDYFSERSNPFYDRTCNNEVVKMQRLTLEHLNQMVGIEYILLHAQEPILFIIRKQQRQSPAQVIPLADYYIIAGVIYQAPDLGSVINSRVLTAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDHEEQDKVRPKAKRKEEPSSIFQRQRVDALLLDLRQKFPPKFVQLKPGEKPVPVDQTKKEAEPIPETVKPEEKETTKNVQQTVSAKGPPEKRMRLQ

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 36 Entity 36 polymer

Description description	Mediator of RNA polymerase II transcription subunit 8
Molecular weight formula_weight	29112.9 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	b

MQREEKQLEASLDALLSQVADLKNSLGSFICKLENEYGRLTWPSVLDSFALLSGQLNTLNKVLKHEKTPLFRNQVIIPLVLSPDRDEDLMRQTEGRVPVFSHEVVPDHLRTKPDPEVEEQEKQLTTDAARIGADAAQKQIQSLNKMCSNLLEKISKEERESESGGLRPNKQTFNPTDTNALVAAVAFGKGLSNWRPSGSSGPGQAGQPGAGTILAGTSGLQQVQMAGAPSQQQPMLSGVQMAQAGQPGKMPSGIKTNIKSASMHPYQR

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 37 Entity 37 polymer

Description description	Mediator of RNA polymerase II transcription subunit 11
Molecular weight formula_weight	13145.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	c

MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARLKLSDVARTCEQMLEN

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 38 Entity 38 polymer

Description description	Mediator of RNA polymerase II transcription subunit 17
Molecular weight formula_weight	72984.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	d

MSGVRAVRISIESACEKQVHEVGLDGTETYLPPLSMSQNLARLAQRIDFSQGSGSEEEEAAGTEGDAQEWPGAGSSADQDDEEGVVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQNPQTLQLISKKKSLAGAAQILLKGAERLTKSVTENQENKLQRDFNSELLRLRQHWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDLDLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQVPHIVVKNQIISQPFPSLQLSISLCHSSNDKKSQKFATEKQCPEDHLYVLEHNLHLLIREFHKQTLSSIMMPHPASAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRSRAAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSYQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKSDVLQDNKWSHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 39 Entity 39 polymer

Description description	Mediator of RNA polymerase II transcription subunit 18
Molecular weight formula_weight	23693.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	e

MEAPPVTMMPVTGGTINMMEYLLQGSVLDHSLESLIHRLRGLCDNMEPETFLDHEMVFLLKGQQASPFVLRARRSMDRAGAPWHLRYLGQPEMGDKNRHALVRNCVDIATSENLTDFLMEMGFRMDHEFVAKGHLFRKGIMKIMVYKIFRILVPGNTDSTEALSLSYLVELSVVAPAGQDMVSDDMKNFAEQLKPLVHLEKIDPKRLM

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 40 Entity 40 polymer

Description description	Mediator of RNA polymerase II transcription subunit 20
Molecular weight formula_weight	23243.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	f

MGVTCVSQMPVAEGKSVQQTVELLTRKLEMLGAEKQGTFCVDCETYHTAASTLGSQGQTGKLMYVMHNSEYPLSCFALFENGPCLIADTNFDVLMVKLKGFFQSAKASKIETRGTRYQYCDFLVKVGTVTMGPSARGISVEVEYGPCVVASDCWSLLLEFLQSFLGSHTPGAPAVFGNRHDAVYGPADTMVQYMELFNKIRKQQQVPVAGIR

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 41 Entity 41 polymer

Description description	Mediator of RNA polymerase II transcription subunit 22
Molecular weight formula_weight	22243.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	g

MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYEMHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRTLQEECDRKLITLRDEISIDLYELEEEYYSSSSSLCEANDLPLCEAYGRLDLDTDSADGLSAPLLASPEPSAGPLQVAAPAHSHAGGPGPTEHA

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 42 Entity 42 polymer

Description description	Mediator of RNA polymerase II transcription subunit 4
Molecular weight formula_weight	29781.4 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	h

MAASSSGEKEKERLGGGLGVAGGNSTRERLLSALEDLEVLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRPYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSSDFLLEPPGHNKENEDDVEIMSTDSSSSSSESD

