6ltj

Structure of nucleosome-bound human BAF complex

Method: ELECTRON MICROSCOPY
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1. 蛋白身份与相关结构 Protein Identity & Related Structures

Histone H3.3

Xenopus laevis

UniProt Q6PI79

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H4 × 2 (P62799) Histone H2A type 1 × 2 (P06897) Histone H2B × 2 (Q92131) Transcription activator BRG1 × 1 (P51532) Actin-like protein 6A × 1 (O96019) Actin, cytoplasmic 1 × 1 (P60709) AT-rich interactive domain-containing protein 1A × 1 (O14497) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 × 1 (Q12824) SWI/SNF complex subunit SMARCC2 × 2 (Q8TAQ2) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 × 1 (Q96GM5) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 × 1 (Q969G3) Zinc finger protein ubi-d4 × 1 (Q92785) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 H33_XENLA
Isoform —
PDB实体 1
链与序列区间 作者链 A; PDB构建体 1–136; UniProt 1–136 作者链 E; PDB构建体 1–136; UniProt 1–136

Histone H4

Xenopus laevis

UniProt P62799

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H3.3 × 2 (Q6PI79) Histone H2A type 1 × 2 (P06897) Histone H2B × 2 (Q92131) Transcription activator BRG1 × 1 (P51532) Actin-like protein 6A × 1 (O96019) Actin, cytoplasmic 1 × 1 (P60709) AT-rich interactive domain-containing protein 1A × 1 (O14497) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 × 1 (Q12824) SWI/SNF complex subunit SMARCC2 × 2 (Q8TAQ2) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 × 1 (Q96GM5) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 × 1 (Q969G3) Zinc finger protein ubi-d4 × 1 (Q92785) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 H4_XENLA
Isoform —
PDB实体 2
链与序列区间 作者链 B; PDB构建体 1–103; UniProt 1–103 作者链 F; PDB构建体 1–103; UniProt 1–103

Histone H2A type 1

Xenopus laevis

UniProt P06897

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H3.3 × 2 (Q6PI79) Histone H4 × 2 (P62799) Histone H2B × 2 (Q92131) Transcription activator BRG1 × 1 (P51532) Actin-like protein 6A × 1 (O96019) Actin, cytoplasmic 1 × 1 (P60709) AT-rich interactive domain-containing protein 1A × 1 (O14497) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 × 1 (Q12824) SWI/SNF complex subunit SMARCC2 × 2 (Q8TAQ2) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 × 1 (Q96GM5) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 × 1 (Q969G3) Zinc finger protein ubi-d4 × 1 (Q92785) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 H2A1_XENLA
Isoform —
PDB实体 3
链与序列区间 作者链 C; PDB构建体 1–130; UniProt 1–130 作者链 G; PDB构建体 1–130; UniProt 1–130

Histone H2B

Xenopus laevis

UniProt Q92131

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H3.3 × 2 (Q6PI79) Histone H4 × 2 (P62799) Histone H2A type 1 × 2 (P06897) Transcription activator BRG1 × 1 (P51532) Actin-like protein 6A × 1 (O96019) Actin, cytoplasmic 1 × 1 (P60709) AT-rich interactive domain-containing protein 1A × 1 (O14497) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 × 1 (Q12824) SWI/SNF complex subunit SMARCC2 × 2 (Q8TAQ2) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 × 1 (Q96GM5) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 × 1 (Q969G3) Zinc finger protein ubi-d4 × 1 (Q92785) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 Q92131_XENLA
Isoform —
PDB实体 4
链与序列区间 作者链 D; PDB构建体 1–126; UniProt 1–126 作者链 H; PDB构建体 1–126; UniProt 1–126

Transcription activator BRG1

Homo sapiens

UniProt P51532

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H3.3 × 2 (Q6PI79) Histone H4 × 2 (P62799) Histone H2A type 1 × 2 (P06897) Histone H2B × 2 (Q92131) Actin-like protein 6A × 1 (O96019) Actin, cytoplasmic 1 × 1 (P60709) AT-rich interactive domain-containing protein 1A × 1 (O14497) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 × 1 (Q12824) SWI/SNF complex subunit SMARCC2 × 2 (Q8TAQ2) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 × 1 (Q96GM5) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 × 1 (Q969G3) Zinc finger protein ubi-d4 × 1 (Q92785) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SMCA4_HUMAN
Isoform —
PDB实体 5
链与序列区间 作者链 I; PDB构建体 1–1647; UniProt 1–1647

Actin-like protein 6A

Homo sapiens

UniProt O96019

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H3.3 × 2 (Q6PI79) Histone H4 × 2 (P62799) Histone H2A type 1 × 2 (P06897) Histone H2B × 2 (Q92131) Transcription activator BRG1 × 1 (P51532) Actin, cytoplasmic 1 × 1 (P60709) AT-rich interactive domain-containing protein 1A × 1 (O14497) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 × 1 (Q12824) SWI/SNF complex subunit SMARCC2 × 2 (Q8TAQ2) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 × 1 (Q96GM5) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 × 1 (Q969G3) Zinc finger protein ubi-d4 × 1 (Q92785) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ACL6A_HUMAN
Isoform —
PDB实体 6
链与序列区间 作者链 J; PDB构建体 1–406; UniProt 12–417

