SAXSdb — 9pvo

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1. Structure Basics

entry_id	9pvo
deposition_date	2025-08-03
title	Novel site 1 interaction of the IR/Ins-AC-S2 complex
keywords	Antagonism, receptor tyrosine kinase, MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	37.29 Å
rg_electron	36.53 Å
i0	132400000.00
molecular_weight	91729.0 kDa
excluded_volume	114430 Å³
envelope_volume	163460 Å³
shell_volume	37828 Å³
envelope_diameter	115.4 Å
shell_rg	42.55 Å
envelope_rg	35.03 Å
shape_rg	36.51 Å
total_rg	37.00 Å
total_atoms	12697
n_residues	801
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	118.5 Å
rg_real	37.18 Å
rg_real_error	0.80 Å
i0_real	1.3240e+08
i0_real_error	2.1530e+06
rg_reciprocal	37.25 Å
i0_reciprocal	132400000.0000
total_estimate	0.8319
solution_quality	GOOD a GOOD solution
n_peaks	2
r_peak_primary	53.6 Å
skewness	0.072
kurtosis	-0.770
angular_range	— – 0.2100 Å⁻¹
current_alpha	0.0001
highest_alpha	9816000.0000
n_real_points	43
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.939; Stabil: 1.000; Sysdev: 1.000; Positv: 1.000; Valcen: 0.992; Smooth: 0.000

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4. Crystallography & Experiment

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5. Entities & Polymer Info (3)

Entity 1 polymer

description	Isoform Long of Insulin receptor
formula_weight	109477.6 kDa
ec_number	2.7.10.1
src_method	man
entity_count	2

Polymer

type	polypeptide(L)
strand_id	A,B
atom_count	12697

HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKSSGPSGSHHHHHHGSDYKDDDDKDYKDDDDK

Source

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

Entity 2 polymer

description	Insulin chain A
formula_weight	5520.0 kDa
src_method	syn
entity_count	1

Polymer

type	polypeptide(L)
strand_id	Q

GIVEQCCTSICSLYQLENYCGGSLPETGGGSLEEEWAQIQSEVWGRGCPSY

Entity 3 polymer

description	Insulin chain B
formula_weight	3332.8 kDa
src_method	syn
entity_count	1

Polymer

type	polypeptide(L)
strand_id	R

FVNQHLCGSHLVEALYLVCGERGFFYTPK

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6. Citations (1)

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resolution	3.89 Å
resolution_method	—
num_particles	212201

fit	/app/data/saxs_computation/pv/9pvo/9pvo.fit
pddf	/app/data/pr_computation/pv/9pvo/9pvo.pr.out
profile	/app/data/saxs_computation/pv/9pvo/9pvo.dat

Novel site 1 interaction of the IR/Ins-AC-S2 complex

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

EM 3D

5. Entities & Polymer Info (3)

Entity 1 polymer

Polymer

Source

Entity 2 polymer

Polymer

Entity 3 polymer

Polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)