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 43 Entity 43 polymer

Description description	Mediator of RNA polymerase II transcription subunit 7
Molecular weight formula_weight	27285.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	i

MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDADDSNNCTGQNEHQRENSGHRRDQIIEKDAALCVLIDEMNERP

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 44 Entity 44 polymer

Description description	Mediator of RNA polymerase II transcription subunit 9
Molecular weight formula_weight	16422.8 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	j

MASAGVAAGRQAEDVLPPTSDQPLPDTKPLPPPQPPPVPAPQPQQSPAPRPQSPARAREEENYSFLPLVHNIIKCMDKDSPEVHQDLNALKSKFQEMRKLISTMPGIHLSPEQQQQQLQSLREQVRTKNELLQKYKSLCMFEIPKE

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 45 Entity 45 polymer

Description description	Mediator of RNA polymerase II transcription subunit 10
Molecular weight formula_weight	15711.0 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	k

MAEKFDHLEEHLEKFVENIRQLGIIVSDFQPSSQAGLNQKLNFIVTGLQDIDKCRQQLHDITVPLEVFEYIDQGRNPQLYTKECLERALAKNEQVKGKIDTMKKFKSLLIQELSKVFPEDMAKYRSIRGEDHPPS

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 46 Entity 46 polymer

Description description	Mediator of RNA polymerase II transcription subunit 14
Molecular weight formula_weight	160787.6 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	l

MAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSECLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 47 Entity 47 polymer

Description description	Mediator of RNA polymerase II transcription subunit 19
Molecular weight formula_weight	26321.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	m

MENFTALFGAQADPPPPPTALGFGPGKPPPPPPPPAGGGPGTAPPPTAATAPPGADKSGAGCGPFYLMRELPGSTELTGSTNLITHYNLEQAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILSSSFNPITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPDRKRKKKEKKKKKNRHSPDHPGMGSSQASSSSSLR

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 48 Entity 48 polymer

Description description	Mediator of RNA polymerase II transcription subunit 21
Molecular weight formula_weight	15575.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	n

MADRLTQLQDAVNSLADQFCNAIGVLQQCGPPASFNNIQTAINKDQPANPTEEYAQLFAALIARTAKDIDVLIDSLPSEESTAALQAASLYKLEEENHEAATCLEDVVYRGDMLLEKIQSALADIAQSQLKTRSGTHSQSLPDS

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 49 Entity 49 polymer

Description description	Mediator of RNA polymerase II transcription subunit 31
Molecular weight formula_weight	15826.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	o

MAAAVAMETDDAGNRLRFQLELEFVQCLANPNYLNFLAQRGYFKDKAFVNYLKYLLYWKDPEYAKYLKYPQCLHMLELLQYEHFRKELVNAQCAKFIDEQQILHWQHYSRKRMRLQQALAEQQQQNNTSGK

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 50 Entity 50 polymer

Description description	Mediator of RNA polymerase II transcription subunit 27
Molecular weight formula_weight	35478.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	p

MADVINVSVNLEAFSQAISAIQALRSSVSRVFDCLKDGMRNKETLEGREKAFIAHFQDNLHSVNRDLNELERLSNLVGKPSENHPLHNSGLLSLDPVQDKTPLYSQLLQAYKWSNKLQYHAGLASGLLNQQSLKRSANQMGVSAKRRPKAQPTTLVLPPQYVDDVISRIDRMFPEMSIHLSRPNGTSAMLLVTLGKVLKVIVVMRSLFIDRTIVKGYNENVYTEDGKLDIWSKSNYQVFQKVTDHATTALLHYQLPQMPDVVVRSFMTWLRSYIKLFQAPCQRCGKFLQDGLPPTWRDFRTLEAFHDTCRQ

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 51 Entity 51 polymer

Description description	Mediator of RNA polymerase II transcription subunit 28
Molecular weight formula_weight	19540.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	q

MAAPLGGMFSGQPPGPPQAPPGLPGQASLLQAAPGAPRPSSSTLVDELESSFEACFASLVSQDYVNGTDQEEIRTGVDQCIQKFLDIARQTECFFLQKRLQLSVQKPEQVIKEDVSELRNELQRKDALVQKHLTKLRHWQQVLEDINVQHKKPADIPQGSLAYLEQASANIPAPLKPT