Actin, cytoplasmic 1

Homo sapiens

UniProt P60709

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H3.3 × 2 (Q6PI79) Histone H4 × 2 (P62799) Histone H2A type 1 × 2 (P06897) Histone H2B × 2 (Q92131) Transcription activator BRG1 × 1 (P51532) Actin-like protein 6A × 1 (O96019) AT-rich interactive domain-containing protein 1A × 1 (O14497) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 × 1 (Q12824) SWI/SNF complex subunit SMARCC2 × 2 (Q8TAQ2) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 × 1 (Q96GM5) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 × 1 (Q969G3) Zinc finger protein ubi-d4 × 1 (Q92785) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ACTB_HUMAN
Isoform —
PDB实体 7
链与序列区间 作者链 K; PDB构建体 1–375; UniProt 1–375

AT-rich interactive domain-containing protein 1A

Homo sapiens

UniProt O14497

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H3.3 × 2 (Q6PI79) Histone H4 × 2 (P62799) Histone H2A type 1 × 2 (P06897) Histone H2B × 2 (Q92131) Transcription activator BRG1 × 1 (P51532) Actin-like protein 6A × 1 (O96019) Actin, cytoplasmic 1 × 1 (P60709) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 × 1 (Q12824) SWI/SNF complex subunit SMARCC2 × 2 (Q8TAQ2) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 × 1 (Q96GM5) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 × 1 (Q969G3) Zinc finger protein ubi-d4 × 1 (Q92785) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 ARI1A_HUMAN
Isoform —
PDB实体 8
链与序列区间 作者链 L; PDB构建体 1–1295; UniProt 991–2285

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

Homo sapiens

UniProt Q12824

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H3.3 × 2 (Q6PI79) Histone H4 × 2 (P62799) Histone H2A type 1 × 2 (P06897) Histone H2B × 2 (Q92131) Transcription activator BRG1 × 1 (P51532) Actin-like protein 6A × 1 (O96019) Actin, cytoplasmic 1 × 1 (P60709) AT-rich interactive domain-containing protein 1A × 1 (O14497) SWI/SNF complex subunit SMARCC2 × 2 (Q8TAQ2) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 × 1 (Q96GM5) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 × 1 (Q969G3) Zinc finger protein ubi-d4 × 1 (Q92785) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SNF5_HUMAN
Isoform —
PDB实体 9
链与序列区间 作者链 M; PDB构建体 1–113; UniProt 1–113 作者链 M; PDB构建体 123–336; UniProt 172–385

SWI/SNF complex subunit SMARCC2

Homo sapiens

UniProt Q8TAQ2

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H3.3 × 2 (Q6PI79) Histone H4 × 2 (P62799) Histone H2A type 1 × 2 (P06897) Histone H2B × 2 (Q92131) Transcription activator BRG1 × 1 (P51532) Actin-like protein 6A × 1 (O96019) Actin, cytoplasmic 1 × 1 (P60709) AT-rich interactive domain-containing protein 1A × 1 (O14497) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 × 1 (Q12824) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 × 1 (Q96GM5) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 × 1 (Q969G3) Zinc finger protein ubi-d4 × 1 (Q92785) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SMRC2_HUMAN
Isoform —
PDB实体 10
链与序列区间 作者链 N; PDB构建体 1–1214; UniProt 1–1214 作者链 O; PDB构建体 1–1214; UniProt 1–1214

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

Homo sapiens

UniProt Q96GM5

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H3.3 × 2 (Q6PI79) Histone H4 × 2 (P62799) Histone H2A type 1 × 2 (P06897) Histone H2B × 2 (Q92131) Transcription activator BRG1 × 1 (P51532) Actin-like protein 6A × 1 (O96019) Actin, cytoplasmic 1 × 1 (P60709) AT-rich interactive domain-containing protein 1A × 1 (O14497) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 × 1 (Q12824) SWI/SNF complex subunit SMARCC2 × 2 (Q8TAQ2) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 × 1 (Q969G3) Zinc finger protein ubi-d4 × 1 (Q92785) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SMRD1_HUMAN
Isoform —
PDB实体 11
链与序列区间 作者链 P; PDB构建体 1–515; UniProt 1–515

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

Homo sapiens

UniProt Q969G3

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H3.3 × 2 (Q6PI79) Histone H4 × 2 (P62799) Histone H2A type 1 × 2 (P06897) Histone H2B × 2 (Q92131) Transcription activator BRG1 × 1 (P51532) Actin-like protein 6A × 1 (O96019) Actin, cytoplasmic 1 × 1 (P60709) AT-rich interactive domain-containing protein 1A × 1 (O14497) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 × 1 (Q12824) SWI/SNF complex subunit SMARCC2 × 2 (Q8TAQ2) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 × 1 (Q96GM5) Zinc finger protein ubi-d4 × 1 (Q92785) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 SMCE1_HUMAN
Isoform —
PDB实体 12
链与序列区间 作者链 Q; PDB构建体 1–411; UniProt 1–411

