Cryo-EM structure of Vasopressin receptor 2 (V2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with OPC51803, focused on receptor

Method: ELECTRON MICROSCOPY D_max: 67.7 Å Quality: REASONABLE

SAXS Profile

P(r) Distribution

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1. Structure Basics

entry_id	9uvx
deposition_date	2025-05-11
title	Cryo-EM structure of Vasopressin receptor 2 (V2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with OPC51803, focused on receptor
keywords	GPCR, V2R, vasopressin, OPC51803, MEMBRANE PROTEIN; MEMBRANE PROTEIN
method	ELECTRON MICROSCOPY

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Download Data

SAXS curve (.dat) P(r) distribution (.pr.out) Structure (CIF)

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2. SAXS Parameters (CRYSOL)

rg_guinier	20.69 Å
rg_electron	19.71 Å
i0	26746800.00
molecular_weight	27492.0 kDa
excluded_volume	27135 Å³
envelope_volume	43942 Å³
shell_volume	18986 Å³
envelope_diameter	70.7 Å
shell_rg	25.79 Å
envelope_rg	20.23 Å
shape_rg	19.70 Å
total_rg	20.41 Å
total_atoms	2089
n_residues	263
n_harmonics	20
q_range	— – 0.5000 Å⁻¹
n_points	101
shell_type	directional
solvent_density	0.3340 e/Å³
contrast_shell	0.0300 e/Å³
crysol_version	4.1.3

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3. P(r) Analysis (GNOM)

dmax	67.7 Å
rg_real	20.68 Å
rg_real_error	0.42 Å
i0_real	2.6750e+07
i0_real_error	3.3500e+05
rg_reciprocal	20.68 Å
i0_reciprocal	26750000.0000
total_estimate	0.6399
solution_quality	REASONABLE a REASONABLE solution
n_peaks	2
r_peak_primary	24.5 Å
skewness	0.342
kurtosis	-0.353
angular_range	— – 0.3850 Å⁻¹
current_alpha	0.0000
highest_alpha	2818000.0000
n_real_points	70
gnom_version	4.1.3
quality_criteria	AN1: 0.000; Oscil: 0.867; Stabil: 0.999; Sysdev: 0.242; Positv: 1.000; Valcen: 0.988; Smooth: 0.000

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4. Crystallography & Experiment

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5. Entities & Polymer Info (2)

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6. Citations (1)

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length_a	1.000 Å
length_b	1.000 Å
length_c	1.000 Å
angle_alpha	90.00 °
angle_beta	90.00 °
angle_gamma	90.00 °
z_pdb	—

space_group	P 1
int_tables_number	1
crystal_system	—

resolution	3.310 Å
resolution_low	3.310 Å
r_factor	—
r_work	0.4219
r_free	—

resolution	3.31 Å
resolution_method	—
num_particles	115437

description	Vasopressin V2 receptor,Soluble cytochrome b562
formula_weight	53595.0 kDa
mutation	M243W/H338I/R342L
src_method	man
entity_count	1

Cryo-EM structure of Vasopressin receptor 2 (V2R)-BRIL/anti BRIL SRP2070 Fab antibody complex with OPC51803, focused on receptor

SAXS Profile

P(r) Distribution

1. Structure Basics

Download Data

2. SAXS Parameters (CRYSOL)

3. P(r) Analysis (GNOM)

4. Crystallography & Experiment

Unit Cell

Symmetry

Refinement

EM 3D

5. Entities & Polymer Info (2)

Entity 1 polymer

Polymer

Source

Entity 2 non-polymer

6. Citations (1)

7. Files & Curves (10)

Files (7)

Curves (3)

organism	Homo sapiens
common_name	human
ncbi_taxonomy_id	9606
host_organism	Homo sapiens

description	2-[(5~{R})-1-(2-chloranyl-4-pyrrolidin-1-yl-phenyl)carbonyl-2,3,4,5-tetrahydro-1-benzazepin-5-yl]-~{N}-propan-2-yl-ethanamide
formula_weight	454.0 kDa
src_method	syn
entity_count	1

fit	/app/data/saxs_computation/uv/9uvx/9uvx.fit
pddf	/app/data/pr_computation/uv/9uvx/9uvx.pr.out
profile	/app/data/saxs_computation/uv/9uvx/9uvx.dat

type	polypeptide(L)
strand_id	A
atom_count	2089