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 52 Entity 52 polymer

Description description	unassigned peptide (MED29 or MED30)
Molecular weight formula_weight	1720.1 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	r

XXXXXXXXXXXXXXXXXXXX

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 53 Entity 53 polymer

Description description	Mediator of RNA polymerase II transcription subunit 30
Molecular weight formula_weight	20301.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	s

MSTPPLAASGMAPGPFAGPQAQQAAREVNTASLCRIGQETVQDIVYRTMEIFQLLRNMQLPNGVTYHTGTYQDRLTKLQDNLRQLSVLFRKLRLVYDKCNENCGGMDPIPVEQLIPYVEEDGSKNDDRAGPPRFASEERREIAEVNKKLKQKNQQLKQIMDQLRNLIWDINAMLAMRN

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 54 Entity 54 polymer

Description description	unassigned peptide (MED14)
Molecular weight formula_weight	1890.3 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	v

XXXXXXXXXXXXXXXXXXXXXX

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 55 Entity 55 polymer

Description description	unassigned peptide (MED6)
Molecular weight formula_weight	1379.7 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	w

XXXXXXXXXXXXXXXX

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 56 Entity 56 polymer

Description description	unassigned peptide (MED17)
Molecular weight formula_weight	954.2 kDa
Source method src_method	man
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	x

XXXXXXXXXXX

Source Source

Source organism organism	Homo sapiens
Common name common_name	Human
NCBI taxonomy ID ncbi_taxonomy_id	9606
Host organism host_organism	Trichoplusia ni

Entity 57 Entity 57 polymer

Description description	unassigned peptide (MED29 or MED30)
Molecular weight formula_weight	1549.9 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	y

XXXXXXXXXXXXXXXXXX

Entity 58 Entity 58 polymer

Description description	unassigned peptide (MED29 or MED30)
Molecular weight formula_weight	1975.4 kDa
Source method src_method	nat
Copy count entity_count	1

Polymer Polymer

Polymer type type	polypeptide(L)
Chain IDs strand_id	z

XXXXXXXXXXXXXXXXXXXXXXX

Entity 59 Entity 59 non-polymer

Description description	IRON/SULFUR CLUSTER
Molecular weight formula_weight	351.6 kDa
Source method src_method	syn
Copy count entity_count	1

Entity 60 Entity 60 non-polymer

Description description	ZINC ION
Molecular weight formula_weight	65.4 kDa
Source method src_method	syn
Copy count entity_count	18

Entity 61 Entity 61 non-polymer

Description description	MAGNESIUM ION
Molecular weight formula_weight	24.3 kDa
Source method src_method	syn
Copy count entity_count	1

▶

Unit-cell length a length_a	1.000 Å
Unit-cell length b length_b	1.000 Å
Unit-cell length c length_c	1.000 Å
Unit-cell angle α angle_alpha	90.00 °
Unit-cell angle β angle_beta	90.00 °
Unit-cell angle γ angle_gamma	90.00 °
Molecules per unit cell Z z_pdb	—

Space group space_group	P 1
Space-group number int_tables_number	1
Crystal system crystal_system	—

Resolution resolution	4.50 Å
Resolution测定Method resolution_method	—
颗粒数 num_particles	25967

Human Mediator with RNA Polymerase II Pre-initiation complex

1. Protein Identity and Related Structures Protein Identity & Related Structures

TFIIH basal transcription factor complex helicase XPD subunit

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

General transcription factor IIH subunit 1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

General transcription factor IIH subunit 4

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

CDK-activating kinase assembly factor MAT1

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

General transcription factor IIH subunit 3

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

General transcription factor IIH subunit 5

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

General transcription factor IIH subunit 2

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

General transcription and DNA repair factor IIH helicase subunit XPB

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Cyclin-dependent kinase 7

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer

Other homooligomers

Heteromeric or nucleic-acid complex

Cyclin-H

State in the Current Structure

Other States of the Same Protein in the Database

Monomer

Homodimer

Homotetramer