Zinc finger protein ubi-d4

Homo sapiens

UniProt Q92785

当前结构中的状态

Assembly 物理组成 蛋白状态 分子拷贝数 共同组分 数据核对
1 蛋白–DNA 异源复合物 蛋白 18 DNA 2 Histone H3.3 × 2 (Q6PI79) Histone H4 × 2 (P62799) Histone H2A type 1 × 2 (P06897) Histone H2B × 2 (Q92131) Transcription activator BRG1 × 1 (P51532) Actin-like protein 6A × 1 (O96019) Actin, cytoplasmic 1 × 1 (P60709) AT-rich interactive domain-containing protein 1A × 1 (O14497) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 × 1 (Q12824) SWI/SNF complex subunit SMARCC2 × 2 (Q8TAQ2) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 × 1 (Q96GM5) SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 × 1 (Q969G3) DNA (119-MER) × 1 DNA (119-MER) × 1 ZINC ION × 1 与全部聚合物一致

数据库中的同蛋白其他状态

查看构建体与数据证据
UniProt名称 REQU_HUMAN
Isoform —
PDB实体 13
链与序列区间 作者链 R; PDB构建体 1–100; UniProt 1–100 作者链 R; PDB构建体 110–292; UniProt 209–391

页面优先展示蛋白身份、当前 assembly、共同组分、聚集状态和跨 PDB 结构链接。 链映射与序列区间收在“数据证据”中;数据库内部编号、导入时间和 assembly 操作表达式仅用于维护,因此不在读者页面展示。

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2. 结构基本信息 2. Structure Basics

条目编号 entry_id6ltj
沉积日期 deposition_date2020-01-22
结构标题 titleStructure of nucleosome-bound human BAF complex
关键词 keywordsChromatin remodeler, Complex, GENE REGULATION; GENE REGULATION
实验方法 methodELECTRON MICROSCOPY
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3. Official assembly/model 理论 SAXS Official SAXS Profiles

页面只读取最新 assembly 计算结果。每一条曲线都对应明确的 PDB、official biological assembly 和 coordinate model。

6ltj__assembly_1__model_1

Assembly 1 · Model 1 · CRYSOL 4.1.3-1-20251215 (887e7ef)

下载该曲线 .dat

6ltj__assembly_1__model_1 | I(q)

10-2 10-1 106 107 108 109 q (1/Angstrom) I(q)
100 个绘图点;横轴和纵轴均采用对数尺度。

6ltj__assembly_1__model_1 | P(r) · Pending

新版 assembly/model P(r) 尚未计算 此处仅保留位置,不展示旧数据 r (Angstrom) P(r)
P(r) 将按相同 assembly/model 分别计算和展示。
Rg(Guinier)64.16 Å
Rg(电子密度)64.10 Å
总 Rg64.28 Å
原子数34283
残基数3894
排除体积596150 ų
最大 q0.500 Å⁻¹
Assembly Model 结构单元 聚集说明 状态 CRYSOL 操作
1 1 6ltj__assembly_1__model_1 eicosameric (20) 成功 4.1.3-1-20251215 (887e7ef) 查看 下载
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4. 晶体学与实验 4. Crystallography & Experiment

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5. 实体与聚合物信息 Entities & Polymers (16)

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6. 折叠分类 (SCOP + CATH) 8 domains

CATH v4.4 (8 domains)

结构域编号 domain_id6ltjA00
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology20 — Histone, subunit A
同源超家族 H-superfamily homologous superfamily10 — Histone, subunit A
结构域编号 domain_id6ltjB00
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology20 — Histone, subunit A
同源超家族 H-superfamily homologous superfamily10 — Histone, subunit A
结构域编号 domain_id6ltjC00
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology20 — Histone, subunit A
同源超家族 H-superfamily homologous superfamily10 — Histone, subunit A
结构域编号 domain_id6ltjD00
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology20 — Histone, subunit A
同源超家族 H-superfamily homologous superfamily10 — Histone, subunit A
结构域编号 domain_id6ltjE00
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology20 — Histone, subunit A
同源超家族 H-superfamily homologous superfamily10 — Histone, subunit A
结构域编号 domain_id6ltjF00
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology20 — Histone, subunit A
同源超家族 H-superfamily homologous superfamily10 — Histone, subunit A
结构域编号 domain_id6ltjG00
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology20 — Histone, subunit A
同源超家族 H-superfamily homologous superfamily10 — Histone, subunit A
结构域编号 domain_id6ltjH00
类 Class class1 — Mainly Alpha
架构 Architecture architecture10 — Orthogonal Bundle
拓扑 Topology topology20 — Histone, subunit A
同源超家族 H-superfamily homologous superfamily10 — Histone, subunit A
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7. 引用文献 (1)